메뉴 건너뛰기




Volumn 54, Issue 2, 2001, Pages 59-70

Microglial interaction with β-amyloid: Implications for the pathogenesis of Alzheimer's disease

Author keywords

Alzheimer's Disease; Beta amyloid; Inflammation; Microglia; Neurotoxicity; NSAIDs; Receptors; Signal transduction

Indexed keywords

BACTERIOPHAGES; CELL MEMBRANES; CHEMICAL ACTIVATION; GENE EXPRESSION; GLYCOPROTEINS; MOLECULES; NEURODEGENERATIVE DISEASES; PATIENT TREATMENT; TOXICITY;

EID: 0035879373     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.1121     Document Type: Article
Times cited : (66)

References (143)
  • 1
    • 0023838532 scopus 로고
    • Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
    • Abraham CR, Selkoe DJ, Potter H. 1988. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell 52:487-501.
    • (1988) Cell , vol.52 , pp. 487-501
    • Abraham, C.R.1    Selkoe, D.J.2    Potter, H.3
  • 3
    • 0025162755 scopus 로고
    • Brain microglia constitutively express beta-2 integrins
    • Akiyama H, McGeer PL. 1990. Brain microglia constitutively express beta-2 integrins. J Neuroimmunol 30:81-93.
    • (1990) J Neuroimmunol , vol.30 , pp. 81-93
    • Akiyama, H.1    McGeer, P.L.2
  • 4
    • 0027219569 scopus 로고
    • Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders
    • Akiyama H, Kawamata T, Yamada T, Tooyama I, Ishii T, McGeer PL. 1993. Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders. Acta Neuropathol 85:628-634.
    • (1993) Acta Neuropathol , vol.85 , pp. 628-634
    • Akiyama, H.1    Kawamata, T.2    Yamada, T.3    Tooyama, I.4    Ishii, T.5    McGeer, P.L.6
  • 6
    • 0034008663 scopus 로고    scopus 로고
    • Engagement of the scavenger receptor is not responsible for beta-amyloid stimulation of monocytes to a neurocytopathic state
    • Antic A, Dzenko KA, Pachter JS. 2000. Engagement of the scavenger receptor is not responsible for beta-amyloid stimulation of monocytes to a neurocytopathic state. Exp Neurol 161:96-101.
    • (2000) Exp Neurol , vol.161 , pp. 96-101
    • Antic, A.1    Dzenko, K.A.2    Pachter, J.S.3
  • 7
    • 0026602079 scopus 로고
    • Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease
    • Araujo DM, Cotman CW. 1992. Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res 569:141-145.
    • (1992) Brain Res , vol.569 , pp. 141-145
    • Araujo, D.M.1    Cotman, C.W.2
  • 8
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: New discoveries and insights
    • Baldwin AS Jr. 1996. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649-683.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 12
    • 0026638409 scopus 로고
    • Inflammatory cytokines within the central nervous system: Sources, function, and mechanism of action
    • Benveniste EN. 1992. Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am J Physiol 263:C1-16.
    • (1992) Am J Physiol , vol.263
    • Benveniste, E.N.1
  • 15
    • 0032983334 scopus 로고    scopus 로고
    • Beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease
    • Bianca VD, Dusi S, Bianchini E, Dal Pra I, Rossi F. 1999. beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease. J Biol Chem 274:15493-15499.
    • (1999) J Biol Chem , vol.274 , pp. 15493-15499
    • Bianca, V.D.1    Dusi, S.2    Bianchini, E.3    Dal Pra, I.4    Rossi, F.5
  • 16
    • 0029998346 scopus 로고    scopus 로고
    • The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-beta peptide but not aggregated, cytotoxic amyloid-beta peptide
    • Boland K, Behrens M, Choi D, Manias K, Perlmutter DH. 1996. The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-beta peptide but not aggregated, cytotoxic amyloid-beta peptide. J Biol Chem 271:18032-18044.
    • (1996) J Biol Chem , vol.271 , pp. 18032-18044
    • Boland, K.1    Behrens, M.2    Choi, D.3    Manias, K.4    Perlmutter, D.H.5
  • 17
    • 0029347102 scopus 로고
    • Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin 1
    • Bornstein P. 1995. Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1. J Cell Biol 130:503-506.
    • (1995) J Cell Biol , vol.130 , pp. 503-506
    • Bornstein, P.1
  • 18
    • 0032479929 scopus 로고    scopus 로고
    • Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide
    • Bradt BM, Kolb WP, Cooper NR. 1998. Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide. J Exp Med 188:431-438.
    • (1998) J Exp Med , vol.188 , pp. 431-438
    • Bradt, B.M.1    Kolb, W.P.2    Cooper, N.R.3
  • 19
    • 0030000385 scopus 로고    scopus 로고
    • The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease
    • Breitner JC. 1996. The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease. Annu Rev Med 47:401-411.
    • (1996) Annu Rev Med , vol.47 , pp. 401-411
    • Breitner, J.C.1
  • 20
    • 0025666501 scopus 로고
    • Integrin-associated protein: A 50-kD plasma membrane antigen physically and functionally associated with integrins
    • Brown E, Hooper L, Ho T, Gresham H. 1990. Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins. J Cell Biol 111:2785-2794.
    • (1990) J Cell Biol , vol.111 , pp. 2785-2794
    • Brown, E.1    Hooper, L.2    Ho, T.3    Gresham, H.4
  • 24
    • 0034658555 scopus 로고    scopus 로고
    • Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells
    • Chen LM, Bailey D, Fernandez-Valle C. 2000. Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells. J Neurosci 20:3776-3784.
    • (2000) J Neurosci , vol.20 , pp. 3776-3784
    • Chen, L.M.1    Bailey, D.2    Fernandez-Valle, C.3
  • 25
    • 0030250758 scopus 로고    scopus 로고
    • Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: Complement activation and therapeutic approaches
    • Chen S, Frederickson RC, Brunden KR. 1996. Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: complement activation and therapeutic approaches. Neurobiol Aging 17: 781-787.
    • (1996) Neurobiol Aging , vol.17 , pp. 781-787
    • Chen, S.1    Frederickson, R.C.2    Brunden, K.R.3
  • 26
    • 0030039871 scopus 로고    scopus 로고
    • Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease
    • Christie RH, Freeman M, Hyman BT. 1996. Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease. Am J Pathol 148:399-403.
    • (1996) Am J Pathol , vol.148 , pp. 399-403
    • Christie, R.H.1    Freeman, M.2    Hyman, B.T.3
  • 27
    • 0037615532 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and phorbol 12-myristate 13-acetate differentially modulate cytotoxic effect of nitric oxide generated by serum deprivation in neuronal PC12 cells
    • Chung KC, Park JH, Kim CH, Ahn YS. 1999. Tumor necrosis factor-alpha and phorbol 12-myristate 13-acetate differentially modulate cytotoxic effect of nitric oxide generated by serum deprivation in neuronal PC12 cells. J Neurochem 72:1482-1488.
    • (1999) J Neurochem , vol.72 , pp. 1482-1488
    • Chung, K.C.1    Park, J.H.2    Kim, C.H.3    Ahn, Y.S.4
  • 28
    • 0028987936 scopus 로고
    • Integrins and signal transduction pathways: The road taken
    • Clark EA, Brugge JS. 1995. Integrins and signal transduction pathways: the road taken. Science 268:233-239.
    • (1995) Science , vol.268 , pp. 233-239
    • Clark, E.A.1    Brugge, J.S.2
  • 29
    • 0033080919 scopus 로고    scopus 로고
    • Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of β-amyloid and prion proteins
    • Combs CK, Johnson DJ, Cannady SB, Lehman TM, Landreth GE. 1999. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of β-amyloid and prion proteins. J Neurosci 19:928-939.
    • (1999) J Neurosci , vol.19 , pp. 928-939
    • Combs, C.K.1    Johnson, D.J.2    Cannady, S.B.3    Lehman, T.M.4    Landreth, G.E.5
  • 30
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: Inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
    • Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE. 2000. Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci 20:558-567.
    • (2000) J Neurosci , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 31
    • 0035866060 scopus 로고    scopus 로고
    • Beta-amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    • Combs CK, Karlo JC, Kao S-C, Landreth GE. 2001. Beta-amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci, 21:1179-1188.
    • (2001) J Neurosci , vol.21 , pp. 1179-1188
    • Combs, C.K.1    Karlo, J.C.2    Kao, S.-C.3    Landreth, G.E.4
  • 32
    • 0023899417 scopus 로고
    • Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis
    • Coria F, Castano E, Prelli F, Larrondo-Lillo M, van Duinen S, Shelanski ML, Frangione B. 1988. Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis. Lab Invest 58:454-458.
    • (1988) Lab Invest , vol.58 , pp. 454-458
    • Coria, F.1    Castano, E.2    Prelli, F.3    Larrondo-Lillo, M.4    Van Duinen, S.5    Shelanski, M.L.6    Frangione, B.7
  • 33
    • 0030066326 scopus 로고    scopus 로고
    • Activation-induced association of a 145kDa tyrosine phosphorylated protein with Shc and Syk in B-lymphocytes and macrophages
    • Crowley M, Harmer S, DeFranco A. 1996. Activation-induced association of a 145kDa tyrosine phosphorylated protein with Shc and Syk in B-lymphocytes and macrophages. J Biol Chem 271:1145-1152.
    • (1996) J Biol Chem , vol.271 , pp. 1145-1152
    • Crowley, M.1    Harmer, S.2    DeFranco, A.3
  • 34
    • 18544403201 scopus 로고    scopus 로고
    • A 70-kDa protein facilitates interleukin-4 signal transduction in the absence of the common gamma receptor chain
    • Dawson CH, Brown BL, Dobson PR. 1997. A 70-kDa protein facilitates interleukin-4 signal transduction in the absence of the common gamma receptor chain. Biochem Biophys Res Commun 233: 279-282.
    • (1997) Biochem Biophys Res Commun , vol.233 , pp. 279-282
    • Dawson, C.H.1    Brown, B.L.2    Dobson, P.R.3
  • 35
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
    • Delhase M, Hayakawa M, Chen Y, Karin M. 1999. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation [see comments]. Science 284:309-313.
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 36
    • 18144453796 scopus 로고    scopus 로고
    • Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease
    • DeWitt DA, Perry G, Cohen M, Doller C, Silver J. 1998. Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease. Exp Neurol 149:329-340.
    • (1998) Exp Neurol , vol.149 , pp. 329-340
    • DeWitt, D.A.1    Perry, G.2    Cohen, M.3    Doller, C.4    Silver, J.5
  • 37
    • 0033230204 scopus 로고    scopus 로고
    • Neuronal death in cytokine-activated primary human brain cell culture: Role of tumor necrosis factor-alpha
    • Downen M, Amaral TD, Hua LL, Zhao ML, Lee SC. 1999. Neuronal death in cytokine-activated primary human brain cell culture: role of tumor necrosis factor-alpha. Glia 28:114-127.
    • (1999) Glia , vol.28 , pp. 114-127
    • Downen, M.1    Amaral, T.D.2    Hua, L.L.3    Zhao, M.L.4    Lee, S.C.5
  • 38
    • 0031017154 scopus 로고    scopus 로고
    • C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease
    • Duong T, Nikolaeva M, Acton PJ. 1997. C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease. Brain Res 749:152-156.
    • (1997) Brain Res , vol.749 , pp. 152-156
    • Duong, T.1    Nikolaeva, M.2    Acton, P.J.3
  • 40
    • 0031444893 scopus 로고    scopus 로고
    • Inhibiting the formation of classical C3-convertase on the Alzheimer's beta-amyloid peptide
    • Emmerling MR, Spiegel K, Watson MD. 1997. Inhibiting the formation of classical C3-convertase on the Alzheimer's beta-amyloid peptide. Immunopharmacology 38:101-109.
    • (1997) Immunopharmacology , vol.38 , pp. 101-109
    • Emmerling, M.R.1    Spiegel, K.2    Watson, M.D.3
  • 43
    • 0034123963 scopus 로고    scopus 로고
    • Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma
    • Feng J, Han J, Pearce SF, Silverstein RL, Gotto AM Jr, Hajjar DP, Nicholson AC. 2000. Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. J Lipid Res 41:688-696.
    • (2000) J Lipid Res , vol.41 , pp. 688-696
    • Feng, J.1    Han, J.2    Pearce, S.F.3    Silverstein, R.L.4    Gotto Jr., A.M.5    Hajjar, D.P.6    Nicholson, A.C.7
  • 46
    • 0034650572 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the alpha4beta1 integrin to mitogen-activated protein kinase signalling
    • Finkelstein LD, Shimizu Y. 2000. Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the alpha4beta1 integrin to mitogen-activated protein kinase signalling. Biochem J 345 Pt 2:385-392.
    • (2000) Biochem J , vol.345 , Issue.2 PART , pp. 385-392
    • Finkelstein, L.D.1    Shimizu, Y.2
  • 49
    • 0025881467 scopus 로고
    • Alpha 2-macroglobulin synthesis in interleukin-6-stimulated human neuronal (SH-SY5Y neuroblastoma) cells. Potential significance for the processing of Alzheimer beta-amyloid precursor protein
    • Ganter U, Strauss S, Jonas U, Weidemann A, Beyreuther K, Volk B, Berger M, Bauer J. 1991. Alpha 2-macroglobulin synthesis in interleukin-6-stimulated human neuronal (SH-SY5Y neuroblastoma) cells. Potential significance for the processing of Alzheimer beta-amyloid precursor protein. FEBS Lett 282:127-131.
    • (1991) FEBS Lett , vol.282 , pp. 127-131
    • Ganter, U.1    Strauss, S.2    Jonas, U.3    Weidemann, A.4    Beyreuther, K.5    Volk, B.6    Berger, M.7    Bauer, J.8
  • 50
    • 0029862392 scopus 로고    scopus 로고
    • Thrombospondin modulates alpha v beta 3 function through integrin-associated protein
    • Gao AG, Lindberg FP, Dimitry JM, Brown EJ, Frazier WA. 1996a. Thrombospondin modulates alpha v beta 3 function through integrin-associated protein. J Cell Biol 135:533-544.
    • (1996) J Cell Biol , vol.135 , pp. 533-544
    • Gao, A.G.1    Lindberg, F.P.2    Dimitry, J.M.3    Brown, E.J.4    Frazier, W.A.5
  • 52
    • 0028239549 scopus 로고
    • Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells
    • Gazizadeh S, Bolen JB, Fleit HB. 1994. Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells. J Biol Chem 269:8878-8884.
    • (1994) J Biol Chem , vol.269 , pp. 8878-8884
    • Gazizadeh, S.1    Bolen, J.B.2    Fleit, H.B.3
  • 53
    • 0027082156 scopus 로고
    • A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion
    • Ghiso J, Rostagno A, Gardella JE, Liem L, Gorevic PD, Frangione B. 1992. A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion. Biochem J 288:1053-1059.
    • (1992) Biochem J , vol.288 , pp. 1053-1059
    • Ghiso, J.1    Rostagno, A.2    Gardella, J.E.3    Liem, L.4    Gorevic, P.D.5    Frangione, B.6
  • 55
    • 0009627006 scopus 로고
    • Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
    • Goldstein JL, Ho YK, Basu SK, Brown MS. 1979. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci U S A 76:333-337.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 333-337
    • Goldstein, J.L.1    Ho, Y.K.2    Basu, S.K.3    Brown, M.S.4
  • 56
    • 0026601404 scopus 로고
    • Alpha 1-antitrypsin and alpha 1-antichymotrypsin are in the lesions of Alzheimer's disease
    • Gollin PA, Kalaria RN, Eikelenboom P, Rozemuller A, Perry G. 1992. Alpha 1-antitrypsin and alpha 1-antichymotrypsin are in the lesions of Alzheimer's disease. Neuroreport 3:201-203.
    • (1992) Neuroreport , vol.3 , pp. 201-203
    • Gollin, P.A.1    Kalaria, R.N.2    Eikelenboom, P.3    Rozemuller, A.4    Perry, G.5
  • 57
    • 0029902166 scopus 로고    scopus 로고
    • Evidence of neuronal oxidative damage in Alzheimer's disease
    • Good PF, Werner P, Hsu A, Olanow CW, Perl DP. 1996. Evidence of neuronal oxidative damage in Alzheimer's disease. Am J Pathol 149:21-28.
    • (1996) Am J Pathol , vol.149 , pp. 21-28
    • Good, P.F.1    Werner, P.2    Hsu, A.3    Olanow, C.W.4    Perl, D.P.5
  • 59
    • 0027468515 scopus 로고
    • Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells
    • Haga S, Ikeda K, Sato M, Ishii T. 1993. Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells. Brain Res 601:88-94.
    • (1993) Brain Res , vol.601 , pp. 88-94
    • Haga, S.1    Ikeda, K.2    Sato, M.3    Ishii, T.4
  • 60
    • 0033968252 scopus 로고    scopus 로고
    • Transforming growth factor-betal (TGF-beta1) and TGF-beta2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma
    • Han J, Hajjar DP, Tauras JM, Feng J, Gotto AM Jr, Nicholson AC. 2000, Transforming growth factor-betal (TGF-beta1) and TGF-beta2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma. J Biol Chem 275: 1241-1246.
    • (2000) J Biol Chem , vol.275 , pp. 1241-1246
    • Han, J.1    Hajjar, D.P.2    Tauras, J.M.3    Feng, J.4    Gotto Jr., A.M.5    Nicholson, A.C.6
  • 61
    • 0022539353 scopus 로고
    • Stimulation of the scavenger receptor on monocytes-macrophages evokes release of arachidonic acid metabolites and reduced oxygen species
    • Hartung HP, Kladetzky RG, Melnik B, Hennerici M. 1986. Stimulation of the scavenger receptor on monocytes-macrophages evokes release of arachidonic acid metabolites and reduced oxygen species. Lab Invest 55:209-216.
    • (1986) Lab Invest , vol.55 , pp. 209-216
    • Hartung, H.P.1    Kladetzky, R.G.2    Melnik, B.3    Hennerici, M.4
  • 62
    • 2642605346 scopus 로고    scopus 로고
    • Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide
    • Heneka MT, Loschmann PA, Gleichmann M, Weller M, Schulz JB, Wullner U, Klockgether T. 1998. Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide. J Neurochem 71:88-94.
    • (1998) J Neurochem , vol.71 , pp. 88-94
    • Heneka, M.T.1    Loschmann, P.A.2    Gleichmann, M.3    Weller, M.4    Schulz, J.B.5    Wullner, U.6    Klockgether, T.7
  • 63
    • 0034666289 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo
    • Heneka MT, Klockgether T, Feinstein DL. 2000. Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. J Neurosci 20:6862-6867.
    • (2000) J Neurosci , vol.20 , pp. 6862-6867
    • Heneka, M.T.1    Klockgether, T.2    Feinstein, D.L.3
  • 64
    • 0031028141 scopus 로고    scopus 로고
    • Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
    • Heyser CJ, Masliah E, Samimi A, Campbell IL, Gold LH. 1997. Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc Natl Acad Sci USA 94:1500-1505.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1500-1505
    • Heyser, C.J.1    Masliah, E.2    Samimi, A.3    Campbell, I.L.4    Gold, L.H.5
  • 66
    • 0032732224 scopus 로고    scopus 로고
    • Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors
    • Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L. 1999. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am J Pathol 155:1741-1747.
    • (1999) Am J Pathol , vol.155 , pp. 1741-1747
    • Huang, F.1    Buttini, M.2    Wyss-Coray, T.3    McConlogue, L.4    Kodama, T.5    Pitas, R.E.6    Mucke, L.7
  • 69
    • 0030988629 scopus 로고    scopus 로고
    • Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease
    • Ishizuka K, Kimura T, Igata-yi R, Katsuragi S, Takamatsu J, Miyakawa T. 1997. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin Neurosci 51:135-138.
    • (1997) Psychiatry Clin Neurosci , vol.51 , pp. 135-138
    • Ishizuka, K.1    Kimura, T.2    Igata-yi, R.3    Katsuragi, S.4    Takamatsu, J.5    Miyakawa, T.6
  • 70
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
    • Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D. 1989. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J. Neuroimmunol 24:173-182.
    • (1989) J. Neuroimmunol , vol.24 , pp. 173-182
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.5
  • 71
    • 0027938567 scopus 로고
    • Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: Immunohistochemical study using formic acid pretreatment of tissue sections
    • Iwamoto N, Nishiyama E, Ohwada J, Arai H. 1994. Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections. Neurosci Lett 177:23-26.
    • (1994) Neurosci Lett , vol.177 , pp. 23-26
    • Iwamoto, N.1    Nishiyama, E.2    Ohwada, J.3    Arai, H.4
  • 72
    • 0032077890 scopus 로고    scopus 로고
    • Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures
    • Jeohn GH, Kong LY, Wilson B, Hudson P, Hong JS. 1998. Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures. J Neuroimmunol 85:1-10.
    • (1998) J Neuroimmunol , vol.85 , pp. 1-10
    • Jeohn, G.H.1    Kong, L.Y.2    Wilson, B.3    Hudson, P.4    Hong, J.S.5
  • 73
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C, Ting AT, Seed B. 1998. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 74
    • 0028178458 scopus 로고
    • Beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain
    • Jiang H, Burdick D, Glabe CG, Cotman CW, Tenner AJ. 1994. beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol 152:5050-5059.
    • (1994) J Immunol , vol.152 , pp. 5050-5059
    • Jiang, H.1    Burdick, D.2    Glabe, C.G.3    Cotman, C.W.4    Tenner, A.J.5
  • 75
    • 0033534716 scopus 로고    scopus 로고
    • Integrin-associated protein is a ligand for the P84 neural adhesion molecule
    • Jiang P, Lagenaur CF, Narayanan V. 1999. Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem 274:559-562.
    • (1999) J Biol Chem , vol.274 , pp. 559-562
    • Jiang, P.1    Lagenaur, C.F.2    Narayanan, V.3
  • 76
    • 0032904130 scopus 로고    scopus 로고
    • Microglia and Alzheimer's Disease
    • Kalaria RN. 1999. Microglia and Alzheimer's Disease. Curr Opin Hematol 6:15-24.
    • (1999) Curr Opin Hematol , vol.6 , pp. 15-24
    • Kalaria, R.N.1
  • 77
    • 0030795049 scopus 로고    scopus 로고
    • Beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate
    • Klegeris A, McGeer PL. 1997. beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate. J Neurosci Res 49:229-235.
    • (1997) J Neurosci Res , vol.49 , pp. 229-235
    • Klegeris, A.1    McGeer, P.L.2
  • 79
    • 0031056029 scopus 로고    scopus 로고
    • Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha
    • Klegeris A, Walker DG, McGeer PL. 1997. Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha. Brain Res 747:114-121.
    • (1997) Brain Res , vol.747 , pp. 114-121
    • Klegeris, A.1    Walker, D.G.2    McGeer, P.L.3
  • 80
    • 0028173897 scopus 로고
    • Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP)
    • Krieger M, Herz J. 1994. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem 63:601-637.
    • (1994) Annu Rev Biochem , vol.63 , pp. 601-637
    • Krieger, M.1    Herz, J.2
  • 81
    • 0027298505 scopus 로고
    • Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta
    • Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW. 1993. Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J Immunol 150: 2659-2667.
    • (1993) J Immunol , vol.150 , pp. 2659-2667
    • Lee, S.C.1    Liu, W.2    Dickson, D.W.3    Brosnan, C.F.4    Berman, J.W.5
  • 82
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA. 1997. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272:3406-3410.
    • (1997) J Biol Chem , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 85
    • 0029005762 scopus 로고
    • Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase
    • Lin TH, Rosales C, Mondal K, Bolen JB, Haskill S, Juliano RL. 1995. Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase. J Biol Chem 270:16189-16197.
    • (1995) J Biol Chem , vol.270 , pp. 16189-16197
    • Lin, T.H.1    Rosales, C.2    Mondal, K.3    Bolen, J.B.4    Haskill, S.5    Juliano, R.L.6
  • 86
    • 0027443140 scopus 로고
    • Molecular cloning of integrin-associated protein: An immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding
    • Lindberg FP, Gresham HD, Schwarz E, Brown EJ. 1993. Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. J Cell Biol 123:485-496.
    • (1993) J Cell Biol , vol.123 , pp. 485-496
    • Lindberg, F.P.1    Gresham, H.D.2    Schwarz, E.3    Brown, E.J.4
  • 88
    • 0030153520 scopus 로고    scopus 로고
    • Beta-Amyloid induces increased release of interleukin-1 beta from lipopolysaccharide-activated human monocytes
    • Lorton D, Kocsis JM, King L, Madden K, Brunden KR. 1996. beta-Amyloid induces increased release of interleukin-1 beta from lipopolysaccharide-activated human monocytes. J Neuroimmunol 67: 21-29.
    • (1996) J Neuroimmunol , vol.67 , pp. 21-29
    • Lorton, D.1    Kocsis, J.M.2    King, L.3    Madden, K.4    Brunden, K.R.5
  • 89
    • 0031900411 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
    • Mackenzie IR, Munoz DG. 1998. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology 50: 986-990.
    • (1998) Neurology , vol.50 , pp. 986-990
    • Mackenzie, I.R.1    Munoz, D.G.2
  • 90
    • 0028901016 scopus 로고
    • Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fcγ receptors
    • Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC. 1995. Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fcγ receptors. J Biol Chem 270:9115-9120.
    • (1995) J Biol Chem , vol.270 , pp. 9115-9120
    • Marcilla, A.1    Rivero-Lezcano, O.M.2    Agarwal, A.3    Robbins, K.C.4
  • 92
    • 0031596988 scopus 로고    scopus 로고
    • The alpha5beta1 integrin mediates elimination of amyloid-beta peptide and protects against apoptosis
    • Matter ML, Zhang Z, Nordstedt C, Ruoslahti E. 1998. The alpha5beta1 integrin mediates elimination of amyloid-beta peptide and protects against apoptosis. J Cell Biol 141:1019-1030.
    • (1998) J Cell Biol , vol.141 , pp. 1019-1030
    • Matter, M.L.1    Zhang, Z.2    Nordstedt, C.3    Ruoslahti, E.4
  • 94
    • 0030961544 scopus 로고    scopus 로고
    • Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia
    • McDonald DR, Brunden KR, Landreth GE. 1997. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J Neurosci 17:2284-2294.
    • (1997) J Neurosci , vol.17 , pp. 2284-2294
    • McDonald, D.R.1    Brunden, K.R.2    Landreth, G.E.3
  • 95
    • 0032526423 scopus 로고    scopus 로고
    • β-amyloid fibril activate parallel mitogen-activated protein kinase pathways in microglia and THP-1 monocytes
    • McDonald D, Bamberger M, Combs C, Landreth G. 1998. β-amyloid fibril activate parallel mitogen-activated protein kinase pathways in microglia and THP-1 monocytes. J Neurosci 18:4451-4460.
    • (1998) J Neurosci , vol.18 , pp. 4451-4460
    • McDonald, D.1    Bamberger, M.2    Combs, C.3    Landreth, G.4
  • 96
    • 0030948463 scopus 로고    scopus 로고
    • VLA-4 integrin cross-linking on human monocytic THP-1 cells induces tissue factor expression by a mechanism involving mitogen-activated protein kinase
    • McGilvray ID, Lu Z, Bitar R, Dackiw APB, Davreux CJ, Rotstein OD. 1997. VLA-4 integrin cross-linking on human monocytic THP-1 cells induces tissue factor expression by a mechanism involving mitogen-activated protein kinase. J Biol Chem 272:10287-10294.
    • (1997) J Biol Chem , vol.272 , pp. 10287-10294
    • McGilvray, I.D.1    Lu, Z.2    Bitar, R.3    Dackiw, A.P.B.4    Davreux, C.J.5    Rotstein, O.D.6
  • 98
    • 0030210955 scopus 로고    scopus 로고
    • Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells
    • Meda L, Bernasconi S, Bonaiuto C, Sozzani S, Zhou D, Otvos L Jr, Mantovani A, Rossi F, Cassatella MA. 1996. Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells. J Immunol 157:1213-1218.
    • (1996) J Immunol , vol.157 , pp. 1213-1218
    • Meda, L.1    Bernasconi, S.2    Bonaiuto, C.3    Sozzani, S.4    Zhou, D.5    Otvos Jr., L.6    Mantovani, A.7    Rossi, F.8    Cassatella, M.A.9
  • 99
    • 0032891880 scopus 로고    scopus 로고
    • Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35]
    • Meda L, Baron P, Prat E, Scarpini E, Scarlato G, Cassatella MA, Rossi F. 1999. Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35]. J Neuroimmunol 93:45-52.
    • (1999) J Neuroimmunol , vol.93 , pp. 45-52
    • Meda, L.1    Baron, P.2    Prat, E.3    Scarpini, E.4    Scarlato, G.5    Cassatella, M.A.6    Rossi, F.7
  • 100
    • 0034237388 scopus 로고    scopus 로고
    • Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with alzheimer pathology
    • Mehlhorn G, Hollborn M, Schliebs R. 2000. Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with alzheimer pathology. Int J Dev Neurosci 18:423-431.
    • (2000) Int J Dev Neurosci , vol.18 , pp. 423-431
    • Mehlhorn, G.1    Hollborn, M.2    Schliebs, R.3
  • 101
    • 0032479979 scopus 로고    scopus 로고
    • A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration
    • Meng F, Lowell CA. 1998. A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. Embo J 17:4391-4403.
    • (1998) Embo J , vol.17 , pp. 4391-4403
    • Meng, F.1    Lowell, C.A.2
  • 102
    • 0034677162 scopus 로고    scopus 로고
    • Expression of a synapse-associated membrane protein, P84/ SHPS-1, and its ligand, IAP/CD47, in mouse retina
    • Mi ZP, Jiang P, Weng WL, Lindberg FP, Narayanan V, Lagenaur CF. 2000. Expression of a synapse-associated membrane protein, P84/ SHPS-1, and its ligand, IAP/CD47, in mouse retina. J Comp Neurol 416:335-344.
    • (2000) J Comp Neurol , vol.416 , pp. 335-344
    • Mi, Z.P.1    Jiang, P.2    Weng, W.L.3    Lindberg, F.P.4    Narayanan, V.5    Lagenaur, C.F.6
  • 104
    • 3542996239 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells
    • Murphy GM Jr, Yang L, Cordell B. 1998. Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells. J Biol Chem 273:20967-20971.
    • (1998) J Biol Chem , vol.273 , pp. 20967-20971
    • Murphy Jr., G.M.1    Yang, L.2    Cordell, B.3
  • 105
    • 0031821321 scopus 로고    scopus 로고
    • Indomethacin reverses the microglial response to amyloid beta-protein
    • Netland EE, Newton JL, Majocha RE, Tate BA. 1998. Indomethacin reverses the microglial response to amyloid beta-protein. Neurobiol Aging 19:201-204.
    • (1998) Neurobiol Aging , vol.19 , pp. 201-204
    • Netland, E.E.1    Newton, J.L.2    Majocha, R.E.3    Tate, B.A.4
  • 107
    • 0031589217 scopus 로고    scopus 로고
    • TNF-alpha mediates inducible nitric oxide synthase expression in human neuroblastoma cell line by cisplatin
    • Ogura T, Tatemichi M, Esumi H. 1997. TNF-alpha mediates inducible nitric oxide synthase expression in human neuroblastoma cell line by cisplatin. Biochem Biophys Res Commun 233:788-791.
    • (1997) Biochem Biophys Res Commun , vol.233 , pp. 788-791
    • Ogura, T.1    Tatemichi, M.2    Esumi, H.3
  • 108
    • 0030248270 scopus 로고    scopus 로고
    • Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
    • Paresce DM, Ghosh RN, Maxfield FR. 1996. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron 17:553-565.
    • (1996) Neuron , vol.17 , pp. 553-565
    • Paresce, D.M.1    Ghosh, R.N.2    Maxfield, F.R.3
  • 109
    • 0032551633 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain
    • Pasinetti GM, Aisen PS. 1998. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience 87:319-324.
    • (1998) Neuroscience , vol.87 , pp. 319-324
    • Pasinetti, G.M.1    Aisen, P.S.2
  • 110
    • 0027331779 scopus 로고
    • Identification of Fc gamma RI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease
    • Peress NS, Fleit HB, Perillo E, Kuljis R, Pezzullo C. 1993. Identification of Fc gamma RI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease. J Neuroimmunol 48:71-79.
    • (1993) J Neuroimmunol , vol.48 , pp. 71-79
    • Peress, N.S.1    Fleit, H.B.2    Perillo, E.3    Kuljis, R.4    Pezzullo, C.5
  • 111
    • 0025095717 scopus 로고
    • Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease
    • Perlmutter LS, Barron E, Chui HC. 1990. Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neurosci Lett 119:32-36.
    • (1990) Neurosci Lett , vol.119 , pp. 32-36
    • Perlmutter, L.S.1    Barron, E.2    Chui, H.C.3
  • 112
    • 0033451738 scopus 로고    scopus 로고
    • TNF-induced signaling in apoptosis
    • Rath PC, Aggarwal BB. 1999. TNF-induced signaling in apoptosis. J Clin Immunol 19:350-364.
    • (1999) J Clin Immunol , vol.19 , pp. 350-364
    • Rath, P.C.1    Aggarwal, B.B.2
  • 114
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK 1998. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 117
    • 0030583248 scopus 로고    scopus 로고
    • Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes
    • Rossi F, Bianchini E. 1996. Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes. Biochem Biophys Res Commun 225:474-478.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 474-478
    • Rossi, F.1    Bianchini, E.2
  • 118
    • 0030989545 scopus 로고    scopus 로고
    • 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
    • Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA. 1997. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem 68: 2092-2097.
    • (1997) J Neurochem , vol.68 , pp. 2092-2097
    • Sayre, L.M.1    Zelasko, D.A.2    Harris, P.L.3    Perry, G.4    Salomon, R.G.5    Smith, M.A.6
  • 119
    • 0032590201 scopus 로고    scopus 로고
    • The betaA4 amyloid peptide complexes to and enhances the uptake of beta- Very low density lipoproteins by the low density lipoprotein receptor-related protein and heparan sulfate proteoglycans pathway
    • Scharnagl H, Tisljar U, Winkler K, Huttinger M, Nauck MA, Gross W, Wieland H, Ohm TG, Marz W. 1999. The betaA4 amyloid peptide complexes to and enhances the uptake of beta- very low density lipoproteins by the low density lipoprotein receptor-related protein and heparan sulfate proteoglycans pathway. Lab Invest 79:1271-1286.
    • (1999) Lab Invest , vol.79 , pp. 1271-1286
    • Scharnagl, H.1    Tisljar, U.2    Winkler, K.3    Huttinger, M.4    Nauck, M.A.5    Gross, W.6    Wieland, H.7    Ohm, T.G.8    Marz, W.9
  • 121
    • 0025092159 scopus 로고
    • Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor
    • Selmaj KW, Farooq M, Norton WT, Raine CS, Brosnan CF. 1990. Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J Immunol 144:129-135.
    • (1990) J Immunol , vol.144 , pp. 129-135
    • Selmaj, K.W.1    Farooq, M.2    Norton, W.T.3    Raine, C.S.4    Brosnan, C.F.5
  • 123
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • Stewart WF, Kawas C, Corrada M, Metter EJ. 1997. Risk of Alzheimer's disease and duration of NSAID use. Neurology 48:626-632.
    • (1997) Neurology , vol.48 , pp. 626-632
    • Stewart, W.F.1    Kawas, C.2    Corrada, M.3    Metter, E.J.4
  • 124
    • 0026553710 scopus 로고
    • Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients
    • Strauss S, Bauer J, Ganter U, Jonas U, Berger M, Volk B. 1992. Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients. Lab Invest 66:223-230.
    • (1992) Lab Invest , vol.66 , pp. 223-230
    • Strauss, S.1    Bauer, J.2    Ganter, U.3    Jonas, U.4    Berger, M.5    Volk, B.6
  • 125
  • 127
    • 0034667558 scopus 로고    scopus 로고
    • CD45 opposes beta -amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase
    • Tan J, Town T, Mori T, Wu Y, Saxe M, Crawford F, Mullan M. 2000. CD45 opposes beta -amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase. J Neurosci 20:7587-7594.
    • (2000) J Neurosci , vol.20 , pp. 7587-7594
    • Tan, J.1    Town, T.2    Mori, T.3    Wu, Y.4    Saxe, M.5    Crawford, F.6    Mullan, M.7
  • 128
    • 0032868874 scopus 로고    scopus 로고
    • Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia
    • Tarkowski E, Blennow K, Wallin A, Tarkowski A. 1999. Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia. J Clin Immunol 19:223-230.
    • (1999) J Clin Immunol , vol.19 , pp. 223-230
    • Tarkowski, E.1    Blennow, K.2    Wallin, A.3    Tarkowski, A.4
  • 129
    • 0026722679 scopus 로고
    • Interleukin 1 and tumor necrosis factor-alpha stimulate the production of colony-stimulating factor 1 by murine astrocytes
    • Thery C, Stanley ER, Mallat M. 1992. Interleukin 1 and tumor necrosis factor-alpha stimulate the production of colony-stimulating factor 1 by murine astrocytes. J Neurochem 59:1183-1186.
    • (1992) J Neurochem , vol.59 , pp. 1183-1186
    • Thery, C.1    Stanley, E.R.2    Mallat, M.3
  • 130
    • 0029971210 scopus 로고    scopus 로고
    • Amyloid beta protein primes cultured rat microglial cells for an enhanced phorbol 12-myristate 13-acetate-induced respiratory burst activity
    • Van Muiswinkel FL, Veerhuis R, Eikelenboom P. 1996. Amyloid beta protein primes cultured rat microglial cells for an enhanced phorbol 12-myristate 13-acetate-induced respiratory burst activity. J Neurochem 66:2468-2476.
    • (1996) J Neurochem , vol.66 , pp. 2468-2476
    • Van Muiswinkel, F.L.1    Veerhuis, R.2    Eikelenboom, P.3
  • 131
    • 0033118464 scopus 로고    scopus 로고
    • The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages
    • Van Muiswinkel FL, Raupp SF, de Vos NM, Smits HA, Verhoef J, Eikelenboom P, Nottet HS. 1999. The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages. J Neuroimmunol 96:121-130.
    • (1999) J Neuroimmunol , vol.96 , pp. 121-130
    • Van Muiswinkel, F.L.1    Raupp, S.F.2    De Vos, N.M.3    Smits, H.A.4    Verhoef, J.5    Eikelenboom, P.6    Nottet, H.S.7
  • 132
    • 0033578426 scopus 로고    scopus 로고
    • A new mechanism of neurodegeneration: A proinflammatory cytokine inhibits receptor signaling by a survival peptide
    • Venters HD, Tang Q, Liu Q, VanHoy RW, Dantzer R, Kelley KW. 1999. A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide. Proc Natl Acad Sci U S A 96:9879-9884.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 9879-9884
    • Venters, H.D.1    Tang, Q.2    Liu, Q.3    Vanhoy, R.W.4    Dantzer, R.5    Kelley, K.W.6
  • 133
    • 0032103358 scopus 로고    scopus 로고
    • Glia increase degeneration of hippocampal neurons through release of tumor necrosis factor-alpha
    • Viviani B, Corsini E, Galli CL, Marinovich M. 1998. Glia increase degeneration of hippocampal neurons through release of tumor necrosis factor-alpha. Toxicol Appl Pharmacol 150:271-276.
    • (1998) Toxicol Appl Pharmacol , vol.150 , pp. 271-276
    • Viviani, B.1    Corsini, E.2    Galli, C.L.3    Marinovich, M.4
  • 134
    • 0031947966 scopus 로고    scopus 로고
    • The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells
    • Wang XQ, Frazier WA. 1998. The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells. Mol Biol Cell 9:865-874.
    • (1998) Mol Biol Cell , vol.9 , pp. 865-874
    • Wang, X.Q.1    Frazier, W.A.2
  • 135
    • 0031467313 scopus 로고    scopus 로고
    • Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red
    • Watson DJ, Lander AD, Selkoe DJ. 1997. Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red. J Biol Chem 272: 31617-31624.
    • (1997) J Biol Chem , vol.272 , pp. 31617-31624
    • Watson, D.J.1    Lander, A.D.2    Selkoe, D.J.3
  • 136
    • 0030978135 scopus 로고    scopus 로고
    • Charge-based binding of complement component C1q to the Alzheimer amyloid beta-peptide
    • Webster S, Bonnell B, Rogers J. 1997. Charge-based binding of complement component C1q to the Alzheimer amyloid beta-peptide. Am J Pathol 150:1531-1536.
    • (1997) Am J Pathol , vol.150 , pp. 1531-1536
    • Webster, S.1    Bonnell, B.2    Rogers, J.3
  • 137
    • 0032521111 scopus 로고    scopus 로고
    • Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo
    • Weldon DT, Rogers SD, Ghilardi JR, Finke MP, Cleary JP, O'Hare E, Esler WP, Maggio JE, Mantyh PW. 1998. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J Neurosci 18:2161-2173.
    • (1998) J Neurosci , vol.18 , pp. 2161-2173
    • Weldon, D.T.1    Rogers, S.D.2    Ghilardi, J.R.3    Finke, M.P.4    Cleary, J.P.5    O'Hare, E.6    Esler, W.P.7    Maggio, J.E.8    Mantyh, P.W.9
  • 138
    • 0026018693 scopus 로고
    • Tyrosine phosphorylation systems in Alzheimer's disease pathology
    • Wood JG, Zinsmeister P. 1991. Tyrosine phosphorylation systems in Alzheimer's disease pathology. Neurosci Lett 121:12-16.
    • (1991) Neurosci Lett , vol.121 , pp. 12-16
    • Wood, J.G.1    Zinsmeister, P.2
  • 139
    • 0030951449 scopus 로고    scopus 로고
    • Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease
    • Xia M, Qin S, McNamara M, Mackay C, Hyman BT. 1997. Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease. Am J Pathol 150:1267-1274.
    • (1997) Am J Pathol , vol.150 , pp. 1267-1274
    • Xia, M.1    Qin, S.2    McNamara, M.3    Mackay, C.4    Hyman, B.T.5
  • 140
    • 0031848322 scopus 로고    scopus 로고
    • Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains
    • Xia MQ, Qin SX, Wu LJ, Mackay CR, Hyman BT. 1998. Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am J Pathol 153:31-37.
    • (1998) Am J Pathol , vol.153 , pp. 31-37
    • Xia, M.Q.1    Qin, S.X.2    Wu, L.J.3    Mackay, C.R.4    Hyman, B.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.