Glial activation in Alzheimer's disease: The role of Aβ and its associated proteins

Neurobiology of Aging

Volumn 22, Issue 6, 2001, Pages 885-893

  Meda, Lucia ^a   Baron, Pierluigi ^a   Scarlato, Guglielmo ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

A ; ACT; Alzheimer's disease; ApoE; Astrocytes; Chemokines; Cytokines; Free radicals; Microglia; Senile plaques

Indexed keywords

AMYLOID BETA PROTEIN; CHEMOKINE; CYTOKINE; FREE RADICAL; PROTEIN;

ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; BRAIN; CELL ACTIVATION; DISEASE ASSOCIATION; DISEASE COURSE; GLIA CELL; HUMAN; IN VITRO STUDY; INFLAMMATION; MEDIATOR; MICROGLIA; NERVE DEGENERATION; NEURITIS; NEUROPATHOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SENILE PLAQUE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; HUMANS; MACROPHAGE ACTIVATION; NEUROGLIA;

EID: 0035690720     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(01)00307-4     Document Type: Article

References (98)

1. Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
2. Amyloid-β-peptide stimulates nitric oxide production in astrocytes through an NFKb-dependent mechanism
3. β-amyloid stimulation of inducible nitric oxide synthase in astrocytes is IL-1β -, and TNF-dependent, and involves TNFα receptor-associated factor, and NFKb-inducing kinase-dependent signaling mechanism
4. Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice
5. β-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease
6. Cytotoxicity of microglia
7. TNFs alpha, and beta protect neurons against amyloid beta-peptide toxicity: Evidence for involvement of a kappa B-binding factor, and attenuation of peroxide, and Ca+ accumulation
8. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
9. Inflammatory cytokines within the central nervous system: Sources, function and mechanisms of action
10. Synaptic signaling by nitric oxide
11. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid precursor protein
12. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
13. Transforming growth factor beta in Alzheimer's disease
14. Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism
15. Glutamate receptors and the induction of excitotoxic neuronal death
16. Microglia contribution to oxidative stress in Alzheimer's disease
17. β-amyloid stimulation of microglia, and monocytes results in TNFα-dependent expression of inducible nitric oxide synthase, and neuronal apoptosis
18. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
19. IL-1 receptors in the brain, and endocrine tissue
20. Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1
21. β-amyloid activates the O2 forming NADPH oxidase in microglia, monocytes and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease
22. Inflammatory mechanisms in Alzheimer's disease
23. Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
24. α1-antichymotrypsin regulates Alzheimer's β-amyloid peptide fibril formation
25. Apolipoprotein E is a kinetic but not thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis, and treatment of Alzheimer's disease
26. Elevated circulating TNF levels in Alzheimer's disease
27. Transforming growth factor-betas in neurodegenerative disease
28. α1-antichymotrypsin binding to Alzheimer Aβ peptides is sequence specific, and induces fibril disaggregation in vitro
29. Glutamate, nitric oxide, and cell-cell signalling in the nervous system
30. Amyloid-β peptide potentiates cytokine secretion by IL-1β-activated human astrocytoma cells
31. The HHQK domain of β-amyloid provides a structural basis for the immunopathology of Alzheimer's disease
32. Alzheimer's disease: Initial report of the purification, and characterization of a novel cerebrovascular amyloid protein
33. Evidence of neuronal oxidative damage in Alzheimer's disease
34. Microglia release of nitric oxide by the synergistic action of β-amyloid and IFN-γ
35. IL-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution
36. Glial-neuronal interactions in Alzheimer's disease: The potential role of a cytokine cycle in disease progression
37. Production and function of monocyte-chemoattractant protein-1 and other β-chemokines in murine glial cells
38. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation
39. Amyloid-β peptide activates cultured astocytes: Morphological alterations, cytokine induction, and nitric oxide release
40. Glial-derived proteins activate cultured astrocytes and enhance β amyloid-induced glial activation
41. Occurrence of IL-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques
42. A specific structural interaction of Alzheimer's peptide Aβ 1-42 with α1-antichymotrypsin
43. Alzheimer's peptide Aβ1-42 binds to two β-sheet of α1-antichymotrypsin, and transforms it from inhibitor to substrate
44. A central role for astrocytes in the inflammatory response to β-amyloid: Chemokines, cytokines, and reactive oxygen species are produced
45. Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: Reversal by inhibition of the inducible NO synthase
46. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease
47. ApoE4-associated Alzheimer's disease risk is modified by α1-antichymotrypsin polymorphism
48. Activation of macrophages by Alzheimer's β amyloid peptide
49. Apolipoprotein E suppresses glial cell secretion of TNFα
50. Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production
51. Say NO to Alzheimer's disease: The putative links between nitric oxide, and dementia of the Alzheimer's type
52. IL-10, IL-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines, and nitric oxide in co-cultures of rat astroglial, and microglial cells
53. Induction of nitric oxide synthase activity in human astrocytes by IL-1 beta and interferon-gamma
54. Apolipoprotein E gene mapping, and expression: Localization of the structural gene to human chromosome 19, and expression of ApoE mRNA in lipoprotein-, and non-lipoprotein-producing tissues
55. Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
56. Chemokines-chemotactic cytokines that mediate inflammation
57. Amyloid-associated protein α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β protein into filaments
58. β-amyloid (25-35) induces the production of IL-8 from human monocytes
59. Activation of microglial cells by β-amyloid protein and IFNγ
60. β-amyloid (25-35) peptide, and IFNγ synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes, and microglial cells
61. Priming of monocyte respiratory burst by β-amyloid fragment (25-35)
62. Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with β-amyloid (25-35)
63. Production of IL-10 by mouse glial cells in culture
64. Transforming growth factor beta mediates increase of mature transmembrane amyloid precursor protein in microglial cells
65. IL-1, and the immunogenetics of Alzheimer's disease
66. Apolipoprotein E immunoreactivity in cerebral amyloid deposits, and neurofibrillary tangles in Alzheimer's disease, and kuru plaque amyloid in Creutzfeldt-Jakob disease
67. Inflammation and Alzheimer's disease
68. Astrocytes in Alzheimer's disease gray matter express α1-antichymotrypsin mRNA
69. Differential production of and migratory response to beta chemokines by human microglia and astrocytes
70. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
71. The human astrocytoma cell line U373MG produces monocyte chemotactic protein (MCP)-1 upon stimulation with β-amyloid protein
72. Synergistic induction of nitric oxide by β-amyloid and cytokines in astrocytes
73. Cytokines and the nervous system II. Actions and mechanisms of action
74. TNF alpha induces IL-6 production by astrocytes but not microglia
75. Expression of the IL-6 receptor complex (IL-6RC) in human rapid autopsy tissue
76. Beta-amyloid peptide induces TNFα and nitric oxide production in murine macrophages cultures
77. Human brain S100 beta and S100 beta mRNA expression increase with age: Pathogenetic implications for Alzheimer's disease
78. Widespread peroxynitrite-mediated damage in Alzheimer's disease
79. Apolipoprotein E: High-avidity binding to β-amyloid, and increased frequency of type 4 allele in late-onset familial Alzheimer's disease
80. Binding of human apolipoprotein E to synthetic amyloid β peptide: Isoform-specific effects and implication for late-onset Alzheimer's disease
81. Intracerebral production of TNF-α a local neuroprotective agent, in Alzheimer's disease and vascular dementia
82. Amyloid β-protein primes cultured rat microglial cells for an enhanced phorbol 12-myristate 13-acetate-induced respiratory burst activity
83. The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages
84. Is amyloidogenesis during Alzheimer's disease due to an IL-1/IL-6 mediated "acute phase" response in the brain?
85. Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies
86. Modulation of nitric oxide production in human macrophages by apolipoprotein E and amyloid-β peptide
87. Nitric oxide synthase in reactive astrocytes adjacent to β-amyloid plaques
88. Apolipoprotein E: Structure-function relationship
89. Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro
90. Seeding of Aβ fibril formation is inhibited by all three isotypes of apolipoprotein E
91. Chronic overproduction of tranforming growth factor-beta by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice
92. IL-8 receptor B immunoreactivity in brain, and neuritic plaques of Alzheimer's disease
93. Chemokines/chemokine receptors in the central nervous system, and Alzheimer's disease
94. RAGE, and amyloid-β peptide neurotoxicity in Alzheimer's disease
95. Neurotrophic and neurotoxic effects of amyloid- β protein: Reversal by tachykinin neuropeptides
96. Chemotaxis by a central nervous system macrophage, the microglia
97. IL-6 is elevated in Alzhemer's disease brain