β-adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia

Brain Research

Volumn 899, Issue 1-2, 2001, Pages 264-270

  Prinz, Marco ^a,b   Häusler, Karl Georg ^a   Kettenmann, Helmut ^a   Hanisch, Uwe Karsten ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b Institute of Neuropathology   (Switzerland)

Author keywords

2 Adrenoreceptor; Chemokines; Cytokines; Kv1.3; Margatoxin; Salbutamol

Indexed keywords

BETA ADRENERGIC RECEPTOR; CYCLIC AMP; FORSKOLIN; INTERLEUKIN 12; INTERLEUKIN 6; ISOPRENALINE; ISOPROTEIN; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; OXPRENOLOL; POTASSIUM CHANNEL; PROCATEROL; SALBUTAMOL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BRAIN; CELL ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DIMERIZATION; DRUG EFFECT; DRUG INHIBITION; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

ADRENERGIC BETA-AGONISTS; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; RECEPTORS, ADRENERGIC, BETA;

EID: 0035957814     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02174-6     Document Type: Article

References (25)

1. IL-12 production by central nervous system microglia is inhibited by astrocytes
2. Compartmentalization of lipopolysaccharide production correlates with clinical presentation in meningococcal disease
3. Inhibition of microglial superoxide anion production by isoproterenol and dexamethasone
4. Astrocytes and microglia produce interleukin12p40
5. Production of natural killer cell stimulatory factor (interleukin-12) by peripheral blood mononuclear cells
6. + channels in mouse brain microglia: Cells acquire responsiveness to pneumococcal cell wall components during late development
7. 2-adrenergic receptor
8. Characterization of ameboid microglia isolated from developing mammalian brain
9. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor alpha
10. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
11. Cytotoxic lymphocyte maturation factor (interleukin-12) is a synergistic growth factor for hematopoietic stem cells
12. Local production of the p40 subunit of interleukin-12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection
13. Identification and purification of natural killer cell stimulating factor (NKSF): A cytokine with multiple biologic effects on human lymphocytes
14. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
15. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
16. Endotoxin concentrations in cerebrospinal fluid correlate with clinical severity and neurologic outcome of Haemophilus influenzae type B meningitis
17. + outward current in cultured rat microglia
18. Microglial activation by components of Gram-positive and -negative bacteria: Distinct and common routes to the induction of ion channels and cytokines
19. Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia
20. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
21. Production of interleukin-12 and expression of its receptors by murine microglia
22. Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation
23. Interleukin-12: A potential link between nerve cells and the immune response in inflammatory disorders
24. Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12
25. Interleukin-12 at the site of disease in tuberculosis