메뉴 건너뛰기




Volumn 79, Issue 3, 1997, Pages 799-818

Neurotoxic consequences of central long-term administration of interleukin-2 in rats

Author keywords

Cytokines; Glia; IL 3; Neural immune; Neuroendocrine

Indexed keywords

CELL ADHESION MOLECULE; CORTICOSTERONE; CORTICOTROPIN; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; FIBRONECTIN; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; RECOMBINANT INTERLEUKIN 2;

EID: 0030844836     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00040-7     Document Type: Article
Times cited : (50)

References (130)
  • 2
    • 0026594436 scopus 로고
    • Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin-2 in islet beta cells
    • Allison J., Malcolm L., Chosich N., Miller J. F. Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin-2 in islet beta cells. Eur. J. Immunol. 22:1992;1115-1121.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1115-1121
    • Allison, J.1    Malcolm, L.2    Chosich, N.3    Miller, J.F.4
  • 4
    • 0024582321 scopus 로고
    • Toxicity of human recombinant interleukin-2 in rats. Pathologic changes are characterized by marked lymphocytic and eosinophilic proliferation and multisystem involvement
    • Anderson T. D., Hayes T. J. Toxicity of human recombinant interleukin-2 in rats. Pathologic changes are characterized by marked lymphocytic and eosinophilic proliferation and multisystem involvement. Lab. Invest. 60:1989;331-346.
    • (1989) Lab. Invest. , vol.60 , pp. 331-346
    • Anderson, T.D.1    Hayes, T.J.2
  • 5
    • 0027345589 scopus 로고
    • Comparative toxicity and pathology associated with administration of recombinant IL-2 to animals
    • Anderson T. D., Hayes T. J., Powers G. D., Gately M. K., Tudor R., Rushton A. Comparative toxicity and pathology associated with administration of recombinant IL-2 to animals. Int. Rev. exp. Path. 34(A):1993;57-77.
    • (1993) Int. Rev. Exp. Path. , vol.34 , Issue.A , pp. 57-77
    • Anderson, T.D.1    Hayes, T.J.2    Powers, G.D.3    Gately, M.K.4    Tudor, R.5    Rushton, A.6
  • 6
    • 0002608108 scopus 로고
    • Contrasting effects of specific lymphokines on the survival of hippocampal neurons in culture
    • Araujo D. M. Contrasting effects of specific lymphokines on the survival of hippocampal neurons in culture. Adv. behav. Biol. 40:1992;113-122.
    • (1992) Adv. Behav. Biol. , vol.40 , pp. 113-122
    • Araujo, D.M.1
  • 7
    • 0028141540 scopus 로고
    • Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: Selective effects on specific interleukins and interleukin receptors
    • Araujo D. M., Lapchak P. A. Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors. Neuroscience. 61:1994;745-754.
    • (1994) Neuroscience , vol.61 , pp. 745-754
    • Araujo, D.M.1    Lapchak, P.A.2
  • 8
    • 0024439539 scopus 로고
    • Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: Interaction with the cholinergic system
    • Araujo D. M., Lapchak P. A., Collier B., Quirion R. Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system. Brain Res. 498:1989;257-266.
    • (1989) Brain Res. , vol.498 , pp. 257-266
    • Araujo, D.M.1    Lapchak, P.A.2    Collier, B.3    Quirion, R.4
  • 9
    • 0027388940 scopus 로고
    • Interleukin involvement in anterior pituitary cell growth regulation: Effects of IL-2 and IL-6
    • Arzt E., Buric R., Stelzer G., Stalla J., Sauer J., Renner U., Stalla G. K. Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6. Endocrinology. 132:1993;459-467.
    • (1993) Endocrinology , vol.132 , pp. 459-467
    • Arzt, E.1    Buric, R.2    Stelzer, G.3    Stalla, J.4    Sauer, J.5    Renner, U.6    Stalla, G.K.7
  • 10
    • 0029003781 scopus 로고
    • Cholinergic markers in aged cognitively impaired Long-Evans rats
    • Aubert I., Rowe W., Meaney M. J., Gauthier S., Quirion R. Cholinergic markers in aged cognitively impaired Long-Evans rats. Neuroscience. 67:1995;277-292.
    • (1995) Neuroscience , vol.67 , pp. 277-292
    • Aubert, I.1    Rowe, W.2    Meaney, M.J.3    Gauthier, S.4    Quirion, R.5
  • 11
    • 0027180945 scopus 로고
    • Interleukin-2 as a neurotrophic factor for supporting the survival of neurons cultured from various regions of fetal rat brain
    • Awatsuji H., Furukawa Y., Nakajima M., Furukawa S., Hayashi K. Interleukin-2 as a neurotrophic factor for supporting the survival of neurons cultured from various regions of fetal rat brain. J. Neurosci. Res. 35:1993;305-311.
    • (1993) J. Neurosci. Res. , vol.35 , pp. 305-311
    • Awatsuji, H.1    Furukawa, Y.2    Nakajima, M.3    Furukawa, S.4    Hayashi, K.5
  • 12
    • 0028012270 scopus 로고
    • Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines
    • Balasingam V., Tejada Berges T., Wright E., Bouckova R., Yong V. W. Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J. Neurosci. 14:1994;846-856.
    • (1994) J. Neurosci. , vol.14 , pp. 846-856
    • Balasingam, V.1    Tejada Berges, T.2    Wright, E.3    Bouckova, R.4    Yong, V.W.5
  • 14
    • 0026680318 scopus 로고
    • The interleukins-1 alpha, -1 beta, and -2 do not acutely disrupt the murine blood-brain barrier
    • Banks W. A., Kastin A. J. The interleukins-1 alpha, -1 beta, and -2 do not acutely disrupt the murine blood-brain barrier. Int. J. Immunopharmac. 14:1992;629-636.
    • (1992) Int. J. Immunopharmac. , vol.14 , pp. 629-636
    • Banks, W.A.1    Kastin, A.J.2
  • 15
    • 0022446998 scopus 로고
    • Stimulation of oligodendroglial proliferation and maturation by interleukin-2
    • Benveniste E. N., Merrill J. E. Stimulation of oligodendroglial proliferation and maturation by interleukin-2. Nature. 321:1986;610-613.
    • (1986) Nature , vol.321 , pp. 610-613
    • Benveniste, E.N.1    Merrill, J.E.2
  • 17
    • 0030043899 scopus 로고    scopus 로고
    • Immune-neuro-endocrine interactions: Facts and hypotheses
    • Besedovsky H. O., del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 17:1996;64-102.
    • (1996) Endocr. Rev. , vol.17 , pp. 64-102
    • Besedovsky, H.O.1    Del Rey, A.2
  • 18
    • 0027180457 scopus 로고
    • Interleukin-2 enhances scopolamine-induced amnesia and hyperactivity in the mouse
    • Bianchi M., Panerai A. E. Interleukin-2 enhances scopolamine-induced amnesia and hyperactivity in the mouse. NeuroReport. 4:1993;1046-1048.
    • (1993) NeuroReport , vol.4 , pp. 1046-1048
    • Bianchi, M.1    Panerai, A.E.2
  • 19
    • 0023741188 scopus 로고
    • Interleukin 2 modifies the bioelectric activity of some neurosecretory nuclei in the rat hypothalamus
    • Bindoni M., Perciavalle V., Beretta S., Belluardo N., Diamantstein T. Interleukin 2 modifies the bioelectric activity of some neurosecretory nuclei in the rat hypothalamus. Brain Res. 462:1988;10-14.
    • (1988) Brain Res. , vol.462 , pp. 10-14
    • Bindoni, M.1    Perciavalle, V.2    Beretta, S.3    Belluardo, N.4    Diamantstein, T.5
  • 20
    • 0028858985 scopus 로고
    • Enduring effects of chronic corticosterone treatment on spatial learning,synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats
    • Bodnoff S. R., Humphreys A. G., Lehman J. C., Diamond D. M., Rose G. M., Meaney M. J. Enduring effects of chronic corticosterone treatment on spatial learning,synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats. J. Neurosci. 15:1995;61-69.
    • (1995) J. Neurosci. , vol.15 , pp. 61-69
    • Bodnoff, S.R.1    Humphreys, A.G.2    Lehman, J.C.3    Diamond, D.M.4    Rose, G.M.5    Meaney, M.J.6
  • 21
    • 0028108663 scopus 로고
    • Loco-regional immunotherapy with recombinant interleukin-2 and adherent lymphokine-activated killer cells (A-LAK) in recurrent glioblastoma patients
    • Boiardi A., Silvani A., Ruffini P. A., Rivoltini L., Parmiani G., Broggi G., Salmaggi A. Loco-regional immunotherapy with recombinant interleukin-2 and adherent lymphokine-activated killer cells (A-LAK) in recurrent glioblastoma patients. Cancer Immunol. Immunother. 39:1994;193-197.
    • (1994) Cancer Immunol. Immunother. , vol.39 , pp. 193-197
    • Boiardi, A.1    Silvani, A.2    Ruffini, P.A.3    Rivoltini, L.4    Parmiani, G.5    Broggi, G.6    Salmaggi, A.7
  • 22
    • 0027301435 scopus 로고
    • Characterization of normal brain-reactive antibodies in glioma cyst fluids
    • Brunet J. M., Berger F., Gustin T., Laine M., Benabid A. L. Characterization of normal brain-reactive antibodies in glioma cyst fluids. J. Neuroimmunol. 47:1993;63-72.
    • (1993) J. Neuroimmunol. , vol.47 , pp. 63-72
    • Brunet, J.M.1    Berger, F.2    Gustin, T.3    Laine, M.4    Benabid, A.L.5
  • 23
    • 0026675193 scopus 로고
    • Interleukin-2 induces corticotropin-releasing hormone release from superfused rat hypothalami: Influence of glucocorticoids
    • Cambronero J. C., Rivas F. J., Borrell J., Guaza C. Interleukin-2 induces corticotropin-releasing hormone release from superfused rat hypothalami: influence of glucocorticoids. Endocrinology. 131:1992;677-683.
    • (1992) Endocrinology , vol.131 , pp. 677-683
    • Cambronero, J.C.1    Rivas, F.J.2    Borrell, J.3    Guaza, C.4
  • 24
    • 0027191341 scopus 로고
    • Neuropsychological and neurophysiological assessment of the central effects of interleukin-2 administration
    • Caraceni A., Martini C., Belli F., Mascheroni L., Rivoltini L., Arienti F., Cascinelli N. Neuropsychological and neurophysiological assessment of the central effects of interleukin-2 administration. Eur. J. Cancer. 29A:1993;1266-1269.
    • (1993) Eur. J. Cancer , vol.29 , pp. 1266-1269
    • Caraceni, A.1    Martini, C.2    Belli, F.3    Mascheroni, L.4    Rivoltini, L.5    Arienti, F.6    Cascinelli, N.7
  • 26
    • 0028821242 scopus 로고
    • Complete recovery of mice from a pre-established tumor by direct intratumoral delivery of an adenovirus vector harboring the murine IL-2 gene
    • Cordier L., Duffour M. -T., Sabourin J. -C., Lee M. G., Cabannes J., Ragot T., Perricaudet M., Haddada H. Complete recovery of mice from a pre-established tumor by direct intratumoral delivery of an adenovirus vector harboring the murine IL-2 gene. Gene Ther. 2:1995;16-21.
    • (1995) Gene Ther. , vol.2 , pp. 16-21
    • Cordier, L.1    Duffour M., -T.2    Sabourin J., -C.3    Lee, M.G.4    Cabannes, J.5    Ragot, T.6    Perricaudet, M.7    Haddada, H.8
  • 27
    • 0028386641 scopus 로고
    • A role of IL-2 in gene therapy
    • Dalgleish A. G. A role of IL-2 in gene therapy. Gene Ther. 1:1994;83-87.
    • (1994) Gene Ther. , vol.1 , pp. 83-87
    • Dalgleish, A.G.1
  • 28
    • 0028260210 scopus 로고
    • Cellular forms and functions of brain microglia
    • Davis E. J., Foster T. D., Thomas W. E. Cellular forms and functions of brain microglia. Brain Res. Bull. 34:1994;73-78.
    • (1994) Brain Res. Bull. , vol.34 , pp. 73-78
    • Davis, E.J.1    Foster, T.D.2    Thomas, W.E.3
  • 29
    • 0026181979 scopus 로고
    • Effects of pertussis toxin, dibutyryl-cyclic-AMP, bromo-cyclic-AMP and forskolin on the behavioural and electrocortical power spectrum changes induced by microinfusion of interleukin-2 into the locus coeruleus
    • De Sarro G., Nistico G. Effects of pertussis toxin, dibutyryl-cyclic-AMP, bromo-cyclic-AMP and forskolin on the behavioural and electrocortical power spectrum changes induced by microinfusion of interleukin-2 into the locus coeruleus. Int. J. Neurosci. 59:1991;67-79.
    • (1991) Int. J. Neurosci. , vol.59 , pp. 67-79
    • De Sarro, G.1    Nistico, G.2
  • 31
    • 0023915311 scopus 로고
    • An anatomical study of cholinergic innervation in rat cerebral cortex
    • Eckenstein F. P., Baughman R. W., Quinn J. An anatomical study of cholinergic innervation in rat cerebral cortex. Neuroscience. 25:1988;457-474.
    • (1988) Neuroscience , vol.25 , pp. 457-474
    • Eckenstein, F.P.1    Baughman, R.W.2    Quinn, J.3
  • 32
    • 0027314268 scopus 로고
    • Molecular profile of reactive astrocytes - implications for their role in neurologic disease
    • Eddleston M., Mucke L. Molecular profile of reactive astrocytes - implications for their role in neurologic disease. Neuroscience. 54:1993;15-36.
    • (1993) Neuroscience , vol.54 , pp. 15-36
    • Eddleston, M.1    Mucke, L.2
  • 33
    • 0027218283 scopus 로고
    • A transglutaminase that converts interleukin-2 into a factor cytotoxic to oligodendrocytes
    • Eitan S., Schwartz M. A transglutaminase that converts interleukin-2 into a factor cytotoxic to oligodendrocytes. Science. 261:1993;106-108.
    • (1993) Science , vol.261 , pp. 106-108
    • Eitan, S.1    Schwartz, M.2
  • 34
    • 0028455060 scopus 로고
    • Recovery of visual response of injured adult rat optic nerves treated with transglutaminase
    • Eitan S., Solomon A., Lavie V., Yoles E., Hirschberg D. L., Belkin M., Schwartz M. Recovery of visual response of injured adult rat optic nerves treated with transglutaminase. Science. 264:1994;1764-1768.
    • (1994) Science , vol.264 , pp. 1764-1768
    • Eitan, S.1    Solomon, A.2    Lavie, V.3    Yoles, E.4    Hirschberg, D.L.5    Belkin, M.6    Schwartz, M.7
  • 35
    • 0026724971 scopus 로고
    • Identification of an interleukin 2-like substance as a factor cytotoxic to oligodendrocytes and associated with central nervous system regeneration
    • Eitan S., Zisling R., Cohen A., Belkin M., Hirschberg D. L., Lotan M., Schwartz M. Identification of an interleukin 2-like substance as a factor cytotoxic to oligodendrocytes and associated with central nervous system regeneration. Proc. natn. Acad. Sci. U.S.A. 89:1992;5442-5446.
    • (1992) Proc. Natn. Acad. Sci. U.S.A. , vol.89 , pp. 5442-5446
    • Eitan, S.1    Zisling, R.2    Cohen, A.3    Belkin, M.4    Hirschberg, D.L.5    Lotan, M.6    Schwartz, M.7
  • 37
    • 0028961890 scopus 로고
    • Interleukin-2 transcripts in human and rodent brains: Possible expression by astrocytes
    • Eizenberg O., Faber-Elman A., Lotan M., Schwartz M. Interleukin-2 transcripts in human and rodent brains: Possible expression by astrocytes. J. Neurochem. 64:1995;1928-1936.
    • (1995) J. Neurochem. , vol.64 , pp. 1928-1936
    • Eizenberg, O.1    Faber-Elman, A.2    Lotan, M.3    Schwartz, M.4
  • 38
    • 0025864518 scopus 로고
    • Appearance of cytokine-associated central nervous system myelin damage coincides temporally with serum tumor necrosis factor induction after recombinant interleukin-2 infusion in rats
    • Ellison M. D., Merchant R. E. Appearance of cytokine-associated central nervous system myelin damage coincides temporally with serum tumor necrosis factor induction after recombinant interleukin-2 infusion in rats. J. Neuroimmunol. 33:1991;245-251.
    • (1991) J. Neuroimmunol. , vol.33 , pp. 245-251
    • Ellison, M.D.1    Merchant, R.E.2
  • 39
    • 0028264855 scopus 로고
    • Neurologic complications of cytokine therapy
    • Forman A. D. Neurologic complications of cytokine therapy. Oncology (Williston Park). 8:1994;105-110.
    • (1994) Oncology (Williston Park) , vol.8 , pp. 105-110
    • Forman, A.D.1
  • 41
    • 0028233178 scopus 로고
    • Autoimmunity as a complication of interleukin 2 immunotherapy
    • Gaspari A. A. Autoimmunity as a complication of interleukin 2 immunotherapy. Archs Dermatol. 130:1994;894-898.
    • (1994) Archs Dermatol. , vol.130 , pp. 894-898
    • Gaspari, A.A.1
  • 42
    • 0025267491 scopus 로고
    • Cortical projection patterns of the medial septum-diagonal band comlex
    • Gaykema R. P. A., Luiten P. M., Nyakas C., Traber J. Cortical projection patterns of the medial septum-diagonal band comlex. J. comp. Neurol. 293:1990;103-124.
    • (1990) J. Comp. Neurol. , vol.293 , pp. 103-124
    • Gaykema, R.P.A.1    Luiten, P.M.2    Nyakas, C.3    Traber, J.4
  • 43
  • 44
    • 0027343618 scopus 로고
    • Reactive glia as rivals in regulating neuronal survival
    • Giulian D. Reactive glia as rivals in regulating neuronal survival. Glia. 7:1993;102-110.
    • (1993) Glia , vol.7 , pp. 102-110
    • Giulian, D.1
  • 45
    • 0028596581 scopus 로고
    • The impact of microglia-derived cytokines upon gliosis in the CNS
    • Giulian D., Li J., Li X., George J., Rutecki P.A. The impact of microglia-derived cytokines upon gliosis in the CNS. Devl Neurosci. 16:1994;128-136.
    • (1994) Devl Neurosci. , vol.16 , pp. 128-136
    • Giulian, D.1    Li, J.2    Li, X.3    George, J.4    Rutecki, P.A.5
  • 46
    • 0023772364 scopus 로고
    • Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization
    • Giulian D., Woodward J., Young D. G., Krebs J. F., Lachman L. B. Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. J. Neurosci. 8:1988;2485-2490.
    • (1988) J. Neurosci. , vol.8 , pp. 2485-2490
    • Giulian, D.1    Woodward, J.2    Young, D.G.3    Krebs, J.F.4    Lachman, L.B.5
  • 49
  • 50
    • 0029550589 scopus 로고    scopus 로고
    • Interleukin-2 as a neuroregulatory cytokine
    • Hanisch U.-K., Quirion R. Interleukin-2 as a neuroregulatory cytokine. Brain Res. Rev. 21:1996;246-284.
    • (1996) Brain Res. Rev. , vol.21 , pp. 246-284
    • Hanisch, U.-K.1    Quirion, R.2
  • 51
    • 0026802137 scopus 로고
    • Muscarinic cholinergic receptor binding in rat hindlimb somatosensory cortex following partial deafferentation by sciatic nerve transection
    • Hanisch U.-K., Rothe T., Krohn K., Dykes R. W. Muscarinic cholinergic receptor binding in rat hindlimb somatosensory cortex following partial deafferentation by sciatic nerve transection. Neurochem. Int. 21:1992;313-327.
    • (1992) Neurochem. Int. , vol.21 , pp. 313-327
    • Hanisch, U.-K.1    Rothe, T.2    Krohn, K.3    Dykes, R.W.4
  • 52
    • 0028116162 scopus 로고
    • Hypothalamic-pituitary-adrenal activity during chronic central administration of interleukin-2
    • Hanisch U.-K., Rowe W., Sharma S., Meaney M. J., Quirion R. Hypothalamic-pituitary-adrenal activity during chronic central administration of interleukin-2. Endocrinology. 135:1994;2465-2472.
    • (1994) Endocrinology , vol.135 , pp. 2465-2472
    • Hanisch, U.-K.1    Rowe, W.2    Sharma, S.3    Meaney, M.J.4    Quirion, R.5
  • 53
    • 0030454373 scopus 로고    scopus 로고
    • Phasic hyperactivity of the HPA axis resulting from chronic central IL-2 administration
    • Hanisch U.-K., Rowe W., van Rossum D., Meaney M.J., Quirion R. Phasic hyperactivity of the HPA axis resulting from chronic central IL-2 administration. NeuroReport. 7:1996;2883-2888.
    • (1996) NeuroReport , vol.7 , pp. 2883-2888
    • Hanisch, U.-K.1    Rowe, W.2    Van Rossum, D.3    Meaney, M.J.4    Quirion, R.5
  • 54
    • 0027249566 scopus 로고
    • Modulation of hippocampal acetylcholine release: A potent central action of interleukin-2
    • Hanisch U.-K., Seto D., Quirion R. Modulation of hippocampal acetylcholine release: a potent central action of interleukin-2. J. Neurosci. 13:1993;3368-3374.
    • (1993) J. Neurosci. , vol.13 , pp. 3368-3374
    • Hanisch, U.-K.1    Seto, D.2    Quirion, R.3
  • 56
    • 0028818154 scopus 로고
    • Local modulation of hippocampal acetylcholine release by dopamine D1 receptors: A combined receptor autoradiography and in vivo dialysis study
    • Hersi A. I., Richard J. W., Gaudreau P., Quirion R. Local modulation of hippocampal acetylcholine release by dopamine D1 receptors: a combined receptor autoradiography and in vivo dialysis study. J. Neurosci. 15:1995;7150-7157.
    • (1995) J. Neurosci. , vol.15 , pp. 7150-7157
    • Hersi, A.I.1    Richard, J.W.2    Gaudreau, P.3    Quirion, R.4
  • 57
    • 0028283224 scopus 로고
    • Interleukin-2 stimulates the secretion of arginine vasopressin but not corticotropin-releasing hormone from rat hypothalamic cells in vitro
    • Hillhouse E. W. Interleukin-2 stimulates the secretion of arginine vasopressin but not corticotropin-releasing hormone from rat hypothalamic cells in vitro. Brain Res. 650:1994;323-325.
    • (1994) Brain Res. , vol.650 , pp. 323-325
    • Hillhouse, E.W.1
  • 58
    • 0028800715 scopus 로고
    • Cytokines and the nervous system I: Expression and recognition
    • Hopkins S. J., Rothwell N. J. Cytokines and the nervous system I: expression and recognition. Trends Neurosci. 18:1995;83-88.
    • (1995) Trends Neurosci. , vol.18 , pp. 83-88
    • Hopkins, S.J.1    Rothwell, N.J.2
  • 59
    • 0028199942 scopus 로고
    • Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage
    • Huberman M., Shalit F., Roth Deri I., Gutman B., Brodie C., Kott E., Sredni B. Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage. J. Neuroimmunol. 52:1994;147-152.
    • (1994) J. Neuroimmunol. , vol.52 , pp. 147-152
    • Huberman, M.1    Shalit, F.2    Roth Deri, I.3    Gutman, B.4    Brodie, C.5    Kott, E.6    Sredni, B.7
  • 60
    • 0025500122 scopus 로고
    • Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats
    • Issa A. M., Rowe W., Gauthier S., Meaney M. J. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats. J. Neurosci. 10:1990;3247-3254.
    • (1990) J. Neurosci. , vol.10 , pp. 3247-3254
    • Issa, A.M.1    Rowe, W.2    Gauthier, S.3    Meaney, M.J.4
  • 62
    • 0027438260 scopus 로고
    • Circulating autoantibody to mature neurons and astrocytes of humans and some mammals present in a demented patient with autoimmune disorder
    • Kaneko K., Seki K., Ishida K., Uchihara T., Kanda T., Inuzuka T., Miyatake T. Circulating autoantibody to mature neurons and astrocytes of humans and some mammals present in a demented patient with autoimmune disorder. Eur. Neurol. 33:1993;450-453.
    • (1993) Eur. Neurol. , vol.33 , pp. 450-453
    • Kaneko, K.1    Seki, K.2    Ishida, K.3    Uchihara, T.4    Kanda, T.5    Inuzuka, T.6    Miyatake, T.7
  • 63
    • 0027456714 scopus 로고
    • Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami
    • Karanth S., Krzysztof L., McCann S. M. Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami. Proc. natn. Acad. Sci. U.S.A. 90:1993;3383-3387.
    • (1993) Proc. Natn. Acad. Sci. U.S.A. , vol.90 , pp. 3383-3387
    • Karanth, S.1    Krzysztof, L.2    McCann, S.M.3
  • 64
    • 0025756334 scopus 로고
    • Anterior pituitary hormone control by interleukin 2
    • Karanth S., McCann S. M. Anterior pituitary hormone control by interleukin 2. Proc. natn. Acad. Sci. U.S.A. 88:1991;2961-2965.
    • (1991) Proc. Natn. Acad. Sci. U.S.A. , vol.88 , pp. 2961-2965
    • Karanth, S.1    McCann, S.M.2
  • 65
    • 0026017110 scopus 로고
    • The immunolocalisation of the neuroendocrine specific protein PGP9.5 during neurogenesis in the rat
    • Kent C., Clarke P. J. The immunolocalisation of the neuroendocrine specific protein PGP9.5 during neurogenesis in the rat. Devl Brain Res. 58:1991;147-150.
    • (1991) Devl Brain Res. , vol.58 , pp. 147-150
    • Kent, C.1    Clarke, P.J.2
  • 66
    • 0027190418 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of production of multiple lymphokines by in vivo administration of dexamethasone
    • Kunicka J. E., Talle M. A., Denhardt G. H., Brown M., Prince L. A., Goldstein G. Immunosuppression by glucocorticoids: inhibition of production of multiple lymphokines by in vivo administration of dexamethasone. Cell Immunol. 149:1993;39-49.
    • (1993) Cell Immunol. , vol.149 , pp. 39-49
    • Kunicka, J.E.1    Talle, M.A.2    Denhardt, G.H.3    Brown, M.4    Prince, L.A.5    Goldstein, G.6
  • 67
    • 0026504683 scopus 로고
    • A role for interleukin-2 in the regulation of striatal dopaminergic function
    • Lapchak P. A. A role for interleukin-2 in the regulation of striatal dopaminergic function. NeuroReport. 3:1992;165-168.
    • (1992) NeuroReport , vol.3 , pp. 165-168
    • Lapchak, P.A.1
  • 68
    • 0025769432 scopus 로고
    • Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain
    • Lapchak P. A., Araujo D. M., Quirion R., Beaudet A. Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain. Neuroscience. 44:1991;173-184.
    • (1991) Neuroscience , vol.44 , pp. 173-184
    • Lapchak, P.A.1    Araujo, D.M.2    Quirion, R.3    Beaudet, A.4
  • 74
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer P. L., McGeer E. G. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Rev. 21:1995;195-218.
    • (1995) Brain Res. Rev. , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 76
    • 0027278981 scopus 로고
    • Delayed neurotoxicity of intraventricular interleukin-2: A case report
    • Meyers C. A., Yung W. K. Delayed neurotoxicity of intraventricular interleukin-2: a case report. J. Neurooncol. 15:1993;265-267.
    • (1993) J. Neurooncol. , vol.15 , pp. 265-267
    • Meyers, C.A.1    Yung, W.K.2
  • 77
    • 0028309371 scopus 로고
    • Administration of high-dose recombinant interleukin 2 after autologous bone marrow transplantation in patients with neuroblastoma: Toxicity, efficacy and survival. A Lyon-Marseille-Curie-East of France Group Study
    • Michon J., Negrier S., Coze C., Mathiot C., Frappaz D., Oskam R., Pacquement H., Quintana E., Bouffet E., Bernard J. L.et al. Administration of high-dose recombinant interleukin 2 after autologous bone marrow transplantation in patients with neuroblastoma: toxicity, efficacy and survival. A Lyon-Marseille-Curie-East of France Group Study. Prog. clin. Biol. Res. 385:1994;293-300.
    • (1994) Prog. Clin. Biol. Res. , vol.385 , pp. 293-300
    • Michon, J.1    Negrier, S.2    Coze, C.3    Mathiot, C.4    Frappaz, D.5    Oskam, R.6    Pacquement, H.7    Quintana, E.8    Bouffet, E.9    Bernard, J.L.10
  • 78
    • 0027367945 scopus 로고
    • Astrocytes in infectious and immune-mediated diseases of the central nervous system
    • Mucke L., Eddleston M. Astrocytes in infectious and immune-mediated diseases of the central nervous system. Fedn Am. Soc. exp. Biol. J. 7:1993;1226-1232.
    • (1993) Fedn Am. Soc. Exp. Biol. J. , vol.7 , pp. 1226-1232
    • Mucke, L.1    Eddleston, M.2
  • 79
    • 0026713997 scopus 로고
    • Effect of chronic treatment with recombinant interleukin-2 on the central nervous system of adult and old mice
    • Nemni R., Iannaccone S., Quattrini A., Smirne S., Sessa M., Lodi M., Erminio C., Canal N. Effect of chronic treatment with recombinant interleukin-2 on the central nervous system of adult and old mice. Brain Res. 591:1992;248-252.
    • (1992) Brain Res. , vol.591 , pp. 248-252
    • Nemni, R.1    Iannaccone, S.2    Quattrini, A.3    Smirne, S.4    Sessa, M.5    Lodi, M.6    Erminio, C.7    Canal, N.8
  • 80
    • 0023193783 scopus 로고
    • Interleukin-2-like activity in injured rat brain
    • Nieto Sampedro M., Chandy K. G. Interleukin-2-like activity in injured rat brain. Neurochem.Res. 12:1987;723-727.
    • (1987) Neurochem.Res. , vol.12 , pp. 723-727
    • Nieto Sampedro, M.1    Chandy, K.G.2
  • 81
    • 0026393431 scopus 로고
    • Behavioral and electrocortical spectrum power effects after microinfusion of lymphokines in several areas of the rat brain
    • Nistico G., De Sarro G. Behavioral and electrocortical spectrum power effects after microinfusion of lymphokines in several areas of the rat brain. Ann. N. Y. Acad. Sci. 621:1991;119-134.
    • (1991) Ann. N. Y. Acad. Sci. , vol.621 , pp. 119-134
    • Nistico, G.1    De Sarro, G.2
  • 82
    • 0028449389 scopus 로고
    • Cytokine receptors on glial cells
    • Otero G. C., Merrill J. E. Cytokine receptors on glial cells. Glia. 11:1994;117-128.
    • (1994) Glia , vol.11 , pp. 117-128
    • Otero, G.C.1    Merrill, J.E.2
  • 83
    • 0028813289 scopus 로고
    • Molecular cloning of IL-2a, IL-2b, and IL-2R gamma cDNAs from a human oligodendroglioma cell line: Presence of IL-2R mRNAs in the human central nervous system
    • Otero G. C., Merrill J. E. Molecular cloning of IL-2a, IL-2b, and IL-2R gamma cDNAs from a human oligodendroglioma cell line: presence of IL-2R mRNAs in the human central nervous system. Glia. 14:1995;295-302.
    • (1995) Glia , vol.14 , pp. 295-302
    • Otero, G.C.1    Merrill, J.E.2
  • 84
    • 0029036943 scopus 로고
    • Interleukin 2 suppresses afferent sensory transmission in the primary somatosensory cortex
    • Park H. J., Won C. K., Pyun K. H., Shin H. C. Interleukin 2 suppresses afferent sensory transmission in the primary somatosensory cortex. NeuroReport. 6:1995;1018-1020.
    • (1995) NeuroReport , vol.6 , pp. 1018-1020
    • Park, H.J.1    Won, C.K.2    Pyun, K.H.3    Shin, H.C.4
  • 86
    • 0028321580 scopus 로고
    • Molecular cloning of a partial cDNA of the interleukin-2 receptor-b in normal mouse brain: In situ localization in the hippocampus and expression by neuroblastoma cells
    • Petitto J. M., Huang Z. Molecular cloning of a partial cDNA of the interleukin-2 receptor-b in normal mouse brain: In situ localization in the hippocampus and expression by neuroblastoma cells. Brain Res. 650:1994;140-145.
    • (1994) Brain Res. , vol.650 , pp. 140-145
    • Petitto, J.M.1    Huang, Z.2
  • 87
    • 0027251406 scopus 로고
    • Interleukin-2 modulates calcium currents in dissociated hippocampal CA1 neurons
    • Plata Salaman C. R., ffrench Mullen J. M. Interleukin-2 modulates calcium currents in dissociated hippocampal CA1 neurons. NeuroReport. 4:1993;579-581.
    • (1993) NeuroReport , vol.4 , pp. 579-581
    • Plata Salaman, C.R.1    Ffrench Mullen, J.M.2
  • 88
    • 0028210854 scopus 로고
    • Immunotherapy of tumor metastasis via gene therapy
    • Porgador A., Feldman M., Eisenbach L. Immunotherapy of tumor metastasis via gene therapy. Natur. Immun. 13:1994;113-130.
    • (1994) Natur. Immun. , vol.13 , pp. 113-130
    • Porgador, A.1    Feldman, M.2    Eisenbach, L.3
  • 89
    • 0028111418 scopus 로고
    • IL-2 induces vasopressin release from the hypothalamus and the amygdala: Role of nitric oxide-mediated signaling
    • Raber J., Bloom F. E. IL-2 induces vasopressin release from the hypothalamus and the amygdala: role of nitric oxide-mediated signaling. J. Neurosci. 14:1994;6187-6195.
    • (1994) J. Neurosci. , vol.14 , pp. 6187-6195
    • Raber, J.1    Bloom, F.E.2
  • 90
    • 0030063945 scopus 로고    scopus 로고
    • Arginine vasopressin release by acetylcholine or norepinephrine: Region-specific and cytokine-specific regulation
    • Raber J., Bloom F. E. Arginine vasopressin release by acetylcholine or norepinephrine: region-specific and cytokine-specific regulation. Neuroscience. 71:1996;747-759.
    • (1996) Neuroscience , vol.71 , pp. 747-759
    • Raber, J.1    Bloom, F.E.2
  • 91
    • 0028887898 scopus 로고
    • Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; Comparison with the hypothalamic response
    • Raber J., Koob G. F., Bloom F. E. Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response. J. Pharmac. exp. Ther. 272:1995;815-824.
    • (1995) J. Pharmac. Exp. Ther. , vol.272 , pp. 815-824
    • Raber, J.1    Koob, G.F.2    Bloom, F.E.3
  • 92
    • 0028218528 scopus 로고
    • In vivo transfer of the human interleukin-2 gene: Negative tumoricidal results in experimental brain tumors
    • Ram Z., Walbridge S., Heiss J. D., Culver K. W., Blaese R. M., Oldfield E. H. In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors. J. Neurosurg. 80:1994;535-540.
    • (1994) J. Neurosurg. , vol.80 , pp. 535-540
    • Ram, Z.1    Walbridge, S.2    Heiss, J.D.3    Culver, K.W.4    Blaese, R.M.5    Oldfield, E.H.6
  • 93
    • 0004155913 scopus 로고
    • Urban and Schwarzenberg, München.
    • Romeis (1989) Mikroskopische Technik. Urban and Schwarzenberg, München.
    • (1989) Mikroskopische Technik.
    • Romeis1
  • 95
    • 0027270718 scopus 로고
    • Tolerance and cerebrospinal fluid pharmacokinetics of intrathecally administered human natural interleukin-2: A phase I trial
    • Rosener M., Schwulera U., Menke G., Thrun A., Lissner R., Krauseneck P., Bogdahn U., Martin R. Tolerance and cerebrospinal fluid pharmacokinetics of intrathecally administered human natural interleukin-2: a phase I trial. Eur. Cytokine Netw. 4:1993;189-195.
    • (1993) Eur. Cytokine Netw. , vol.4 , pp. 189-195
    • Rosener, M.1    Schwulera, U.2    Menke, G.3    Thrun, A.4    Lissner, R.5    Krauseneck, P.6    Bogdahn, U.7    Martin, R.8
  • 96
    • 0028869476 scopus 로고
    • Cytokines and the nervous system II: Actions and mechanisms of action
    • Rothwell N. J., Hopkins S. J. Cytokines and the nervous system II: actions and mechanisms of action. Trends Neurosci. 18:1995;130-136.
    • (1995) Trends Neurosci. , vol.18 , pp. 130-136
    • Rothwell, N.J.1    Hopkins, S.J.2
  • 97
    • 0027300024 scopus 로고
    • Involvement of cytokines in acute neurodegeneration in the CNS
    • Rothwell N. J., Relton J. K. Involvement of cytokines in acute neurodegeneration in the CNS. Neurosci. Biobehav. Rev. 17:1993;217-227.
    • (1993) Neurosci. Biobehav. Rev. , vol.17 , pp. 217-227
    • Rothwell, N.J.1    Relton, J.K.2
  • 99
    • 0027494447 scopus 로고
    • Interleukin-2 promotes survival and neurite extension of cultured neurons from fetal rat brain
    • Sarder M., Saito H., Abe K. Interleukin-2 promotes survival and neurite extension of cultured neurons from fetal rat brain. Brain Res. 625:1993;347-350.
    • (1993) Brain Res. , vol.625 , pp. 347-350
    • Sarder, M.1    Saito, H.2    Abe, K.3
  • 101
    • 0026521970 scopus 로고
    • Treatment of murine primary brain tumors with systemic interleukin-2 and tumor-infiltrating lymphocytes
    • Saris S. C., Spiess P., Lieberman D. M., Lin S., Walbridge S., Oldfield E. H. Treatment of murine primary brain tumors with systemic interleukin-2 and tumor-infiltrating lymphocytes. J. Neurosurg. 76:1992;513-519.
    • (1992) J. Neurosurg. , vol.76 , pp. 513-519
    • Saris, S.C.1    Spiess, P.2    Lieberman, D.M.3    Lin, S.4    Walbridge, S.5    Oldfield, E.H.6
  • 102
    • 0028986067 scopus 로고
    • Induction of interleukin-2 receptor in mouse microglia
    • Sawada M., Suzumura A., Marunouchi T. Induction of interleukin-2 receptor in mouse microglia. J. Neurochem. 64:1995;1973-1979.
    • (1995) J. Neurochem. , vol.64 , pp. 1973-1979
    • Sawada, M.1    Suzumura, A.2    Marunouchi, T.3
  • 103
    • 0028268673 scopus 로고
    • Lymphokines in autoimmunity - A critical review
    • Schattner A. Lymphokines in autoimmunity - a critical review. Clin. Immunol. Immunopath. 70:1994;177-189.
    • (1994) Clin. Immunol. Immunopath. , vol.70 , pp. 177-189
    • Schattner, A.1
  • 104
    • 0028130126 scopus 로고
    • Systemic interleukin-1 alpha and interleukin-2 secretion in response to acute stress and to corticotropin-releasing hormone in humans
    • Schulte H. M., Bamberger C. M., Elsen H., Herrmann G., Bamberger A. M., Barth J. Systemic interleukin-1 alpha and interleukin-2 secretion in response to acute stress and to corticotropin-releasing hormone in humans. Eur. J. clin. Invest. 24:1994;773-777.
    • (1994) Eur. J. Clin. Invest. , vol.24 , pp. 773-777
    • Schulte, H.M.1    Bamberger, C.M.2    Elsen, H.3    Herrmann, G.4    Bamberger, A.M.5    Barth, J.6
  • 105
    • 0023904746 scopus 로고
    • Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
    • Selmaj K. W., Raine C. S. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol. 23:1988;339-346.
    • (1988) Ann. Neurol. , vol.23 , pp. 339-346
    • Selmaj, K.W.1    Raine, C.S.2
  • 109
    • 0028492819 scopus 로고
    • Studies of neuroimmune markers in Alzheimer's disease
    • Singh V. K. Studies of neuroimmune markers in Alzheimer's disease. Molec. Neurobiol. 9:1994;73-81.
    • (1994) Molec. Neurobiol. , vol.9 , pp. 73-81
    • Singh, V.K.1
  • 110
    • 0024587476 scopus 로고
    • Interleukin-2 induction of ACTH secretion: Presence of an interleukin-2 receptor alpha-chain-like molecule on pituitary cells
    • Smith L. R., Brown S. L., Blalock J. E. Interleukin-2 induction of ACTH secretion: presence of an interleukin-2 receptor alpha-chain-like molecule on pituitary cells. J. Neuroimmunol. 21:1989;249-254.
    • (1989) J. Neuroimmunol. , vol.21 , pp. 249-254
    • Smith, L.R.1    Brown, S.L.2    Blalock, J.E.3
  • 113
    • 0025061972 scopus 로고
    • Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus
    • Tancredi V., Zona C., Velotti F., Eusebi F., Santoni A. Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus. Brain Res. 525:1990;149-151.
    • (1990) Brain Res. , vol.525 , pp. 149-151
    • Tancredi, V.1    Zona, C.2    Velotti, F.3    Eusebi, F.4    Santoni, A.5
  • 114
    • 0028964465 scopus 로고
    • Cytokine signaling through nonreceptor protein tyrosine kinases
    • Taniguchi T. Cytokine signaling through nonreceptor protein tyrosine kinases. Science. 268:1995;251-255.
    • (1995) Science , vol.268 , pp. 251-255
    • Taniguchi, T.1
  • 115
    • 0030272248 scopus 로고    scopus 로고
    • Interleukin-2 and its receptors: Recent advances and new immunological functions
    • Theze J., Alzari P. M., Bertoglio J. Interleukin-2 and its receptors: recent advances and new immunological functions. Immunol. Today. 17:1996;481-486.
    • (1996) Immunol. Today , vol.17 , pp. 481-486
    • Theze, J.1    Alzari, P.M.2    Bertoglio, J.3
  • 116
    • 0028907313 scopus 로고
    • RG-2 glioma growth attenuation and severe brain edema caused by localproduction of interleukin-2 and interferon-gamma
    • Tjuvajev J., Gansbacher B., Desai R., Beattie B., Kaplitt M., Matei C., Gilboa E., Blasberg R. RG-2 glioma growth attenuation and severe brain edema caused by localproduction of interleukin-2 and interferon-gamma. Cancer Res. 55:1995;1902-1910.
    • (1995) Cancer Res. , vol.55 , pp. 1902-1910
    • Tjuvajev, J.1    Gansbacher, B.2    Desai, R.3    Beattie, B.4    Kaplitt, M.5    Matei, C.6    Gilboa, E.7    Blasberg, R.8
  • 117
    • 0025165585 scopus 로고
    • Electrophysiological studies of acetylcholine and the role of the basal forebrain in the somatosensory cortex of the cat. II. Cortical neurons excited by somatic stimuli
    • Tremblay N., Warren R. A., Dykes R. W. Electrophysiological studies of acetylcholine and the role of the basal forebrain in the somatosensory cortex of the cat. II. Cortical neurons excited by somatic stimuli. J. Neurophysiol. 64:1990;1212-1222.
    • (1990) J. Neurophysiol. , vol.64 , pp. 1212-1222
    • Tremblay, N.1    Warren, R.A.2    Dykes, R.W.3
  • 120
    • 0026475205 scopus 로고
    • Clinical toxicity of interleukin-2
    • Vial T., Descotes J. Clinical toxicity of interleukin-2. Drug Saf. 7:1992;417-433.
    • (1992) Drug Saf. , vol.7 , pp. 417-433
    • Vial, T.1    Descotes, J.2
  • 121
    • 0028294042 scopus 로고
    • Interleukin-2 does not cross the blood-brain barrier by a saturable transport system
    • Waguespack P. J., Banks W. A., Kastin A. J. Interleukin-2 does not cross the blood-brain barrier by a saturable transport system. Brain Res. Bull. 34:1994;103-109.
    • (1994) Brain Res. Bull. , vol.34 , pp. 103-109
    • Waguespack, P.J.1    Banks, W.A.2    Kastin, A.J.3
  • 122
    • 0027252110 scopus 로고
    • The IL-2/IL-2 receptor system: A target for rational immune intervention
    • Waldmann T. A. The IL-2/IL-2 receptor system: a target for rational immune intervention. Immunol. Today. 14:1993;264-270.
    • (1993) Immunol. Today , vol.14 , pp. 264-270
    • Waldmann, T.A.1
  • 123
    • 0343073422 scopus 로고
    • Effects of interleukin-1 and interleukin-2 on rat hippocampal neurons in culture
    • Wang F. Z., Yao H., Ding A. S. Effects of interleukin-1 and interleukin-2 on rat hippocampal neurons in culture. Soc. Neurosci. Abstr. 20:1994;1687.
    • (1994) Soc. Neurosci. Abstr. , vol.20 , pp. 1687
    • Wang, F.Z.1    Yao, H.2    Ding, A.S.3
  • 124
    • 0026344752 scopus 로고
    • Basal forebrain lesions with or without reserpine injection inhibit cortical reorganization in rat hindpaw primary somatosensory cortex following sciatic nerve section
    • Webster H. H., Hanisch U. K., Dykes R. W., Biesold D. Basal forebrain lesions with or without reserpine injection inhibit cortical reorganization in rat hindpaw primary somatosensory cortex following sciatic nerve section. Somatosens. Mot. Res. 8:1991;327-346.
    • (1991) Somatosens. Mot. Res. , vol.8 , pp. 327-346
    • Webster, H.H.1    Hanisch, U.K.2    Dykes, R.W.3    Biesold, D.4
  • 125
    • 0026780219 scopus 로고
    • Changes in plasma cytokines associated with peripheral nerve injury
    • Wells M. R., Racis S. P. Jr., Vaidya U. Changes in plasma cytokines associated with peripheral nerve injury. J. Neuroimmunol. 39:1992;261-268.
    • (1992) J. Neuroimmunol. , vol.39 , pp. 261-268
    • Wells, M.R.1    Racis S.P., Jr.2    Vaidya, U.3
  • 126
    • 0027522021 scopus 로고
    • Interleukin-2. A review of its pharmacological properties and therapeutic use in patients with cancer
    • Whittington R., Faulds D. Interleukin-2. A review of its pharmacological properties and therapeutic use in patients with cancer. Drugs. 46:1993;446-514.
    • (1993) Drugs , vol.46 , pp. 446-514
    • Whittington, R.1    Faulds, D.2
  • 127
    • 0027427524 scopus 로고
    • Immunoendocrine communication via the hypothalamo-pituitary-adrenal axis in autoimmune diseases
    • Wick G., Hu Y., Schwarz S., Kroemer G. Immunoendocrine communication via the hypothalamo-pituitary-adrenal axis in autoimmune diseases. Endocr. Rev. 14:1993;539-563.
    • (1993) Endocr. Rev. , vol.14 , pp. 539-563
    • Wick, G.1    Hu, Y.2    Schwarz, S.3    Kroemer, G.4
  • 128
    • 0022644493 scopus 로고
    • Immunocytochemical characterization of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth
    • Woodroofe M. N., Bellamy A. S., Feldmann M., Davison A. N., Cuzner M. L. Immunocytochemical characterization of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth. J. neurol. Sci. 74:1986;135-152.
    • (1986) J. Neurol. Sci. , vol.74 , pp. 135-152
    • Woodroofe, M.N.1    Bellamy, A.S.2    Feldmann, M.3    Davison, A.N.4    Cuzner, M.L.5
  • 130
    • 0030026798 scopus 로고    scopus 로고
    • Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy
    • Zier K., Gansbacher B., Salvadori S. Preventing abnormalities in signal transduction of T cells in cancer: the promise of cytokine gene therapy. Immunol. Today. 17:1996;39-45.
    • (1996) Immunol. Today , vol.17 , pp. 39-45
    • Zier, K.1    Gansbacher, B.2    Salvadori, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.