Amyloid β and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia

Journal of Neurochemistry

Volumn 74, Issue 3, 2000, Pages 1017-1025

  Yates, Stephen L ^a   Burgess, Loyd H ^a   Kocsis Angle, June ^a   Antal, Joyce M ^a   Dority, Michael D ^a   Embury, Paula B ^a   Piotrkowski, Anthony M ^a   Brunden, Kurt R ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Alzheimer's disease; Amylin; Amyloid ; Chemokines; Cytokines; Microglia; THP 1 cells

Indexed keywords

AMYLIN; AMYLOID; AMYLOID BETA PROTEIN; CHEMOKINE; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; INFLAMMATION; MICROGLIA; MOUSE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; SENILE PLAQUE; SIGNAL TRANSDUCTION;

AMYLOID; AMYLOID BETA-PROTEIN; ANIMALS; CELL LINE; CELLS, CULTURED; CHEMOKINES; CYTOKINES; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1; MICE; MICROGLIA; MONOCYTES; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RNA, MESSENGER;

ANIMALIA; MURINAE;

EID: 0033982028     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0741017.x     Document Type: Article

References (42)

1. Araujo D. M. and Cotman C. W. (1992) β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res. 569, 141-145.
2. SW transgenic mice. Neurobiol. Aging (in press).
3. Boland K., Manias K., and Perlmutter D. H. (1995) Specificity in recognition of amyloid-beta peptide by the serpin-enzyme complex receptor in hepatoma cells and neuronal cells. J. Biol. Chem. 270, 28022-28028.
4. Brunden K. R., Kocsis-Angle J., Embury P., and Yates S. L. (1999) Aβ-Induced proinflammatory cytokine release from differentiated human THP-1 monocytes, in Alzheimer's Disease (Hooper N. M., ed), pp. 101-112. Humana Press Inc., Totowa, New Jersey.
5. Castillo M. J., Scheen A. J., and Lefèbvre P. J. (1995) Amylin/islet amyloid polypeptide: biochemistry, physiology, patho-physiology. Diabetes Metab. 21, 3-25.
6. Combs C. K., Johnson D. E., Cannady S. B., Lehman T. M., and Landreth G. E. (1999) Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of β-amyloid and prion proteins. J. Neurosci. 19, 928-939.
7. Cooper G. J., Willis A. C., Clark A., Turner R. C., Sim R. B., and Reid K. B. (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc. Natl. Acad. Sci. USA 84, 8628-8632.
8. Das S. and Potter H. (1995) Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1. Neuron 14, 447-456.
9. de Koning E. J., van den Brand J. J., Mott V. L., Charge S. B., Hansen B. C., Bodkin N. L., Morris J. F., and Clark A. (1998) Macrophages and pancreatic islet amyloidosis. Amyloid 5, 247-254.
10. Dickson D. W. (1997) The pathogenesis of senile plaques. J. Neuropathol. Exp. Neurol. 56, 321-339.
11. El Khoury J., Hickman S. E., Thomas C. A., Cao L., Silverstein S. C., and Loike J. D. (1996) Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature 382, 716-719.
12. Fiala M., Zhang L., Gan X., Sherry B., Taub D., Graves M. C., Hama S., Way D., Weinand M., Witte M., Lorton D., Kuo Y. M., and Roher A. E. (1998) Amyloid-β induces chemokine secretion and monocyte migration across a human blood-brain barrier model. Mol. Med. 4, 480-489.
13. Griffin W. S., Stanley L. C., Ling C., White L., MacLeod V., Perrot L. J., White C. L. III, and Araoz C. (1989) Brain interleukin-1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. USA 86, 7611-7615.
14. Griffin W. S., Sheng J. G., Roberts G. W., and Mrak R. E. (1995) Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J. Neuropathol. Exp. Neurol. 54, 276-281.
15. Gupta-Bansal R. and Brunden K. R. (1998) Congo red inhibits proteoglycan and serum amyloid P binding to amyloid β fibrils. J. Neurochem. 70, 292-298.
16. Haga S., Adai K., and Ishii T. (1989) Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain: an immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol. 77, 569-575.
17. Hansson E. and Rönnbäck L. (1989) Primary cultures of astroglia and neurons from different brain regions, in A Dissection and Tissue Culture Manual of the Nervous System (Shahar A., de Vellis J., Vernadakis A., and Haber B., eds), pp. 92-104. Alan R. Liss, Inc., New York.
18. Hardy J., Duff K., Hardy K. G., Perez-Tur J., and Hutton M. (1998) Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nat. Neurosci. 1, 355-358.
19. Joslin G., Krause J. E., Hershey A. D., Adams S. P., Fallon R. J., and Perlmutter D. H. (1991) Amyloid-β peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor. J. Biol. Chem. 266, 21897-21902.
20. Klegeris A., Walker D. G., and McGeer P. L. (1997) Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-α. Brain Res. 747, 114-121.
21. Lee S. C., Dickson D. W., and Brosnan C. F. (1995) Interleukin-1, nitric oxide and reactive astrocytes. Brain Behav. Immun. 9, 345-354.
22. LeVine H. (1993) Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci. 2, 404-410.
23. Lorenzo A. and Yankner B. A. (1994) β-Amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl. Acad. Sci. USA 91, 12243-12247.
24. Lorton D. (1997) β-Amyloid-induced IL-1β release from an activated human monocyte cell line is calcium-and G-protein-dependent. Mech. Ageing Dev. 94, 199-211.
25. Lorton D., Kocsis J., King L., Madden K., and Brunden K. R. (1996) β-Amyloid induces increased release of interleukin-1β from lipopolysaccharide-activated human monocytes. J. Neuroimmunol. 67, 21-29.
26. May P. C., Boggs L. N., and Fuson K. S. (1993) Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-β neurotoxicity. J. Neurochem. 61, 2330-2333.
27. McDonald D. R., Brunden K. R., and Landreth G. E. (1997) Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J. Neurosci. 17, 2284-2294.
28. McDonald D. R., Bamberger M. E., Combs C. K., and Landreth G. E. (1998) β-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP-1 monocytes. J. Neurosci. 18, 4451-4460.
29. McGeer P. L. and McGeer E. G. (1995) The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Rev. 21, 195-218.
30. McGeer P. L., Itagaki S., Tago H., and McGeer E. G. (1987) Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompalibility glycoprotein HLA-DR. Neurosci. Lett. 9, 195-200.
31. McGeer P. L., Schulzer M., and McGeer E. G. (1996) Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 47, 425-432.
32. Meda L., Cassatella M. A., Szendrei G. I., Otvos L. Jr., Baron P., Villalba M., Ferrari D., and Rossi F. (1995) Activation of microglial cells by β-amyloid protein and interferon-γ. Nature 374, 647-650.
33. Mrak R. E., Sheng J. G., and Griffin W. S. (1995) Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum. Pathol. 26, 816-823.
34. Stalder M., Phinney A., Probst A., Sommer B., Staufenbiel M., and Jucker M. (1999) Association of microglia with amyloid plaques in brains of APP23 transgenic mice. Am. J. Pathol. 154, 1673-1684.
35. Stewart W. F., Kawas C., Corrada S. M., and Metter E. J. (1997) Risk of Alzheimer's disease and duration of NSAID use. Neurology 48, 626-632.
36. Tsuchiya S., Yamabe M., Yamaguchi Y., Kobayashi Y., Konno T., and Tada K. (1980) Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int. J. Cancer 26, 171-176.
37. Westermark P., Engstrom U., Johnson K. H., Westermark G. T., and Betsholtz C. (1990) Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc. Natl Acad. Sci. USA 87, 5036-5040.
38. Xia M. Q. and Hyman B. T. (1999) Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. J. Neurovirol. 5, 32-41.
39. Yan S. D., Chen X., Fu J., Chen M., Zhu H., Roher A., Slattery T., Zhao L., Nagashima M., Morser J., Migheli A., Nawroth P., Stern D., and Schmidt A. M. (1996) RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382, 685-691.
40. Yao J. and Johnson R. W. (1997) Induction of interleukin-1β-converting enzyme (ICE) in murine microglia by lipopolysaccharide. Mol. Brain Res. 51, 170-178.
41. Yates S. L., Kocsis-Angle J., Embury P., and Brunden K. R. (1999) Inflammatory responses to amyloid fibrils. Methods Enzymol. 309, 723-733.
42. Zhu S. G., Sheng J. G., Jones R. A., Brewer M. M., Zhou X. Q., Mrak R. E., and Griffin W. S. (1999) Increased interleukin-1β converting enzyme expression and activity in Alzheimer disease. J. Neuropathol. Exp. Neurol. 58, 582-587.