Immunotherapy for multiple sclerosis: From theory to practice

Nature Medicine

Volumn 2, Issue 10, 1996, Pages 1074-1075

  Antel, Jack P ^a   Becher, Burkhard ^a   Owens, Trevor ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

HUMAN; IMMUNOTHERAPY; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; SHORT SURVEY;

ANIMALS; AUTOIMMUNE DISEASES; CLINICAL TRIALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; IMMUNOTHERAPY, ACTIVE; MICE; MULTIPLE SCLEROSIS; PEPTIDE FRAGMENTS; RATS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 0029794107     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1096-1074     Document Type: Short Survey

References (11)

1. Katz, D. et al. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis. Ann. Neurol. 34, 661-669 (1993).
2. Talbot, P.J., Paquette, J.S., Ciurli, C., Antel, J.P. & Quellet, F. Myelin basic protein and human coronavirus 229E cross-reactive T cells in MS. Ann. Neurol. 39, 233-240 (1996).
3. Lehman, P.V., Forsthuber, T., Miller, A. & Sercarz, E.E. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358, 155-157 (1992).
4. Vandenbark, A.A. Treatment of multiple sclerosis with T-cell receptor peptides: Results of a double-blind pilot trial. Nature Med. 2, 1109-1115 (1996).
5. Ben-Nun, A., Wekerle, H. & Cohen, I.R. Vaccination against autoimmune encephalomyelitis with T-lymphocyte cell lines reactive against myelin basic protein. Nature 292, 60-61 (1981).
6. Jerne, N.K. Idiotypic networks and other preconceived ideas. Immunol. Rev. 79, 5-24 (1984).
7. Bell, J.I. & Lathrop, G.M. Multiple loci for multiple sclerosis. Nature Genet. 13, 377-378 (1996).
8. Rudick, R. et al. Clinical outcomes assessment in multiple sclerosis. Ann. Neurol. (in the press).
9. Chen, Y., Kuchroo, V.K., Inobe, J., Hafler, D.A. & Weiner, H.L. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis. Science 265, 1237-1240 (1994).
10. Windhagen, A., Anderson, D.A., Carrizosa, A., Williams, R.E. & Hafler, D.A. IL-12 induces human T cells secreting IL-10 with IFN-γ. J Immunol. 157, 1127-1131 (1996).
11. Brocke, S. et al. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379, 343-346 (1996).