Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein

Journal of Clinical Investigation

Volumn 99, Issue 12, 1997, Pages 2930-2940

  Gabay, Cem ^a,c   Smith Jr , Michael F ^b   Eidlen, Denise ^a   Arend, William P ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Acute phase response; C EBP; HepG2 cells; Human primary hepatocytes; NF B

Indexed keywords

ACUTE PHASE PROTEIN; COMPLEMENTARY DNA; CYTOKINE; DEXAMETHASONE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLUCOCORTICOID; HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PHASE RESPONSE; ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HEPATOMA CELL; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0030961241     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119488     Document Type: Article

References (58)

1. Kushner, I. 1982. The phenomenon of the acute phase response. Ann. NY Acad. Sci. 389:39-18.
2. Volanakis, J.E., and D.T. Fearon. 1993. The molecular biology of the complement system. In Arthritis and Allied Conditions. Textbook of Rheumatology. D.J. McCarty and W.J. Koopman, editors. Lea and Febiger, Malvern, PA. 455-467.
3. Szalai, A.J., D.E. Briles, and J.E. Volanakis. 1995. Human C-reactive protein is protective against fatal streptococcus pneumoniae infection in transgenic mice. J. Immunol. 155:2557-2563.
4. Kilpatrick, L., L. McCawley, V. Vasanthi, W. Greer, S. Majumdar, H.M. Korchak, and S.D. Douglas. 1992. α-1-antichymotrypsin inhibits the NADPH oxidase-enzyme complex in phorbol ester-stimulated neutrophil membranes. J. Immunal. 149:3059-3065.
5. Bucurenci, N., D.R. Blake, K. Chidwick, and P.G. Winyard. 1992. Inhibition of neutrophil Superoxide production by human plasma alpha-1-antitrypsin. FEBS (Fed. Eur. Biochem. Soc.) Lett. 300:21.
6. Heinrich, P.C., J.V. Castell, and T. Andus. 1990. Interleukin-6 and the acute-phase response. Biochem. J. 265:621-636.
7. Dinarello, C.A. 1996. Biologic basis for interleukin-1 in disease. Blood 87:2095-2147.
8. Dripps, D.J., B.J. Brandhuber, R.C. Thompson, and S.P. Eisenberg. 1991. Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor hut does not initiate IL-1 signal transduction. J. Biol. Chem. 266:10331-10336.
9. Granowitz, E.V., B.D. Clarck, J. Mancilla, and C.A. Dinarello. 1991. Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor. J. Biol. Chem. 266:14147-14150.
10. Cominelli, F., C.C. Nast, B.D. Clark, R. Schindler, R. Llerena, V.E. Eysselein, R.C. Thompson, and C.A. Dinarello. 1990. Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rahhit immune complex colitis. J. Clin. Invest. 86:972-980.
11. Wooley, P.H., J.D. Whalen, D.L. Chapman, A.E. Berger, K.A. Richard, D.G. Aspar, and N.D. Staite. 1993. The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice. Arthritis Rheum. 9:1305-1314.
12. Granowitz, E.V., A.A. Santos, D.D. Poutsiaka, J.G. Cannon, D.W. Wilmore, S.M. Wolff, and C.A. Dinarello. 1991. Production of interleukin-1-receptor antagonist during experimental endotoxemia. Lancet. 338:1423-1424.
13. Prieur, A.-M., M.-T. Kaufmann, C. Griscelli, and J.-M. Dayer. 1987. Specific interleukin-1 inhibitor in serum and urine of children with systemic juvenile chronic arthritis. Lancet. 2:1240-1242.
14. Gahay, C., F. Gay-Crosier, P. Roux-Lombard, O. Meyer, P.-A. Guerne, T. Vischer, and J.-M. Dayer. 1994. Elevated serum levels of interleukin-1 receptor antagonist in polymyositis-dermatomyositis: a biological marker of disease activity with a possible role in the lack of acute-phase protein response. Arthritis Rheum. 37:1744-1751.
15. Suzuki, H., H. Takemura, and H. Kashiwagi. 1996. Interleukin-1 receptor antagonist in patients with active systemic lupus erythematosus. Arthritis Rheum. 38:1055-1059.
16. Grzelak, I., W.L. Olszewski, M. Zaleska, M. Durlik, B. Lagiewska, M. Muszynski, and W. Rowinski. 1996. Blood cytokine levels rise even after minor surgical trauma. J. Clin. Immunol. 15:159-164.
17. De Benedetti, F., P. Pignatti, M. Massa, P. Sartirana, A. Ravelli, and A. Martini. 1995. Circulating levels of interleukin 1β and of interleukin 1 receptor antagonist in systemic juvenile chronic arthritis. Clin. Exp. Rheumatol. 13:779-784.
18. Bargetzi, M.J., M. Lantz, C.G. Smith, F.M. Torli, I. Olsson, S.P. Eisenberg, and H.F. Starnes, Jr. 1993. Interleukin-1β induces interleukin-1 receptor antagonist and tumor necrosis factor binding protein in humans. Cancer Res. 53:4010-4013.
19. Tilg, H., E. Trehu, M.B. Atkins, C.A. Dinarello, and J.W. Mier. 1994. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood. 83:113-118.
20. Gabay, C., B. Genin, G. Mentha, P.B. Iynedjian, P. Roux-Lombard, and P.-A. Guerne. 1995. IL-1 receptor antagonist (IL-1Ra) does not inhibit the production of C-reactive protein or serum amyloid A protein by human primary hepatocytes. Differential regulation in normal and tumour cells. Clin. Exp. Immunol. 100:306-313.
21. Gabay, C., P. Silacci, B. Genin, G. Mentha, C. Le Coultre, and P.-A. Guerne. 1995. Soluble interleukin-6 receptor strongly increases the production of acute-phase protein by hepatoma cells but exerts minimal changes on human primary hepatocytes. Eur. J. Immunol. 25:2378-2383.
22. Seglen, P.O. 1976. Preparation of isolated rat liver cells. Methods Cell Biol. 13:29-83.
23. Malyak, M., F.G. Joslin, E.L. Verderber, S.P. Eisenberg, and W.P. Arenti. 1993. IL-1Ra ELISA: reduction and alkylation of synovial fluid eliminates interference by IgM rheumatoid factors. J. Immunol. Methods. 36:781-789.
24. Arend, W.P., M. Malyak, M.F. Smith, Jr., T.D. Whisenand, J.L. Slack, I.E. Sims, J.G. Giri, and S.K. Dower. 1994. Binding of IL-1α, IL-1β, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. J. Immunol. 153:4766-4774.
25. Chirgwin, J.M., A.E. Przybyla, R.J. MacDonald, and W.J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294-5299.
26. Malyak, M., M.F. Smith, Jr., A.A. Abel, and W.P. Arend. 1994. Peripheral blood neutrophil production of interleukin-1 receptor antagonist and interleukin-1β. J. Clin. Immunol. 14:20-30.
27. Smith, M.F., Jr., D. Eidlen, W.P. Arend, and A. Gutierrez-Hartmann. 1994. LPS-induced expression of the human IL-1 receptor antagonist gene is controlled by multiple interacting promoter elements. J. Immunol. 153:3584-3593.
28. Jenkins, J.K., R.F. Drong, M.E. Shuck, M.J. Bienkowski, J.L. Slightom, W.P. Arend, and M.F. Smith, Jr. 1997. Intracellular interleukin-1 receptor antagonist promoter: cell type-specific and inducible regulatory regions. J. Immunol. 158:748-755.
29. Dignam, I.D., R.M. Lebovitz, and R.G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
30. Jenkins, J.K., and W.P. Arend. 1993. Interleukin 1 receptor antagonist production in human monocytes is induced by IL-1α, IL-3, IL-4 and GM-CSF. Cytokine. 5:407-415.
31. Janson, R.W., T.E. King, K.R. Hance, and W.P. Arend. 1993. Enhanced production of IL-1 receptor antagonist by alveolar macrophages from patients with interstitial lung disease. Am. Rev. Respir. Dis. 148:495-503.
32. Baumann, H., and J. Gauldie. 1990. Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Mol. Biol. Med. 7:147-160.
33. Baumann, H., K.R. Prowse, S. Marinkovic, K.-A. Won, and O.P. Jahreis. 1989. Stimulation of hepatic acute phase response by cytokines and glucocorticoids. Ann. NY Acad. Sci. 557:280-295.
34. Haskill, S., G. Martin, L. van Le, J. Morris, A. Peace, C.F. Bigler, G.J. Jaffe, C. Hammerberg, S.A. Sporn, S. Fong, et al. 1991. cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium. Proc. Natl. Acad. Sci. USA. 88:3681-3685.
35. Ramji, D.P., A. Vitelli, F. Tronche, R. Cortese, and G. Ciliberto. 1993. The two C/EBP isoforms. IL-6DBP/NF-IL6 and C/EBPδ/NF-IL6β, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res. 21:289-294.
36. Akira, S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO (Eur. Mol. Biol. Organ.) J. 9:1897-1906.
37. Steinkasserer, A., C. Estaller, E.H. Weiss, and R.B. Sim. 1992. Human interleukin-1 receptor antagonist is expressed in liver. FEBS (Fed Eur. Biochem. Soc.) Lett. 310:60-62.
38. Fujioka, N., N. Mukaida, A. Harada, M. Akiyama, T. Kasahara, K. Kuno, A. Ooi, M. Mai, and K. Matsushima. 1995. Preparation of specific antibodies against murine IL-1ra and the establishment of IL-1ra as an endogenous regulator of bacteria-induced fulminant hepatitis in mice. J. Leukocyte Biol. 58: 90-98.
39. Vannier, E., L.C. Miller, and C.A. Dinarello. 1992. Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist. Proc. Natl. Acad. Sci. USA. 89:4076-4080.
40. Brown, E.A., H.A. Dare, C.B. Marsh, and M.D. Wewers. 1996. The combination of endotoxin and dexamethasone induces type II interleukin 1 receptor (IL-1r II) in monocytes: a comparison to interleukin 1β (IL-1β) and interleukin 1 receptor antagonist (IL-1ra). Cytokine. 8:828-836.
41. Phillips, W.G., M. Feldmann. S.M. Breathnach, and F.M. Brennan. 1995. Modulation of the IL-1 cytokine network in keratinocytes by intracellular IL-1α and IL-1 receptor antagonist. Clin. Exp. Immunol. 101:177-182.
42. Lai, Ch.-F., and H. Baumann. 1996. Interleukin-1β induces production of granulocyte colony-stimulating factor in human hepatoma cells. Blood. 87: 4143-4148.
43. Hannum, C.H., C.J. Wilcox, W.P. Arend, F.G. Joslin, D.J. Dripps, P.L. Heimdal, L.G. Armes, A. Sommer, S.P. Eisenberg, and R.C. Thompson. 1990. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature (Lond.). 343:336-340.
44. Ganapathi, M.K., D. Rzewnicki, D. Samols, S.-L. Jiang, and I. Kushner. 1991. Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in Hep 3B cells. J. Immunol. 147:1261-1265.
45. Baumann, H., and P. Schendel. 1991. Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6. J. Biol. Chem. 30:20424-20427.
46. Baumann, H., and G.G. Wong. 1989. Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor. J. Immunol 143:1163-1167.
47. Richards, C., T.J. Brown, M. Shovab, H. Baumann, and J. Gauldie. 1992. Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro. J. Immunol. 148: 1731-1736.
48. Schooltink, H., T. Stoyan, E. Roeb, P.C. Heinrich, and S. Rose-John. 1992. Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes. FEBS (Fed. Eur. Biochem. Soc.) Lett. 314:280-284.
49. Castell, J.V., M.J. Gomez-Lechon, M. David, T. Andus, T. Geiger, R. Trullenque, R. Fabra, and P.C. Heinrich. 1989. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS (Fed. Eur. Biochem. Soc.) Lett. 242:237-239.
50. Osborn, L., S. Kunkel, and G.J. Nabel. 1989. Tumor necrosis factor α and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor κB. Proc. Natl. Acad. Sci. USA. 86:2336-2340.
51. Alam, T., M.R. An, and J. Papaconstantinou. 1992. Differential expression of three C/EBP isoforms in multiple tissues during acute phase response. J. Biol. Chem. 267:5021-5024.
52. Kinoshita, S., S. Akira, and T. Kishimoto. 1992. A member of the C/EBP family. NF-IL6β, forms a heterodimer and transcriplionally synergizes with NF-IL6. Proc. Nutl. Acad. Sci. USA. 89:1473-1476.
53. Matsusaka, T., K. Fujikawa, Y. Nishio, N. Mukaida, K. Matsushima, T. Kishimoto, and S. Akira. 1993. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. USA. 90:10193-10197.
54. Betts, J.C., J.K. Cheshire, S. Akira, T. Kishimoto, and P. Woo. 1993. The role of NF-κB and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6. J. Biol. Chem. 268:25624-25631.
55. Shirakawa, F., K. Saito, C.A. Bonagura, D.L. Galson, M.J. Fenton, A.C. Webb, and P.E. Auron. 1993. The human prointerleukin 1β gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction. Mol. Cell. Biol. 13:1332-1344.
56. Natsuka, S., S. Akira, Y. Nishio, S. Hashimoto, T. Sugita, H. Isshiki, and T. Kishimoto. 1992. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood. 79:460-466.
57. Stein, B., P.C. Cogswell, and A.S. Baldwin, Jr. 1993. Functional and physical associations between NF-κB and C/EBP family members: a rel domain-bZIP interaction. Mol. Cell. Bioi. 13:3964-3974.
58. LeClair, K.P., M.A. Blanar, and P.A. Sharp. 1992. The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA. 89:8145-8149.