Brain-immune connection: Immuno-regulatory properties of CNS-resident cells

GLIA

Volumn 29, Issue 4, 2000, Pages 293-304

  Becher, Burkhard ^a,b   Prat, Alexandre ^b   Antel, Jack P ^b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Adaptive; Antigen presenting cells; Apoptosis; Astroglia; CD14; CD40; Encephalopathies; Endothelial cells; Immune regulation; Immunity; Infection; Inna te; Interleukin 12; Microglia; Multiple sclerosis; Neurodegeneration; Pattern recognition; Th1; Th2; Tumor necrosis factor

Indexed keywords

CYTOKINE; INTERLEUKIN 12;

ANIMAL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ASTROCYTE; AUTOIMMUNE DISEASE; BLOOD BRAIN BARRIER; BRAIN; CELL COMMUNICATION; CYTOLOGY; DEGENERATIVE DISEASE; HUMAN; IMMUNOLOGY; IMMUNOMODULATION; IMMUNOSURVEILLANCE; INFECTION; INFLAMMATION; MICROGLIA; MULTIPLE SCLEROSIS; PATHOLOGY; PHYSIOLOGY; RAT; REVIEW; SECRETION; TH1 CELL; TH2 CELL; VASCULAR ENDOTHELIUM; VIRUS ENCEPHALITIS;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ASTROCYTES; AUTOIMMUNE DISEASES; BLOOD-BRAIN BARRIER; BRAIN; CELL COMMUNICATION; CYTOKINES; ENCEPHALITIS, VIRAL; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOLOGIC SURVEILLANCE; INFECTION; INFLAMMATION; INTERLEUKIN-12; MICROGLIA; MULTIPLE SCLEROSIS; NEURODEGENERATIVE DISEASES; NEUROIMMUNOMODULATION; RATS; TH1 CELLS; TH2 CELLS;

EID: 0034652416     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(20000215)29:4<293::AID-GLIA1>3.0.CO;2-A     Document Type: Review

References (131)

1. Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, Kollias G, Probert L. 1998. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol 153:801-813.
2. Allen JE, Maizels RM. 1997. Th1-Th2: reliable paradigm or dangerous dogma? Immunol Today 18:387-392.
3. Allison JP. 1994. CD28-B7 interactions in T-cell activation. Curr Opin Immunol 6:414-419.
4. Aloisi F, Penna G, Cerase J, Menendez IB, Adorini L. 1997. IL-12 production by central nervous system microglia is inhibited by astrocytes. J Immunol 159:1604-1612.
5. Aloisi F, Ria F, Penna G, Adorini L. 1998. Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation. J Immunol 160:4671-4680.
6. Andersson PB, Waubant E, Goodkin DE. 1997. How should we proceed with disease-modifying treatments for multiple sclerosis? Lancet 349:586-587.
7. Ando DG, Clayton J, Kono D, Urban JL, Sercarz EE. 1989. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol 124:132-143.
8. Austrup F, Vestweber D, Borges E, Lohning M, Brauer R, Herz U, Renz H, Hallmann R, Scheffold A, Radbruch A, Hamann A. 1997. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 385:81-83.
9. Baggiolini M, Dewald B, Moser B. 1997. Human chemokines: an update. Annu Rev Immunol 15:675-705.
10. Banchereau J, Bazan F, Blanchard D, Briere F, Galizzi JP, van Kooten C, Liu YJ, Rousset F, Saeland S. 1994. The CD40 antigen and its ligand. Annu Rev Immunol 12:881-922.
11. Barger SW, Harmon AD. 1997. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388:878-881.
12. Bauer J, Bradl M, Hickley WF, Forss-Petter S, Breitschopf H, Linington C, Wekerle H, Lassmann H. 1998. T-cell apoptosis in inflammatory brain lesions: destruction of T cells does not depend on antigen recognition. Am J Pathol 153:715-724.
13. Becher B, Antel JP. 1996. Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia. Glia 18:1-10.
14. Becher B, Barker PA, Owens T, Antel JP. 1998a. CD95-CD95L - can the brain learn from the immune system? Trends Neurosci 21:114-117.
15. Becher B, Giacomini PS, McCrea E, Pelletier D, Prat A, Antel JP. 1998b. Interferon gamma secretion by peripheral blood T cell subsets in multiple sclerosis: correlation with disease phase and IFN-therapy. Ann Neurol 45:247-250.
16. Becher B, Blain M, Antel JP. 1998c. CD40 engagement stimulates IL-12 p70 production by human microglial cells: basis for Th1 polarization in the CNS. J Neuroimmunol (in press).
17. Becher B, Blain M, Giacomini PS, Antel JP. 1999. Inhibition of Th1 polarization by soluble TNF receptor is dependent on antigen-presenting cell-derived IL-12. J Immunol 162:684-688.
18. Becher B, Fedorowicz V, Antel JP. 1996a. Regulation of CD14 expression on human adult central nervous system-derived microglia. J Neurosci Res 45:375-381.
19. Becher B, Dodelet V, Fedorowicz V, Antel JP. 1996b. Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro. J Clin Invest 98:1539-1543.
20. Birnbaum G. 1998. Introduction to immunology. In: Antel JP, Birnbaum G, Hartung HP, editors. Clinical neuroimmunology. Oxford: Blackwell Science Inc. p 1-12.
21. Bo L, Mork S, Kong PA, Nyland H, Pardo CA, Trapp BD. 1994. Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions. J Neuroimmunol 51:135-146.
22. Boom WH, Liano D, Abbas AK. 1988. Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes. J Exp Med 167:1350-1363.
23. Boussiotis VA, Gribben JG, Freeman GJ, Nadler LM. 1994. Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Curr Opin Immunol 6:797-807.
24. Carson MJ, Reilly CR, Sutcliffe JG, Lo D. 1998. Mature microglia resemble immature antigen presenting cells. Glia 22:72-85.
25. Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 184:747-752.
26. Clevers H, Alarcon B, Wileman T, Terhorst C. 1988. The T cell receptor/CD3 complex: a dynamic protein ensemble. Annu Rev Immunol 6:629-662.
27. Conboy IM, DeKruyff RH, Tate KM, Cao ZA, Moore TA, Umetsu DT, Jones PP. 1997. Novel genetic regulation of T helper 1 (Th1)/Th2 cytokine production and encephalitogenicity in inbred mouse strains. J Exp Med 185:439-451.
28. + T cell responses: the alternative approaches. Annu Rev Immunol 15:297-322.
29. Cua DJ, Hinton DR, Stohlman SA. 1995. Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease. J Immunol 155:4052-4059.
30. Daniel PT, Kroidl A, Cayeux S, Bargou R, Blankenstein T, Dorken B. 1997. Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis. J Immunol 159:3808-3815.
31. De Carli M, D'Elios MM, Zancuoghi G, Romagnani S, Del Prete G. 1994. Human Th1 and Th2 cells: functional properties, regulation of development and role in autoimmunity. Autoimmunity 18:301-308.
32. Devitt A, Moffatt OD, Raykundalia C, Capra JD, Simmons DL, Gregory CD. 1998. Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature 392:505-509.
33. Eikelenboom P, Rozemuller JM, van Muiswinkel FL 1998. Inflammation and Alzheimer's disease: relationships between pathogenic mechanisms and clinical expression. Exp Neurol 154:89-98.
34. El Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD. 1996. Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature 382:716-719.
35. Fierz W, Endler B, Reske K, Wekerle H, Fontana A. 1985. Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation. J Immunol 134:3785-3793.
36. Fischer HG, Nitzgen B, Reichmann G, Hadding U. 1997. Cytokine responses induced by Toxoplasma gondii in astrocytes and microglial cells. Eur J Immunol 27:1539-1548.
37. Flesch IE, Hess JH, Huang S, Aguet M, Rothe J, Bluethmann H, Kaufmann SH. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J Exp Med 181:1615-1621.
38. Fontana A, Erb P, Pircher H, Zinkernagel R, Weber E, Fierz W. 1986. Astrocytes as antigen-presenting cells. Part II: unlike H-2K-dependent cytotoxic T cells, H-2Ia-restricted T cells are only stimulated in the presence of interferon-gamma. J Neuroimmunol 12:15-28.
39. Ford AL, Foulcher E, Lemckert FA, Sedgwick JD. 1996. Microglia induce CD4 T lymphocyte final effector function and death. J Exp Med 184:1737-1745.
40. + T cells compared. J Immunol 154:4309-4321.
41. Foy TM, Aruffo A, Bajorath J, Buhlmann JE, Noelle RJ. 1996. Immune regulation by CD40 and its ligand GP39. Annu Rev Immunol 14:591-617.
42. Frei K, Eugster HP, Bopst M, Constantinescu CS, Lavi E, Fontana A. 1997. Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis. J Exp Med 185:2177-2182.
43. Gehrmann J, Banati RB, Kreutzberg GW. 1993. Microglia in the immune surveillance of the brain: human microglia constitutively express HLA-DR molecules. J Neuroimmunol 48:189-198.
44. Genain CP, Abel K, Belmar N, Villinger F, Rosenberg DP, Linington C, Raine CS, Hauser SL. 1996. Late complications of immune deviation therapy in a nonhuman primate. Science 274:2054-2057.
45. Genain CP, Cannella B, Hauser SL, Raine CS. 1999. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 5:170-175.
46. Gerritse K, Laman JD, Noelle RJ, Aruffo A, Ledbetter JA, Boersma WJ, Claassen E. 1996. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci USA 93:2499-2504.
47. Golde DW, Gasson JC. 1988. Hormones that stimulate the growth of blood cells. Sci Am 259:62-71.
48. Hassan-Zahraee M, Ladiwala U, Lavoi PM, McCrea E, Secaly SP, Owens T, Antel JP. 1999. Superantigen presenting capacity of human astrocytes. J Neuroimmunol (in press).
49. Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ. 1994. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J Exp Med 180:631-640.
50. Hickey WF, Kimura H. 1988. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239:290-292.
51. Hollenbaugh D, Mischel-Petty N, Edwards CP, Simon JC, Denfeld RW, Kiener PA, Aruffo A. 1995. Expression of functional CD40 by vascular endothelial cells. J Exp Med 182:33-40.
52. Howard LM, Miga AJ, Vanderlugt CL, Dal Canto MC, Laman JD, Noelle RJ, Miller SD. 1999. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis. J Clin Invest 103:281-290.
53. Jemison LM, Williams SK, Lublin FD, Knobler RL, Korngold R. 1993. Interferon-gamma-inducible endothelial cell class II major histocompatibility complex expression correlates with strain- and site-specific susceptibility to experimental allergic encephalomyelitis. J Neuroimmunol 47:15-22.
54. Jenkins MK. 1994. The ups and downs of T cell costimulation. Immunity 1:443-446.
55. Jenkins MK, Schwartz RH. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 165:302-319.
56. June CH, Bluestone JA, Nadler LM, Thompson CB. 1994. The B7 and CD28 receptor families. Immunol Today 15:321-331.
57. Karlsen AE, Dyrberg T. 1998. Molecular mimicry between non-self, modified self and self in autoimmunity. Semin Immunol 10:25-34.
58. Kassiotis G, Bauer J, Akassoglou K, Lassmann H, Kollias G, Probert L. 1999. A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice. Eur J Immunol 29:912-917.
59. Kelsall BL, Stuber E, Neurath M, Strober W. 1996. Interleukin-12 production by dendritic cells. The role of CD40-CD40L interactions in Th1 T-cell responses. Ann NY Acad Sci 795:116-126.
60. Kelso A. 1995. Th1 and Th2 subsets: paradigms lost? Immunol Today 16:374-379.
61. Kerschensteiner M, Gallmeiner E, Behrens L, Leal W, Misgeld T, Klinkert WF, Kolbeck R, Hoppe E, Oropeza-Wekerle RL, Bartke I, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld R. 1999. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 189:865-870.
62. Khoruts A, Miller SD, Jenkins MK. 1995. Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells. J Immunol 155:5011-5017.
63. Klinkert WE, Kojima K, Lesslauer W, Rinner W, Lassmann H, Wekerle H. 1997. TNF-alpha receptor fusion protein prevents experimental auto-immune encephalomyelitis and demyelination in Lewis rats: an overview. J Neuroimmunol 72:163-168.
64. Koch F, Stanzl U, Jennewein P, Janke K, Heufler C, Kampgen E, Romani N, Schuler G. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and down-regulation by IL-4 and IL-10. J Exp Med 184:741-746.
65. Koka P, He K, Zack JA, Kitchen S, Peacock W, Fried I, Tran T, Yashar SS, Merrill JE. 1995. Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain. J Exp Med 182:941-951.
66. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH. 1994. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84:1415-1420.
67. Korner H, Lemckert FA, Chaudhri G, Etteldorf S, Sedgwick JD. 1997a. Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system. Eur J Immunol 27:1973-1981.
68. Korner H, Riminton DS, Strickland DH, Lemckert FA, Pollard JD, Sedgwick JD. 1997b. Critical points of tumor necrosis factor action in CNS autoimmune inflammation defined by gene targeting. J Exp Med 186:1585-1590.
69. Leonard JP, Waldburger KE, Goldman SJ. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J Exp Med 181:381-386.
70. Ling EA, Wong WC. 1993. The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia 7:9-18.
71. Liu J, Marino MW, Wong G, Grail D, Dunn A, Bettadapura J, Slavin AJ, Old L, Bernard CC. 1998. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nature Med 4: 78-83.
72. Ma X, Aste-Amezaga M, Trinchieri G. 1996. Regulation of interleukin-12 production. Ann NY Acad Sci 795:13-25.
73. Mackay CR. 1997. Chemokines: what chemokine is that? Curr Biol 7:R384-R386.
74. Martin SJ, Reutelingsperger CP, McGahon AJ, Rader JA, van Schie RC, LaFace DM, Green DR. 1995. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 182:1545-1556.
75. Matsumoto Y, Ohmori K, Fujiwara M. 1992. Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions. Immunity 76:209-216.
76. McCarron RM, Spatz M, Kempski O, Hogan RN, Muehl L, McFarlin DE. 1986. Interaction between myelin basic protein-sensitized T lymphocytes and murine cerebral vascular endothelial cells. J Immunol 137:3428-3435.
77. McGeer PL, Kawamata T, Walker DG, Akiyama H, Tooyama I, McGeer EG. 1993. Microglia in degenerative neurological disease. Glia 7:84-92.
78. Medzhitov R, Janeway CAJ. 1997. Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 9:4-9.
79. Miller SD, Vanderlugt CL, Begolka WS, Pao W, Yauch RL, Neville KL, Katz-Levy Y, Carrizosa A, Kim BS. 1997. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat Med 3:1133-1136.
80. Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M. 1999. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 5:49-55.
81. Monteyne P, Bureau JF, Brahic M. 1998. Viruses and multiple sclerosis. Curr Opin Neurol 11:287-291.
82. Moreland LW, Baumgartner SW, Schiff MH, Tindall EA, Fleishmann RM, Weaver AL, Ettlinger RE, Cohen S, Koopman WJ, Mohler K, Widmer MB, Blosch CM. 1997. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med 337:141-147.
83. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136:2348-2357.
84. Mosmann TR, Coffman RL. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145-173.
85. Nakajima K, Kohsaka S. 1993. Functional roles of microglia in the brain. Neurosci Res 17:187-203.
86. Nikcevich KM, Gordon KB, Tan L, Hurst SD, Kroepfl JF, Gardinier M, Barrett TA, Miller SD. 1997. IFN-gamma-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells. J Immunol 158:614-621.
87. Oldstone MB, von Herrath M, Evans CF, Horwitz MS. 1996. Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis. Curr Topic Microbiol Immunol 206:67-83.
88. Olsson T. 1995. Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis. Neurology 45[suppl 6]:S11-S5.
89. Pan Y, Lloyd C, Zhou H, Dolich S, Deeds J, Gonzalo JA, Vath J, Gosselin M, Ma J, Dussault B, Woolf E, Alperin G, Culpepper J, Gutierrez-Ramos JC, Gearing D. 1997. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 387:611-617.
90. Pasinetti GM. 1998. Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions. J Neurosci Res 54:1-6.
91. Pearson AM. 1996. Scavenger receptors in innate immunity. Curr Opin Immunol 8:20-28.
92. Prat A, Biernacki K, Becher B, Antel JP. 1999. B7 expression and antigen presentation by human brain endothelial cells: requirement for pro-inflammatory' cytokines. J Neuropath Exp Neurol (in press).
93. Racke MK, Bonomo A, Scott DE, Cannella B, Levine A, Raine CS, Shevach EM, Rocken M. 1994. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 180:1961-1966.
94. Renno T, Krakowski M, Piccirillo C, Lin JY, Owens T. 1995. TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines. J Immunol 154:944-953.
95. Risau W, Engelhardt B, Wekerle H. 1990. Immune function of the blood-brain barrier: incomplete presentation of protein (auto-) antigens by rat brain microvascular endothelium in vitro. J Cell Biol 110:1757-1766.
96. Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR, Kay AB. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 326:298-304.
97. Romagnani S. 1994. Regulation of the development of type 2 T-helper cells in allergy. Curr Opin Immunol 6:838-846.
98. Romagnani S. 1995. Biology of human TH1 and TH2 cells. J Clin Immunol 15:121-129.
99. Rott O, Fleischer B, Cash E. 1994. Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur J Immunol 24:1434-1440.
100. Rudensky AY, Maric M, Eastman S, Shoemaker L, DeRoos PC, Blum JS. 1994. Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity 1:585-594.
101. Satoh J, Lee, YB, Kim SU. 1995. T-cell co-stimulatory molecules B7-1 (CD80) and B7-2 (CD86) are expressed in human microglia but not in astrocytes in culture. Brain Res 704:92-96.
102. Schmidtmayer J, Jacobsen C, Miksch G, Sievers J. 1994. Blood monocytes and spleen macrophages differentiate into microglia-like cells on monolayers of astrocytes: membrane currents. Glia 12:259-267.
103. Schulze-Koops H, Lipsky PE, Kavanaugh AF, Davis LS. 1995. Elevated Th1- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. Modulation by treatment with anti-ICAM-1 correlates with clinical benefit. J Immunol 155:5029-5037.
104. + T cells. Annu Rev Immunol 12:635-673.
105. Sedgwick JD, Ford AL, Foulcher E, Airriess R. 1998. Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts. J Immunol 160: 5320-5330.
106. Sedgwick JD, Schwender S, Gregersen R, Dorries R, ter Meulen V. 1993. Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive. J Exp Med 177:1145-1152.
107. Segal BM, Dwyer BK, Shevach EM. 1998. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J Exp Med 187:537-546.
108. Segal BM, Shevach EM. 1996. IL-12 unmasks latent autoimmune disease in resistant mice. J Exp Med 184:771-775.
109. Sobel RA, Blanchette BW, Bhan AK, Colvin RB. 1984. The immunopathology of experimental allergic encephalomyelitis. II. Endothelial cell Ia increases before inflammatory cell infiltration. J Immunol 132:2402-2407.
110. Stalder AK, Pagenstecher A, Yu NC, Kincaid C, Chiang CS, Hobbs MV, Bloom FE, Campbell IL. 1997. Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia. J Immunol 159:1344-1351.
111. Streit WJ, Graeber MB. 1993. Heterogeneity of microglial and perivascular cell populations: insights gained from the facial nucleus paradigm. Glia 7:68-74.
112. Talbot PJ, Paquette JS, Ciurli C, Antel JP, Quellet F. 1996. Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis. Ann Neurol 39:233-240.
113. Tan L, Gordon KB, Mueller JP, Matis LA, Miller SD. 1998. Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes. J Immunol 160:4271-4279.
114. Tran EH, Hoekstra K, van Rooijen N, Dijkstra CD, Owens T. 1998. Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J Immunol 161:3767-3775.
115. Trembleau S, Germann T, Gately MK, Adorini L. 1995. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol Today 16:383-386.
116. Ulvestad E, Williams K, Mork S, Antel J, Nyland H. 1994a. Phenotypic differences between human monocytes/macrophages and microglial cells studied in situ and in vitro. J Neuropath Exp Neurol 53:492-501.
117. Ulvestad E, Williams K, Bo L, Trapp B, Antel J, Mork S. 1994b. HLA class II molecules (HLA-DR, -DP, -DQ) on cells in the human CNS studied in situ and in vitro. Immunology 82:535-541,
118. Ulvestad E, Williams K, Bjerkvig R, Tiekotter K, Antel J, Matre R. 1994c. Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells. J Leukocyte Biol 56:732-740.
119. Utans-Schneitz U, Lorez H, Klinkert WE, da Silva J, Lesslauer W. 1998. A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation. J Neuroimmunol 92:179-190.
120. van Reijsen FC, Bruijnzeel-Koomen CA, Kalthoff FS, Maggi E, Romagnani S, Westland JK, Mudde GC. 1992. Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis. J Allergy Clin Immunol 90:184-193.
121. Vanderlugt CJ, Miller SD. 1996. Epitope spreading. Curr Opin Immunol 8:831-836.
122. Wekerle H, Sun D, Oropeza-Wekerle RL, Meyermann R. 1987. Immune reactivity in the nervous system: modulation of T-lymphocyte activation by glial cells. J Exp Biol 132:43-57.
123. Williams K, Ulvestad E, Antel J. 1994a. Immune regulatory and effector properties of human adult microglia studies in vitro and in situ. Adv Neuroimm 4:273-281.
124. Williams KC, Ulvestad E, Hickey WF. 1994b. Immunology of multiple sclerosis. Clin Neurosci 2:229-245.
125. Williams K, Ulvestad E, Antel JP. 1994c. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ. Eur J Immunol 24:3031-3037.
126. Williams KC, Dooley NP, Ulvestad E, Waage A, Blain M, Yong VW, Antel JP. 1995. Antigen presentation by human fetal astrocytes with the cooperative effect of microglia or the microglial-derived cytokine IL-1. J Neurosci 15:1869-1878.
127. Windhagen A, Anderson DE, Carrizosa A, Williams RE, Hafler DA. 1996. IL-12 induces human T cells secreting IL-10 with IFN-gamma. J Immunol 157:1127-1131.
128. Windhagen A, Newcombe J, Dangond F, Strand C, Woodroofe MN, Cuzner ML, Hafler DA. 1995. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J Exp Med 182:1985-1996.
129. Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM. 1996. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 382:685-691.
130. Yeung MC, Pulliam L, Lau AS. 1995. The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-alpha. AIDS 9:137-143.
131. Yong VW, Moumdjian R, Yong FP, Ruijs TC, Freedman MS, Cashman N, Antel JP. 1991. Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo. Proc Natl Acad Sci USA 88:7016-7020.