IL-12 Production by Central Nervous System Microglia is Inhibited by Astrocytes

Journal of Immunology

Volumn 159, Issue 4, 1997, Pages 1604-1612

  Aloisi, Francesca ^a   Penna, Giuseppe ^b   Cerase, Joanna ^a   Iglesias, Begoña Menéndez ^a   Adorini, Luciano ^b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b ROCHE MILANO RICERCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; MESSENGER RNA; PROSTAGLANDIN E2;

ANIMAL; ARTICLE; ASTROCYTE; BIOSYNTHESIS; BRAIN; CELL CULTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOLOGY; MICROGLIA; MOUSE; PHYSIOLOGY;

ANIMALS; ASTROCYTES; BRAIN; CELLS, CULTURED; DINOPROSTONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-10; INTERLEUKIN-12; MICE; MICROGLIA; RNA, MESSENGER;

EID: 0031571317     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
2. Gubler, U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, P. C. Familletti, and M. K. Gately. 1991. Coexpression of two distinct genes is required to generate secreted, bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88:4143.
3. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzonite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
4. Heufler, C., F. Koch, U. Stanzl, G. Topar, M. Wysocka, G. Trinchieri, A. Enk, R. M. Steinman, N. Romani, and G. Schuler. 1996. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-γ production by T helper 1 cells. Eur. J. Immunol. 26:659.
5. Hendrzak, J. A., and M. J. Brunda. 1995. Biology of disease: interleukin-12: biologic activity, therapeutic utility, and role in disease. Lab. Invest. 72:619.
6. Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer stimulatory factor (NKSF/IL-12) induces Th1-type specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 177:1199.
7. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
8. Afonso, L. C. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235.
9. Murphy, E. E., G. Terres, S. E. Macatonia, C.-S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223.
10. Germann, T., M. K. Gately, D. S. Schoenhaut, M. Lohoff, F. Mattner, S. Fischer, S. C. Jin, E. Schmitt, and E. Rude. 1995. Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper lype 1 (Th1) but not on Th2 cells. Eur. J. Immunol. 23:1762.
11. Trembleau, S., T. Germann, M. K. Gately, and L. Adorini. 1995. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol. Today 16:383.
12. Santambrogio, L., G. M. Crisi, J. Leu, G. M. Hochwald, T. Ryan, and G. J. Thorbecke. 1995. Tolerogenic forms of auto-antigens and cytokines in the induction of resistance to experimental allergic encephalomyelitis. J. Neuroimmunol. 58:211.
13. Leonard, J. P., K. E. Waldburger, and S. J. Goldman. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181:381.
14. Issazadeh, S., Å. Ljungdahl, B. Höjeberg, M. Mustafa, and T. Olsson. 1995. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, tumor necrosis factor α and tumor necrosis factor β. J. Neuroimmunol. 61:205.
15. Raine, C. S. 1991. Demyelinating diseases. In Textbook of Neuropathology. R. L. Davis and D. M. Robertson, eds. Williams & Wilkins, Baltimore, p. 535.
16. Hofman, F. M., D. R. Hinton, K. Johnson, and J. E. Merrill. 1989. Tumor necrosis factor identified in multiple sclerosis brain. J. Exp. Med. 170:607.
17. Traugott, U., and P. Lebon. 1988. Multiple sclerosis involvement of interferons in lesion pathogenesis. Ann. Neurol. 24:243.
18. Selmaj, K., C. S. Raine, B. Cannella, and C. F. Brosnan. 1991. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J. Clin. Invest. 87:949.
19. Cannella, B., and C. S. Raine. 1995. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann. Neurol. 37:424.
20. Brod, S. A., D. Benjamin, and D. A. Hafler. 1991. Restricted T cell expression of IL-2/IFN-γ mRNA in human inflammatory disease. J. Immunol. 147:810.
21. Windhagen, A., J. Newcombe, F. Dangond, C. Strand, M. N. Woodroofe, M. L. Cuzner, and D. A. Hafler. 1995. Expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J. Exp. Med. 182:1985.
22. Hart, M. N., and Z. Fabry. 1995. CNS antigen presentation. Trends Neurosci. 18:475.
23. Hopkins, S. J., and N. J. Rothwell. 1995. Cytokines and the nervous system I: expression and recognition. Trends Neurosci. 18:83.
24. Kreutzberg, G. W. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:312.
25. De Simone, R., A. Giampaolo, B. Giometto, P. Gallo, G. Levi, C. Peschle, and F. Aloisi. 1995. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J. Neuropathol. Exp. Neurol. 54:175.
26. Williams, K., E. Ulvestad, and J. P. Antel. 1994. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ. Eur. J. Immunol. 24:3031.
27. Frei, K., C. Siepl, P. Groscurth, S. Bodmer, C. Schwerdel, and A. Fontana. 1987. Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells. Eur. J. Immunol. 17:1271.
28. + T lymphocytes in the central nervous system. Clin. Exp. Immunol. 98:313.
29. Williams, K., E. Ulvestad, L. Cragg, M. Blain, and J. P. Antel. 1993. Induction of primary T cell responses by human glial cells. J. Neurosci. Res. 36:382.
30. Ford, A. L., A. L. Goodsall, W. F. Hickey, and J. D. Sedgwick. 1995. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. J. Immunol. 154:4309.
31. Ford, A. L., E. Foulcher, F. A. Lemckert, and J. D. Sedgwick. 1996. Microglia induce CD4 T lymphocyte final effector function and death. J. Exp. Med. 184: 1737.
32. Bö, L., S. Mö, P. A. Kong, H. Nyland, C. A. Pardo, and B. D. Trapp. 1994. Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions. J. Neuroimmunol. 51:135.
33. Fontana, A., W. Fierz, and H. Wekerle. 1984 Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature 307:273.
34. + T cell responses in the central nervous system. J. Exp. Med. 173:1235.
35. Weber, F., E. Meinl, F. Aloisi, C. Nevinny-Stickel, E. Albert, H. Wekerle, and R. Hohlfeld. 1994. Human astrocytes are only partially competent antigen presenting cells: possible implications for lesion development in multiple sclerosis. Brain 117:59.
36. Meinl, E., F. Aloisi, B. Ertl, F. Weber, R. de Waal Malefyt, H. Wekerle, and R. Hohlfeld. 1994. Multiple sclerosis: immunomodulatory effects of human astrocytes on T cells. Brain 117:1323.
37. 2 and cyclic AMP-elevating agents. J. Neuroimmunol. 72:83.
38. Di Marzio, P., P. Puddu, L. Conti, F. Belardelli, and S. Gessani. 1994. Interferon γ up-regulates its own expression in mouse peritoneal macrophages. J. Exp. Med. 179:1731.
39. Chirgwin, M., A. E. Przybyla, R. J. Mac Donald, and W. T. Rutter. 1979. Isolation of a biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294.
40. Gately, M. K., R. Chizzonite, and D. H. Presky 1995. Measurement of human and mouse IL-12. Current Protocols in Immunol. 3:6.16.1.
41. Tracey, W. R. 1992. Spectrophotometric determination of nitrogen oxides using azo dyes. Neuroprotocols 1:125.
42. Aloisi, F., A. Carè, G. Borsellino, P. Gallo, S. Rosa, A. Bassani, A. Cabibbo, U. Testa, G. Levi, and C. Peschle. 1992. Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1β and tumor necrosis factor-α. J. Immunol. 149:2358.
43. Frei, K., H. Lins, C. Schwerdel, and A. Fontana. 1994. Antigen presentation in the central nervous system: the inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed. J. Immunol. 152:2720.
44. Lieberman, A. P., P. M. Pitha, H. S. Shin, and M. L. Shin. 1989. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc. Natl. Acad. Sci. USA 86:6348.
45. Moore, K. W., A. O'Garra, R. de Waal Malefyt, P. Vieira, and T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165.
46. Chao, C. C., S. Hu, W. S. Sheng, M. Tsang, and P. K. Peterson. 1995. Tumor necrosis factor-alpha mediates the release of bioactive transforming growth factor-beta in murine microglial cell cultures. Clin. Immunol. Immunopathol. 77: 358.
47. Snyder, D. S., D. I. Beller, and E. Unanue. 1982. Prostaglandins modulate macrophage Ia expression. Nature 299:163.
48. 2, cholera toxin and 8-bromo-cyclic AMP on lipopolysaccharide-induced gene expression of cytokines in human macrophages. Immunology 84:446.
49. 2 and a beta-adrenergic agonist. Glia 11:383.
50. 2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:775.
51. Kammer, G. M. 1988. The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response. Immunol. Today 9:222.
52. Matsumoto, Y., H. Hanawa, M. Tsuchida, and T. Abo. 1993. In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis: the role of astrocytes. Immunology 79:381.
53. Minghetti, L., E. Polazzi, A. Nicolini, C. Créminon, and G. Levi. 1996. Interferon-γ and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression. J. Neurochem. 66:1963.
54. Ma, X., A. D'Andrea, M. Kubin, M. Aste-Amezaga, A. Sartori, J. Monteiro, L. Showe, M. Wysocka, and G. Trinchieri. 1995. Production of IL-12. Res. Immunol. 146:423.
55. Hayes, M. P., J. Wang, and M. A. Norcross. 1995. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-γ of lipopolysaccharide-inducible p35 and p40 genes. Blood 86:646.
56. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells. J. Exp. Med. 183:147.
57. Mattner, F., S. Fischer, S. Guckes, S. Jin, H. Kaulen, E. Schmitt, E. Rüde, and T. Germann. 1993. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23:2202.
58. Gillessen, S., D. Carvajal, P. Ling, F. J. Podlaski, D. L. Stremlo, P. C. Familletti, U. Gubler, D. H. Presky, A. S. Stern, and M. K. Gately. 1995. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25: 200.
59. Ling, P., M. K. Gately, U. Gubler, A. S. Stern, P. Lin, K. Hollfelder, C. Su, Y. C. Pan, and J. Hakimi. 1995. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J. Immunol. 195:116.
60. Streit, W. J., M. H. Graeber, and G. W. Kreutzberg. 1988. Functional plasticity of microglia: a review. Glia 1:301.
61. Becher, B., V. Dodelet, V. Fedorowicz, and J. P. Antel. 1996. Soluble tumor necrosis factor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro. J. Clin. Invest. 98:1539.
62. Mizuno, T., M. Sawada, T. Marunouchi, and A. Suzumura. 1994. Production of IL-10 by mouse glial cells in culture. Biochem. Biophys. Res. Commun. 205: 1907.
63. Murphy, S., B. Pearce, J. Jeremy, and P. Dandona. 1988. Astrocytes as eicosanoid-producing cells. Glia 1:241.
64. D'Andrea, A., M. Aste-Amegaza, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin-10 (IL-10) inhibits human lymphocyte interferon γ production by suppressing natural killer cell stimulatory factor IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
65. Goodman, R. E., F. Nestle, Y. M. Naidu, J. M. Green, C. B. Thompson, B. J. Nickoloff, and L. A. Turka. 1994. Keratinocyte-derived T cell costimulation induces preferential production of IL-2 and IL-4 but not IFN-γ. J. Immunol. 152:5189.
66. Selmaj, K. W., C. S. Raine, M. Farooq, W. T. Norton, and C. F. Brosnan. 1991. Cytokine cytotoxicity against oligodendrocytes. J. Immunol. 147:1522.
67. Zajicek, J. P., M. Wing, N. J. Scolding, and D. A. S. Compston. 1991. Interactions between oligodendrocytes and microglia: a major role for complement and tumor necrosis factor in oligodendrocyte adherence and killing. Brain 115:1611.
68. Agresti, C., D. D'Urso, and G. Levi. 1996. Reversible inhibitory effects of interferon-gamma and tumor necrosis factor-alpha on oligodendrocyte proliferation and differentiation in vitro. Eur. J. Neurosci. 8:1106.