The role of Alzheimer’s disease-related presenilin 1 in intercellular adhesion

Experimental Cell Research

Volumn 263, Issue 1, 2001, Pages 1-13

  Singh, Nandita ^a   Talalayeva, Yelena ^a   Tsiper, Maria ^a   Romanov, Victor ^a   Dranovsky, Alex ^a   Colflesh, Dave ^a   Rudamen, Gregory ^a   Vitek, Michael P ^b   Shen, Jie ^c   Yang, Xudong ^c   Goldgaber, Dmitry ^a   Schwarzman, Alexander L ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Alzheimer s disease; Cell cell adhesion; Epithelial cells; Presenilin 1; Primary neuronal cultures

Indexed keywords

BETA CATENIN; COMPLEMENTARY DNA; PRESENILIN 1;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL AGGREGATION; CELL CONTACT; CELL MEMBRANE; CONTROLLED STUDY; EPITHELIUM CELL; GENE MUTATION; GENETIC TRANSFECTION; GROWTH CONE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

EID: 0035242437     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5098     Document Type: Article

References (87)

1. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons
2. Notch signaling: Cell fate control and signal integration in development
3. The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium
4. Proteolytic fragment of Alzheimer’s disease-associated presenilin 1 are present in synaptic organells and growth cone membranes of rat brain
5. N-cadherin redistribution during synaptogenesis in hippocampal neurons
6. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons
7. Membrane traffic in polarized neurons
8. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
9. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer’s disease
10. Neurites, synapses, and cadherin reconciled
11. Expression and analysis of presenilin 1 in a human neuronal system: Localization in cell bodies and dendrites
12. A variant of Alzheimer’s disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
13. An Alzheimer’s disease-linked PS1 variant rescues the developmental abnormalities of PSi-deficient embryos
14. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer’s disease-associated presenilins
15. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
16. A presenilin1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
17. The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells
18. Protein topology of presenilin 1
19. Polarized sorting of viral glycoproteins to the exon and dendrites of hippocampal neurons in culture
20. Inhibition of neurite outgrowth by familial Alzheimer’s disease-linked presenilin-1 mutations
21. Cellular expression of liver and neural cell adhesion molecules after transfection with their cDNAs results in specific cell-cell binding
22. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles
23. A model for central synaptic junction complex formation based on the differential adhesive specificity of the cadherins
24. Cell sorting-out is modulated by both specificity and amount of different cell adhesion molecules (CAMs) expressed on cell surface
25. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts
26. Mechanism and molecules that control growth cone guidance
27. Integrin-mediated short-term memory in Drosophila
28. The presenilins in Alzheimer’s disease - Proteolysis holds the key
29. Amyloid, the presenilins and Alzheimer’s disease
30. Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
31. Lamina-specific connectivity in the brain: Regulation by N-cadherin, neurotrophins, and glycoconjugates
32. Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS
33. Aggresomes: A cellular response to misfolded proteins
34. Presenilin i facilitates the constitutive turnover of beta-catenin: Differential activity of Alzheimer’s disease-linked PS1 mutants in the beta-catenin-signaling pathway
35. Neural cell adhesion molecules L1: Relating disease to function
36. Diversity revealed by a novel family of cadherins expressed in neurons at synaptic complex
37. Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
38. Light and electron microscopic localization of presenilin-1 in primate brain
39. Evidence for a six-transmembrane domain structure of presenilin 1
40. CD44 and its interaction with extracellular matrix
41. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer’s disease gene
42. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
43. Membrane topology of the C. Elegans SEL-12 presenilin
44. Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins
45. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosomal segregation
46. Actin crosslinking proteins at the leading edge
47. Cell and molecular neurobiology of presenilins: A role for the endoplasmic reticulum in the pathogenesis of Alzheimer’s disease?
48. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer’s disease
49. Construction of epithelioid sheets by transfection of mouse sarcoma cells with c DNAs for chicken cell adhesion molecules
50. Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing
51. Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA
52. Membrane topology of Alzheimer’s disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure
53. Expressed recombinant cadherins mediate cell sorting in model systems
54. Synaptic transmission and hippocampal long-term potentiatin in transgenic mice expressing FAD-linked presenilin 1
55. The morphology of synapses
56. A mutation in Alzheimer’s disease destroying a splice acceptor site in the presenilin-1 gene
57. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abetal-42/43 expression
58. Forced transmembrane orientation of hydrophilic polypeptide segments in multispanning membrane proteins
59. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch
60. The function of presenilin 1 in amyloid beta-peptide generation and brain development
61. Identification of peptides binding to presenilin 1 by screening of random peptide display libraries
62. Endogenous presenilin 1 redistributes to the lamellipodia upon adhesion of Jurkat cells to a collagen matrix
63. Skeletal and CNS defects in presenilin-1-deficient mice
64. Cloning of gene bearing missense mutations in early-onset familial Alzheimer’s disease
65. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
66. Presenilin is required for activity and nuclear access of Notch in Drosophila
67. Localization of Alzheimer-associated presenilin 1 in transfected COS-7 cells
68. Morphogenetic roles of classic cadherins
69. A role for the cadherin family of cell adhesion molecules in hippocampal long term potentiation
70. Abrogation of the presenilin 1/β-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation
71. Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer’s disease gene ALG-3
72. Beta-catenin: A key mediator of Wnt signaling
73. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
74. Presenilin 1 required for Notch 1 and DLL1 expression in the paraxial mesoderm
75. The cadherin superfamily at the synapse: More members, more missions
76. Characterization of Drosophila presenilin and its co-localization with Notch during development
77. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants
78. New perspectives on mechanisms involved in generating epithelial cell polarity
79. Interaction of presenilins with the filamin family of actin-binding proteins
80. Presenilin 1 interaction in the brain with a novel member of the Armadillo
81. Beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion
82. Rapid and efficient site-specific mutagenesis without phenotypic selection
83. Membrane proteins which exhibit multiple topological orientation
84. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex
85. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: Evidence for novel species-specific properties of human presenilin-1
86. Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1