Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein

Virology

Volumn 282, Issue 1, 2001, Pages 14-25

  Shisler, Joanna L ^a   Moss, Bernard ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; INHIBITOR OF APOPTOSIS PROTEIN; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLLUSCIPOXVIRUS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ARBOVIRUS; DNA VIRUSES; INVERTEBRATA; MOLLUSCIPOXVIRUS; MOLLUSCUM CONTAGIOSUM VIRUS; VACCINIA; VACCINIA VIRUS;

EID: 0035970321     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2001.0834     Document Type: Article

References (38)

1. The baculovirus p35 protein inhibits Fas- and tumor necrosis factor- induced apoptosis
2. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis
3. Langerhans cells in molluscum contagiosum, verruca vulgaris, plantar wart, and condyloma acuminatum
4. Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and γ-radiation downstream from caspase-8 activation
5. Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog
6. The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors
7. Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product
8. Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB
9. Generation of recombinant vaccinia viruses
10. CASH, a novel caspase homologue with death effector domains
11. Molluscum contagiosum
12. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
13. MRIT, a novel death-effector domain-containing protein, interacts with caspases and Bcl-XI and initiates cell death
14. Lack of host cellular immune response in eruptive molluscum contagiosum
15. Caspases are activated in a branched protease cascade and control distinct down-stream processes in Fas-induced apoptosis
16. A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis
17. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
18. Inhibition of death receptor signals by cellular FLIP
19. Vaccinia virus encodes two proteins that are structurally related to members of the plasma serine protease inhibitors superfamily
20. CD95(APO-1/Fas)-mediated apoptosis: Live and let die
21. Functional characterization of the C-C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2
22. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
23. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
24. Two CD95 (APO-1/Fas) signaling pathways
25. The role of c-FLIP in modulation of CD95-induced apoptosis
26. The genome of molluscum contagiosum virus: Analysis and comparison with other poxviruses
27. Domain structure, intracellular trafficking, and beta2-microglobulin binding of a major histocompatibility complex class I homolog encoded by molluscum contagiosum virus
28. Vaccinia virus serpin-1 deletion mutant exhibits a host range defect characterized by low levels of intermediate and late mRNAs
29. Ultraviolet-induced cell death blocked by a selenoprotein from a human dermatotropic poxvirus
30. Casper is a FADD- and caspase-related inducer of apoptosis
31. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE- like cysteine proteases
32. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
33. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
34. Viral FLICE inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
35. Requirement of cooperative functions of two repeated death effector domains in caspase-8 and in MC159 for induction and inhibition of apoptosis, respectively
36. Immunocompetent cells and epithelial cell modifications in molluscum contagiosum
37. Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)
38. IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins