Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen

Journal of Virology

Volumn 71, Issue 6, 1997, Pages 4536-4543

  Conzen, Suzanne D ^a   Snay, Christine A ^a   Cole, Charles N ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; EMBRYO; ETIOLOGY; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RAT; SEQUENCE HOMOLOGY; SIMIAN VIRUS 40;

EID: 0030923807     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.6.4536-4543.1997     Document Type: Article

References (46)

1. Almasan, A., Y. Yin, R. Kelly, E. Lee, A. Bradley, W. Li, J. Bertino, and G. Wahl. 1995. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc. Natl. Acad. Sci. USA 92:5436-5440.
2. Atadja, P., H. Wong, I. Garkavstev, C. Veillette, and K. Riabowol. 1995. Increased activity of p53 in senescing fibroblasts. Proc. Natl. Acad. Sci. USA 92:8348-8352.
3. Bakhshi, A., J. Jensen, P. Goldman, J. Wright, O. McBride, A. Epstein, and S. J. Korsmeyer. 1985. Cloning the chromosomal break-point of the t(14:18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41:889-906.
4. Braithwaite, A. W., G. E. Blair, C. C. Nelson, J. McGovern, and A. J. Bellett. 1991. Adenovirus E1b-58 kD antigen binds to p53 during infection of rodent cells: evidence for an N-terminal binding site on p53. Oncogene 6:781-786.
5. Chen, G., P. E. Branton, E. Yang, S. J. Korsmeyer, and G. C. Shore. 1996. Adenovirus E1B 19-kDa death suppressor protein interacts with Bax but not with Bad. J. Biol. Chem. 271:24221-24225.
6. Chen, X., L. Ko, L. Jayaraman, and C. Prives. 1996. p53 levels, functional domains and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10:2238-2451.
7. Chiou, S.-K., C.-C. Tseng, L. Rao, and E. White. 1994. Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells. J. Virol. 68:6553-6566.
8. Clem, R., and L. Miller. 1994. Control of programmed cell death by the baculovirus genes p35 and iap. Mol. Cell. Biol. 14:5212-5222.
9. Cole, C., J. Tornow, R. Clark, and R. Tjian. 1986. Properties of the simian virus 40 (SV40) large T antigens encoded by SV40 mutants with deletions in gene A. J. Virol. 57:539-546.
10. Cole, C. N. Unpublished data.
11. Conzen, S. D., and C. N. Cole. 1995. The three transforming regions of large T antigen are required for primary mouse embryo fibroblast immortalization. Oncogene 11:2295-2302.
12. Conzen, S. D., C. A. Snay, and C. N. Cole. Unpublished data.
13. Debbas, M. and E. White. 1993. Wild type p53 mediates apoptosis by E1A which is inhibited by E1B. Genes Dev. 7:546-554.
14. Dobner, T., N. Horikoshi, S. Rubenwolf, and T. Shenk. 1996. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science 272:1470-1473.
15. Duckett, C. S., V. E. Nava, R. W. Gedrich, R. J. Clem, J. L. Van Dongen, M. C. Gilfillan, H. Shiels, J. M. Hardwick, and C. B. Thompson. 1996. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J. 15:2685-2694.
16. Han, J., P. Sabbatini, D. Perez, L. Rao, D. Modha, and E. White. 1996. The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein. Genes Dev. 10:461-477.
17. Howes, K. A., N. Ransom, D. S. Papermaster, J. G. H. Lasudry, D. M. Albert, and J. J. Windle. 1994. Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes Dev. 8:1300-1310.
18. Lowe, S., T. Jacks, D. Housman, and H. Ruley. 1994. Abrogation of oncogene associated apoptosis allows transformation of p53-deficient cells. Proc. Natl. Acad. Sci. USA 91:1026-1030.
19. Lowe, S., and H. E. Ruley. 1993. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev. 7:535-545.
20. Jacks, T., A. Fazeli, E. M. Schmitt, R. T. Bronson, M. A. Goodell, and R. A. Weinberg. 1992. Effects of an Rb mutation in the mouse. Nature 359:295-300.
21. Kierstead, T., and M. J. Tevethia. 1993. Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T antigen mutants bearing internal overlapping deletion mutations. J. Virol. 4:1817-1829.
22. Marcellus, R., J. Teodoro, T. Wu, D. Brough, G. Ketner, G. Shore, and P. Branton. 1996. Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis. J. Virol. 10:6207-6215.
23. Morgenbesser, S., B. Williams, T. Jacks, and R. DePinho. 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371:72-74.
24. Naik, P., J. Karrim, and D. Hanahan. 1996. The rise and fall of apoptosis during multistage tumorigenesis: down modulation contributes to tumor progression from angiogenic progenitors. Genes Dev. 10:2105-2116.
25. Oltvai, Z., and S. J. Korsmeyer. 1994. Checkpoint of dueling dimers foil death wishes. Cell 79:189-192.
26. Pan, H., and A. Griep. 1994. Altered cell cycle regulation in the lens of HP-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev. 8:1285-1299.
27. Qin, X.-Q., D. M. Livingston, W. G. Kaelin, and P. D. Adams. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91:10918-10922.
28. Rao, L., M. Debbas, P. Sabbatini, D. Hockenberry, S. Korsmeyer, and E. White. 1992. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc. Natl. Acad. Sci. USA 89:7742-7746.
29. Sabbatini, P., S.-K. Chiou, L. Rao, and E. White. 1995. Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein. Mol. Cell. Biol. 15:1060-1070.
30. Sompayrac, L., and K. Danna. 1991. The amino terminal 147 amino acids of SV40 large T antigen transform secondary rat embryo fibroblasts. Virology 181:412-115.
31. Southern, P., and P. Berg. 1982. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet. 1:324-341.
32. Srinivasan, A., K. W. Peden, and J. M. Pipas. 1989. The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions. J. Virol. 63:5459-5463.
33. Subramanian, T., B. Tarodi, and G. Chinnadurai. 1995. p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: suppression by E1B 19K and Bcl-2 proteins. Cell Growth Differ. 652:131-137.
34. Sugimoto, A., R. Hozak, T. Nakashima, T. Nishimoto, and J. Rothman. 1995. dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates. EMBO J. 14:4434-4441.
35. Symonds, H., L. Krall, L. Remington, M. Saenz-Robles, S. Lowe, T. Jacks, and T. Van Dyke. 1994. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78:703-711.
36. Teodoro, J., G. Shore, and P. Branton. 1996. Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms. Oncogene 11:467-474.
37. Tevethia, M. J., J. M. Pipas, T. Kierstead, and C. N. Cole. 1988. Requirements for immortalization of primary mouse embryo fibroblasts probed with mutants bearing deletions in the 3′ end of the SV40 gene A. Virology 162:76-89.
38. Tsujimoto, Y., and C. Croce. 1986. Analysis of the structure, transcripts and protein products of bcl-2, the gene involved in follicular lymphomas. Proc. Natl. Acad. Sci. USA 83:5214-5418.
39. Wagner, A., J. Kokontis, and N. Hay. 1994. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell-cycle arrest and the ability of p53 to induce p21 waf1/cip1. Genes Dev. 8:2817-2830.
40. White, E. 1996. Life death and the pursuit of apoptosis. Genes Dev. 10:1-15.
41. White, E., R. Cipriani, P. Sabbatini, and A. Denton. 1991. Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins. J. Virol. 65:2968-2978.
42. Yaciuk, P., M. C. Carter, J. M. Pipas, and E. Moran. 1991. Simian virus 40 large T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products. Mol. Cell. Biol. 11:2116-2124.
43. Yin, X.-M., Z. N. Oltvai, and S. J. Korsmeyer. 1994. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369:321-323.
44. Zhu, J., P. Rice, M. Abate, and C. N. Cole. 1992. The ability of SV40 large T antigen to immortalize mouse embryo fibroblasts cosegregates with its ability to bind p53. J. Virol. 65:6872-6880.
45. Zhu, J., P. Rice, M. Chamberlain, and C. N. Cole. 1991. Mapping the transcriptional transactivation function of simian virus 40 large T antigen. J. Virol. 65:2778-2790.
46. Zhu, J., P. W. Rice, L. Gorsch, M. Abate, and C. N. Cole. 1992. Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen. J. Virol. 66:2780-2791.