Herpes simplex virus 1716, an ICP 34.5 null mutant, is unable to replicate in CV-1 cells due to a translational block that can be overcome by coinfection with SV40

Journal of General Virology

Volumn 78, Issue 12, 1997, Pages 3333-3339

  Randazzo, Bruce P ^a,b,c   Tal Singer, Ruth ^a   Zabolotny, Janice M ^a   Kesari, Santosh ^a,b   Fraser, Nigel W ^a  

^a WISTAR INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c JANSSEN RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DOUBLE STRANDED RNA; OKADAIC ACID; PROTEIN KINASE; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; ARTICLE; CANCER THERAPY; CELL STRAIN COS1; CONTROLLED STUDY; GENE DELETION; HERPES SIMPLEX VIRUS; HOST CELL; KIDNEY CELL; MONKEY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SIMIAN VIRUS 40; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS MUTATION; VIRUS REPLICATION;

ANIMALIA; HERPES; HUMAN HERPESVIRUS 1; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40; SIMPLEXVIRUS;

EID: 0030727823     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-78-12-3333     Document Type: Article

References (32)

1. + are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures. Journal of Virology 68, 48-55.
2. Brown, S. M., Harland, J., MacLean, A. R., Podlech, J. & Clements, J. B. (1994). Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2. Journal of General Virology 75, 2367-2377.
3. Chambers, R., Gillespie, G. Y., Soroceanu, L., Andreansky, S., Chatterjee, S., Chou, J., Roizman, B. & Whitley, R. J. (1995). Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma. Proceedings of the National Academy of Sciences, USA 92, 1411-1415.
4. Chou, J. & Roizman, B. (1992). The γ134.5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells. Proceedings of the National Academy of Sciences, USA 89, 3266-3270.
5. Chou, J., Kern, E. R., Whitley, R. J. & Roizman, B. (1990). Mapping of herpes simplex virus neurovirulence to gamma 1 34.5, a gene nonessential for growth in culture. Science 252, 1262-1266.
6. Cohen, P., Holmes, C. & Tsukitani, Y. (1990). Okadaic acid: a new probe for the study of cellular regulation. Trends in Biochemical Sciences 15, 98-102.
7. Gluzman, Y. (1981). SV40-transformed simian cells support the replication of early SV40 mutants. Cell 23, 175-182.
8. He, B., Gross, M. & Roizman, B. (1997). The γ 1 34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proceedings of the National Academy of Sciences, USA 94, 843-848.
9. Hung, S.-L., Srinivasan, S., Friedman, H. M., Eisenberg, R. J. & Cohen, G. H. (1992). The structural basis of C3b binding by glycoprotein C of herpes simplex virus. Journal of Virology 66, 4013-4027.
10. Javier, R. T., Thompson, R. L. & Stevens, J. G. (1987). Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence. Journal of Virology 61, 1978-1984.
11. Katze, M. G. (1995). Regulation of the interferon-induced PKR: can viruses cope? Trends in Microbiology 3, 75-78.
12. Kesari, S., Randazzo, B. P., Valyi-Nagy, T., Huang, Q. S., Brown, S. M., MacLean, A. R., Lee, V. M.-Y., Trojanowski, J. Q. & Fraser, N. W. (1995). Therapy of experimental human brain tumors using a neuro-attenuated herpes simplex virus mutant. Laboratory Investigation 73, 636-648.
13. Kucharczuk, J. C., Randazzo, B. P., Chang, M. Y., Amin, K. M., Elshami, A. A., Sterman, D. H., Rizk, N. P., Molnar-Kimber, K. L., Brown, S. M., MacLean, A. R., Litzky, L. A., Fraser, N. W., Albelda, S. M. & Kaiser, L. R. (1997). Use of a 'replication-restricted' herpes virus to treat experimental human malignant mesothelioma. Cancer Research 57, 466-471.
14. Lasner, T. M., Kesari, S., Brown, S. M., Lee, V. M.-Y., Fraser, N. W. & Trojanowski, J. Q. (1996). Therapy of a murine model of pediatric brain tumors using a herpes simplex virus type-1 ICP34.5 mutant and demonstration of viral replication within the CNS. Journal of Neuropathology and Experimental Neurology 55, 1259-1269.
15. Lord, K. A., Hoffman-Liebermann, B. & Liebermann, D. A. (1990). Sequence of MyD116 cDNA: a novel myeloid differentiation primary response gene induced by IL6. Nucleic Acids Research 18, 2823-2828.
16. McGeoch, D. J. & Barnett, B. C. (1991). Neurovirulence factor. Nature 353, 609.
17. + between immediate early gene 1 and the 'a' sequence. Journal of General Virology 72, 631-639.
18. Markert, J. M., Malick, A., Coen, D. M. & Martuza, R. L. (1993). Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir. Neurosurgery 32, 597-603.
19. Mathews, M. B. & Shenk, T. (1991). Adenovirus virus-associated RNA and translation control. Journal of Virology 65, 5657-5662.
20. Mckie, E. A., MacLean, A. R., Lewis, A. D., Cruickshank, G., Rampling, R., Barnett, S. C., Kennedy, P. G. E. & Brown, S. M. (1996). Selective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34.5 null mutants in primary human CNS tumors - evaluation of a potentially effective clinical therapy. British Journal of Cancer 74, 745-752.
21. Perng, G.-C., Thompson, R. L., Sawtell, N. M., Taylor, W. E., Slanina, S. M., Ghiasi, H., Kaiwar, R., Nesburn, A. B. & Wechsler, S. L. (1995). An avirulent ICP34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation. Journal of Virology 69, 3033-3041.
22. Perng, G. C., Ghiasi, H., Slanina, S. M., Nesburn, A. B. & Wechsler, S. L. (1996). The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1·5 kilobases of the 8·3 kilobase primary transcript. Journal of Virology 70, 976-984.
23. Rajan, P., Swaminathan, S., Zhu, J., Cole, C. N., Barber, G., Tevethia, M. J. & Thimmapaya, B. (1995). A novel translational regulation function for the simian virus 40 large-T antigen gene. Journal of Virology 69, 785-795.
24. Randazzo, B. P., Kesari, S., Gesser, R. M., Alsop, D., Ford, J. C., Brown, S. M., MacLean, A. R. & Fraser, N. W. (1995). Treatment of experimental intracranial murine melanoma with a neuro-attenuated herpes simplex virus-1 mutant. Virology 211, 94-101.
25. Randazzo, B., Kucharczuk, J. C., Litzky, L., Kaiser, L., Brown, S., Maclean, A., Albelda, S. & Fraser, N. (1996). Herpes simplex 1716 - an ICP 34.5 mutant - is severely replication restricted in human skin xenografts in vivo. Virology 223, 392-396.
26. Randazzo, B. P., Bhat, M. G., Kesari, S., Fraser, N. W. & Brown, S. M. (1997). Treatment of experimental subcutaneous human melanoma with a replication restricted herpes simplex virus mutant. Journal of Investigative Dermatology 108, 993-1001.
27. Spivack, J. G. & Fraser, N. W. (1987). Detection of herpes simplex virus type 1 transcripts during a latent infection in mice. Journal of Virology 61, 3841-3847.
28. Spivack, J. G., Fareed, M. U., Valyi-Nagy, T., Nash, T. C., O'Keefe, J. S., Gesser, R. M., McKie, E. A., MacLean, A. R., Fraser, N. W. & Brown, S. M. (1995). Replication, establishment of latent infection, expression of the latency-associated transcripts and expiant reactivation of herpes simplex virus type 1 γ34.5 mutants in a mouse eye model. Journal of General Virology 76, 321-332.
29. Swaminathan, S., Rajan, P., Savinova, O., Jagus, R. & Thimmapaya, B. (1996). Simian virus 40 large-T bypasses the translational block imposed by the phosphorylation of eIF-2α. Virology 219, 321-323.
30. Taha, M. Y., Brown, S. M., Clements, G. B. & Graham, D. I. (1990). The JH2604 deletion variant of herpes simplex virus type 2 (HG52) fails to produce necrotizing encephalitis following intracranial inoculation of trace. Journal of General Virology 71, 1597-1601.
31. Tal-Singer, R., Lasner, T. M., Podrzuckl, W., Skokotas, A., Leary, J. J., Berger, S. L. & Fraser, N. W. (1997). Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures. Journal of Virology 71, 5268-5276.
32. + γ34.5 deletion mutant 1716 is avirulent in SCID mice. Journal of General Virology 75, 2059-2063.