HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons

Biochemical and Biophysical Research Communications

Volumn 288, Issue 2, 2001, Pages 301-308

  Bonavia, Rudy ^a,b   Bajetto, Adriana ^a,b   Barbero, Simone ^a,b   Albini, Adriana ^a   Noonan, Douglas M ^a   Schettini, Gennaro ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

AIDS Dementia Complex; Caspases; Glutamate ionotropic receptors; Intracellular calcium; Neuronal apoptosis; Tat; Voltage gated calcium channels

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CASPASE; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; TRANSACTIVATOR PROTEIN; VIRUS PROTEIN;

AIDS RELATED COMPLEX; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DEMENTIA; HIPPOCAMPUS; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MACROGLIA; MICROFLUOROMETRY; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VIRUS PATHOGENESIS;

EID: 0035955343     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5743     Document Type: Article

References (41)

1. The AIDS dementia complex: I. Clinical features
2. Human immunodeficiency virus and the central nervous system
3. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy
4. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system
5. The trans-activator gene of the human T cell lymphotropic virus type III is required for replication
6. Cellular uptake of the Tat protein from human immunodeficiency virus
7. HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix associated heparan sulfate proteoglycans through its basic region
8. HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1
9. HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state
10. Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages
11. Regulation of TNFalpha and TGFbeta-1 gene transcription by HIV-1 Tat in CNS cells
12. Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes
13. Human immunodeficiency virus type i infection alters chemokine β peptide expression in human monocytes: Implications for recruitment of leukocytes into brain and lymph nodes
14. Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia
15. Angiogenic properties of human immunodeficiency virus type 1 Tat protein
16. Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides
17. HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes
18. Human immunodeficiency virus-1-tat protein induces the cell surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in human endothelial cells
19. Tat protein of HIVol stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients
20. Expression of HIV regulatory and structural mRNA in the central nervous system
21. Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein
22. Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat
23. β-chemokines and human immunodeficiency virus type-1 proteins evoke intracellular calcium increases in human microglia
24. HIV-1 Tat protein mimicry of chemokines
25. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress
26. Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1
27. Neurotoxicity of peptide analogues of the transactivating protein tat from Maedi-Visna virus and human immunodeficiency virus
28. Rat hippocampal neurons in low-density culture
29. Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor1
30. 2+ homeostasis and rescues cortical neurons from apoptotic death
31. 2+ indicators with greatly improved fluorescence properties
32. The Tat protein of human immunodeficiency virus type I, a growth factor for AIDS Kaposi's sarcoma and cytokine activated vascular cells induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence
33. The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells
34. Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome
35. gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: Protective action of TGF-β1
36. Human immunodeficiency virus type 1 tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8
37. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic
38. HIV-1 Tat induces neuronal death via tumor necrosis factor-α and activation of non-N-methyl-D-aspartate receptors by a NFκB-independent mechanism
39. HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels
40. Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats
41. HIV-1 gp120 glycoprotein affects the astrocyte control of extracelular glutamate by both inhibiting the uptake and stimulating the release of the amino acid