Characterization of the ectromelia virus serpin, SPI-2

Journal of General Virology

Volumn 81, Issue 10, 2000, Pages 2425-2430

  Turner, S J ^a   Silke, J ^a   Kenshole, B ^a   Ruby, J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CASPASE 3; CASPASE 8; GRANZYME B; INTERLEUKIN 1BETA CONVERTING ENZYME; SERINE PROTEINASE INHIBITOR; TUMOR NECROSIS FACTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; COMPARATIVE STUDY; CONTROLLED STUDY; ECTROMELIA VIRUS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE FUNCTION; GENETIC CODE; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POXVIRUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; VIRUS GENE;

ANIMALIA; COWPOX VIRUS; DNA VIRUSES; ECTROMELIA VIRUS; POXVIRIDAE; VACCINIA; VARIOLA; VARIOLA VIRUS;

EID: 0033799438     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-81-10-2425     Document Type: Article

References (39)

1. Mechanisms of recovery from a generalized viral infection: Mousepox
2. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
3. Poxvirus pathogenesis
4. Molecular cloning of the interleukin-1 beta converting enzyme
5. Restricted replication of ectromelia virus in cell culture correlates with mutations in virus-encoded host range gene
6. Analysis of host response modifier ORFs of ectromelia virus, the causative agent of mousepox
7. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
8. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
9. Conversion of procapsase-3 to an autoactivating caspase by fusion to the caspase-2 domain
10. Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: Optimal caspase substrates are not necessarily optimal inhibitors
11. Inhibition of human caspases by peptide-based and macromolecular inhibitors
12. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
13. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
14. 1 and adenovirus protein E1B19KD are functionally equivalent in their ability to inhibit cell death
15. Importance of interferons in recovery from mousepox
16. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase
17. Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection
18. Vaccinia virus serpins B13R (SPI-2) and B22R (SPI-1) encode M(r) 38·5 and 40K, intracellular polypeptides that do not affect virus virulence in a murine intranasal model
19. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans death gene ced-3 and the mammalian IL-1β-converting enzyme
20. The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism
21. Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway
22. Perforin is essential for control of ectromelia virus but not related poxviruses in mice
23. Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recovery from primary infections
24. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
25. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
26. Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virus
27. Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases
28. Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A
29. Cytokines and immunity to viral infections
30. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
31. Granzymes: Exogenous proteinases that induce target cell apoptosis
32. Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits
33. A novel domain within the 55 kd TNF receptor signals cell death
34. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product
35. CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis
36. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
37. Control of apoptosis by poxviruses
38. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
39. Target protease specificity of the viral serpin CrmA. Analysis of five caspases