Inhibition of human lung carcinoma cell growth by apoptosis induction using Semliki Forest virus recombinant particles

Gene Therapy

Volumn 7, Issue 17, 2000, Pages 1477-1482

  Murphy, A M ^a   Morris Downes, M M ^a   Sheahan, B J ^b   Atkins, G J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Alphavirus; Apoptosis; Cancer gene therapy; Lung carcinoma; Semliki Forest virus; Virus vector

Indexed keywords

EPIDERMAL GROWTH FACTOR; PROTEIN P53; VIRUS RNA; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER THERAPY; CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; EXPRESSION VECTOR; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SEMLIKI FOREST ALPHAVIRUS; TUMOR GROWTH; TUMOR REGRESSION; TUMOR SPHEROID; TUMOR XENOGRAFT; VIRUS GENOME; VIRUS RECOMBINANT;

ALPHAVIRUS; ANIMALIA; MUS MUSCULUS; RABBIT FIBROMA VIRUS; RNA VIRUSES; SEMLIKI FOREST VIRUS;

EID: 0033795498     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301263     Document Type: Article

References (22)

1. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer
2. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
3. Cancer gene therapy using a novel adeno-associated virus vector expressing human wild-type p53
4. P53: A frequent target for genetic abnormalities in lung cancer
5. Semliki forest virus expression system: Production of conditionally infectious recombinant particles
6. Two-helper RNA system for production of recombinant Semliki forest virus particles
7. The molecular pathogenesis of Semliki forest virus: A model virus made useful?
8. Immunization with recombinant Semliki Forest virus induces protection against influenza challenge in mice
9. Recombinant Semliki Forest virus particles expressing louping ill virus antigens induce a better protective response than plasmid-based DNA vaccines or an inactivated whole particle vaccine
10. Death mechanisms in cultured cells infected by Semliki Forest virus
11. The Semliki Forest virus vector induces p53-independent apoptosis
12. Cell and environment interactions in tumor microregions: The multicell spheroid model
13. Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography
14. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene
15. Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model
16. Apoptosis, oncosis, and necrosis. An overview of cell death
17. DNA vaccines
18. Cancer therapy using a self-replicating RNA vaccine
19. Induction of P815 tumor immunity by recombinant Semliki Forest virus expressing the P1A gene
20. Cell-specific targeting of Sindbis virus vectors displaying IgG-binding domains of Protein A
21. New colorimetric cytotoxicity assay for anticancer-drug screening
22. Integration of endothelial cells in multi-cellular spheroids prevents apoptosis and induces differentiation