Serp2, an inhibitor of the interleukin-1β-converting enzyme, is critical in the pathobiology of myxoma virus

Journal of Virology

Volumn 72, Issue 10, 1998, Pages 7830-7839

  Messud Petit, Frederique ^a   Gelfi, Jacqueline ^a   Delverdier, Maxence ^a   Amardeilh, Marie France ^a   Py, Robert ^a   Sutter, Gerd ^b   Bertagnoli, Stephane ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; GENE STRUCTURE; HISTOPATHOLOGY; MYXOMATOSIS; NONHUMAN; PATHOGENESIS; POXVIRUS; PRIORITY JOURNAL; VIRUS MUTANT; VIRUS PATHOGENESIS;

EID: 0031666179     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.10.7830-7839.1998     Document Type: Article

References (72)

1. Aiken, C., J. Konner, N. R. Landau, M. E. Lenburg, and D. Trono. 1994. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76:853-864.
2. Alcami, A., and G. L. Smith. 1992. A soluble receptor for interleukin-1β encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infection. Cell 71:153-167.
3. Alcami, A., and G. L. Smith. 1995. Cytokine receptors encoded by poxviruses: a lesson in cytokine biology. Immunol. Today 16:474-478.
4. Alcami, A., and G. L. Smith. 1995. Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity. J. Virol. 69:4633-4639.
5. Alcami, A., and G. L. Smith. 1996. Soluble interferon-gamma receptors encoded by poxviruses. Comp. Immunol. Microbiol. Infect. Dis. 19:305-317.
6. Ali, A. N., P. C. Turner, M. A. Brooks, and R. W. Mover. 1994. The SPI-1 gene of rabbitpox virus determines host range and is required for hemorrhagic pock formation. Virology 202:305-314.
7. Anderson, P. 1997. Kinase cascades regulating entry into apoptosis. Microbiol. Mol. Biol. Rev. 61:33-46.
8. + T lymphocytes. J. Virol. 69:5243-5251.
9. Bertin, J., R. C. Armstrong, S. Ottilie, D. A. Martin, Y. Wang, S. Banks, G.-H. Wang, T. G. Senkevitch, E. S. Alnemri, B. Moss, M. J. Leonardo, K. J. Tomaselli, and J. I. Cohen. 1997. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc. Natl. Acad. Sci. USA 94:1172-1176.
10. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-gamma. Annu. Rev. Immunol. 15:749-795.
11. Boshkov, L. K., J. L. Macen, and G. McFadden. 1992. Virus-induced loss of class 1 MHC antigens from the surface of cells infected with myxoma virus and malignant rabbit fibroma virus. J. Immunol. 148:881-887.
12. Boyle, D. B., and B. E. H. Coupar. 1988. A dominant selectable marker for the construction of recombinant poxviruses. Gene 65:123-128.
13. Brooks, M. A., A. N. Ali, P. C. Turner, and R. W. Moyer. 1995. A rabbitpox virus serpin gene controls host range by inhibiting apoptosis in restrictive cells. J. Virol. 69:7688-7698.
14. Dianzani, U., and F. Malavasi. 1995. Lymphocyte adhesion to endothelium. Crit. Rev. Immunol. 15:167-200.
15. Dinarello, C. A. 1994. The biological properties of interleukin-1. Eur. Cytokine Netw. 5:517-531.
16. Dobbelstein, M., and T. Shenk. 1996. Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product. J. Virol. 70:6479-6485.
17. Drillien, R., D. Spehner, D. Villeval, and J.-P. Lecoq. 1987. Similar genetic organization between a region of fowlpox virus DNA and the vaccinia virus HindIIIJ fragment despite divergent location of the thymidine kinase gene. Virology 160:203-209.
18. Falkner, F. G., and B. Moss. 1988. Escherichia coli gpt gene provides dominant selection for vaccinia virus open reading frame expression vectors. J. Virol. 62:1849-1854.
19. Falkner, F. G., and B. Moss. 1990. Transient dominant selection of recombinant vaccinia viruses. J. Virol. 64:3108-3111.
20. Fenner, F., and F. N. Ratcliff. 1965. Myxomatosis. Cambridge University Press, Cambridge, England.
21. Foghsgaard, L., and M. Jaattela. 1997. The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type. J. Virol. 71:7509-7517.
22. Fredrickson, T. N., J. M. G. Sechler, G. J. Palumbo, J. Albert, L. H. Khairallah, and R. M. L. Buller. 1992. Acute inflammatory response to cowpox virus infection of the chorioallantoic membrane of the chick embryo. Virology 187:693-704.
23. Ghayur, T., S. Banerjee, M. Hugunin, D. Butler. L. Herzog, A. Carter, L. Quintal, L. Skut, R. Talanian, M. Paskind, W. Wong, R. Kamen, D. Tracey, and H. Allen. 1997. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature 386:619-623.
24. Girard, J.-P., and T. A. Springer. 1995. High endolhelial venulcs (HEV): specialized endothelium for lymphocyte migration. Immunol. Today 16:449-457.
25. Graham, K. A., A. S. Lalani, J. L. Macen, T. L. Ness, M. Barry, L.-Y. Liu, A. Lucas, I. dark-Lewis, R. W. Moyer, and G. McFadden. 1997 The T1/35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues. Virology 229:12-24.
26. Gu, Y., K. Kuida, H. Tsutsui, G. Ku, K. Hsiao, M. A. Fleming, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, M. Kurimoto, T. Tanimoto, R. A. Flavell, V. Sato, M. W. Harding, D. J. Livingston, and M. S. Su. 1997. Activation of interfcron-γ inducing factor mediated by interleukin-lβ converting enzyme. Science 275:206-209.
27. Hu, F.-Q., C. A. Smith, and D. J. Pickup. 1994. Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor. Virology 204:343-356.
28. Isaacs, S. N., G. J. Kotwal, and B. Moss. 1990. Reverse guanine phosphoribosyltransferase selection of recombinant vaccinia viruses. Virology 178:626-630.
29. Kaschka-Dierich, C., F. J. Werner, I. Bauer, and B. Fleckenstein. 1982. Structure of nonintegrated, circular herpesvirus saimiri and herpesvirus ateles aenomes in tumor cell lines and in vitro-transformed cells. J. Virol. 44:295-310.
30. Kerr, S. M., L. H. Johnston, M. Odel, S. A. Duncan, K. M. Law, and G. L. Smith. 1991. Vaccinia DNA ligase complements Saccharomyces cerevisiae cdc9, localizes in cytoplasmic factories and affects virulence and virus sensitivity to DNA damaging agents. EMBO J. 10:4343-4350.
31. Kettle, S., N. W. Blake, K. M. Law, and G. L. Smith. 1995. Vaccinia virus serpins B13R (SPI-2) and B22R (SPII) encode Mr38.5 and 40K, intracellular polypeptides that do not affect virus virulence in a murine intranasal model. Virology 206:136-147.
32. Kettle, S., A. Alcami, A. Khanna, R. Ehret, C. Jassoy, and G. L. Smith. 1997. Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1β-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1β-induced fever. J. Gen. Virol. 78:677-685.
33. Komiyama, T., C. A. Ray, D. J. Pickup, A. D. Howard, N. A. Thornberry, E. B. Peterson, and G. Salvesen. 1994. Inhibition of interleukin-1β converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. J. Biol. Chem. 269:19331-19337.
34. Macen, J. L., C. Upton, N. Nation, and G. McFadden. 1993. SERP-1. a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammation. Virology 195:348-363.
35. Macen, J. L., K. A. Graham, S. F. Lee, M. Schreiber, L. K. Boshkov, and G. McFadden. 1996. Expression of the myxoma virus tumor necrosis factor receptor homologue and M11L genes is required to prevent virus-induced apoptosis in infected rabbit T lymphocytes. Virology 218:232-237.
36. Macen, J. L., A. Takahashi, K. B. Moon, R. Nathaniel, P. C. Turner, and R. W. Moyer. 1998. Activation of easpases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses. J. Virol. 72:3524-3533.
37. McFadden, G. 1988. Poxviruses of rabbits, 37-62. In G. Darai (ed.), Virus diseases in laboratory and captive animals. Martinus Nijhoff, Boston, Mass.
38. McFadden, G. (ed.). 1995. Viroceptors, virokines and related immune modulators encoded by DNA viruses. R. G. Landes Co., Austin. Tex.
39. Mossman, K., S. F. Lee, M. Barry, L. Boshkov, and G. McFadden. 1996. Disruption of M-T5, a novel myxoma virus gene member of the poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits. J. Virol. 70:4394-4410.
40. Mossman, K., P. Nation, J. Macen, M. Garbutt, A. Lucas, and G. McFadden. 1996. Myxoma virus M-T7, a secreted homolog of the interferon-γ receptor, is a critical virulence factor for the development of myxomatosis in European rabbits. Virology 215:17-30.
41. Nagata, S. 1997. Apoptosis by death factor. Cell 88:355-365.
42. Nakamura, K., H. Okamura, K. Nagata, T. Komatsu, and T. Tamura. 1993. Purification of a factor which provides a costimulatory signal for gamma Interferon production. Infect. Immun. 61:64-70.
43. Ohh, M., and F. Takei. 1996. New insights into the regulation of ICAM-1 gene expression. Leuk. Lymphoma 20:223-228.
44. Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, K. Akita, M. Namba, F. Tanabe, K. Konishi, S. Fukuda, and M. Kurimoto. 1995. Cloning of a new cytokine that induces IFN-γ production by T-cells. Nature 378:88-91.
45. Opgenorth, A., K. Graham, N. Nation, D. Strajer, and G. McFadden. 1992. Deletion analysis of two tandemly arranged virulence genes in myxoma virus, M11L and myxoma growth factor. J. Virol. 66:4720-4731.
46. Petit, F., S. Bertagnoli, J. Gelfi, F. Fassy, C. Boucraut-Baralon, and A. Milon. 1996. Characterization of a myxoma virus-encoded serpin-like protein with activity against interleukin-1β-converting enzyme. J. Virol. 70:5860-5866.
47. Pickup, D. J. 1994. Poxviral modifiers of cytokines responses to infection. Infect. Agents Dis. 3:116-127.
48. Pickup, D. J., B. S. Ink, C. A. Ray, and W. K. Joklik. 1986. Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. Proc. Natl. Acad. Sci. USA 83:7698-7702.
49. Quan, L. T., A. Caputo, R. C. Bleakley, D. J. Pickup, and G. Salvesen. 1995. Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. J. Biol. Chem. 270:10377-10379.
50. Ray, C A., R. A. Black, S. R. Kronheim, T. A. Greenstreet, P. R. Sleath, G. S. Salvesen, and D. J. Pickup. 1992. Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme. Cell 69:597-604.
51. Ray, C. A., and D. J. Pickup. 1996, The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene. Virology 217:384-391.
52. Schreiber, M., and G. McFadden. 1994. The myxoma virus TNF-receptor homologue (T2) inhibits tumor necrosis factor α in a species-specific fashion. Virology 204:692-705.
53. Schreiher, M., L. Sedger, and G. McFadden. 1997. Distinct domains of M-T2, the myxoma virus tumor necrosis factor (TNF) receptor homolog, mediate extracellular TNF binding and intracellular apoplosis inhibition. J. Virol. 71:2171-2181.
54. Schwartz, O., V. Marechal, S. L. Gall, F. Lemonnier, and J. M. Heard. 1996. Endocytosis of major histocompatibility complex class I molecules is induced by HlV-1 Nef protein. Nature Med. 2:338-342.
55. Smith, C. A., T. Davis Smith, P. J. Smolak, D. Friend, H. Hagen, M. Gerhart, L. Park, D. J. Pickup, D. Torrance, K. Mohler, K. Schooley, and R. Goodwin. 1997. Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits β chemokine activity yet lacks sequence homology to known chemokine receptors. Virology 236:316-327.
56. Smith, C. A., T. Davis, J. M. Wignall, W. S. Din, T. Farrah, C. Upton, G. McFadden, and R. G. Goodwin. 1991. T2 open reading frame from the Shope fibroma virus encodes a soluble form of the TNF receptor. Biochem. Biophys. Res. Commun. 176:335-342.
57. Smith, G. L. 1994. Virus strategies for evasion of the host response to infection. Trends Microbiol. 2:81-88.
58. Smith, G. L., S. T. Howard, and Y. S. Chan. 1989. Vaccinia virus encodes a family of genes with homology to serine proteinase inhibitors. J. Gen. Virol. 70:2333-2343.
59. Spriggs, M. K., D. E. Hruby, C. R. Maliszewski, D. J. Pickup, J. E. Sims, R. M. L. Buller, and J. Van Slyke. 1992. Vaccinia and cowpox viruses encode a novel secreted interleukin-1 binding protein. Cell 71:145-152.
60. Spriggs, M. K. 1996. One step ahead of the game: viral immunomodulatory molecules. Ann. Rev. Immunol. 14:101-130.
61. Symons, J. A., A. Alcami, and G. L. Smith. 1995. Vaccinia virus encodes a soluble type I Interferon receptor of novel structure and broad species specificity. Cell 81:551-560.
62. Tewari, M., and V. M. Dixit. 1995. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem. 270:3255-3260.
63. Thompson, J. P., P. C. Turner, A. N. Ali, B. C. Crenshaw, and R. W. Moyer. 1993. The effects of serpin gene mutations on the distinctive pathobiology of cowpox and rabbitpox virus following intranasal inoculation of BALB/c mice. Virology 197:328-338.
64. Turner, P. C, P. Y. Musy, and R. W. Moyer. 1995. Poxvirus serpins, p. 67-88. In G. McFadden (ed.). Viroceptors, virokines and related immune modulators encoded by DNA viruses. R. G. Landes Co., Austin, Tex.
65. Upton, C., and G. McFadden. 1986. Tumorigenic poxviruses: analysis of viral DNA sequences implicated in the tumorigenicity of Shope fibroma virus and malignant rabbit virus. Virology 61:1271-1275.
66. Upton, C-, J. L. Macen, and G. McFadden. 1987. Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor α. J. Virol. 152:308-321.
67. Upton, C., J. L. Macen, D. S. Wishard, and G. McFadden. 1990. Myxoma virus and malignant rabbit fibroma virus encode a serpin-likc protein important for virus virulence. Virology 179:618-631.
68. Upton, C., J. L. Macen, M. Schreiber, and G. McFadden. 1991. Myxoma virus expresses a secreted protein with homology to the tumor necrosis factor receptor gene family that contributes to viral virulence. Virology 184:370-382.
69. Upton. C., K. Mossman, and G. McFadden. 1992. Encoding of a homolog of the gamma-IFN receptor by myxoma virus. Science 258:1369-1372.
70. Vaux, D. L., G. Haecker, and A. Strasser. 1994. An evolutionary perspective on apoptosis. Cell 76:777-779.
71. Young, H. A., and K. J. Hardy. 1995. Role of interferon-gamma in immune cell regulation. J. Leukoc. Biol. 58:373-381.
72. Zhou, Q., S. Snipas, K. Orth, M. Muzio, V. M. Dixit, and G. S. Salvesen. 1997. Target protease specificity of the viral serpin CrmA. Analysis of five caspascs. J. Biol. Chem. 272:7797-7800.