Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells

Journal of Virology

Volumn 74, Issue 20, 2000, Pages 9717-9726

  Patel, C A ^a   Mukhtar, M ^a   Pomerantz, R J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; GLYCOPROTEIN GP 120; INTEGRASE; LIPOCORTIN 5; MALTOSE BINDING PROTEIN; RETINOIC ACID; VPR PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NICK END LABELING; PRECURSOR CELL; PRIORITY JOURNAL;

AIDS DEMENTIA COMPLEX; APOPTOSIS; CASPASES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE PRODUCTS, VPR; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMAN; NEURONS; RECOMBINANT FUSION PROTEINS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033819719     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.20.9717-9726.2000     Document Type: Article

References (53)

1. Neuronal apoptosis in HIV infection in adults
2. Fas ligand mediates activation-induced cell death in human T lymphocytes
3. Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: Identification by the combination of in situ polymerase chain reaction and immunohistochemistry
4. Self-association of the 'death domains' of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects
5. Involvement of MACH, a novel MORT1/FADD-interacting protease in Fas/Apo-1- and TNF receptor-induced cell death
6. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
7. RGD peptides induce apoptosis by direct caspase-3 activation
8. Apopain/CPP32 cleaves proteins that are essential for cellular repair: A fundamental principal of apoptotic death
9. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
10. Autocrine T-cell suicide mediated by APO-1
11. A matter of life and cell death
12. The HIV-1 Vpr displays strong anti-apoptotic activity
13. Apoptotic neurons in brains from pediatric patients with HIV-1 encephalitis and progressive encephalopathy
14. Cell cycle- and Vpr-mediated regulation of human immunodeficiency virus type 1 expression in primary and transformed T-cell lines
15. 2 phase of the cell cycle by inhibiting p34(cdc2) activity
16. Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
17. Human immunodeficiency virus type 1 (HIV-1) Vpr functions as an immediate-early protein during HIV-1 infection
18. The CED-4 homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis
19. 2 + M phase of the cell cycle
20. Fas(CD95)/Fas-L interactions required for programmed cell death after T-cell activation
21. Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection
22. Protein stability influences human immunodeficiency virus type 2 Vpr incorporation and cell cycle effect
23. Activities and substrate specificity of the evolutionary conserved central domain of retroviral integrase
24. Human immunodeficiency virus type 1 Vpr alters bone marrow cell function
25. CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons
26. hNT neurons: Human postmitotic CNS neurons
27. Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency
28. Single step procedure for labeling DNA strand breaks with fluorescein- or BODIPY-conjugated deoxynucleotides. Detection of apoptosis and bromodeoxyuridine incorporation
29. Identification of residues in the N-terminal acidic domain of HIV-1 Vpr essential for virion incorporation
30. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
31. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity
32. Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease
33. Extracellular HIV-1 Tat protein differentially activates the JNK and ERK/MAPK pathways in CD4 T cells
34. Anti-human immunodeficiency virus type 1 gene therapy in human central nervous system-based cells: An initial approach against a potential viral reservoir
35. Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: Evidence for a role of the envelope
36. Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals
37. Induction of apoptosis by La Crosse virus infection and role of neuronal differentiation and human bcl-2 expression in its prevention
38. Evidence of apoptotic cell death in HIV encephalitis
39. Chronic systemic administration of tumor necrosis factor alpha and HIV gpl20: Effects on adult rodent brain and blood-brain barrier
40. Extracellular HIV-1 virus protein R causes a large inward current and cell death in cultured hippocampal neurons: Implications for AIDS pathology
41. Pure, postmitotic, polarized human neurons derived from Ntera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons
42. NTera 2 cells: A human cell line which displays characteristics expected of a human committed neuronal progenitor cell
43. Apoptosis induced by HIV-1 infection of the central nervous system
44. Neuronal apoptosis induced by HIV-1 Tat protein and TNF-α: Potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia
45. Roles of p53 and caspases in the induction of cell cycle arrest and apoptosis by HIV-1 vpr
46. Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest
47. Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells
48. Human immunodeficiency virus type 1 Vpr induces apoptosis through caspase activation
49. Mutagenic analysis of human immunodeficiency virus type 1 Vpr: Role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation
50. Vpr stimulates viral expression and induces cell killing in human immunodeficiency virus type 1-infected dividing Jurkat T cells
51. Biochemical mechanism of HIV-1 Vpr function. Oligomerization mediated by the N-terminal domain
52. Chemokine receptors and the molecular basis for human immunodeficiency virus type 1 entry into peripheral hematopoietic stem cells and their progeny
53. Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-l-associated dementia