TNF-α signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K

Molecular Cell

Volumn 6, Issue 1, 2000, Pages 53-63

  Perez, Denise ^b   White, Eileen ^a,b,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; GENE PRODUCT; PROTEIN BAX; TUMOR NECROSIS FACTOR ALPHA;

ADENOVIRUS; APOPTOSIS; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA CLEAVAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ADENOVIRIDAE; ALPHAVIRUS;

EID: 0033634781     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(05)00013-4     Document Type: Article

References (37)

1. Functional complementation of the adenovirus E1B 19K protein with Bcl-2 in the inhibition of apoptosis in infected cells
2. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release and apoptosis
3. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
4. Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K
5. The E1B-19K protein of group C adenoviruses prevents cytolysis by tumor necrosis factor of human cells but not mouse cells
6. Cell damage-induced conformational changes of the proapoptotic protein Bak in vivo precede the onset of apoptosis
7. Enforced dimerization of Bax results in its translocation, mitochondrial dysfunction and apoptosis
8. BCL-2 family members and the mitochondria in apoptosis
9. The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein
10. Interaction of E1B 19K with Bax is required to block Bax-induced loss of mitochondrial membrane potential and apoptosis
11. Nonionic detergents induce dimerization among members of the Bcl-2 family
12. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
13. The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis
14. An adenovirus type 5 early gene function regulates expression of other viral genes
15. Btf: A novel death-promoting transcriptional repressor that interacts with Bcl-2 related proteins
16. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
17. Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade
18. Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis
19. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
20. Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions
21. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
22. X-ray and NMR structure of human Bcl-x(L), an inhibitor of programmed cell death
23. Apoptosis by death factor
24. E1B 19K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE
25. Deletion of the gene encoding the adenovirus 5 early region 1B - 21,000-molecular weight polypeptide leads to degradation of viral and cellular DNA
26. Two CD95 (APO-1/Fas) signaling pathways
27. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2-3-6-7-8 and -10 in a caspase-9-dependent manner
28. Pro-caspase-3 is a major physiologic target of caspase-8
29. A combinatorial approach defines specificities of members of the caspase family and granzyme B
30. Targeted disruption of the mouse caspase-8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
31. Regulation of apoptosis by adenovirus E1A and E1B oncogenes
32. Nuclear envelope localization of an adenovirus tumor antigen maintains the integrity of cellular DNA
33. The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha
34. Immune responses to adenoviruses: Viral evasion mechanisms and their implications for the clinic
35. Suicidal tendencies: Apoptotic cell death by caspase family proteinases
36. Movement of Bax from the cytosol to mitochondria during apoptosis
37. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis