Proteolysis and antigen presentation by MHC class II molecules

Advances in Immunology

Volumn 80, Issue , 2002, Pages 71-114

  Bryant, Paula Wolf ^a   Lennon Duménil, Ana Maria ^a   Fiebiger, Edda ^a   Lagaudrière Gesbert, Cécile ^a   Ploegh, Hidde L ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; CYSTEINE PROTEINASE INHIBITOR; CYTOKINE; HLA ANTIGEN CLASS 2; PROTEINASE; CATHEPSIN; CATHEPSIN L; DIAZOMETHYLKETONE DERIVATIVE; EPOXYSUCCINATE DERIVATIVE; KETONE DERIVATIVE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG; VINYL DERIVATIVE; VINYLSULFONE DERIVATIVE;

ANIMAL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ENDOCYTOSIS; GENETIC TRANSCRIPTION; HUMAN; INVARIANT CHAIN; METABOLISM; PH; PHYSIOLOGY; REVIEW; CELL PH; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SYNTHESIS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; CYSTEINE PROTEINASE INHIBITORS; CYTOKINES; ENDOCYTOSIS; ENDOPEPTIDASES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; HYDROGEN-ION CONCENTRATION; TRANSCRIPTION, GENETIC;

EID: 0036017395     PISSN: 00652776     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0065-2776(02)80013-X     Document Type: Article

References (212)

1. Nonclassical MHC class II molecules
2. Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site
3. Fc receptor signaling and trafficking: A connection for antigen processing
4. Fc receptors for IgG and antigen presentation on MHC class I and class II molecules
5. Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles
6. Control of antigen presentation by a single protease cleavage site
7. Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence
8. Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)
9. Negative regulation of epidermal growth factor signaling by selective proteolytic mechanisms in the endosome mediated by cathepsin B
10. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
11. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
12. Intracellular traffic to compartments for MHC class II peptide loading: Signals for endosomal and polarized sorting
13. L-trans-epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L
14. How MHC class II molecules reach the endocytic pathway
15. Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E
16. Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L
17. Interaction between chicken cystatin and the cysteine proteinases actinidin, chymopapain A, and ficin
18. Role for intracellular proteases in the processing and transport of class II HLA antigens
19. Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
20. Bafilomycins: A class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells
21. Early endosomes are required for major histocompatibility complex class II transport to peptide-loading compartments
22. Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes
23. An LI and ML motif in the cytoplasmic tail of the MHC-associated invariant chain mediate rapid internalization
24. High level expression and crystallization of recombinant human cathepsin S
25. The specificity of bovine spleen cathepsin S: A comparison with rat liver cathepsins L and B
26. Friends and relations of the cystatin superfamily - New members and their evolution
27. Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties
28. Accessory molecules for MHC class II peptide loading
29. CA074 methyl ester: A proinhibitor for intracellular cathepsin B
30. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
31. Origin, maturation and antigen presenting function of dendritic cells
32. Endosomal proteolysis and MHC class II function
33. Emerging roles for cysteine proteases in human biology
34. Cystatin D, a natural salivary cysteine protease inhibitor, inhibits coronavirus replication at its physiologic concentration
35. Reduction of disulfide bonds within lysosomes is a key step in antigen processing
36. Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment
37. The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B
38. Invariant chain structure and MHC class II function
39. Proregion structure of members of the papain superfamily: Mode of inhibition of enzymatic activity
40. The role of aquaporins in dendritic cell macropinocytosis
41. HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading
42. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
43. Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
44. Determination of the HLA-DM interaction site on HLA-DR molecules
45. In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen
46. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells
47. Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors
48. The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells
49. Biosynthesis of lysosomal endopeptidases
50. Secreted cathepsin L generates endostatin from collagen XVIII
51. Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells
52. Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41
53. The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain
54. A possible role for Na+, K+-ATPase in regulating ATP-dependent endosome acidification
55. The crystal structure of human cathepsin L complexed with E-64
56. Antigen presentation and T cell development in H2-M-deficient mice
57. Exon 6 is essential for invariant chain trimerization and induction of large endosomal structures
58. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
59. Biosynthesis and transport of cathepsin D in cultured human fibroblasts
60. Invariant chain induces a delayed transport from early to late endosomes
61. Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
62. CD14-dependent clearance of apoptotic cells: Relevance to the immune system
63. Novel glycosylation of HLA-DRalpha disrupts antigen presentation without altering endosomal localization
64. Crystal structure of porcine cathepsin H determined at 2.1 Å resolution: Location of the minichain C-terminal carboxyl group defines cathepsin H aminopeptidase function
65. Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S
66. Leukocystatin, a new class II cystatin expressed selectively by hematopoietic cells
67. Class II antigen processing: Analysis of compartments and functions
68. The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains
69. Cathepsin S regulates the expression of cathepsin L and the turnover of GILT in B lymphocytes
70. Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene
71. Role of the occluding loop in cathepsin B activity
72. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
73. Gene regulation and extracellular functions of procathepsin L
74. Reduction of disulfide bonds during antigen processing: Evidence from a thiol-dependent insulin determinant
75. Acidification and disulfide reduction can be sufficient to allow intact proteins to bind class II MHC
76. pH-induced conformational transitions of the propeptide of human cathepsin L: A role for a molten globule state in zymogen activation
77. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
78. Class II major histocompatibility complex molecules of murine dendritic cells: Synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture
79. Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes
80. Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo
81. Posttranslational modifications of the Ia-associated invariant protein p41 after gene transfer
82. Differential expression of the invariant chain in mouse tumor cells: Relationship to B lymphoid development
83. A cellular anti-apoptosis protein is cleaved by the HIV-1 protease
84. Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins
85. The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules
86. IFN-gamma increases cathepsin H mRNA levels in mouse macrophages
87. The crystal structure of human procathepsin K
88. T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides
89. The p41 isoform of invariant chain is a chaperon for cathepsin L
90. Modulation of interferon gamma induced increases in cathepsin B in THP-1 cells by adrenergic agonists and antagonists
91. Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin
92. Effect of carbohydrate position on lysosomal transport of procathepsin L
93. Inflammatory mediators regulate cathepsin S in macrophages and microglia: A role in attenuating heparan sulfate interactions
94. Intracellular transport of class II MHC molecules directed by invariant chain
95. The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments
96. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing
97. An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation
98. Endosomal aspartic proteinases are required for invariant-chain processing
99. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection
100. 125I]iodotyrosylalanyldiazomethane as a probe for active cysteme proteinases in human tissues
101. The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor
102. The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation
103. Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation
104. Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals
105. The lysosomal cysteine proteases
106. Crystal structure of human cathepsin K complexed with a potent inhibitor
107. Crystal structure of human cathepsin S
108. Acidification of the endocytic and exocytic pathways
109. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway
110. Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain
111. Cathepsin B
112. Delivery of nascent MHC class II-invariant chain complexes to lysosomal compartments and proteolysis of invariant chain by cysteine proteases precedes peptide binding in B-lymphoblastoid cells
113. The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation
114. Novel epoxysuccinyl peptides: Selective inhibitors of cathepsin B, in vitro
115. The refined 2.15 Å X-ray crystal structure of human liver cathepsin B: The structural basis for its specificity
116. Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts
117. Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen
118. Cathepsin L: Critical role in Ii degradation and CD4 T cell selection in the thymus
119. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice
120. The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentation
121. Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes
122. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route
123. The vacuolar H(+)-ATP-ase-One of the most fundamental ion pumps in nature
124. Dominant-interfering hsc70 mutants disrupt multiple stages of the clathrin coated vesicles cycle in vivo
125. Two-step mechanism of inhibition of cathepsin B by cystatin C due to displacement of the proteinase occluding loop
126. Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment
127. Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney
128. Presentation of antigens derived from microorganisms residing in host-cell vacuoles
129. Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation
130. Vinyl sulfones as mechanism-based cysteine protease inhibitors
131. The HSC73 molecular chaperone: Involvement in MHC class II antigen presentation
132. Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop: Demonstration by release of loop anchoring through mutation of his110
133. Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41
134. Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action
135. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
136. The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail
137. Peptide loading onto recycling HLA-DR molecules occurs in early endosomes
138. Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases
139. Crystal structure of the wild-type human procathepsin B at 2.5 Å resolution reveals the native active site of a papain-like cysteine protease zymogen
140. The two mannose 6-phosphate receptors transport distinct complements of lysosomal proteins
141. Characterization by spectroscopic, kinetic and equilibrium methods of the interaction between recombinant human cystatin A (stefin A) and cysteine proteinases
142. Functional early endosomes are required for maturation of major histocompatibility complex class II molecules in human B lymphoblastoid cells
143. The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules
144. Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages
145. Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain
146. The occluding loop in cathepsin B defines the pH dependence of inhibition by its propeptide
147. Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages
148. Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains
149. Cathepsins and compartmentalization in antigen presentation
150. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading
151. Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules
152. Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization
153. Role of cathepsin D in antigen presentation of ovalbumin
154. Destructive proteolysis by eysteine proteases in antigen presentation of ovalbumin
155. Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments
156. Cathepsin L deficiency as molecular defect of furless: Hyperproliferation of keratinocytes and pertubation of hair follicle cycling
157. A role for peptide in determining MHC class II structure
158. Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
159. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
160. Extracellular antigen processing and presentation by immature dendritic cells
161. Abundant empty class II MHC molecules on the surface of immature dendritic cells
162. An enzyme that removes clathrin coats: Purification of an uncoating ATPase
163. Regulation of cathepsin E expression during human B cell differentiation in vitro
164. Peptidyl diazomethanes as inhibitors of cysteine and serine proteinases
165. Peptidyl fluoromethyl ketones as thiol protease inhibitors
166. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
167. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease
168. Cathepsin S required for normal MHC class II peptide loading and germinal center development
169. The control and facilitation of MHC class II antigen processing by the BCR
170. Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer
171. Inhibition of cruzipain, the major cysteine proteinase of the protozoan parasite, Trypanosoma cruzi, by proteinase inhibitors of the cystatin superfamily
172. Two forms of the Ia antigen-associated invariant chain result from alternative initiations at two in-phase AUGs
173. The refined 2.4 Å X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: A novel type of proteinase inhibitor interaction
174. Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain
175. In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain
176. Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells
177. The proregion of cathepsin L is required for proper folding, stability, and ER exit
178. Perturbation of vesicular traffic with the carboxylic ionophore monensin
179. The cell biology of antigen presentation in dendritic cells
180. Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion
181. Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo
182. Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex
183. Human cathepsin B is a metastable enzyme stabilized by specific ionic interactions associated with the active site
184. High-affinity binding of two molecules of cysteine proteinases to low-molecular-weight kininogen
185. High-molecularweight kininogen binds two molecules of cysteine proteinases with different rate constants
186. Lysosomal cysteine proteases: More than scavengers
187. Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors
188. Revised definition of substrate binding sites of papain-like cysteine proteases
189. The p41 fragment story
190. Crystal structures of human procathepsin B at 3.2 and 3.3 angstroms resolution reveal an interaction motif between a papainlike cysteine protease and its propeptide
191. Crystal structure of cathepsin B inhibited with CA030 at 2.0-Å resolution: A basis for the design of specific epoxysuccinyl inhibitors
192. The cystatins: Protein inhibitors of cysteine proteinases
193. Get into the groove! Targeting antigens to MHC class II
194. Cathepsin D, but not cathepsin B, releases T cell stimulatory fragments from lysozyme that are functional in the context of multiple murine class II MHC molecules
195. Processing of the papain precursor: The ionization state of a conserved amino acid motif within the Pro region participates in the regulation of intramolecular processing
196. Diversity in MHC class II ovalbumin T cell epitopes generated by distinct proteases
197. Proteases involved in MHC class II antigen presentation
198. Proteolysis in MHC class II antigen presentation: Who's in charge?
199. Degradation of mouse invariant chain: Roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism
200. MHC class II expression is regulated in dendritic cells independently of invariant chain degradation
201. Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM
202. Interferon gamma induction of pulmonary emphysema in the adult murine lung
203. Capture and processing of exogenous antigens for presentation on MHC molecules
204. Antigen processing in the endocytic compartment
205. Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like cysteine proteases
206. How MHC class II molecules acquire peptide cargo: Biosynthesis and trafficking through the endocytic pathway
207. Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774
208. Quantification of cathepsins B and L in cells
209. Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells
210. Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice
211. Crystal structure of human osteoclast cathepsin K complex with E-64
212. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein