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Nores J.E.R., Bensussan A., Vita N., Stelter F., Arias M.A., Jones M., Lefort S., Borysiewicz L.K., Ferrara P., Labeta M.O. Soluble CD14 acts as a negative regulator of human T cell activation and function. Eur J Immunol. 29:1999;265-276. This paper reports an entirely novel mode of negative cellular regulation by sCD14. The work indicates that activated T cells express receptors for CD14 that generate inhibitory signals for proliferative activity and cytokine productivity.
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