T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides

Journal of Experimental Medicine

Volumn 184, Issue 1, 1996, Pages 183-189

  Larsen, Sanne Lise ^a   Pedersen, Lars Østergaard ^a   Buus, Søren ^a   Stryhn, Anette ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MICROSOMAL AMINOPEPTIDASE; PROTEINASE INHIBITOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; ENZYME REGULATION; HYBRIDOMA; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD13; HISTOCOMPATIBILITY ANTIGENS CLASS II; HYBRIDOMAS; LYMPHOCYTE ACTIVATION; MICE; MOLECULAR SEQUENCE DATA; MURAMIDASE; PEPTIDES; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0030036617     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.1.183     Document Type: Article

References (37)

1. Germain, R.N., and D.H. Margulies. 1993. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol. 11:403-450.
2. Babbitt, B.P., P.M. Allen, G. Matsueda, E. Haber, and E.R. Unanue. 1985. Binding of immunogenic peptides to la histocompatibility molecules. Nature (Lond.). 317:359-361.
3. Buus, S., A. Sette, S.M. Colon, D.M. Jenis, and H.M. Grey. 1986. Isolation and characterization of antigen-la complexes involved in T cell recognition. Cell. 47:1071-1077.
4. Donermeyer, D.L., and P.M. Allen. 1989. Binding to la protects an immunogenic peptide from proteolytic degradation. J. Immunol. 142:1063-1068.
5. Mouritsen, S., M. Meldal, O. Werdelin, A.S. Hansen, and S. Buus. 1992. MHC class II molecules protect T cell epitopes against proteolytic destruction. J. Immunol. 149:1987-1993.
6. Buus, S., and O. Werdelin. 1986. Oligopeptide antigens of the angiotensin lineage compete for presentation by paraformaldehyde-treated accessory cells to T cells. J. Immunol. 136:459-465.
7. Hansen, A.S., O. Norén, H. Sjöström, and O. Werdelin. 1993. A mouse aminopeptidase N is a marker for antigenpresenting cells and appears to be co-expressed with major histocompatibility complex class II molecules. Eur. J. Immunol. 23:2358-2364.
8. 2-terminal including proline as a stop signal for trimming. J. Immunol. 151:4732-4742.
9. Falk, K., O. Rötzschke, S. Stavanovic, J. Jung, and H.-G. Rammensee. 1994. Pool sequencing of natural HLA-DR, DQ and DP ligands reveal detailed peptide motifs, constraints of processing, and general rules. Immunogenetics. 39:230-242.
10. Lanier, L.L., L.W. Arnold, R.B. Rayborne, S. Russell, M.A. Lynes, N.L. Warner, and G. Haughton. 1982. Transplantable B-cell lymphomas in B10.H-2aH-4bp/Wts mice. Immunogenetics. 16:367-371.
11. + and slg- sublines. J. Immunol. 128: 1832-1838.
12. Olsen, A.C., L.Ø. Pedersen, A.S. Hansen, M.H. Nissen, M. Olsen, P.R. Hansen, A. Holm, and S. Buus. 1994. A quantitative assay to measure the interaction between immunogenic peptides and MHC class I molecules. Eur. J. Immunol. 24: 385-392.
13. Mescher, M.F. 1992. Surface contact requirements for activation of cytotoxic T lymphocytes. J. Immunol. 149:2402-2405.
14. Stryhn, A., L.Ø. Pedersen, V. Ortiz-Navarrete, and S. Buus. 1994. Preformed purified peptide/MHC class I complexes are potent stimulators of class I-restricted T cell hybridomas. Eur. J. Immunol. 24:1404-1409.
15. Kappler, J.W., B. Skidmore, J. White, and P. Marrack. 1981. Antigen-inducible, H-2 restricted, interleukin-2 producing T cell hybridomas. Lack of independent antigen and H-2 recognition. J. Exp. Med. 153:1198-1214.
16. Lehky, P., J. Lisowski, D.P. Wolf, H. Wacker, and E.A. Stein. 1973. Pig kidney particulate aminopeptidase, a zinc metalloenzyme. Biochim. Biophys. Acta. 321:274-281.
17. Buus, S., A. Sette, S.M. Colon, C. Miles, and H.M. Grey. 1987. The relation between major histocompatibility complex restriction and the capacity of la to bind immunogenic peptides. Science (Wash. DC). 235:1353-1358.
18. Buus, S., A. Stryhn, K. Winther, N. Kirkby, and L.Ø. Pedersen. 1995. Receptor-ligand interactions measured by an improved spun column chromatography technique. A high efficiency and high throughput size separation method. Biochim. Biophys. Acta. 1243:453-460.
19. Mouritsen, S., A.S. Hansen, B.L. Petersen, and S. Buus. 1992. The pH dependence of the interaction between immunogenic peptides and MHC class II molecules. Evidence for an acidic intracellular compartment being the organelle of interaction. J. Immunol. 148:1438-1444.
20. Shimonkevitz, R., J.W. Kappler, P. Marrack, and H.M. Grey. 1983. Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J. Exp. Med. 158:303-316.
21. k molecule. J. Immunol. 135:368-373.
22. k. Proc. Nat. Acad. Sci. USA. 89:7380-7383.
23. Vignali, D.A.A., R.G. Urban, R.M. Chicz, and J.L. Strominger. 1993. Minute quantities of a single immunodominant foreign epitope are presented as large nested sets by major histocompatibility complex class II molecules. Eur. J. Immunol. 23: 1602-1607.
24. Ziegler, H.K., and E.R. Unanue. 1981. Identification of a macrophage antigen-processing event required for I-regionrestricted antigen presentation to T lymphocytes. J. Immunol. 127:1869-1874.
25. Scala, G., and J.J. Oppenheim. 1983. Antigen presentation by human monocytes: evidence for stimulant processing and requirement for interleukin 1. J. Immunol. 131:1160-1165.
26. Sherman, L.A., T.A. Burke, and J.A. Biggs. 1992. Extracellular processing of peptide antigens that bind class I major histocompatibility molecules. J. Exp. Med. 175:1221-1226.
27. Newell, W.R., J. Trowsdale, and S. Beck. 1994. MHCDB-database of the human MHC. Immunogenetics. 40:109-115.
28. Rudensky, A.Y., P. Preston-Hurlburt, S.-C. Hong, A. Barlow, and C.A. Janeway. 1991. Sequence analysis of peptides bound to MHC class II molecules. Nature (Lond.). 353:622-627.
29. d. Science (Wash. DC). 256:1817-1820.
30. Allen, P.M., D.J. Strydom, and E.R. Unanue. 1984. Processing of lysozyme by macrophages: identification of the determinant recognized by two T-cell hybridomas. Proc. Natl. Acad. Sci. USA. 81:2489-2493.
31. Lee, P., G.R. Matsueda, and P.M. Allen. 1988. T cell recognition of fibrinogen. A determinant on the Aa-chain does not require processing. J. Immunol. 140:1063-1068.
32. Sette, A., L. Adorini, S.M. Colon, S. Buus, and H.M. Grey. 1989. Capacity of intact proteins to bind MHC class II molecules. J. Immunol. 143:1265-1267.
33. Brown, J.H., T.S. Jardetzky, J.C. Gorga, L.J. Stern, R.G. Urban, J.L. Strominger, and D.W. Wiley. 1993. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR 1. Nature (Lond.). 364:33-39.
34. Werdelin, O. 1986. Determinant protection. A hypothesis for the activity of immune respons genes in the processing and presentation of antigens by macrophages. Scand. J. Immunol. 24:625-636.
35. Hiwada, K., M. Yokoyama, and T. Kokubu. 1981. Comparison of membrane-bound arylamidases from human, bovine, hog, dog, rabbit and rat kidneys. Comp. Biochem. Physiol. 68B:485-489.
36. Ward, P.E., I.F. Benter, L. Dick, and S. Wilk. 1990. Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M. Biochem. Pharmacol. 40:1725-32.
37. Eisenlohr, L.C., I. Bacik, J.R. Bennink, K. Bernstein, and J.W. Yewdell. 1992. Expression of a membrane protease enhances presentation of endogenous antigens to MHC class 1-restricted T lymphocytes. Cell. 71:963-972.