A cellular anti-apoptosis protein is cleaved by the HIV-1 protease

Advances in Experimental Medicine and Biology

Volumn 436, Issue , 1998, Pages 27-29

  Korant, Bruce D ^a   Strack, Peter ^a   Frey, Michelle W ^a   Rizzo, Christopher J ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEINASE;

APOPTOSIS; CELL DEATH; CONFERENCE PAPER; CYTOTOXICITY; HUMAN IMMUNODEFICIENCY VIRUS 1; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031896045     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5373-1_3     Document Type: Conference Paper

References (5)

1. J. Bartlett. Protease inhibitors for HIV infection. Ann. Intern. Med. 124, (1996), 1086-1087.
2. A. Tomasselli and R. Heinrikson. Specificity of retroviral protease: An analysis of viral and non-viral protein substrates, Meth. Enzymol. 241, (1994), 279-301.
3. B. Korant, Z. Lu, P. Strack and C. Rizzo. HIV protease mutations leading to reduced inhibitor sensitivity, Adv. Exp. Med. Biol., 389 (1996), 241-246.
4. H.-G. Kraüsslich. Human immunodeficiency virus proteinase dimer as a component of the viral polyprotein prevents particle assembly and viral infectivity, Proc. Natl. Acad. Sci. USA 88, (1991), 3213-3217.
5. P. Strack et al. Apoptosis mediated by the HIV protease is preceded by cleavage of bcl-2, Proc. Natl. Acad. Sci. USA 93, (1996), 9571-9576.