Proteolysis in MHC class II antigen presentation: Who's in charge?

Immunity

Volumn 12, Issue 3, 2000, Pages 233-239

  Villadangos, José A ^a   Ploegh, Hidde L ^b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN D; CATHEPSIN L; CATHEPSIN S; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN PRESENTATION; DNA POLYMORPHISM; HUMAN; IMMUNOGENETICS; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW;

EID: 0033695299     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80176-4     Document Type: Review

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4. Dendritic cells and the control of immunity
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22. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells
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24. The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain
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31. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
32. Thyropins - New structurally related proteinase inhibitors
33. Altered antigen presentation in mice lacking H2-O
34. Germinal center development
35. Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules
36. An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation
37. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection
38. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway
39. Immunodominance is independent of structural constraints: Each region within hen eggwhite lysozyme is potentially available upon processing of native antigen
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41. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice
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45. HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments
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48. Cathepsin S activity regulates antigen presentation and immunity
49. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading
50. Sequence analysis of peptides bound to MHC class II molecules
51. Association between HLA-DM and HLA-DR in vivo
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53. Cathepsin S required for normal MHC class II peptide loading and germinal center development
54. Role for cathepsin F in invariant chain processing and MHC class II peptide loading by macrophages
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56. DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules
57. Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain
58. Late events in the intracellular sorting of major histocompatibility complex class II molecules are regulated by the 80-82 segment of the class II beta chain
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65. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein