MHC class II expression is regulated in dendritic cells independently of invariant chain degradation

Immunity

Volumn 14, Issue 6, 2001, Pages 739-749

  Villadangos, José A ^a   Cardoso, María ^b   Steptoe, Raymond J ^a   Van Berkel, Dionne ^a   Pooley, Joanne ^a   Carbone, Francis R ^b   Shortman, Ken ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; CYSTATIN C; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; PROTEIN CHAPERONE INVARIANT CHAIN; PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; CELL ACTIVATION; CELL SURFACE; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; ENDOCYTOSIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; SPLEEN CELL; STEM CELL;

EID: 0034954037     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00148-0     Document Type: Article

References (43)

1. Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles
2. CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms
3. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
4. Intracellular traffic to compartments for MHC class II peptide loading: Signals for endosomal and polarized sorting
5. Immunobiology of dendritic cells
6. Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen-presenting cells
7. Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes
8. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
9. Assembly, transport, and function of MHC class II molecules
10. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells
11. Cytokines regulate proteolysis in MHC class II-dependent antigen presentation by dendritic cells
12. Dendritic cells in cancer immunotherapy
13. Developmental control of endocytosis in dendritic cells by Cdc42
14. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding
15. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
16. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
17. Class II major histocompatibility complex molecules of murine dendritic cells: Synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture
18. How HLA-DM edits the MHC class II peptide repertoire: Survival of the fittest?
19. The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules
20. Cytoplasmic processing is a prerequisite for presentation of an endogenous antigen by major histocompatibility complex class II proteins
21. Cathepsin L: Critical role in Ii degradation and CD4 T cell selection in the thymus
22. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice
23. Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes
24. Identification of two distinct properties of class II major histocompatibility complex-associated peptides
25. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
26. Developmental regulation of MHC class II transport in mouse dendritic cells
27. Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain
28. Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells
29. Dendritic cell maturation and antigen presentation in the absence of invariant chain
30. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
31. Extracellular antigen processing and presentation by immature dendritic cells
32. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
33. Cathepsin S required for normal MHC class II peptide loading and germinal center development
34. Dendritic cells and the pathogenesis of rheumatoid arthritis
35. Transport of peptide-MHC class II complexes in developing dendritic cells
36. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM
37. Proteolysis in MHC class II antigen presentation: Who's in charge?
38. Degradation of mouse invariant chain: Roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism
39. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen
40. Dendritic cell subtypes in mouse lymphoid organs: Cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes
41. The surface phenotype of dendritic cells purified from mouse thymus and spleen: Investigation of the CD8 expression by a subpopulation of dendritic cells
42. Capture and processing of exogenous antigens for presentation on MHC molecules
43. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures