Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes

Journal of Cell Biology

Volumn 134, Issue 3, 1996, Pages 615-623

  Kasper, Dagmar ^a   Dittmer, Frank ^a   Von Figura, Kurt ^a   Pohlmann, Regina ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR SUBTYPE; SOMATOMEDIN B RECEPTOR;

ANIMAL CELL; ARTICLE; INTRACELLULAR TRANSPORT; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEIN TRANSPORT;

ANIMALIA;

EID: 0029737710     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.134.3.615     Document Type: Article

References (31)

1. Artelt, P., C. Morelle, M. Ausmeier, M. Fitzek, and H. Hauser. 1988. Vectors for efficient expression in mammalian fibroblastoid myeloid and lymphoid cells via transfection and infection. Gene (Amst.). 68:213-219.
2. Bresciani, R., C. Peters, and K. von Figura. 1992. Lysosomal acid phosphatase is not involved in the dephosphorylation of mannose 6-phosphate containing lysosomal proteins. Eur. J. Cell Biol. 58:57-61.
3. Chao, H.H.J., A. Waheed, R. Pohlmann, A. Hille, and K. von Figura. 1990. Mannose 6-phosphate receptor-dependent secretion of lysosomal enzymes. EMBO (Eur. Mol. Biol. Organ.) J. 9:3507-3513.
4. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7(8):2745-2752.
5. Feunteun, J., M. Kress, F. Garde, and R. Monier. 1978. Viable deletion mutants in the simian virus 40 early region. Proc. Natl. Acad. Sci. USA. 75:4455-4459.
6. Filson, A.J., A. Louvi, A. Efstratiadis, and E.J. Robertson. 1993. Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes. Development (Camb.). 118:731-736.
7. Gabel, C.A., D.E. Goldberg, and S. Kornfeld. 1993. Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting. Proc. Natl. Acad. Sci. USA. 80:775-779.
8. Geuze, H.J., J.W. Slot, G.J.A.M. Strous, A. Hasilik, and K. von Figura. 1985. Ultrastructural localization of the mannose 6-phosphate receptor in rat liver. J. Cell Biol. 98:2047-2054.
9. Gieselmann, V., A. Hasilik, and K. von Figura. 1984. Tartrate-inhibitable acid phosphatase: Purification from placenta, characterization and subcellular distribution in fibroblasts. Hoppe-Seyler's Z. Physiol. Chem. 365:651-660.
10. Hoflack, B., and S. Kornfeld. 1985. Purification and characterization of a cation-dependent mannose 6-phosphate receptor from murine P388D1 macrophages and bovine liver. J. Biol. Chem. 260:12008-12014.
11. Johnson, K.F., and S. Kornfeld. 1992a. The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor II receptor has two signals for lysosomal enzyme sorting in the Golgi. J. Cell Biol. 119:249-257.
12. Johnson, K.F., and S. Kornfeld. 1992b. A His-Leu-Leu sequence near the carboxy-terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function. J. Biol. Chem. 267:17110-17118.
13. Klumperman, J., A. Hille, T. Veenendahl, V. Oorschot, W. Stoorvogel, K. von Figura, and H.J. Geuze. 1993. Differences in the endosomal distributions of the two mannose 6-phosphate receptors. J. Cell Biol. 121:997-1010.
14. Körner, C., B. Nürnberg, M. Uhde, and T. Braulke. 1995. Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. J. Biol. Chem. 270:287-295.
15. r 46000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins. EMBO (Eur. Mol. Biol. Organ.) J. 12:5219-5223.
16. Kornfeld, S. 1992. Structure and function of the mannose 6-phosphate/insulin-like growth factor II receptors. Annu. Rev. Biochem. 61:307-330.
17. Kornfeld, S., and I. Mellman. 1989. The biogenesis of lysosomes. Annu. Rev. Cell Biol. 5:483-525.
18. Kornfeld, S., and W.S. Sly. 1995. I-cell disease and pseudo-Hurler polydystrophy: disorders of lysosomal enzyme phosphorylation. In The Metabolic and Molecular Basis of Inherited Disease. C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, editors. McGraw-Hill, New York. 2495-2508.
19. Lobel, P., K. Fujimoto, R.D. Ye, G. Griffith, and S. Kornfeld. 1989. Mutations in the cytoplasmic domain of the 275 kD mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis. Cell. 57:787-796.
20. Ludwig, T., C.E. Ovitt, U. Bauer, M. Hollinshead, J. Remmler, P. Lobel, U. Rüther, and B. Hoflack. 1993. Targeted disruption of the mouse cation-dependent mannose 6-phosphate receptor results in a phenotype similar to the human disease mucolipidosis III. EMBO (Eur. Mol. Biol. Organ.) J. 12: 5225-5235.
21. Ma, Z., J.H. Grubb, and W.S. Sly. 1991. Cloning, sequencing and functional characterization of the murine 46-kDa mannose 6-phosphate receptor. J. Biol. Chem. 266:10589-10595.
22. i2) produced by gene targeting of both alleles. Proc. Natl. Acad Sci. USA. 88:7036-7040.
23. Okamoto, T., T. Katada, Y. Murayama, M. Ui, E. Ogata, and I. Nishimoto. 1990. A simple structure encodes G protein-activating function of the IGFII/ mannose 6-phosphate receptor. Cell. 62:709-717.
24. Pohlmann, R., M. Wendland, C. Boeker, and K. von Figura. 1995. The two mannose 6-phosphate receptors transport distinct complements of lysosomal enzymes. J. Biol. Chem. 270:27311-27318.
25. r 46,000 mannose 6-phosphate receptor to the trans-Golgi network. J. Cell Biol. 122:541-551.
26. r 46,000 mannose 6-phosphate specific receptor: its role in tageting of lysosomal enzymes. EMBO (Eur. Mol. Biol. Organ.) J. 6:2677-2681.
27. von Figura, K. 1978. Secretion of β-hexosaminidase by cultured human skin fibroblasts. Kinetics, effect of temperature, cell density, serum concentration and pH. Exp. Cell Res. 111:15-21.
28. von Figura, K., V. Gieselmann, and A. Hasilik. 1984. Antibody to mannose 6-phosphate specific receptors induces receptor deficiency in human fibroblasts. EMBO (Eur. Mol. Biol. Organ.) J. 3:1281-1286.
29. Wang, Z.Q., M.R. Fung,. D.P. Barlow, and E.F. Wagner. 1994. Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene. Nature (Lond.). 372:464-467.
30. Waheed, A., S. Goltschalk, A. Hille, C. Krentler, R. Pohlmann, T. Braulke, H. Hauser, H. Geuze, and K. von Figura. 1988. Human lysosomal acid phosphatase is transported as a trans-membrane protein to lysosomes in transfected baby hamster kidney cells. EMBO (Eur. Mol. Biol. Organ.) J. 7:2351-2358.
31. Watanabe, H., J.H. Grubb, and W.S. Sly. 1990. The overexpressed human 46 kDa mannose 6-phosphate receptor mediates endocytosis and sorting of β-glucuronidase. Proc. Natl. Acad. Sci. USA. 87:8036-8040.