Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing

Current Biology

Volumn 11, Issue 6, 2001, Pages 447-451

  Manoury, Bénédicte ^a   Gregory, William F ^b   Maizels, Rick M ^b   Watts, Colin ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BRUGIA MALAYI; EUKARYOTA; PHASEOLUS VULGARIS; VERMES;

EID: 0035916803     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00118-X     Document Type: Article

References (24)

1. Development regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
2. The 2.0 Å X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases
3. Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site
4. Differentially expressed, abundant trans-spliced cDNAs from larval Brugia malayi
5. An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation
6. Control of antigen presentation by a single protease cleavage site
7. Role for intracellular proteases in the processing and transport of class II HLA antigens
8. Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS-resistant αβ heterodimers in endosomes
9. Capture and processing of exogenous antigens for presentation on MHC molecules
10. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
11. Selective inhibition of li-dependent antigen presentation by Helicobacter pylori toxin VacA
12. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus
13. A filarial cysteine protease inhibitor down-regulates T cell proliferation and enhances interleukin-10 production
14. Analysis of genes expressed at the infective larval stage validate the utility of Litomosoides sigmodontis as a murine model for filarial vaccine development
15. Inhibition of antigen-driven proliferative responses and enhancement of antibody production during infection with Brugia pahangi
16. Specificity of predominant IgG4 antibodies to adult and microfilarial stages of Brugia malayi
17. Viral strategies of immune evasion
18. Viral mechanisms of immune evasion
19. Viral subversion of the immune system
20. Deep within the filarial genome: An update on progress in the Filarial Genome Project
21. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway
22. Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin. Implications for T cell epitope generation
23. Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase
24. Functional early endosomes are required for maturation of major histocompatibility complex class II molecules in human B lymphoblastoid cells