Crystal structures of human procathepsin B at 3.2 and 3.3 Å resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide

FEBS Letters

Volumn 384, Issue 3, 1996, Pages 211-214

  Turk, Dušan ^a,b   Podobnik, Marjeta ^a   Kuhelj, Robert ^a   Dolinar, Marko ^a   Turk, Vito ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Cathepsin B; Crystal structure; Cysteine protease; Papain; Proenzyme

Indexed keywords

CATHEPSIN B; ENZYME PRECURSOR; PEPTIDE; PROCATHEPSIN B; PROPEPTIDE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE EXPRESSION; HUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

BINDING SITES; CATHEPSIN B; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; ENZYME PRECURSORS; HUMANS; MODELS, MOLECULAR; PAPAIN; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029976244     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(96)00309-2     Document Type: Article

References (33)

1. Berti, P.J. and Storer, A.C. (1995) J. Mol. Biol. 246, 273-283.
2. Bond, J.S. and Butler, P.E. (1987) Annu. Rev. Biochem. 56, 333-364.
3. Roche, P.A. and Cresswell, P. (1991) Proc. Natl. Acad. Sci. USA 87, 1927-1933.
4. Morton, P.A., Zacheis, M.L., Giacoletto, K.S., Manning, J.A. and Schwartz, B.D. (1995) J. Immunol. 154, 137-150.
5. Tezuka, K., Tezuka, Y., Maejima, A., Sato, T., Nemoto, K., Kamioka, H., Hakeda, Y. and Kumegawa, M. (1994) J. Biol. Chem. 269, 1106-1109.
6. Krieger, T.J. and Hook, V.Y.H. (1991) J. Biol. Chem. 266, 8376-8383.
7. Buttle, D.J., Saklatvala, J. and Barrett, A.J. (1993) Agents Action Suppl. 39, 161-165.
8. Pentaceska, S., Burke, S., Watson, S.J. and Devi, L. (1994) Neuroscience 59, 729-738.
9. Sloane, B.F., Moin, K. and Lah, T.T. (1994) in: Biochem. Mol. Aspects Select. Cancers, vol. 2 (Pretlow, T.G. and Pretlow, T.P. eds.) pp. 411-460, Academic Press, San Diego.
10. Delaisse, J.M., Pascale, L. and Vaes, G. (1991) Biochem. J. 279, 167-174.
11. Chan, S.J., San Segundo, B., McCormick, M.B. and Steiner, D.F. (1986) Proc. Natl. Acad. Sci. USA 83, 7721-7725.
12. Takio, K., Towatari, T., Katunuma, N., Teller, D.C. and Titani, K. (1983) Proc. Natl. Acad. Sci. USA 80, 3666-3670.
13. Musil, D., Zučič, D., Turk, D., Engh, R.A., Mayr, I., Huber, R., Popovič, T., Turk, V., Towatari, T., Katunuma, N. and Bode, W. (1991) EMBO J. 10, 2321-2330.
14. Jia, Z., Hasnain, S., Hirmama, T., Lee, X., Mort, J.S., To, R. and Huber, C.P. (1995) J. Biol. Chem. 270, 5627-5633.
15. Turk, D., Podobnik, M., Popovič, T., Katunuma, N., Bode, W., Huber, R. and Turk, V. (1995) Biochemistry 34, 4791-4797.
16. Drenth, I., Jansonius, J.N., Koekoek, R., Swen, H.M. and Wolthers, B.G. (1968) Nature 249, 54-57.
17. Rowan, A.D., Mason, P., Mach, L. and Mort, J.S. (1992) J. Biol. Chem. 267, 15993-15999.
18. Mach, L., Stüwe, K., Hagen, A., Ballaun, C. and Glössl, J. (1992) Biochem. J. 282, 577-582.
19. Mach, L., Schwihla, H., Stüwe, K., Rowan, A.D., Mort, J.S. and Glössl, J. (1993) Biochem. J. 293, 437-442.
20. Huber, R. and Bode, W. (1978) Acc. Chem. Res. 11, 114-122.
21. James, M.N.G. and Sielecki, A.R. (1986) Nature 319, 33-38.
22. Coll, M., Guasch, A., Aviles, F.X. and Huber, R. (1991) EMBO J. 10, 1-9.
23. Bryan, P., Wang, L., Hoskins, J., Ruvinov, S., Strausberg, S., Alexander, P., Almog, O., Gilliland, G. and Gallagher, T. (1995) Biochemistry 34, 10310-10318.
24. Kuhelj, R., Dolinar, M., Pungerčar, J. and Turk, V. (1995) Eur. J. Biochem. 229, 533-539.
25. Leslie, A.G.W. (1994) Mosflm Users Guide, Mosflm version 5.23, MRC Laboratory of Molecular Biology, Cambridge, UK.
26. CCP4 (1994) Acta Crystallogr. D50, 760-763.
27. Navaza, J. (1994) Acta Crystallogr. A50, 157-163.
28. Turk, D. (1992) Doctoral Thesis Technische Universität München.
29. Engh, R.A. and Huber, R. (1991) Acta Crystallogr. A47, 392-400.
30. Brünger, A.T. (1992) X-PLOR, Version 3.1, A System for X-ray Crystallography and NMR, Yale University Press, New Haven, CT.
31. Fox, T., De Miguel, E., Mort, J.S. and Storer, A.C. (1992) Biochemistry 31, 12571-12576.
32. Mach, L., Mort, J.S. and Glössl, J. (1994) Maturation of human procathepsin B. J. Biol. Chem. 269, 13030-13035.
33. Mach, L., Mort, J.S. and Glössl, J. (1994) J. Biol. Chem. 269, 13036-13040.