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Volumn 9, Issue 3, 1998, Pages 377-383

The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; HLA DM ANTIGEN; HLA DR1 ANTIGEN; HLA DR4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRYPTOPHAN; UNCLASSIFIED DRUG;

EID: 0032168861     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80620-2     Document Type: Article
Times cited : (128)

References (52)
  • 4
    • 84901961522 scopus 로고
    • Slow-cooling protocols for crystallographic refinement by simulated annealing
    • Brünger, A.T., and Krukowski, A. (1990). Slow-cooling protocols for crystallographic refinement by simulated annealing. Acta Cryst. A 46, 585-593.
    • (1990) Acta Cryst. A , vol.46 , pp. 585-593
    • Brünger, A.T.1    Krukowski, A.2
  • 5
    • 0028051652 scopus 로고
    • Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor
    • Burmeister, W.P., Gastinel, L.N., Simister, N.E., Slum, M.L., and Bjorkman, P.J. (1994). Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor. Nature 372, 336-343.
    • (1994) Nature , vol.372 , pp. 336-343
    • Burmeister, W.P.1    Gastinel, L.N.2    Simister, N.E.3    Slum, M.L.4    Bjorkman, P.J.5
  • 6
    • 0029864967 scopus 로고    scopus 로고
    • Developing and shedding inhibitions: How MHC class II molecules reach maturity
    • Busch, R., and Mellins, E.D. (1996). Developing and shedding inhibitions: how MHC class II molecules reach maturity. Curr. Opin. Immunol. 8, 51-58.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 51-58
    • Busch, R.1    Mellins, E.D.2
  • 7
    • 0031964617 scopus 로고    scopus 로고
    • Abberrant intermolecular disulfide bonding in a mutant HLA-DM molecule: Implications for assembly, maturation, and function
    • Busch, R., Doebele, R.C., von Scheven, E., Fahrni, J., and Mellins, E.D. (1998a). Abberrant intermolecular disulfide bonding in a mutant HLA-DM molecule: implications for assembly, maturation, and function. J. Immunol. 160, 734-743.
    • (1998) J. Immunol. , vol.160 , pp. 734-743
    • Busch, R.1    Doebele, R.C.2    Von Scheven, E.3    Fahrni, J.4    Mellins, E.D.5
  • 8
    • 0032538565 scopus 로고    scopus 로고
    • Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM
    • in press
    • Busch, R., Reich, Z., Zaller, D., Sloan, V., and Mellins, E.D. (1998b). Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM. J. Biol. Chem., in press.
    • (1998) J. Biol. Chem.
    • Busch, R.1    Reich, Z.2    Zaller, D.3    Sloan, V.4    Mellins, E.D.5
  • 9
    • 0023162526 scopus 로고
    • The interaction between protein-derived immunogenic peptides and Ia
    • Buus, S., Sette, A., and Grey, H.M. (1987). The interaction between protein-derived immunogenic peptides and Ia. Immunol. Rev. 98, 115-141.
    • (1987) Immunol. Rev. , vol.98 , pp. 115-141
    • Buus, S.1    Sette, A.2    Grey, H.M.3
  • 10
    • 0023717145 scopus 로고
    • Autologous peptides constitutively occupy the antigen binding site on Ia
    • Buus, S., Sette, A., Colon, S.M., and Grey, H.M. (1988). Autologous peptides constitutively occupy the antigen binding site on Ia. Science 242, 1045-1047.
    • (1988) Science , vol.242 , pp. 1045-1047
    • Buus, S.1    Sette, A.2    Colon, S.M.3    Grey, H.M.4
  • 11
    • 0025940456 scopus 로고
    • New class II-like genes in the murine MHC
    • Cho, S., Attaya, M., and Monaco, J.J. (1991). New class II-like genes in the murine MHC. Nature 353, 573-576.
    • (1991) Nature , vol.353 , pp. 573-576
    • Cho, S.1    Attaya, M.2    Monaco, J.J.3
  • 12
    • 0028103275 scopus 로고
    • The CCP4 suite: Programs for protein crystallography
    • Collaborative Computational Project, N. (1994). The CCP4 suite: Programs for protein crystallography. Acta Cryst. D 50, 760-763.
    • (1994) Acta Cryst. D , vol.50 , pp. 760-763
  • 13
    • 0028313992 scopus 로고
    • Assembly, transport, and function of MHC class II molecules
    • Cresswell, P. (1994). Assembly, transport, and function of MHC class II molecules. Annu. Rev. Immunol. 12, 259-293.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 259-293
    • Cresswell, P.1
  • 14
    • 0030028779 scopus 로고    scopus 로고
    • Invariant chain structure and MHC class II function
    • Cresswell, P. (1996). Invariant chain structure and MHC class II function. Cell 84, 505-507.
    • (1996) Cell , vol.84 , pp. 505-507
    • Cresswell, P.1
  • 15
    • 0028981178 scopus 로고
    • HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading
    • Denzin, L.K., and Cresswell, P. (1995). HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 82, 155-165.
    • (1995) Cell , vol.82 , pp. 155-165
    • Denzin, L.K.1    Cresswell, P.2
  • 16
    • 0030458137 scopus 로고    scopus 로고
    • HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
    • Denzin, L.K., Hammond, C., and Cresswell, P. (1996). HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules. J. Exp. Med. 184, 2153-2165.
    • (1996) J. Exp. Med. , vol.184 , pp. 2153-2165
    • Denzin, L.K.1    Hammond, C.2    Cresswell, P.3
  • 17
    • 0031551492 scopus 로고    scopus 로고
    • Negative regulation by HLA-DO of MHC class II-restricted antigen processing
    • Denzin, L.K., Sant'Angelo, D.B., Hammond, C., Surman, M.J., and Cresswell, P. (1997). Negative regulation by HLA-DO of MHC class II-restricted antigen processing. Science 278, 106-109.
    • (1997) Science , vol.278 , pp. 106-109
    • Denzin, L.K.1    Sant'Angelo, D.B.2    Hammond, C.3    Surman, M.J.4    Cresswell, P.5
  • 18
    • 0030701632 scopus 로고    scopus 로고
    • X-ray crystal structure of HLA-DR4 (DRA1*0101, DRB1 *0401) complexed with a peptide from human collagen II
    • Dessen, A., Lawrence, C.M., Cupo, S., Zaller, D.M., and Wiley, D.C. (1997). X-ray crystal structure of HLA-DR4 (DRA1*0101, DRB1 *0401) complexed with a peptide from human collagen II. Immunity 7, 473-481.
    • (1997) Immunity , vol.7 , pp. 473-481
    • Dessen, A.1    Lawrence, C.M.2    Cupo, S.3    Zaller, D.M.4    Wiley, D.C.5
  • 19
    • 0031049536 scopus 로고    scopus 로고
    • HLA-DO is an intracellular class II molecule with distinctive thymic expression
    • Douek, D.C., and Altmann, D.M. (1997). HLA-DO is an intracellular class II molecule with distinctive thymic expression. Int. Immunol. 9, 355-364.
    • (1997) Int. Immunol. , vol.9 , pp. 355-364
    • Douek, D.C.1    Altmann, D.M.2
  • 20
    • 0028217255 scopus 로고
    • HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells
    • Fing, S.P., Arp, B., and Pious, D. (1994). HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. Nature 368, 554-558.
    • (1994) Nature , vol.368 , pp. 554-558
    • Fing, S.P.1    Arp, B.2    Pious, D.3
  • 21
    • 0029782111 scopus 로고    scopus 로고
    • Structures of an MHC class II molecule with covalently bound single peptides
    • Fremont, D.H., Hendrickson, W.A., Marrack, P., and Kappler, J. (1996). Structures of an MHC class II molecule with covalently bound single peptides. Science 272, 1001-1004.
    • (1996) Science , vol.272 , pp. 1001-1004
    • Fremont, D.H.1    Hendrickson, W.A.2    Marrack, P.3    Kappler, J.4
  • 22
    • 0027303736 scopus 로고
    • Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules
    • Germain, R.N., and Rinker, A.G. (1993). Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules. Nature 363, 725-728.
    • (1993) Nature , vol.363 , pp. 725-728
    • Germain, R.N.1    Rinker, A.G.2
  • 23
    • 0028823585 scopus 로고
    • The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
    • Ghosh, P., Amaya, M., Mellins, E., and Wiley, D.C. (1995). The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378, 457-462.
    • (1995) Nature , vol.378 , pp. 457-462
    • Ghosh, P.1    Amaya, M.2    Mellins, E.3    Wiley, D.C.4
  • 24
    • 0032080436 scopus 로고    scopus 로고
    • Novel glycosylation of HLA-DRa disrupts antigen presentation without altering endosomal localization
    • Guerra, C.B., Busch, R., Doebele, R.C., Liu, W., Sawada, T., Kwok, W.W., Chang, M.Y., and Mellins, E.D. (1998). Novel glycosylation of HLA-DRa disrupts antigen presentation without altering endosomal localization. J. Immunol. 160, 4289-4297.
    • (1998) J. Immunol. , vol.160 , pp. 4289-4297
    • Guerra, C.B.1    Busch, R.2    Doebele, R.C.3    Liu, W.4    Sawada, T.5    Kwok, W.W.6    Chang, M.Y.7    Mellins, E.D.8
  • 26
    • 84889120137 scopus 로고
    • Improved methods for building protein models in electron density maps and the location of errors in these models
    • Jones, T.A., Zou, J.-Y., Cowan, S.W., and Kjeldgaard, M. (1991). Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Cryst. A 47, 110-119.
    • (1991) Acta Cryst. A , vol.47 , pp. 110-119
    • Jones, T.A.1    Zou, J.-Y.2    Cowan, S.W.3    Kjeldgaard, M.4
  • 27
    • 0026093582 scopus 로고
    • A new human HLA class II-related locus, DM
    • Kelly, A.P., Monaco, J.J., Cho, S., and Trowsdale, J. (1991). A new human HLA class II-related locus, DM. Nature 353, 571-573.
    • (1991) Nature , vol.353 , pp. 571-573
    • Kelly, A.P.1    Monaco, J.J.2    Cho, S.3    Trowsdale, J.4
  • 28
    • 0028559548 scopus 로고
    • Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1
    • Kim, J., Urban, R.G., Strominger, J.L., and Wiley, D.C. (1994). Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1. Science 266, 1870-1874.
    • (1994) Science , vol.266 , pp. 1870-1874
    • Kim, J.1    Urban, R.G.2    Strominger, J.L.3    Wiley, D.C.4
  • 29
    • 0030978530 scopus 로고    scopus 로고
    • HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH
    • Kropshofer, H., Arndt, S.O., Moldenhauer, G., Hammerling, G.J., and Vogt, A.B. (1997). HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH. Immunity 6, 293-302.
    • (1997) Immunity , vol.6 , pp. 293-302
    • Kropshofer, H.1    Arndt, S.O.2    Moldenhauer, G.3    Hammerling, G.J.4    Vogt, A.B.5
  • 30
    • 0029790517 scopus 로고    scopus 로고
    • HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport
    • Liljedahl, M., Kuwana, T., Fung-Leung, W.-P., Jackson, M.R., Peterson, P.A., and Karlsson, L. (1996). HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. EMBO J. 15, 4817-4824.
    • (1996) EMBO J. , vol.15 , pp. 4817-4824
    • Liljedahl, M.1    Kuwana, T.2    Fung-Leung, W.-P.3    Jackson, M.R.4    Peterson, P.A.5    Karlsson, L.6
  • 32
    • 0028047736 scopus 로고
    • A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides
    • Mellins, E., Cameron, P., Amaya, M., Goodman, S., Pious, D., Smith, L., and Arp, B. (1994). A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides. J. Exp. Med. 179, 541-549.
    • (1994) J. Exp. Med. , vol.179 , pp. 541-549
    • Mellins, E.1    Cameron, P.2    Amaya, M.3    Goodman, S.4    Pious, D.5    Smith, L.6    Arp, B.7
  • 33
    • 0028350714 scopus 로고
    • An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules
    • Morris, P., Shaman, J., Attaya, M., Amaya, M., Goodman, S., Bergman, C., Monaco, J.J., and Mellins, E. (1994). An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules. Nature 368, 551-554.
    • (1994) Nature , vol.368 , pp. 551-554
    • Morris, P.1    Shaman, J.2    Attaya, M.3    Amaya, M.4    Goodman, S.5    Bergman, C.6    Monaco, J.J.7    Mellins, E.8
  • 34
    • 0028791680 scopus 로고
    • Invariant chain made in E. coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal that binds empty DR1
    • Park, S.-J., Sadegh-Nasseri, S., and Wiley, D.C. (1995). Invariant chain made in E. coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal that binds empty DR1. Proc. Nat. Acad. Sci. USA 92, 11289-11293.
    • (1995) Proc. Nat. Acad. Sci. USA , vol.92 , pp. 11289-11293
    • Park, S.-J.1    Sadegh-Nasseri, S.2    Wiley, D.C.3
  • 35
    • 0026440236 scopus 로고
    • HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides
    • Riberdy, J.M., Newcomb, J.R., Surman, M.J., Barbosa, J.A., and Cresswell, P. (1992). HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature 360, 474-477.
    • (1992) Nature , vol.360 , pp. 474-477
    • Riberdy, J.M.1    Newcomb, J.R.2    Surman, M.J.3    Barbosa, J.A.4    Cresswell, P.5
  • 36
  • 38
    • 0029084023 scopus 로고
    • DM enhances peptide binding to class II MHC by release of invariant-chain derived peptide
    • Sherman, M.A., Weber, D.A., and Jensen, P.E. (1995). DM enhances peptide binding to class II MHC by release of invariant-chain derived peptide. Immunity 3, 197-205.
    • (1995) Immunity , vol.3 , pp. 197-205
    • Sherman, M.A.1    Weber, D.A.2    Jensen, P.E.3
  • 40
    • 0026571278 scopus 로고
    • The human class II MHC protein HLA-DR1 assembles as empty ab heterodimers in the absence of antigenic peptide
    • Stern, L.J., and Wiley, D.C. (1992). The human class II MHC protein HLA-DR1 assembles as empty ab heterodimers in the absence of antigenic peptide. Cell 68, 465-477.
    • (1992) Cell , vol.68 , pp. 465-477
    • Stern, L.J.1    Wiley, D.C.2
  • 41
    • 0028348369 scopus 로고
    • Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
    • Stern, L.J., Brown, J.H., Jardetzky, T.S., Gorga, J.C., Urban, R.G., Strominger, J.L., and Wiley, D.C. (1994). Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368, 215-221.
    • (1994) Nature , vol.368 , pp. 215-221
    • Stern, L.J.1    Brown, J.H.2    Jardetzky, T.S.3    Gorga, J.C.4    Urban, R.G.5    Strominger, J.L.6    Wiley, D.C.7
  • 42
    • 0004155427 scopus 로고
    • New York: W.H. Freeman
    • Stryer, L. (1981). Biochemistry. (New York: W.H. Freeman), pp. 220-227.
    • (1981) Biochemistry , pp. 220-227
    • Stryer, L.1
  • 43
    • 0022153879 scopus 로고
    • DOβ: A new β chain gene in HLA-D with a distinct regulation of expression
    • Tonnelle, C., DeMars, R., and Long, E.O. (1985). DOβ: a new β chain gene in HLA-D with a distinct regulation of expression. EMBO J. 4, 2839-2847.
    • (1985) EMBO J. , vol.4 , pp. 2839-2847
    • Tonnelle, C.1    DeMars, R.2    Long, E.O.3
  • 44
    • 0022125778 scopus 로고
    • The human HLA class II a chain gene DZα is distinct from genes in the DP, DQ and DR subregions
    • Trowsdale, J., and Kelly, A. (1985). The human HLA class II a chain gene DZα is distinct from genes in the DP, DQ and DR subregions. EMBO J. 4, 2231-2237.
    • (1985) EMBO J. , vol.4 , pp. 2231-2237
    • Trowsdale, J.1    Kelly, A.2
  • 45
    • 0030723313 scopus 로고    scopus 로고
    • Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH
    • Ullrich, H.J., Doring, K., Gruneberg, U., Jahnig, F., Trowsdale, J., and van Ham, S.M. (1997). Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH. Proc. Natl. Acad. Sci. USA 94, 13163-13168.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13163-13168
    • Ullrich, H.J.1    Doring, K.2    Gruneberg, U.3    Jahnig, F.4    Trowsdale, J.5    Van Ham, S.M.6
  • 47
    • 0029817784 scopus 로고    scopus 로고
    • Kinetic analysis of peptide loading onto HLY-Dr molecules mediated by HLA-DM
    • Vogt, A.B., Kropshofer, H., Moldenhauer, G., and Hammerling, G.J. (1996). Kinetic analysis of peptide loading onto HLY-Dr molecules mediated by HLA-DM. Immunology 93, 9724-9729.
    • (1996) Immunology , vol.93 , pp. 9724-9729
    • Vogt, A.B.1    Kropshofer, H.2    Moldenhauer, G.3    Hammerling, G.J.4
  • 49
    • 0029824101 scopus 로고    scopus 로고
    • Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
    • Weber, D.A., Evavold, B.D., and Jensen, P.E. (1996). Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM. Science 274, 618-620.
    • (1996) Science , vol.274 , pp. 618-620
    • Weber, D.A.1    Evavold, B.D.2    Jensen, P.E.3
  • 51
    • 0029615496 scopus 로고
    • How MHC class II molecules acquire peptide cargo: Biosynthesis and trafficking through the endocytic pathway
    • Wolf, P.R., and Ploegh, H.L. (1995). How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annu. Rev. Cell Dev. Biol. 11, 267-306.
    • (1995) Annu. Rev. Cell Dev. Biol. , vol.11 , pp. 267-306
    • Wolf, P.R.1    Ploegh, H.L.2
  • 52
    • 0030826423 scopus 로고    scopus 로고
    • Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove
    • Zeng, Z.-H., Castaño, A.R., Segelke, B.W., Stura, E.A., Peterson, P.A., and Wilson, I.A. (1997). Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science 277, 339-345.
    • (1997) Science , vol.277 , pp. 339-345
    • Zeng, Z.-H.1    Castaño, A.R.2    Segelke, B.W.3    Stura, E.A.4    Peterson, P.A.5    Wilson, I.A.6


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