Two-step mechanism of inhibition of cathepsin B by cystatin C due to displacement of the proteinase occluding loop

FEBS Letters

Volumn 422, Issue 1, 1998, Pages 61-64

  Nycander, Maria ^a   Estrada, Sergio ^a   Mort, John S ^b   Abrahamson, Magnus ^c   Björk, Ingemar ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Cathepsin; Cystatin; Cysteine proteinase; Cysteine proteinase inhibitor; Kinetics

Indexed keywords

CATHEPSIN B; CYSTATIN C; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; FLUORESCENCE; PRIORITY JOURNAL; REACTION ANALYSIS;

BINDING SITES; CATHEPSIN B; CYSTATINS; CYSTEINE PROTEINASE INHIBITORS; KINETICS; LYSOSOMES; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 0032559423     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)01604-9     Document Type: Article

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