Antigen processing in the endocytic compartment

Current Opinion in Immunology

Volumn 13, Issue 1, 2001, Pages 26-31

  Watts, C ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; CYSTATIN; CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEINASE; PROTEINASE INHIBITOR;

ALLELE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ENDOSOME; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVIEW;

EID: 0035145332     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00177-1     Document Type: Review

References (59)

1. Lysosomal cysteine proteases: More than scavengers
2. Proteolysis in MHC class II antigen presentation: Who's in charge?
3. Cathepsins and compartmentalization in antigen presentation
4. Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts
5. Sequence analysis of peptides bound to MHC class II molecules
6. Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size
7. Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
8. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells
9. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
10. Capture and processing of exogenous antigens for presentation on MHC molecules
11. Degradation of mouse invariant chain: Roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism
12. Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
13. Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: Importance depends on the nature of the antigen-antibody interaction
14. Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain in ovalbumin-immunized mice
15. Cytoplasmic processing is a prerequisite for presentation of an endogenous antigen by major histocompatibility complex class II proteins
16. Cathepsin L: Critical role in li degradation and CD4 T cell selection in the thymus
17. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice
18. Cathepsin S required for normal MHC class II peptide loading and germinal center development
19. An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation
20. Antigen presentation controlled by a single protease cleavage site
21. Pig kidney legumain: An asparaginyl endopeptidase with restricted specificity
22. Introduction of an endopeptidase cleavage motif into a determinant flanking region of hen egg lysozyme results in enhanced T cell determinant display
23. Reduction of disulfide bonds within lysosomes is a key step in antigen processing
24. Reduction of disulfide bonds during antigen processing: Evidence from a thiol-dependent insulin determinant
25. Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)
26. Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action
27. Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes
28. Distinct antigen MHC class II complexes generated by separate processing pathways
29. Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules
30. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading
31. The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules
32. The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation
33. Role for intracellular proteases in the processing and transport of class II HLA antigens
34. Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes
35. Endosomal aspartic proteinases are required for invariant-chain processing
36. Functional early endosomes are required for maturation of major histocompatibility complex class II molecules in human B lymphoblastoid cells
37. Early endosomes are required for major histocompatiblity complex class II transport to peptide-loading compartments
38. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM
39. Dendritic cells and the control of immunity
40. Development regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
41. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
42. Transport of peptide-MHC class II complexes in developing dendritic cells
43. Developmental regulation of MHC class II transport in mouse dendritic cells
44. Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes
45. The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases
46. Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site
47. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus
48. A filarial cysteine protease inhibitor down-regulates T cell proliferation and enhances interleukin-10 production
49. Thyropins - New structurally related proteinase inhibitors
50. The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain
51. Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathespin L
52. Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S
53. Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells
54. Endosomal proteolysis and MHC class II function
55. In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen
56. +-ATPase in regulating ATP-dependent endosome acidification
57. DM determines the cryptic and immunodominant fate of T cell epitopes
58. 2-terminal including proline as a stop signal for trimming