Peptide loading onto recycling HLA-DR molecules occurs in early endosomes

European Journal of Immunology

Volumn 28, Issue 3, 1998, Pages 799-804

  Pinet, Valérie M ^a,b   Long, Eric O ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b HÔPITAL SAINT ELOI   (France)

Author keywords

Concanamycin B; Exogenous antigen presentation; Recycling MHC class II

Indexed keywords

HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VIRUS PROTEIN;

ARTICLE; ENDOSOME; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLUENZA VIRUS; LYSOSOME; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGENS, VIRAL; CELL COMPARTMENTATION; CELL LINE; CROSS-LINKING REAGENTS; ENDOSOMES; EPITOPE MAPPING; HEMAGGLUTININS, VIRAL; HLA-DR ANTIGENS; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE PROTEINS; PEPTIDES; VIRAL MATRIX PROTEINS;

EID: 0031881533     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199803)28:03<799::AID-IMMU799>3.0.CO;2-5     Document Type: Article

References (20)

1. Lanzavecchia, A., Mechanisms of antigen uptake and presentation. Curr. Opin. Immunol. 1996. 8: 348-354.
2. Tulp, A., Verwoerd, D., Dobberstein, B., Ploegh, H. L. and Pieters, J., Isolation and characterization of the intracellular MHC class II compartment. Nature 1994. 369: 120-126.
3. Peters, P. J., Neefjes, J. J., Oorshot, V., Ploegh, H. L. and Geuze, H. J., Segregation af MHC class II molecules from MHC class I molecules in the Golgi complex for transport of lysosomal compartments. Nature 1991. 349: 669-676.
4. Castellino, F. and Germain, R. N., Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments. Immunity 1995. 2: 73-88.
5. Germain, R. N., Castellino, F., Han, R., Sousa, C. R. E., Romagnoli, P., Sadegh-Nasseri, S. and Zhong, G.-M., Processing and presentation of endocytically acquired protein antigens by MHC class II and class I molecules. Immunol. Rev. 1996. 151: 5-30.
6. Pinet, V., Malnati, M. S. and Long, E. O., Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen. J. Immunol. 1994. 152: 4852-4860.
7. Pinet, V., Vergelli, M., Martin, R., Bakke O. and Long, E. O., Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature 1995. 375: 603-606.
8. Clague, M. J., Urbé, S., Aniento, F. and Gruenberg, J., Vacuolar ATPase activity is required for endosomal carrier vesicle formation. J. Biol. Chem. 1994. 269: 21-24.
9. Lindner, R. and Unanue, E. R., Distinct antigen MHC class II complexes generated by separate processing pathways. EMBO J. 1996. 15: 6910-6920.
10. Vergelli, M., Pinet, V., Vogt, A. B., Kalbus, M., Malnati, M., Riccio, P., Long, E. O. and Martin, R., HLA-DR-restricted presentation of purified myelin basic protein is independent of intracellular processing. Eur. J. Immunol. 1997. 27: 941-951.
11. Zhong, G., Romagnoli, P. and Germain, R. N., Related Leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein. J. Exp. Med. 1997. 185: 429-438.
12. Griffin, J. P., Chu, R. and Harding, C. V., Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms. J. Immunol. 1997. 158: 1523-1532.
13. Collins, D. S., Unanue, E. R. and Harding, C. V., Reduction of disulfide bonds within lysosomes is a key step in antigen processing. J. Immunol. 1991. 147: 4054-4059.
14. Sette, A., Southwood, S., O'Sullivan, D., Gaeta, F. C. A., Sidney, J. and Grey, H. M., Effect of Ph on MHC class II-peptide interactions. J. Immunol. 1992. 148: 844-851.
15. DeMars, R., Chang, C. C., Shaw, S., Reitnauer, P. J. and Sondel, P. M., Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens. Hum. Immunol. 1984. 11: 77-97.
16. Long, E. O., LaVaute, T., Pinet, V. and Jaraquemada, D., Invariant chain prevents the HLA-DR-restricted presentation of a cytosolic peptide. J. Immunol. 1994. 153: 1487-1494.
17. Karp, D. R. and Long, E. O., Identification of HLA-DR1 beta chain residues critical for binding staphylococcal enterotoxins A and E. J. Exp. Med. 1992. 175: 415-424.
18. Snyder, M. H., Stephenson, E. H., Young, H., York, C. J., Tierney, E. L., London, W. T., Chanock, R. M. and Murphy, B. R., Infectivity and antigenicity of live avian-human influenza A reassortant virus: comparison of intranasal and aerosol routes in squirrel monkeys. J. Infect. Dis. 1986. 154: 709-717.
19. Yewdell, J. W., Taylor, A., Yellen, A., Caton, A., Gerhard, W and Bächi, T., Mutations in or near the fusion peptide of influenza virus hemagglutinin affect an antigenic site in the globular region. J. Virol. 1993. 67: 933-942.
20. Vidard, L., Rock, K. L. and Benacerraf, B., Diversity in MHC class II ovalbumin T cell epitopes generated by distinct proteases. J. Immunol. 1990. 149: 498-504.