Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo

FEBS Letters

Volumn 458, Issue 1, 1999, Pages 6-10

  Katunuma, N ^a   Murata, E ^a   Kakegawa, H ^a   Matsui, A ^a   Tsuzuki, H ^a   Tsuge, H ^a   Turk, D ^c   Turk, V ^c   Fukushima, M ^b   Tada, Y ^b   Asao, T ^b  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

^c JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

Cathepsin inhibitor; Cathepsin L; Cathepsin S; Epoxysuccinate; X ray crystallography

Indexed keywords

CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE INHIBITOR; ENZYME INHIBITOR; N (CARBAMOYLOXIRANE 2 CARBONYL)PHENYLALANINE DIMETHYLAMIDE DERIVATIVE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COMPUTER AIDED DESIGN; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBAMATES; CATHEPSINS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER GRAPHICS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; ENDOPEPTIDASES; HUMANS; INTESTINE, SMALL; KINETICS; LEUCINE; LIVER; LYSOSOMES; MICE; PHENYLALANINE; RATS; RECOMBINANT PROTEINS; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 0032835426     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(99)01107-2     Document Type: Article

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