Cathepsins and compartmentalization in antigen presentation

Current Opinion in Immunology

Volumn 12, Issue 1, 2000, Pages 107-113

  Riese, Richard J ^a   Chapman, Harold A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; CATHEPSIN B; CATHEPSIN H; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CHAPERONE; CYSTATIN C; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEINASE;

ANTIGEN PRESENTATION; CELL COMPARTMENTALIZATION; DENDRITIC CELL; ENDOSOME; ENZYME INHIBITION; LYSOSOME; PROTEIN DEGRADATION; PROTEIN INTERACTION; REVIEW;

ANTIGEN PRESENTATION; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; CATHEPSINS; CELL COMPARTMENTATION; ENDOSOMES; HISTOCOMPATIBILITY ANTIGENS CLASS II; PROTEASE INHIBITORS;

EID: 0033966413     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)00058-8     Document Type: Review

References (46)

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36. 3 antibody responses. Interestingly, IgE responses are normal.
37. q mice do demonstrate diminished collagen-induced arthritis. Thus cathepsin S may be required for processing of an immunodominant antigen mediating collagen-induced arthritis in this mouse model, or the absence of cathepsin S may result in a more subtle kinetic alteration in Ii processing and class-II-peptide loading without affecting bulk biochemistry.
38. + T cell positive selection.
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