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Volumn 69, Issue 4, 1997, Pages 1592-1600

Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: Attenuation with riluzole pretreatment

Author keywords

Calcium; Calpain I; CNS injury; Cytoskeleton; Glutamate; Microtubule associated protein 2; Riluzole; Spectrin

Indexed keywords

CALPAIN; CYTOSKELETON PROTEIN; GLUTAMIC ACID; MICROTUBULE ASSOCIATED PROTEIN 2; RILUZOLE; SPECTRIN;

EID: 0030930824     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69041592.x     Document Type: Article
Times cited : (132)

References (60)
  • 1
    • 0027288332 scopus 로고
    • Pathophysiology of spinal cord trauma
    • Anderson D. and Hall E. (1993) Pathophysiology of spinal cord trauma. Ann. Emerg. Med. 22, 987-992.
    • (1993) Ann. Emerg. Med. , vol.22 , pp. 987-992
    • Anderson, D.1    Hall, E.2
  • 2
    • 0025091685 scopus 로고
    • Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slices
    • Arai A., Kessler M., Lee K., and Lynch G. (1990) Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slices. Brain Res. 532, 63-68.
    • (1990) Brain Res. , vol.532 , pp. 63-68
    • Arai, A.1    Kessler, M.2    Lee, K.3    Lynch, G.4
  • 3
    • 0025985357 scopus 로고
    • Improved posthypoxic recovery with a membrane-permeable calpain inhibitor
    • Arlinghaus L., Mehdi S., and Lee K. S. (1991) Improved posthypoxic recovery with a membrane-permeable calpain inhibitor. Eur. J. Pharmacol. 209, 123-125.
    • (1991) Eur. J. Pharmacol. , vol.209 , pp. 123-125
    • Arlinghaus, L.1    Mehdi, S.2    Lee, K.S.3
  • 4
    • 0020284468 scopus 로고
    • Degradation of cytoskeletal proteins in experimental spinal cord injury
    • Banik N., Hogan E., Powers J., and Whetstine L. (1982) Degradation of cytoskeletal proteins in experimental spinal cord injury. Neurochem. Res. 7, 1465-1475.
    • (1982) Neurochem. Res. , vol.7 , pp. 1465-1475
    • Banik, N.1    Hogan, E.2    Powers, J.3    Whetstine, L.4
  • 5
    • 0023360406 scopus 로고
    • Ca2+-mediated degradation of central nervous system (CNS) proteins: Topographic and species variation
    • Banik N., Happel R., Sostek M., Chiu F., and Hogan E. (1987) Ca2+-mediated degradation of central nervous system (CNS) proteins: topographic and species variation. Metab. Brain Dis. 2, 117-126.
    • (1987) Metab. Brain Dis. , vol.2 , pp. 117-126
    • Banik, N.1    Happel, R.2    Sostek, M.3    Chiu, F.4    Hogan, E.5
  • 6
    • 0031002146 scopus 로고    scopus 로고
    • Increased calpain content and progressive degradation of neurofilament protein in spinal cord injury
    • Banik N., Matzelle D., Gantt-Wilford G., Osborne A., and Hogan E. (1997) Increased calpain content and progressive degradation of neurofilament protein in spinal cord injury. Brain Res. 752, 301-306.
    • (1997) Brain Res. , vol.752 , pp. 301-306
    • Banik, N.1    Matzelle, D.2    Gantt-Wilford, G.3    Osborne, A.4    Hogan, E.5
  • 7
    • 0028292190 scopus 로고
    • Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage
    • Bartus R. T., Baker K. L., Heiser A. D., Sawyer S. D., Dean R. L., Elliott P. J., and Straub J. A. (1994) Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J. Cereb. Blood Flow Metab. 14, 537-544.
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 537-544
    • Bartus, R.T.1    Baker, K.L.2    Heiser, A.D.3    Sawyer, S.D.4    Dean, R.L.5    Elliott, P.J.6    Straub, J.A.7
  • 8
    • 0030157694 scopus 로고    scopus 로고
    • Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection
    • Basso D., Beattie M., and Breshnahan J. (1996) Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp. Neurol. 139, 244-256.
    • (1996) Exp. Neurol. , vol.139 , pp. 244-256
    • Basso, D.1    Beattie, M.2    Breshnahan, J.3
  • 10
    • 0022557147 scopus 로고
    • Differential localization of MAP2 and tau in mammalian neurons in situ
    • Binder L. I., Frankfurter A., and Rebhun L. I. (1986) Differential localization of MAP2 and tau in mammalian neurons in situ. Ann. NY Acad. Sci. 466, 145-166.
    • (1986) Ann. NY Acad. Sci. , vol.466 , pp. 145-166
    • Binder, L.I.1    Frankfurter, A.2    Rebhun, L.I.3
  • 11
    • 0027410425 scopus 로고
    • Attenuation of AMPA-induced neurotoxicity by a calpain inhibitor
    • Caner H., Collins J. L., Harris S. M., Kassell N. F., and Lee K. S. (1993) Attenuation of AMPA-induced neurotoxicity by a calpain inhibitor. Brain Res. 607, 354-356.
    • (1993) Brain Res. , vol.607 , pp. 354-356
    • Caner, H.1    Collins, J.L.2    Harris, S.M.3    Kassell, N.F.4    Lee, K.S.5
  • 12
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi D. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.1
  • 13
    • 0024340134 scopus 로고
    • The role of autolysis in activity of the Ca2+-dependent proteinases (μ-calpain and m-calpain)
    • Cong J., Goll D., Peterson A., and Kapprell H. (1989) The role of autolysis in activity of the Ca2+-dependent proteinases (μ-calpain and m-calpain). J. Biol. Chem. 264, 10096-10103.
    • (1989) J. Biol. Chem. , vol.264 , pp. 10096-10103
    • Cong, J.1    Goll, D.2    Peterson, A.3    Kapprell, H.4
  • 14
    • 0027954265 scopus 로고
    • The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats
    • Constantini S. and Young W. (1994) The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J. Neurosurg. 80, 97-111.
    • (1994) J. Neurosurg. , vol.80 , pp. 97-111
    • Constantini, S.1    Young, W.2
  • 15
    • 0023264133 scopus 로고
    • Anatomical organization of excitatory amino acid receptors and their pathways
    • Cotman C., Monaghan D., Ottersen O., and Storm-Mathisen J. (1987) Anatomical organization of excitatory amino acid receptors and their pathways. Trends Neurosci. 10, 273-280.
    • (1987) Trends Neurosci. , vol.10 , pp. 273-280
    • Cotman, C.1    Monaghan, D.2    Ottersen, O.3    Storm-Mathisen, J.4
  • 16
    • 0029753270 scopus 로고    scopus 로고
    • The pharmacology and mechanism of action of riluzole
    • Doble A. (1996) The pharmacology and mechanism of action of riluzole. Neurology 47, S233-S241.
    • (1996) Neurology , vol.47
    • Doble, A.1
  • 17
    • 0023696641 scopus 로고
    • N-Methyl-D-aspartate antagonist MK-801 improves outcome following traumatic spinal cord injury in rats: Behavioral, anatomical, and neurochemical studies
    • Faden A., Lemke M., Simon R., and Noble L. (1988) N-Methyl-D-aspartate antagonist MK-801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomical, and neurochemical studies. J. Neurotrauma 5, 33-45.
    • (1988) J. Neurotrauma , vol.5 , pp. 33-45
    • Faden, A.1    Lemke, M.2    Simon, R.3    Noble, L.4
  • 18
    • 0024365739 scopus 로고
    • The role of excitatory amino acids and NMDA receptors in traumatic brain injury
    • Faden A. I., Demediuk P., Panter S. S., and Vink R. (1989) The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244, 798-800.
    • (1989) Science , vol.244 , pp. 798-800
    • Faden, A.I.1    Demediuk, P.2    Panter, S.S.3    Vink, R.4
  • 19
    • 0027164322 scopus 로고
    • Antagonists of excitatory amino acids and endogenous opioid peptides in the treatment of experimental central nervous system injury
    • Gentile N. and McIntosh T. (1993) Antagonists of excitatory amino acids and endogenous opioid peptides in the treatment of experimental central nervous system injury. Ann. Emerg. Med. 22, 1028-1034.
    • (1993) Ann. Emerg. Med. , vol.22 , pp. 1028-1034
    • Gentile, N.1    McIntosh, T.2
  • 20
    • 0024555204 scopus 로고
    • Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury
    • Gomez-Pinella F., Tram H., Cotman C., and Nieto-Sampedro M. (1989) Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury. Exp. Neurol. 104, 118-124.
    • (1989) Exp. Neurol. , vol.104 , pp. 118-124
    • Gomez-Pinella, F.1    Tram, H.2    Cotman, C.3    Nieto-Sampedro, M.4
  • 21
    • 0031019885 scopus 로고    scopus 로고
    • Oxidation inhibits substrate proteolysis by calpain I but not autolysis
    • Guttmann R., Elce J., Bell P., Isbell J., and Johnson G. (1997) Oxidation inhibits substrate proteolysis by calpain I but not autolysis. J. Biol. Chem. 272, 2005-2012.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2005-2012
    • Guttmann, R.1    Elce, J.2    Bell, P.3    Isbell, J.4    Johnson, G.5
  • 22
    • 0026518645 scopus 로고
    • Neurotransmitter mediated mechanisms of traumatic brain injury: Acetylcholine and excitatory amino acids
    • Hayes R., Jenkin L., and Lyeth B. (1992) Neurotransmitter mediated mechanisms of traumatic brain injury: acetylcholine and excitatory amino acids. J. Neurotrauma 9, 173-187.
    • (1992) J. Neurotrauma , vol.9 , pp. 173-187
    • Hayes, R.1    Jenkin, L.2    Lyeth, B.3
  • 23
    • 0028902692 scopus 로고
    • Temporal response and effects of excitatory amino acid antagonism on microtubule-associated protein 2 immunoreactivity following experimental brain injury in rats
    • Hicks R. R., Smith D. H., and McIntosh T. K. (1995) Temporal response and effects of excitatory amino acid antagonism on microtubule-associated protein 2 immunoreactivity following experimental brain injury in rats. Brain Res. 678, 151-160.
    • (1995) Brain Res. , vol.678 , pp. 151-160
    • Hicks, R.R.1    Smith, D.H.2    McIntosh, T.K.3
  • 24
    • 0022364550 scopus 로고
    • Alleviation of axonal damage in acute spinal cord injury by a protease inhibitor: Automated morphometric analysis of drug effects
    • Iwasaki Y., Iizuka H., Yamamoto T., Konno H., and Kadoya S. (1985) Alleviation of axonal damage in acute spinal cord injury by a protease inhibitor: automated morphometric analysis of drug effects. Brain Res. 347, 124-126.
    • (1985) Brain Res. , vol.347 , pp. 124-126
    • Iwasaki, Y.1    Iizuka, H.2    Yamamoto, T.3    Konno, H.4    Kadoya, S.5
  • 25
    • 0023113537 scopus 로고
    • Suppression of neurofilament degradation by protease inhibitors in experimental spinal cord injury
    • Iwasaki Y., Yamamoto H., Iizuka H., Yamamoto T., and Konno H. (1987) Suppression of neurofilament degradation by protease inhibitors in experimental spinal cord injury. Brain Res. 406, 99-104.
    • (1987) Brain Res. , vol.406 , pp. 99-104
    • Iwasaki, Y.1    Yamamoto, H.2    Iizuka, H.3    Yamamoto, T.4    Konno, H.5
  • 27
    • 0025731595 scopus 로고
    • Degradation of microtubule-associated protein 2 and brain spectrin by calpain: A comparative study
    • Johnson G. V. W., Litersky J. M., and Jope R. S. (1991) Degradation of microtubule-associated protein 2 and brain spectrin by calpain: a comparative study. J. Neurochem. 56, 1630-1638.
    • (1991) J. Neurochem. , vol.56 , pp. 1630-1638
    • Johnson, G.V.W.1    Litersky, J.M.2    Jope, R.S.3
  • 28
    • 0029045236 scopus 로고
    • Calpain inhibitors reduce depolarization induced loss of tau protein in primary septohippocampal cultures
    • Kampfl A., Whitson J. S., Zhao X., Posmantur R., Clifton G. L., and Hayes R. L. (1995) Calpain inhibitors reduce depolarization induced loss of tau protein in primary septohippocampal cultures. Neurosci. Lett. 194, 149-152.
    • (1995) Neurosci. Lett. , vol.194 , pp. 149-152
    • Kampfl, A.1    Whitson, J.S.2    Zhao, X.3    Posmantur, R.4    Clifton, G.L.5    Hayes, R.L.6
  • 30
    • 0030070664 scopus 로고    scopus 로고
    • Calpain inhibitors protect against depolarization-induced neurofilament protein loss of septo-hippocampal neurons in culture
    • Kampfl A., Zhao X., Whitson J. S., Posmantur R., Dixon C. E., Yang K., Clifton G. L., and Hayes R. L. (1996b) Calpain inhibitors protect against depolarization-induced neurofilament protein loss of septo-hippocampal neurons in culture. Eur. J. Neurosci. 8, 344-352.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 344-352
    • Kampfl, A.1    Zhao, X.2    Whitson, J.S.3    Posmantur, R.4    Dixon, C.E.5    Yang, K.6    Clifton, G.L.7    Hayes, R.L.8
  • 32
    • 0028004643 scopus 로고
    • Secondary mechanisms in neuronal trauma
    • Lynch D. R. and Dawson T. M. (1994) Secondary mechanisms in neuronal trauma. Curr. Opin. Neurol. 7, 510-516.
    • (1994) Curr. Opin. Neurol. , vol.7 , pp. 510-516
    • Lynch, D.R.1    Dawson, T.M.2
  • 33
    • 0028087618 scopus 로고
    • Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain
    • Matesic D. F. and Lin R. C. S. (1994) Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain. J. Neurochem. 63, 1012-1020.
    • (1994) J. Neurochem. , vol.63 , pp. 1012-1020
    • Matesic, D.F.1    Lin, R.C.S.2
  • 34
    • 0029175202 scopus 로고
    • Calcium, free radicals, and excitotoxic neuronal death in primary cell culture
    • Mattson M., Barger S., Begley J., and Mark R. (1995) Calcium, free radicals, and excitotoxic neuronal death in primary cell culture. Methods Cell Biol. 46, 187-216.
    • (1995) Methods Cell Biol. , vol.46 , pp. 187-216
    • Mattson, M.1    Barger, S.2    Begley, J.3    Mark, R.4
  • 35
    • 0028132942 scopus 로고
    • Dynamics of extracellular calcium activity following contusion of the rat spinal cord
    • Moriya T., Hassan A. Z., Young W., and Chesler M. (1994) Dynamics of extracellular calcium activity following contusion of the rat spinal cord. J. Neurotrauma 11, 255-263.
    • (1994) J. Neurotrauma , vol.11 , pp. 255-263
    • Moriya, T.1    Hassan, A.Z.2    Young, W.3    Chesler, M.4
  • 36
    • 0026542415 scopus 로고
    • Pretreatment with NMDA antagonists limits release of excitatory amino acids following traumatic brain injury
    • Panter S. S. and Faden A. I. (1992) Pretreatment with NMDA antagonists limits release of excitatory amino acids following traumatic brain injury. Neurosci. Lett. 136, 165-168.
    • (1992) Neurosci. Lett. , vol.136 , pp. 165-168
    • Panter, S.S.1    Faden, A.I.2
  • 37
    • 0025162091 scopus 로고
    • Alteration in extracellular amino acids after traumatic spinal cord injury
    • Panter S. S., Yum S. W., and Faden A. I. (1990) Alteration in extracellular amino acids after traumatic spinal cord injury. Ann. Neurol. 27, 96-99.
    • (1990) Ann. Neurol. , vol.27 , pp. 96-99
    • Panter, S.S.1    Yum, S.W.2    Faden, A.I.3
  • 38
    • 0023866466 scopus 로고
    • The ultrastructural localization of calcium-activated protease "calpain" in rat brain
    • Perlmutter L. S., Siman R., Gall C., Seubert P., Baudry M., and Lynch G. (1988) The ultrastructural localization of calcium-activated protease "calpain" in rat brain. Synapse 2, 79-88.
    • (1988) Synapse , vol.2 , pp. 79-88
    • Perlmutter, L.S.1    Siman, R.2    Gall, C.3    Seubert, P.4    Baudry, M.5    Lynch, G.6
  • 39
    • 0031550631 scopus 로고    scopus 로고
    • A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat
    • Posmantur R., Kampfl A., and Hayes R. (1997) A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat. Neuroscience 77, 875-888.
    • (1997) Neuroscience , vol.77 , pp. 875-888
    • Posmantur, R.1    Kampfl, A.2    Hayes, R.3
  • 40
    • 0030063506 scopus 로고    scopus 로고
    • Cytoskeletal derangements of cortical neuronal processes three hours after traumatic brain injury in rats: An immunofluorescence study
    • Posmantur R. M., Kampfl A., Liu S. J., Heck K., Taft W. C., Clifton G. L., and Hayes R. L. (1996) Cytoskeletal derangements of cortical neuronal processes three hours after traumatic brain injury in rats: an immunofluorescence study. J. Neuropathol. Exp. Neurol. 55, 68-80.
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 68-80
    • Posmantur, R.M.1    Kampfl, A.2    Liu, S.J.3    Heck, K.4    Taft, W.C.5    Clifton, G.L.6    Hayes, R.L.7
  • 42
    • 0027215039 scopus 로고
    • Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo
    • Rami A. and Krieglstein J. (1993) Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain Res. 609, 67-70.
    • (1993) Brain Res. , vol.609 , pp. 67-70
    • Rami, A.1    Krieglstein, J.2
  • 43
    • 0027300884 scopus 로고
    • Spectrin proteolysis in the hippocampus: A biochemical marker for neuronal injury and neuroprotection
    • Roberts-Lewis J. M. and Siman R. (1993) Spectrin proteolysis in the hippocampus: a biochemical marker for neuronal injury and neuroprotection. Ann. NY Acad. Sci. 679, 78-86.
    • (1993) Ann. NY Acad. Sci. , vol.679 , pp. 78-86
    • Roberts-Lewis, J.M.1    Siman, R.2
  • 44
    • 0028282502 scopus 로고
    • Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain
    • Roberts-Lewis J. M., Savage M. J., Marcy V. R., Pinsker L. R., and Siman R. (1994) Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J. Neurosci. 14, 3934-3944.
    • (1994) J. Neurosci. , vol.14 , pp. 3934-3944
    • Roberts-Lewis, J.M.1    Savage, M.J.2    Marcy, V.R.3    Pinsker, L.R.4    Siman, R.5
  • 45
    • 0028088153 scopus 로고
    • Calpain: New perspectives in molecular diversity and physiological-pathological involvement
    • Saido T., Sorimachi H., and Suzuki K. (1994) Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J. 8, 814-822.
    • (1994) FASEB J. , vol.8 , pp. 814-822
    • Saido, T.1    Sorimachi, H.2    Suzuki, K.3
  • 46
    • 0023185155 scopus 로고
    • Calpain I remains intact and intracellular during platelet activation. Immunochemical measurements with monoclonal and polyclonal antibodies
    • Samis J., Zboril G., and Elce J. (1987) Calpain I remains intact and intracellular during platelet activation. Immunochemical measurements with monoclonal and polyclonal antibodies. Biochem. J. 246, 481-488.
    • (1987) Biochem. J. , vol.246 , pp. 481-488
    • Samis, J.1    Zboril, G.2    Elce, J.3
  • 47
    • 0022272961 scopus 로고
    • Calcium-activated proteolysis in intermediate filaments
    • Schlaepfer W. and Zimmerman U. (1985) Calcium-activated proteolysis in intermediate filaments. Ann. NY Acad. Sci. 455, 552-562.
    • (1985) Ann. NY Acad. Sci. , vol.455 , pp. 552-562
    • Schlaepfer, W.1    Zimmerman, U.2
  • 48
    • 0024020782 scopus 로고
    • Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo
    • Siman R. and Noszek J. (1988) Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo. Neuron 1, 279-287.
    • (1988) Neuron , vol.1 , pp. 279-287
    • Siman, R.1    Noszek, J.2
  • 49
    • 0022405117 scopus 로고
    • Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain
    • Siman R., Gall C., Perlmutter L. S., Christian C., Baudry M., and Lynch G. (1985) Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain. Brain Res. 347, 399-403.
    • (1985) Brain Res. , vol.347 , pp. 399-403
    • Siman, R.1    Gall, C.2    Perlmutter, L.S.3    Christian, C.4    Baudry, M.5    Lynch, G.6
  • 50
    • 0024363137 scopus 로고
    • Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage
    • Siman R., Noszek J., and Kegerise C. (1989) Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage. J. Neurosci. 9, 1579-1590.
    • (1989) J. Neurosci. , vol.9 , pp. 1579-1590
    • Siman, R.1    Noszek, J.2    Kegerise, C.3
  • 51
    • 0029976154 scopus 로고    scopus 로고
    • The effect of riluzole on post-traumatic spinal cord injury in the rat
    • Stutzmann J. M., Pratt J., Boraud T., and Gross C. (1996) The effect of riluzole on post-traumatic spinal cord injury in the rat. Neuroreport 7, 387-392.
    • (1996) Neuroreport , vol.7 , pp. 387-392
    • Stutzmann, J.M.1    Pratt, J.2    Boraud, T.3    Gross, C.4
  • 52
    • 0023658410 scopus 로고
    • Calcium-activated neutral protease and its endogenous inhibitor: Activation at the cell membrane and biological function
    • Suzuki K., Imajoh S., Emori Y., Kawasaki H., Minami Y., and Ohno S. (1987) Calcium-activated neutral protease and its endogenous inhibitor: activation at the cell membrane and biological function. FEBS Lett. 220, 271-277.
    • (1987) FEBS Lett. , vol.220 , pp. 271-277
    • Suzuki, K.1    Imajoh, S.2    Emori, Y.3    Kawasaki, H.4    Minami, Y.5    Ohno, S.6
  • 53
    • 0026489693 scopus 로고
    • Microtubule-associated protein 2 levels decrease in hippocampus following traumatic brain injury
    • Taft W. C., Yang K., Dixon C. E., and Hayes R. L. (1992) Microtubule-associated protein 2 levels decrease in hippocampus following traumatic brain injury. J. Neurotrauma 9, 281-290.
    • (1992) J. Neurotrauma , vol.9 , pp. 281-290
    • Taft, W.C.1    Yang, K.2    Dixon, C.E.3    Hayes, R.L.4
  • 54
    • 0026326449 scopus 로고
    • Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
    • Tator C. and Fehlings M. (1991) Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J. Neurosurg. 75, 15-26.
    • (1991) J. Neurosurg. , vol.75 , pp. 15-26
    • Tator, C.1    Fehlings, M.2
  • 55
    • 0027469132 scopus 로고
    • Effect of riluzole on focal cerebral ischemia in rats
    • Wahl F., Allix M., Plotkine M., and Boulu R. G. (1993) Effect of riluzole on focal cerebral ischemia in rats. Eur. J. Pharmacol. 230, 209-214.
    • (1993) Eur. J. Pharmacol. , vol.230 , pp. 209-214
    • Wahl, F.1    Allix, M.2    Plotkine, M.3    Boulu, R.G.4
  • 56
    • 0027939233 scopus 로고
    • Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX
    • Wrathall J. R., Choiniere D., and Teng Y. D. (1994) Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX. J. Neurosci. 14, 6598-6607.
    • (1994) J. Neurosci. , vol.14 , pp. 6598-6607
    • Wrathall, J.R.1    Choiniere, D.2    Teng, Y.D.3
  • 57
    • 0026548593 scopus 로고
    • Role of calcium in central nervous system injuries
    • Young W. (1992) Role of calcium in central nervous system injuries. J. Neurotrauma 9 (Suppl. 1), S9-S25.
    • (1992) J. Neurotrauma , vol.9 , Issue.1 SUPPL.
    • Young, W.1
  • 58
    • 0027475987 scopus 로고
    • Secondary injury mechanisms in acute spinal cord injury
    • Young W. (1993) Secondary injury mechanisms in acute spinal cord injury. J. Emerg. Med. 11 (Suppl. 1), 13-22.
    • (1993) J. Emerg. Med. , vol.11 , Issue.1 SUPPL. , pp. 13-22
    • Young, W.1
  • 59
    • 0021721863 scopus 로고
    • Calcium-activated neutral protease (CANP) in brain and other tissues
    • Zimmerman U. and Schlaepfer W. (1984) Calcium-activated neutral protease (CANP) in brain and other tissues. Prog. Neurobiol. 23, 63-78.
    • (1984) Prog. Neurobiol. , vol.23 , pp. 63-78
    • Zimmerman, U.1    Schlaepfer, W.2
  • 60
    • 0025911090 scopus 로고
    • Two stage autolysis of the catalytic subunit initiates activation of μ-calpain
    • Zimmerman U. and Schlaepfer W. (1991) Two stage autolysis of the catalytic subunit initiates activation of μ-calpain. Biochim. Biophys. Acta 1078, 192-198.
    • (1991) Biochim. Biophys. Acta , vol.1078 , pp. 192-198
    • Zimmerman, U.1    Schlaepfer, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.