Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics

EMBO Journal

Volumn 15, Issue 19, 1996, Pages 5290-5298

  Marklund, Ulrica ^a   Larsson, Niklas ^a   Gradin, Helena Melander ^a   Brattsand, Göran ^a   Gullberg, Martin ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Cell cycle; Cyclin dependent kinases; Microtubule; Oncoprotein 18; Stathmin

Indexed keywords

CELL PROTEIN; CYCLIN DEPENDENT KINASE; MUTANT PROTEIN; ONCOPROTEIN; STATHMIN;

ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL STRAIN K 562; CONTROLLED STUDY; DEPOLYMERIZATION; HUMAN; HUMAN CELL; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0029811662     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00914.x     Document Type: Article

References (33)

1. Belmont, L.D. and Mitchison, T.J. (1996) Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of micotubule. Cell, 84, 623-631.
2. Beretta, L., Dobransky, T. and Sobel, A. (1993) Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2. J. Biol. Chem., 268, 20076-20084.
3. Brattsand, G., Roos, G., Marklund, U., Ueda, H., Landberg, G., Nanberg, E., Sideras, P. and Gullberg, M. (1993) Quantitative analysis of the expression and regulation of an activation-regulated phosphoprotein (oncoprotein 18) in normal and neoplastic cells. Leukemia, 7, 569-579.
4. Brattsand, G., Marklund, U., Nylander, K., Roos, G. and Gullberg, M. (1994) Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38. Eur. J. Biochem., 220, 359-368.
5. Cooper, H.L., Fuldner, R., McDuffie, E. and Braverman, R. (1990) A specific defect of prosolin phosphorylation in T cell leukemic lymphoblasts is associated with impaired down-regulation of DNA synthesis. J. Immunol., 145, 1205-1213.
6. Davis, F.M., Tsao, T.Y., Fowler, S.K. and Rao, P.N. (1983) Monoclonal antibodies to mitotic cells. Proc. Natl Acad. Sci. USA, 80, 2926-2930.
7. Doye, V., Soubrier, F., Bauw, G., Boutterin, M.C., Beretta, L., Koppel, J., Vandekerckhove, J. and Sobel, A. (1989) A single cDNA encodes two isoforms of stathmin, a developmentally regulated neuron-enriched phosphoprotein. J. Biol. Chem., 264, 12134-12137.
8. Doye, V., Boutterin, M.C. and Sobel, A. (1990) Phosphorylation of stathmin and other proteins related to nerve growth factor-induced regulation of PC12 cells. J. Biol. Chem., 265, 11650-11655.
9. Friedrich, B., Gronberg, H., Landstrom, M., Gullberg, M. and Bergh, A. (1995) Differentiation-stage specific expression of oncoprotein 18 in human and rat prostatic adenocarcinoma. Prostate, 27, 102-109.
10. Glotzer, M., Murray, A.W. and Kirschner, M.W. (1991) Cyclin is degraded by the ubiquitin pathway. Nature, 349, 132-138.
11. Groger, R.K., Morrow, D.M. and Tykocinski, M.L. (1989) Directional antisense and sense cDNA cloning using Epstein-Barr virus episomal expression vectors. Gene, 81, 285-294.
12. Gullberg, M., Noreus, K., Brattsand, G., Friedrich, B. and Shingler, V. (1990) Purification and characterization of a 19-kilodalton intracellular protein. An activation-regulated putative protein kinase C substrate of T lymphocytes. J. Biol. Chem., 265, 17499-17505.
13. Hanash, S.M., Strahler, J.R., Kuick, R., Chu, E.H. and Nichols, D. (1988) Identification of a polypeptide associated with the malignant phenotype in acute leukemia. J. Biol. Chem., 263, 12813-12815.
14. Hopp, T.P., Prickett, K.S., Price, V., Libby, R.T., March, C.J., Ceretti, P., Urdal, D.L. and Conlon, P.J. (1988) A short polypeptide marker sequence useful for recombinant protein identification and purification. Bio/Technology, 6, 1205-1210.
15. Kung, A.L., Sherwood, S.W. and Schimke, R.T. (1990) Cell line-specific differences in the control of cell cycle progression in the absence of mitosis. Proc. Natl Acad. Sci. USA, 87, 9553-9557.
16. Labdon, J.E., Nieves, E. and Schubart, U.K. (1992) Analysis of phosphoprotein p19 by liquid chromatography/mass spectrometry. Identification of two proline-directed serine phosphorylation sites and a blocked amino terminus. J. Biol. Chem., 267, 3506-3513.
17. Landberg, G., Tan, E.M. and Roos, G. (1990) Flow cytometric multiparameter analysis of proliferating cell nuclear antigen/cyclin and Ki-67 antigen: a new view of the cell cycle. Exp. Cell Res., 187, 111-118.
18. Larsson, N., Melander, H., Marklund, U., Osterman, O. and Gullberg, M. (1995) G2/M transition requires multisite phosphorylation of oncoprotein 18 by two distinct protein kinase systems. J. Biol. Chem., 270, 14175-14183.
19. Luo, X.N., Mookerjee, B., Ferrari, A., Mistry, S. and Atweh, G.F. (1994) Regulation of phosphoprotein p18 in leukemic cells. Cell cycle regulated phosphorylation by p34cdc2 kinase. J. Biol. Chem., 269, 10312-10318.
20. Marklund, U., Brattsand, G., Osterman, O., Ohlsson, P.I. and Gullberg, M. (1993a) Multiple signal transduction pathways induce phosphorylation of serines 16, 25, and 38 of oncoprotein 18 in T lymphocytes. J. Biol. Chem., 268, 25671-25680.
21. Marklund, U., Brattsand, G., Shingler, V. and Gullberg, M. (1993b) Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. J. Biol. Chem., 268, 15039-15047.
22. 2+/calmodulin-dependent kinase-Gr. Eur. J. Biochem., 225, 53-60.
23. Marklund, U., Osterman, O., Melander, H., Bergh, A. and Gullberg, M. (1994b) The phenotype of a 'Cdc2 kinase target site-deficient' mutant of oncoprotein 18 reveals a role of this protein in cell cycle control. J. Biol. Chem., 269, 30626-30635.
24. Maucuer, A., Camonis, J.H. and Sobel, A. (1995) Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc. Natl Acatl. Sci. USA, 92, 3100-3104.
25. Melhem, R.F., Zhu, X.X., Hailat, N., Strahler, J.R. and Hanash, S.M. (1991) Characterization of the gene for a proliferation-related phosphoprotein (oncoprotein 18) expressed in high amounts in acute leukemia. J. Biol. Chem., 266, 17747-17753.
26. Minotti, A.M., Barlow, S.B. and Cabral, F. (1991) Resistance to antimitotic drugs in Chinese hamster ovary cells correlates with changes in the level of polymerized tubulin. J. Biol. Chem., 266, 3987-3994.
27. Norbury, C. and Nurse, P. (1992) Animal cell cycles and their control. Annu. Rev. Biochem., 61, 441-470.
28. Okazaki, T., Yoshida, B.N., Avraham, K.B., Wang, H., Wuenschell, C.W., Jenkins, N.A., Copeland, N.G., Anderson, D.J. and Mori, N. (1993) Molecular diversity of the SCG10/stathmin gene family in the mouse. Genomics, 18, 360-373.
29. Rieder, C.L. and Palazzo, R.E. (1992) Colcemid and the mitotic cycle. J. Cell Sci., 102, 387-392.
30. Roos, G., Brattsand, G., Landberg, G., Marklund, U. and Gullberg, M. (1993) Expression of oncoprotein 18 in human leukemias and lymphomas. Leukemia, 7, 1538-1546.
31. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
32. Schubart, U.K., Banerjee, M.D. and Eng, J. (1989) Homology between the cDNAs encoding phosphoprotein p19 and SCG10 reveals a novel mammalian gene family preferentially expressed in developing brain. DNA, 8, 389-398.
33. Zhu, X.X. et al. (1989) Molecular cloning of a novel human leukemia-associated gene. Evidence of conservation in animal species. J. Biol. Chem., 264, 14556-14560.