Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells

Journal of Cell Biology

Volumn 148, Issue 3, 2000, Pages 505-517

  Mimori Kiyosue, Yuko ^a   Shiina, Nobuyuki ^a   Tsukita, Shoichiro ^a,b  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Adenomatous polyposis coli; Epithelial cells; Green fluorescent protein; Microtubule associated proteins; Microtubules

Indexed keywords

GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; TUMOR PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SPREADING; COLON POLYPOSIS; EPITHELIUM CELL; IMMUNOELECTRON MICROSCOPY; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE; XENOPUS;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; CELL MOVEMENT; CYTOSKELETAL PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MICROTUBULES; RABBITS; RECOMBINANT FUSION PROTEINS; SUBCELLULAR FRACTIONS; XENOPUS;

EID: 0034614936     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.148.3.505     Document Type: Article

References (54)

1. Cadherins, catenins and APC protein: Interplay between cytoskeletal complexes and signaling pathways
2. 2-terminal deletion of β-catenin results in stable colocalization of mutant β-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion
3. Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer
4. Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly
5. Assembly of chick brain tubulin onto flagellar microtubules from Chlamydomonas and sea urchin sperm
6. Wnt signaling: A common theme in animal development
7. Accessory protein regulation of microtubule dynamics throughout the cell cycle
8. Real-time observations of microtubule dynamic instability in living cells
9. Organization of organelles and membrane traffic by microtubules
10. A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau
11. Microtubule polymerization dynamics
12. Dynamic localization of CLIP-170 to microtubule plus ends is coupled to microtubule assembly
13. Motors and membrane traffic
14. Distribution of microtubule organizing centers in migrating sheets of endothelial cells
15. E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton
16. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin
17. Dimer formation by an N-terminal coiled coil in the APC protein
18. EB/RP gene family encodes tubulin binding proteins
19. Lessons from hereditary colorectal cancer
20. Beyond self-assembly: From microtubules to morphogenesis
21. Low concentrations of nocodazole interfere with fibroblast locomotion without significantly affecting microtubule level: Implications for the role of dynamic microtubules in cell locomotion
22. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein
23. Centripetal transport of microtubules in motile cells
24. Actin-based cell motility and cell locomotion
25. Dynamic instability of microtubule growth
26. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
27. EB1, a protein which interacts with the APC tumor suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle
28. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
29. The APC gene product associates with microtubules in vivo and promotes their assembly in vitro
30. The role of the adenomatous polyposis coli (APC) gene in human cancers
31. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migrations
32. Cell adhesion and signal transduction: The Armadillo connection
33. CLIP-170 highlights growing microtubule ends in vivo
34. Mutations in the APC gene and their implications for protein structure and function
35. The adenomatous polyposis coli (APC) tumor suppressor
36. Dynamics of β-catenin interactions with APC protein regulate epithelial tubulogenesis
37. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells
38. Identification of a novel nucleotide-sensitire microtubule-binding protein in He La cells
39. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly
40. Association of the APC gene product with β-catenin
41. Direct observation of microtubule dynamics in living cells
42. New features of microtubule behaviour observed in vivo
43. Regulation of β-catenin signaling by the B56 subunit of protein phosphatase 2A
44. Observation and quantification of individual microtubule behavior in vivo: Microtubule dynamics are cell-type specific
45. Wild-type but not mutant APC associates with the microtubule cytoskeleton
46. Association between wild type and mutant APC gone products
47. Association of the APC tumor suppressor protein with catenins
48. APC binds to the novel protein EB1
49. The role of microtubule dynamics in growth cone motility and axonal growth
50. Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34
51. Polarization of pseudopodial activities: Cytoskeletal mechanisms
52. Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro
53. Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover and is associated with microtubule breakage and treadmilling
54. Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium