T lymphocyte costimulatory molecules in host defense and immunologic diseases

Annals of Allergy, Asthma and Immunology

Volumn 85, Issue 3, 2000, Pages 164-172

  Tamada, K ^a   Chen, L ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; B7 ANTIGEN; BINDING PROTEIN; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLYPICAN; HYBRID PROTEIN; ICOS LIGAND; ICOS RECEPTOR; IMMUNOGLOBULIN; INTEGRIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ALLERGY; ASTHMA; AUTOIMMUNE DISEASE; CANCER; CANCER IMMUNOLOGY; CELLULAR IMMUNITY; HISTOCOMPATIBILITY; HOST RESISTANCE; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; T LYMPHOCYTE ACTIVATION;

EID: 0034488454     PISSN: 10811206     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1081-1206(10)62462-3     Document Type: Review

References (140)

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3. Costimulation in T cell responses
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5. Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7
6. B70 antigen is a second ligand for CTLA-4 and CD28
7. Cloning of B7-2: A CTLA-4 counter-receptor that co-stimulates human T cell proliferation
8. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
9. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TN-Falpha
10. T-cell co-stimulation through B7RP-1 and ICOS
11. Cutting edge: Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor
12. Costimulation of T cells by B7-H2, a B7-like molecules that binds ICOS
13. Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain
14. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
15. B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas
16. Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations
17. The tissue distribution of the B7-2 costimulator in mice: Abundant expression on dendritic cells in situ and during maturation in vitro
18. Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function
19. Expression and function of B7 on human epidermal Langerhans cells
20. Expression and functional significance of an additional ligand for CTLA-4
21. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
22. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
23. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
24. Role of costimulation in T cell differentiation: Studies using antigen-expressing cells lacking expression of CD80 or CD86
25. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
26. Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals
27. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes
28. Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
29. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28
30. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway
31. Signaling through CD28/CTLA-4 family receptors: Puzzling participation of phosphatidylinositol-3 kinase
32. JNK is involved in signal integration during costimulation of T lymphocytes
33. The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65
34. NK-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-Θ
35. T-cell responses in rheumatoid arthritis: Systemic abnormalities-local disease
36. A new member of the immunoglobulin superfamily-CTLA-4
37. CTLA-4 can function as a negative regulator of T cell activation
38. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics
39. The emerging role of CTLA-4 as an immune attenuator
40. CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion
41. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
42. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
43. + T cells
44. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice
45. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
46. Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail
47. Molecular basis of T cell inactivation by CTLA-4
48. CTLA-4-Mediated inhibition of early events of T cell proliferation
49. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis
50. Protective immunity to nematode infection is induced by CTLA-4 blockade
51. CTLA-4 regulates tolerance induction and T cell differentiation in vivo
52. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses
53. Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells
54. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
55. Acquired thymic tolerance: Role of CTLA4 in the initiation and maintenance of tolerance in a clinically relevant autoimmune disease model
56. AILIM/ICOS: A novel lymphocyte adhesion molecule
57. Differential T cell costimulatory requirements in CD28-deficient mice
58. Skin allograft rejection in CD28-deficient mice
59. Acute graft-versus-host disease without costimulation via CD28
60. Role of 4-1BB in immune responses
61. Costimulation of CD28- T lymphocytes by 4-1BB ligand
62. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death
63. + T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
64. + splenic T cells after CD28 receptor ligation
65. Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
66. 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses
67. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
68. OX-40: Life beyond the effector T cell stage
69. Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells
70. Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis
71. Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: Amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein
72. Ox-40 ligand: A potent costimulatory molecule for sustaining primary CD4 T cell responses
73. CD4 T cell cytokine differentiation: The B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1
74. OX40-ligand has a critiacal costimulatory role in dendritic cell: T cell interactions
75. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection
76. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand
77. Engagement of the OX-40 receptor in vivo enhances antitumor immunity
78. Modulation of T cell-mediated immunity in tumor and graft-versus-host disease models through LIGHT costimulatory pathway
79. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response
80. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator
81. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis
82. Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes
83. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
84. Antibodies to TR2 (herpesvirus entry mediator), a new member of the TNF receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines
85. T cells and eosinophils in the pathogenesis of asthma
86. Predominant TH2-like bronchoal-veolar T-lymphocyte population in atopic asthma
87. Inhibition of T cell co-stimulation abrogates airway hyper-responsiveness in a murine model
88. B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens
89. Development of murine allergic asthma is dependent upon B7-2 costimulation
90. Costimulation through CD86 is involved in airway antigen-presenting cell and T cell responses to allergen in atopic asthmatics
91. Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression
92. Suppression of murine allergic contact dermatitis by CTLA4Ig. Tolerance induction of Th2 responses requires additional blockade of CD40-ligand
93. Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen
94. Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation
95. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
96. CD28/B7 regulation of autoimmune diabetes
97. Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: Requirement for both B7-1 and B7-2
98. Treatment of murine lupus with CTLA4Ig
99. CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris
100. CD28-deficient mice are highly resistant to collagen-induced arthritis
101. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis
102. CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis
103. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
104. Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse
105. Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes
106. Costimulator B7-1 confers anti-gen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice
107. The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen
108. A new era for cancer immunotherapy based on the genes that encode cancer antigens
109. Tumor immunology: The glass is half full
110. Costimulation of T cells for tumor immunity
111. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
112. Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity
113. Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors
114. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy with the CD28 co-stimulatory pathway
115. + cytolytic T lymphocytes
116. + T cell-dependent mechanism
117. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg
118. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo
119. In vivo blockade of CD28/ CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice
120. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
121. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
122. Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts
123. Transplantation of anergic histoincompatible bone marrow allografts
124. + T cells with homology to tumor necrosis factor
125. Control of lymphocyte function through CD27-CD70 interactions
126. CD27 is a signal-transducing molecule involved in CD45RA+ naive T cell costimulation
127. Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation
128. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
129. CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation
130. A novel receptor involved in T-cell activation
131. Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): Differential expression and responsiveness in Th1 and Th2 cells
132. DC-SIGN: A guide to some mysteries of dendritic cells
133. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
134. The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells
135. Impaired immune responses toward alloantigens and tumor cells but normal thymic selection in mice deficient in the beta2 integrin leukocyte function-associated antigen-1
136. A role for CD9 molecules in T cell activation
137. CD81 expressed on human thymocytes mediates integrin activation and interleukin 2-dependent proliferation
138. CD82, member of the tetra-span-transmembrane protein family, is a costimulatory protein for T cell activation
139. Heat-stable antigen is a costimulatory molecule for CD4 T cell growth
140. Heat-stable antigen/CD24 on mouse T lymphocytes: Evidence for a costimulatory function