Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors

Journal of Experimental Medicine

Volumn 183, Issue 2, 1996, Pages 639-644

  Li, Yiwen ^a,b   Hellström, Karl Erik ^a   Newby, Stephanie Ashe ^a   Chen, Lieping ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD2 ANTIGEN; CD48 ANTIGEN; CD8 ANTIGEN; LIGAND;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENETIC TRANSFECTION; IMMUNOGENICITY; LUNG METASTASIS; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOMA; TUMOR IMMUNITY;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD80; BASE SEQUENCE; CLONING, MOLECULAR; FEMALE; FLOW CYTOMETRY; IMMUNIZATION; IMMUNOTHERAPY, ADOPTIVE; LUNG NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C3H; MODELS, IMMUNOLOGICAL; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT PROTEINS; SARCOMA, EXPERIMENTAL; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0030041637     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.2.639     Document Type: Article

References (17)

1. Davis, M.M., and P.J. Bjorkman, 1988. T-cell antigen receptor genes and T-cell recognition. Nature (Lond.). 334:395-402.
2. June, C.H., J.A. Bluestone, L.M. Nadler, and C.B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today. 15:321-331.
3. Bierer, B.E., and W.C. Hahn. 1993. T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2. Semin. Immunol. 5:249-261.
4. Kato, K., M. Koyanagi, H. Okada, T. Takanashi, Y.W. Wong, A.F. Williams, K. Okumura, and H. Yagita. 1992. CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J. Exp. Med. 176:1241-1250.
5. Guckel, B , C. Berek, M. Lutz, P. Altevogt, V. Schirrmacher, and B.A. Kyewski. 1991. Anti-CD2 antibodies induce T cell unresponsiveness in vivo. J. Exp. Med. 174:957-967.
6. Qin, L., K.D. Chavin, J. Lin, H. Yagita, and J.S. Bromberg. 1994. Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. J. Exp. Med. 179:341-346.
7. Chen, L., P.S. Linsley, and K.E. Hellström. 1993. Costimulation of T cells for tumor immunity. Immunol. Today. 14: 482-486.
8. Chen, L., P. McGowan, S. Ashe, J. Johnston, Y. Li, I. Hellström, and K.E. Hellström. 1994. Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity. J. Exp. Med. 179:523-532.
9. Yang, G., K.E. Hellström, I. Hellstrom, and L. Chen. 1995. Antitumor immunity elicited by tumor cells transfected with B7-2, a second ligand for CD28/CTLA-4 costimulatory molecules. J. Immunol. 154:2794-2800.
10. Ward, P.L., H. Koeppen, T. Hurteau, and H. Schreiber. 1989. Tumor antigens defined by cloned immunological probes are highly polymorphic and are not detected on autologous normal cells. J. Exp. Med. 170:217-232.
11. Chen, L., S. Ashe, W.A. Brady, I. Hellström, K.E. Hellström, J.A. Ledbetter, P. McGowan, and P.S. Linsley. 1992. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell. 71:1093-1102.
12. + T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma. J. Immunol. 153:421-428.
13. Wong, Y.W., A.F. Williams, S.F. Kingsmore, and M.F. Seldin. 1990. Structure, expression, and genetic linkage of the mouse BCM-1 (OX45 or Blast-1) antigen: evidence for genetic duplication giving rise to the BCM-1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3. J. Exp. Med. 171:2115-2130.
14. Chen, L., S. Ashe, M.C. Singhal, D.A. Galloway, I. Hellström, and K.E. Hellström. 1993. Metastatic conversion of cells by expression of human papillomavirus type 16 E6 and E7 genes. Proc. Natl. Acad. Sci. USA. 90:6523-6527.
15. Siliciano, R.F., J.C. Pratt, R.E. Schmidt, J. Ritz, and E L. Reinherz. 1985. Activation of cytolytic T lymphocytes and natural killer cell functions through the T11 sheep erythrocyte binding protein. Nature (Lond ) 317:428-430.
16. Nandi, D., J.A. Gross, and J P. Allison. 1994. CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells. J. Immunol. 152:3361-3369.
17. Thiele, D.L., and P.E. Lipsky. 1989. The role of cell surface recognition structures in the initiation of MHC-unrestricted "pronuscuous" killing by T cells. Immunol. Today. 10:375-381