Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses

Journal of Immunology

Volumn 162, Issue 10, 1999, Pages 5784-5791

  Khattri, Roli ^a   Auger, Julie A ^a   Griffin, Matthew D ^a   Sharpe, Arlene H ^b   Bluestone, Jeffrey A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD69 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HOMING RECEPTOR; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 5; INTERLEUKIN 6; PROTEIN BCL X; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELPER CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LYMPHOCYTE PROLIFERATION; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; BCL-X PROTEIN; CD4-POSITIVE T-LYMPHOCYTES; IMMUNE TOLERANCE; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; LYMPHOPROLIFERATIVE DISORDERS; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS C-BCL-2; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TH2 CELLS;

EID: 0033563265     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Lenschow, D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
2. Boussiotis, V. A., G. S. Freeman, J. G. Gribben, and L. M. Nadler. 1996. The role of B7-1/B7-2:CD28/CTLA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response. Immunol. Rev. 153:5.
3. Chambers, C. A., M. F. Krummel, B. Boitel, A. Hurwitz, T. J. Sullivan, S. Fournier, D. Cassell, M. Brunner, and J. P. Allison. 1996. The role of CTLA-4 in the regulation and initiation of T-cell response. Immunol. Rev. 153:27.
4. Fraser, J. D., B. A. Irving, G. R. Crabtree, and A. Weiss. 1991. Regulation of inlerleukin-2 enhancer activity by the T cell accessory molecule CD28. Science 251:313.
5. Lindsten, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339.
6. Cerdan, C., Y. Martin, M. Courcoul, C. Mawas, F. Birg, and D. Olive. 1995. CD28 coslimulation up-regulates long-term IL-2Rβ expression in human T cells through combined transcriptional and post-transcriptional regulation. J. Immunol. 154:1007.
7. L. Immunity 3:87.
8. Sperling, A. I., J. A. Auger, B. D. Ehst, I. C. Rulifson, C. B. Thompson, and J. A. Bluestone. 1996. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation. J. Immunol. 157:3909.
9. Krummel, M. F., and J. P. Allison. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cell. J. Exp. Med. 183:2533.
10. Krummel, M. F., T. J. Sullivan, and J. P. Allison. 1996. Superantigen responses and costimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int. Immunol. 8:519.
11. Walunas, T. L., C. Y. Bakker, and J. A. Bluestone. 1996. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183:2541.
12. Calvo, C. R., D. Amsen, and A. M. Kruisbeek. 1997. Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor ζ and ZAP70. J. Exp. Med. 186:1645.
13. Walunas, T. L., D. J. Lenschow, C. Y. Bakker, P. S. Linsley, G. J. Freeman, J. M. Green, C. B. Thompson, and J. A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
14. Krummel, M. F., and J. P. Allison. 1995. CD28 and CTLA-4 deliver opposing signals which regulate the response of T-cells to stimulation. J. Exp. Med. 182: 459.
15. + T cells in vivo is dependent on CD28 costimulation and is inhibited by CTLA-4. J. Immunol. 155:1032.
16. Karandikar, N., C. L. Vanderlugt, T. L. Walunas, S. D. Miller, and J. A. Bluestone. 1996. CTLA-4: a negative regulator of autoimmune disease. J. Exp. Med. 184:783.
17. Perrin, P., J. Maldonado, T. A. Davis, C. H. June, and M. K. Racke. 1996. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J. Immunol. 157:1333.
18. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
19. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian. K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270: 985.
20. Chambers, C. A., D. Cado, T. Truong, and J. P. Allison. 1997. Thymocyte development is normal in CTLA-4-deficient mice. Proc. Nail. Acad. Sci. USA 94: 9296.
21. Waterhouse, P., M. F. Bachmann, J. M. Penninger, P. S. Ohashi, and T. W. Mak. 1997. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor transgenic CTLA-4-deficient mice. Eur. J. Immunol. 27: 1887.
22. Tivol, E. A., S. D. Boyd, S. McKeon, F. Bordello, P. Nickerson, T. B. Strom, and A. H. Sharpe. 1997. mCTLA-4Ig prevents lymphoproliferation and fatal multi-organ tissue destruction in CTLA-4 deficient mice. J. Immunol. 158:5091.
23. + T cells. Immunity 7:885.
24. Unkeless, J. C. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580.
25. Brace, J., F. Symington, T. McKearn, and J. Sprent. 1981. A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol. 127:2496.
26. b haplotype reveal genetic control of isotype expression. J. Immunol. 126:317.
27. Sarmiento, M., A. L. Glasebrook, and F. W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665.
28. Ceredig, R., J. W. Lowenthal, M. Nabholz, and H. R. MacDonald. 1985. Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells. Nature 314:98.
29. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a mutine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
30. + splenic T cells after CD28 receptor ligation. J. Immunol. 154:985.
31. + T lymphocytes from infected mice: characterization of T cell clones. J. Immunol. 145:702.
32. Linsley, P. S., J. Bradshaw, M. Urnes, L. Grosmaire, and J. A. Ledbetter. 1993. CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling. J. Immunol. 150:3161.
33. Andris, F., M. Van Mechelen, N. Legrand, P. M. Dubois, M. Kaufman, J. Urbain, and O. Leo. 1991. Induction of long-term but reversible unresponsiveness after activation of murine T cell hybridomas. Int. Immunol 3:609.
34. L induction. J. Immunol. 160:12.
35. Bachmann, M. F., P. Waterhouse, D. E. Speiser, K. McKall-Faienza, T. W. Mak, and P. S. Ohashi. 1998. Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells. J. Immunol. 160:95.
36. Lenschow, D., K. Herold, L. Rhee, B. Patel, A. Koons, H.-Y. Qin, E. Fuchs, B. Singh, C. B. Thompson, and J. A. Bluestone. 1996. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity 5:285.
37. Boussiotis, V. A., B. J. Lee, G. J. Freeman, J. G. Gribben, and L. M. Nadler. 1997. Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas-and Bax-mediated programmed cell death. J. Immunol. 159:3156.
38. Kundig, T. M., A. Shahinian, K. Kawai. H. Mittrucker, E. Sebzda, M. F. Bachmann, T. W. Mak, and P. S. Ohashi. 1996. Duration of TCR stimulation determines costimulatory requirements of T cells. Immunity 5:41.
39. Bachmann, M. F., K. McKall-Falenza, R. Schmits, D. Bouchard, J. Beach, D. E. Speiser, T. W. Mak, and P. S. Ohashi. 1997. Distinct roles for LFA-1 and CD28 during activation of naïve T cells: adhesion versus costimulation. Immunity 7:549.
40. Tanchot, C., F. A. Lemonnier, B. Pérarnau, A. A. Freitas, and B. Rocha. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276:2057.
41. Rulifson, I. C., A. I. Sperling, P. E. Fields, F. W. Fitch, and J. A. Bluestone. 1997. CD28 costimulation promotes the production of TH2 cytokines. J. Immunol. 158:658.
42. + T cell responses: the alternative approaches. Annu. Rev. Immunol. 15:297.
43. Walunas, T. L., and J. A. Bluestone. 1998. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J. Immunol. 160:3855.