Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS

Blood

Volumn 96, Issue 8, 2000, Pages 2808-2813

  Wang, S ^a   Zhu, G ^a   Chapoval, A I ^a   Dong, H ^a   Tamada, K ^a   Ni, J ^a   Chen, L ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD3 ANTIGEN; H2 ANTIGEN; HYBRID PROTEIN; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 2;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CHO CELL; CONTROLLED STUDY; CROSS LINKING; CYTOKINE RELEASE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0034667688     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.8.2808     Document Type: Article

References (16)

1. Co-stimulation in T cell responses
2. CD28/B7 system of T cell costimulation
3. Costimulation of T cells for tumor immunity
4. CD28 and apoptosis
5. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
6. CTLA-4 ligation blocks CD28-dependent T cell activation
7. Both extracellular immunoglobulin-like domains of CD80 contain residues critical for binding T cell surface receptor CTLA-4 and CD28
8. Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA-4
9. Immunoglobulin fold characteristics of B7-1 (CD80) and B7-2 (CD86)
10. Identification of conserved amino acids in murine B7-1IgV domain critical for CTLA-4/CD28:B7 interaction by site-directed mutagenesis: A novel structural model of the binding site
11. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
12. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα
13. T-cell co-stimulation through B7RP-1 and ICOS
14. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
15. In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells
16. Cutting edge: Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor