Protective immunity to nematode infection is induced by CTLA-4 blockade

Journal of Experimental Medicine

Volumn 186, Issue 2, 1997, Pages 183-187

  McCoy, Kathy ^a   Camberis, Mali ^a   Le Gros, Graham ^a  

^a MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTRALIZING ANTIBODY; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; IMMUNOTHERAPY; LIGAND BINDING; MOUSE; NEMATODIASIS; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CRICETINAE; IMMUNOCONJUGATES; INTERLEUKIN-4; INTERLEUKIN-5; MICE; MICE, INBRED C57BL; NIPPOSTRONGYLUS; RATS; RATS, INBRED LEW; STRONGYLIDA INFECTIONS;

EID: 0030872154     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.2.183     Document Type: Article

References (17)

1. Linsley, P.S., J.L. Greene, P. Tan, J. Bradshaw, J.A. Ledbetter, C. Anasetti, and N.K. Damle. 1992. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J. Exp. Med. 176:1595-1604.
2. Krummel, M.F., and J.P. Allison. 1995. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:459-465.
3. Krummel, M.F., and J.P. Allison. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183:2533-2540.
4. Walunas, T.L., D.J. Lenschow, C.Y. Bakker, P.S. Linsley, G.J. Freeman, J.M. Green, C.B. Thompson, and J.A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1:405-413.
5. Walunas, T.L., C.Y. Bakker, and J.A. Bluestone. 1996. CTLA-4 ligation blocks Cd28-dependent T cell activation. J. Exp. Med. 183:2541-2550.
6. Waterhouse, P., J.M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K.P. Lee, C.B. Thompson, H. Griesser, and T.W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science (Wash. DC). 270:985-988.
7. Tivol, E.A., F. Borriello, A.N. Schweitzer, W.P. Lynch, J.A. Bluestone, and A.H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 3:541-547.
8. Kearney, E.R., T.L. Walunas, R.W. Karr, P.A. Morton, D.Y. Loh, J.A. Bluestone, and M.K. Jenkins. 1995. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4(+) T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155:1032-1036.
9. Krummel, M.F., T.J. Sullivan, and J.P. Allison. 1996. Super-antigen responses and co-stimulation - CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Intl. Immunol. 8:519-523.
10. Ogilvie, B.M., and V.E. Jones. 1971. Parasitological review. Nippostrongylus brasiliensis: a review of immunity and host-parasite relationship in the rat. Exp. Parasitol. 29:138-177.
11. Urban, J.F., Jr., K.B. Madden, A. Svetic, A. Cheever, P.P. Trotta, W.C. Cause, I.M. Katona, and F.D. Finkelman. 1992. The importance of Th2 cytokines in protective immunity to nematodes. Immunol. Rev. 127:205-220.
12. Katona, I.M., J.F. Urban, Jr., and F.D. Finkelman. 1988. The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis. J. Immunol. 140:3206-3211.
13. Coffman, R.L., B.W. Seymour, S. Hudak, J. Jackson, and D. Rennick. 1989. Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. Science (Wash. DC). 245:308-310.
14. Madden, K.B., J.F. Urban, Jr., H.J. Ziltener, J.W. Schrader, F.D. Finkelman, and I.M. Katona. 1991. Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis. J. Immunol. 147:1387-1391.
15. Kopf, M., G. Le Gros, M. Bachmann, M.C. Lamers, H. Bluethmann, and G. Kohler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature (Lond.). 362: 245-248.
16. Allison, J.P., and M.F. Krummel. 1995. The yin and yang of T cell costimulation. Science (Wash. DC). 270:932-933.
17. Urban, J.F., Jr., K.B. Madden, A.W. Cheever, P.P. Trotta, I.M. Katona, and F.D. Finkelman. 1993. IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis. J. Immunol. 151:7086-7094.