CTLA-4 regulates tolerance induction and T cell differentiation in vivo

Journal of Immunology

Volumn 160, Issue 8, 1998, Pages 3855-3860

  Walunas, Theresa L ^a   Bluestone, Jeffrey A ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b MC1089 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; INTERLEUKIN 4; STAPHYLOCOCCUS ENTEROTOXIN B;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; CROSS LINKING; CYTOTOXIC T LYMPHOCYTE; FEMALE; HELPER CELL; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; ENTEROTOXINS; FEMALE; IMMUNE TOLERANCE; IMMUNOCONJUGATES; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 0032522488     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
2. Walunas, T. L., C. Y. Bakker, and J. A. Bluestone. 1996. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183:2541.
3. Krummel, M. F., and J. P. Allison. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183:2533.
4. Brunner, M., F. Chan, C. Hinkel, J. Hanke, A. Winoto, and J. Allison. 1997. The mechanism of CTLA-4-mediated inhibition of T cell activation [abstract]. In Keystone Symposia: Tolerance and Autoimmunity.
5. Walunas, T. L., D. J. Lenschow, C. Y. Bakker, P. S. Linsley, G. J. Freeman, J. M. Green, C. B. Thompson, and J. A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
6. + T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155:1032.
7. Krummel, M. F., T. J. Sullivan, and J. P. Allison. 1996. Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int. Immunol. 8:519.
8. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
9. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in ctla-4. Science 270:985.
10. Karandikar, N. J., C. L. Vanderlugt, T. L. Walunas, S. D. Miller, and J. A. Bluestone. 1996. CTLA-4: a negative regulator of autoimmune disease. J. Exp. Med. 184:783.
11. Perez, V. L., L. Van Parijs, A. Buickians, X. X. Zheng, T. B. Strom, and A. K. Abbas. 1997. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6:411.
12. Zhou, T., H. Bluethman, J. Zhang, C. K. Edwards III, and J. D. Mountz. 1992. Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice. J. Exp. Med. 176:1063.
13. Renno, T., M. Hahne, J. Tcshopp, and H. R. MacDonald. 1996. Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate fas and fas ligand. J. Exp. Med. 183:431.
14. Vella, A. T., J. E. McCormack, P. S. Linsley, J. W. Kappler, and P. Marrack. 1995. Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2:261.
15. + cells to bacterial superantigens. Eur. J. Immunol. 22:1935.
16. + T cells by staphylococcal en-terotoxin B. J. Exp. Med. 172:1091.
17. + T cells in staphylococcus enterotoxin B-primed mice. J. Exp. Med. 172:1065.
18. Ceredig, R., J. W. Lowenthal, M. Nabholz, and H. R. MacDonald. 1985. Expression of interleukin-2 receptors as a differentiation marker on intramymic stem cells. Nature 314:98.
19. Sarmiento, M., A. L. Glasebrook, and F. W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665.
20. Unkeless, J. C. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580.
21. Cobbold, S. P., A. Jayasuriya, A. Nash, T. D. Prospero, and H. Waldmann. 1984. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312:548.
22. Dialynas, D. P., Z. S. Quan, K. A. Wall, J. Quintans, M. R. Loken, and F. W. Fitch. 1983. Characterization of the murine T cell surface molecule L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to human Leu-3/T4 molecule. J. Immunol. 131:2445.
23. + peripheral T cells responding to staphylococcal enterotoxin B in vivo. Eur. J. Immunol. 21:1963.
24. Baschieri, S., R. K. Lees, A. R. Lussow, and H. R. MacDonald. 1993. Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines. Eur. J. Immunol. 23:2661.
25. Seder, R. A., R. N. Germain, P. S. Linsley, and W. E. Paul. 1994. CD28-mediated co-stimulation of interleukin 2 (1L-2) production plays a critical role in T cell priming for IL-4 and interferon γ production. J. Exp. Med. 179:299.
26. Rulifson, I. C., A. I. Sperling, P. E. Fields. F. W. Fitch, and J. A. Bluestone. 1997. CD28 costimulation promotes the production of Th2 cytokines. J. Immunol. 158: 658.
27. Wu, Y, Y. Guo, A. Huang, P. Zheng, and Y. Liu. 1997. CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion. J. Exp. Med. 185:1327.
28. + T cells from tolerance induction by the superantigen staphylococcal enterotoxin B. Eur. J. Immunol. 26:858.
29. Beverly, B., S. M. Kang, M. J. Lenardo, and R. H. Schwartz. 1992. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int. Immunol. 4:661.
30. Kuroda, K., J. Yagi, K. Imanishi, Z.-J. Yan, X.-Y. Li, W. Fujimaki, H. Kato, T. Miyoshi-Akiyama, Y. Kumazawa, H. Abe, and T. Uchiyama. 1996. Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen. J. Immunol. 157:1422.
31. + T helper cell phenotype development in a T cell receptor αβ-transgenic model. J. Exp. Med. 182:1579.
32. Bluestone, J. A. 1995. New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2:555.
33. Lenschow, D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
34. Schneider, H., K. V. Prasad, S. E. Shoelson, and C. E. Rudd. 1995. CTLA-4 binding to the lipid kinase phosphatidyl inositol 3-kinase in T cells. J. Exp. Med. 181:351.
35. Marengere, L. E., P. Waterhouse, G. S. Duncan, H. W. Mittrucker, G. S. Feng, and T. W. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272:1170.