B7-CD28/CTLA-4 Costimulatory Pathways Are Required for the Development of T Helper Cell 2-Mediated Allergic Airway Responses to Inhaled Antigens

Journal of Immunology

Volumn 158, Issue 5, 1997, Pages 2042-2049

  Keane Myers, Andrea ^a   Gause, William C ^c   Linsley, Peter S ^b   Chen, Shen Jue ^c   Wills Karp, Marsha ^a  

^a Johns Hopkins University   (United States)

^b Bristol Myers Squibb P ^*  (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ANTIBODY CONJUGATE; AUTACOID; B7 ANTIGEN; CD28 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOSUPPRESSIVE AGENT; LEUKOCYTE ANTIGEN; OVALBUMIN;

A J MOUSE; ANIMAL; ARTICLE; BIOSYNTHESIS; BRONCHUS HYPERREACTIVITY; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; LUNG; MALE; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; RESPIRATORY TRACT ALLERGY; TH2 CELL;

ADMINISTRATION, INHALATION; ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; BRONCHIAL HYPERREACTIVITY; CYTOKINES; IMMUNOCONJUGATES; IMMUNOGLOBULIN E; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION MEDIATORS; LUNG; MALE; MICE; MICE, INBRED A; OVALBUMIN; RESPIRATORY HYPERSENSITIVITY; TH2 CELLS;

EID: 0031092655     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. Bentley, C. Corrigan, S. Durham, and B. Kay. 1992. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
2. Walker, C., E. Bode, L. Boer, T. Hansel, K. Blaser, and J. Johann-Christian Virchow. 1992. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 146:109.
3. Del Prete, G. F., M. De Carli, M. M. D'Elios, P. Maestrelli, M. Ricci, L. Fabbri, and S. Romagnini. 1993. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Ear. J. Immunol. 23:1445.
4. Lopez, A. F., C. J. Sanderson, J. R. Gamble, H. R. Campbell, I. G. Young, and M. A. Vadas. 1988. Recombinant human interleukin-5 is a selective activator of human eosinophil function. J. Exp. Med. 167:219.
5. Wang, J. M., A. Rambaldi, A. Biondi, Z. G. Chen, C. J. Sanderson, and A. Montovani. 1989. Recombinant human interleukin-5 is a selective eosinophil chemoattractant. Eur. J. Immunol. 19:701.
6. Finkelman, F. D., I. M. Katona, J F. Urban, Jr., J. Holmes, J. Ohara, A. S. Tung, J. G. Sample, and W. E. Paul. 1988. Interleukin-4 is required to generate and sustain in vivo IgE responses. J. Immunol. 141:2335.
7. Brusselle, G. G., J. C. Kips, J. H. Tavernier, J. G. V. D. Heyden, C. A. Cuvelier, R. A. Pauwels, and H. Bluethmann. 1994. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin. Exp. Allergy 24:73.
8. Lukacs, N. W., R. M. Strieter, S. W. Chensue, and S. L. Kunkel. 1994. Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma. Am. J. Respir. Cell Mol. Biol. 10:526.
9. Kung, T. T., D. M. Stelts, J. A. Zurcher, G. K. Adams III, R. W. Egan, W. Kreutner, A. S. Watnick, H. Jones, and R. W. Chapman. 1995. Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody. Am. J. Respir. Cell Mol. Biol. 13:360.
10. Foster, P. S., S. P. Hogan, A. J. Ramsay, K. I. Matthaei, and I. G. Young. 1996. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse model of asthma. J. Exp. Med. 183:195.
11. Gavett, S. H., D. O'Hearn, C. L. Karp, B. Schofield, F. D. Finkelman, and M. Wills-Karp. 1997. Blockade of the interleukin-4 receptor prevents pulmonary eosinophilia and airway hyperresponsiveness induced by antigen challenge in mice. Am. J. Physiol. In press.
12. Van Oosterhout, A. J. M., A. R. C. Ladenius, H. F. J. Savelkoul, I. Va Ark, K. J. Delsman, and F. P. Nijkamp. 1993. Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs. Am. Rev. Respir Dis. 147:548.
13. Schwartz, R. H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71: 1065.
14. Bluestone, J. A. 1995. New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2:555.
15. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
16. Linsley, P. S., E. A. Clark, and J. A. Ledbetter. 1990. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl. Acad. Sci. USA 87:5031.
17. Linsley, P. S., W. Brady, L. S. Grosmaire, A. Aruffo, N. K. Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 171:721.
18. Gimmi, C. D., G. J. Freeman, J. G. Gribben, K. Sugita, A. S. Freedman, C. Morimoto, and L. M. Nadler. 1991. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc. Natl. Acad. Sci. USA 88:6575.
19. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
20. Brunet, J. F., F. Denizot, M. F. Luciani, M. Roux-Dosseto, M. Susan, M. G. Mattei, and P. Goldstein. 1987. A new member of the immunoglobulin superfamily-CTLA4. Nature 328:267.
21. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
22. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with lethality in mice deficient in CTLA-4. Science 270:985.
23. Wallace, P. M., J. S. Johnson, J. F. MacMaster, K. A. Kennedy, P. Gladstone, and P. S. Linsley. 1994. CTLA4-Ig treatment ameliorates the lethality of murine graft-versus host disease across major histocompatibility complex barriers. Transplantation 58:602.
24. Tan, P., C. Anasetti, J. A. Hansen, J. Melrose, M. Brunvard, K. Bradshaw, J. A. Ledbetter, and P. S. Linsley. 1993. Induction of alloantigen-specific unresponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 177:165.
25. Boussiotis, V. A., G. J. Freeman, G. Gray, J. G. Gribben, and L. M. Nadler. 1993. B7 but not intracellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J. Exp. Med. 178:1753.
26. Linsley, P. S., P. M. Wallace, J. Johnson, M. G. Gibson, J. L. Greene, J. A. Ledbetter, C. Singh, and M. A. Tepper. 1992. Immunosuppression in vivo by a soluble form of the CTLA4 T cell activation molecule. Science 257:792.
27. Lenschow, D. J., Y. Zeng, J. R. Thistlethwaite, A. Montag, W. Brady, M. G. Gibson, P. S. Linsley, and J. A. Bluestone. 1992. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4-Ig. Science 257:789.
28. Finck, B. K., P. S. Linsley, and D. Wofsy. 1994. Treatment of murine lupus with CTLA4-Ig. Science 265:1225.
29. Lu, P., X. Di Zhou, S. J. Chen, M. Moorman, S. C. Morris, F. D. Finkelman, P. Linsley, J. F. Urban, and W. C. Cause. 1994. CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite. J. Exp. Med. 180:693.
30. Corry, D. B., S. L. Reiner, P. S. Linsley, and R. M. Locksley. 1994. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental Leishmaniasis. J. Immunol. 153:4142.
31. Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. C. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
32. Freeman, G. J., V. A. Boussiotis, A. Anumanthan, G. M. Bernstein, X. Ke, P. D. Rennert, G. S. Gray, J. G. Gribben, and L. M. Nadler. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523.
33. + T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am. J. Respir. Cell Mol. Biol. 10:587.
34. Gavett, S. H., D. J. O'Hearn, X. Li, S.-K. Huang, F. D. Finkleman, and M. Wills-Karp. 1995. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. 182:1527.
35. Svetic, A., F. D. Finkelman, Y. C. Jian, C. W. Dieffenbach, D. E. Scott, K. F. McCarthy, A. D. Steinberg, and W. C. Gause. 1991. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147:2391.
36. + T cells. Am. J. Respir. Cell Mol. Biol. 14:627.
37. Golding, B., M. Zaitseva, and H. Golding. 1994. The potential for recruiting immune responses toward type-1 or Type-2 help. Am. J. Trop. Med. Hyg. 50:33.
38. Keane-Myers, A., and S. P. Nickell. 1995. Role of IL-4 and IFN-γ in modulation of immunity to Borrelia burgdorferi in mice. J. Immunol. 155:2020.
39. Rousset, F., J. Robert, M. Andary, J.-P. Bonin, G. Souillet, I. Chretien, F. Briere, J. Pene, and J. E. d. Vries. 1991. Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis. J. Allergy Clin. Immunol. 87:58.
40. Trinchieri, G., and P. Scott. 1994. The role of interleukin 12 in the immune response, disease, and therapy. Immunol. Today 15:460.
41. Le Gros, G., S. Z. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin-4 (IL-4)-producing cells in vitro and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921.
42. Galli, S. J. 1993. New concepts about the mast cell. N. Engl. J. Med. 328:257.
43. Frigas, E., D. A. Loegering, and G. J. Gleich. 1980. Cytotoxic effects of the guinea pig derived major basic protein on tracheal epithelium. Lab. Invest. 42:35.
44. Coyle, A. J., S. Ackerman, R. Burch, D. Proud, and C. G. Irwin. 1995. Human eosinophil granular major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation. J. Clin. Invest. 95:1735.
45. + T cells. J. Exp. Med. 179:819.
46. + T cells and defective antibody production in vivo. J. Exp. Med. 179:8.
47. Wallace, P. M., J. N. Rodgers, G. M. Leytze, J. S. Johnson, and P. S. Linsley. 1995. Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4-Ig treatment. J. Immunol. 154:5885.
48. Lu, P., X. Di Zhou, S. Chen, M. Moorman, A. Schoneveld, S. Morris, F. D. Finkelman, P. Linsley, E. Claassen, and W. C. Gause. 1995. Requirement for CTLA-4 counter receptors for IL-4, but not IL-10 elevations during a primary systemic in vivo immune response. J. Immunol. 154:1078.
49. Khoury, S. J., E. Akalin, A. Chandraker, L. A. Turka, P. S. Linsley, M. H. Sayegh, and W. W. Hancock. 1995. CD28-B7 costimulatory blockade by CTLA4-Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J. Immunol. 155:4521.
50. Turka, L. A., P. S. Linsley, H. Lin, W. Brady, J. M. Leiden, R. Q. Wei, M. L. Gibson, X. G. Zheng, S. Myrdal, D. Gordon, T. Bailey, S. F. Bolling, and C. B. Thompson. 1992. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc. Natl. Acad. Sci. USA 89:11102.
51. Perrin, P. J., D. Scott, L. Quigley, P. S. Albert, P. Feder, G. S. Gray, R. Abe, C. H. June, and M. K. Racke. 1995. Role of B7:CTLA4 in the induction of chronic relapsing experimental allergic encephalomyelitis. J. Immunol. 15:1481.