Impact acceleration injury in the rat: Evidence for focal axolemmal change and related neurofilament sidearm alteration

Journal of Neuropathology and Experimental Neurology

Volumn 56, Issue 4, 1997, Pages 347-359

  Povlishock, J T ^a   Marmarou, A ^a   Mcintosh, T ^b   Trojanowski, J Q ^b   Moroi, J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Axolemmal permeability; Cytoskeleton; Immunocytochemistry; Rat; Traumatic brain injury

Indexed keywords

ACCELERATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CELL MEMBRANE PERMEABILITY; CELL SWELLING; CONTROLLED STUDY; CYTOSKELETON; EARLY DIAGNOSIS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; NERVE FIBER MEMBRANE; NERVE FIBER TRANSECTION; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030725073     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199704000-00003     Document Type: Article

References (51)

1. Adams H, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR. Diffuse axonal injury in head injury: Definition diagnosis and grading. Histopath 1989;15:49-59
2. Adams JH, Graham DI, Gennarelli TA, Maxwell W. Editorial: Diffuse axonal injury in non-missile head injury. J Neurol Neurosurg Psych 1991;54:481-83
3. Adams JH, Graham DI, Murray LS, Scott G. Diffuse axonal injury due to nonmissile head injury in humans. An analysis of 45 cases. Ann Neurol 1982;12:557-63
4. Adams JH, Graham DI, Scott G, Parker LS, Doyle D. Brain damage in fatal non-missile head injury. J Clin Pathol 1980;33:1132-45
5. Blumbergs PC, Jones NR, North JB. Diffuse axonal injury in head trauma. J Neurol Neurosurg Psych 1989;52:838-41
6. Blumbergs PC, Scott G, Manavis J, Wainwright H, Simpson DA, McLean AJ. Staining of amyloid precursor protein to study axonal damage in mild head injury. Lancet 1994;344:1055-56
7. Blumbergs PC, Scott G, Manavis J, Wainwright H, Simpson DA, McLean AJ. Topography of axonal injury as defined by amyloid precursor protein and the sector scoring method in mild and severe closed head injury. J Neurotrauma 1995;12:565-72
8. Christman CW, Grady MS, Walker SA, Holloway KL, Povlishock JT. Ultrastructural studies of diffuse axonal injury in humans. J Neurotrauma 1994;11:173-86
9. Clark JM. Distribution of microglial clusters in the brain after head injury. Neurol Neurosurg Psych 1974;37:463-74
10. Cordobes F, Lobato RD, Rivas JJ, et al. Post-traumatic diffuse axonal brain injury. Analysis of 78 patients studied with computed tomography. Acta Neurochir 1986;81:25-35
11. Crooks DA, Scholtz CL, Vowles G, Greenwald S. Axonal injury in closed head injury by assault: A quantitative study. Med Sci Law 1992;32:109-17
12. Gentleman SM, Nash MJ, Sweeting CJ, Graham DI, Roberts GW. Amyloid precursor protein (APP) as a marker for axonal injury after head injury. Neurosci Lett 1993;160:139-44
13. Gultekin SH, Smith, TW. Diffuse axonal injury in craniocerebral trauma. A comparative histologic and immunohistochemical study. Arch Pathol Lab Med 1994;118:168-71
14. Imajo T, Challener RC, Roessmann U. Diffuse axonal injury by assault. Amer J Forensic Med and Pathol 1987;8:217-19
15. Imajo T, Roessmann U. Diffuse axonal injury. Amer J Forensic Med and Pathol 1984;5:217-22
16. Mitchell DE, Adams JH. Primary focal impact damage to the brain stem in blunt head injuries: Does it exist? Lancet 1973;11:215-18
17. Nevin NC. Neuropathological changes in the white matter following head injury. J Neuropathol Exp Neurol 1967;26:77-84
18. Peerless SJ, Rewcastle NB. Shear injuries of the brain. Can Med Assoc J 1967;96:577-82
19. Pilz P. Axonal injury in head injury. Acta Neurochir Suppl 1983;32: 119-23
20. Oppenheimer DR. Microscopic lesions in the brain following head injury. J Neurol Neurosurg Psych 1968;31:299-306
21. Sahuquillo-Barris J, Lamarca-Ciuro J, Vilalta-Castan J, Rubio-Garcia E, Rodriguez-Pazos M. Acute subdural hematoma and diffuse axonal injury after severe head trauma. J Neurosurg 1988;68: 894-900
22. Sherriff FE, Bridges LR, Gentleman SM, Sivaloganathan S, Wilson S. Markers of axonal injury in post mortem human brain. Acta Neuropathol 1994a;88:433-39
23. Sherriff FE, Bridges LR, Jackson P. Microwave antigen retrieval of amyloid precursor protein immunoreactivity. Neuroreport 1994b;5: 1085-88
24. Strich S. Diffuse degeneration of the cerebral white matter in severe dementia following head injury. J Neurol Neurosurg Psych 1956;19:163-85
25. Strich SJ. Shearing of nerve fibers as a cause of brain damage due to head injury: A pathological study of twenty cases. Lancet 1961;2:443-48
26. Strich S. Lesions in the cerebral hemispheres after blunt head injury. J Clin Pathol 1970;23(Suppl)4:166-71
27. Grady MS, McLaughlin MR, Christman CW, Valadka AB, Fligner CL, Povlishock JT. The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans. J Neuropathol Exp Neurol 1993;52:143-52
28. Povlishock JT, Becker DP, Cheng CLY, Vaughan GW. Axonal change in minor head trauma. J Neuropathol Exp Neurol 1983;42: 225-42
29. Povlishock JT. Traumatically induced axonal injury: Pathogenesis and pathobiological implications. Brain Pathol 1992;2:1-12
30. Sherriff FE, Bridges LR, Sivaloganathan S. Early detection of axonal injury after human head trauma using immunocytochemistry for amyloid precursor protein. Acta Neuropathol 1994c;87:55-62
31. Yaghmai A, Povlishock JT. Traumatically induced reactive change as visualized through the use of monoclonal antibodies targeted to neurofilament subunits. J Neuropathol Exp Neurol 1992;51:158-76
32. Erb DE, Povlishock JT. Axonal damage in severe traumatic brain injury: An experimental study in the cat. Acta Neuropathol 1988;76:347-58
33. Povlishock JT, Jenkins LW. Are the pathological changes evoked by traumatic brain injury immediate and irreversible? Brain Path 1995;5:415-26
34. Maxwell WL, Watt C, Graham DI, Gennarelli TA. Ultrastructural evidence of axonal shearing as a result of lateral acceleration of the head in non-human primates. Acta Neuropathol 1993;86:136-44
35. Pettus EH, Christman CW, Giebel ML, Povlishock JT. Traumatically induced altered membrane permeability: Its relationship to traumatically induced reactive axonal change. J Neurotrauma 1994;11:507-22
36. Pettus EH, Povlishock JT. Characterization of a distinct set of intra-axonal ultrastructural changes associated with traurnatically induced alteration in axolemmal permeability. Brain Res 1996;722:1-11
37. Povlishock JT, Pettus E. Traumatically induced axonal damage: Evidence for enduring changes in axolemmal permeability with associated cytoskeletal change. Acta Neurochir 1995;66:81-86
38. Hall GF, Lee M-Y. Neurofilament sidearm proteolysis is a prominent early effect of axotomy in lamprey giant central neurons. J Comp Neurol 1995;353:38-49
39. Marmarou A, Foda MAA-E, Van Den Brink W, Campbell J, Kita H, Demetriadou K. A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics. J Neurosurg 1994;80: 291-300
40. Foda MAA-E, Marmarou A. A new model of diffuse brain injury in rats. Part II. Morphological characterization. J Neurosurg 1994;80:301-13
41. Carden MJ, Schlaepfer WW, Lee VM-Y. The structure, biochemical properties and immunogenicity of neurofilament peripheral regions are determined by phosphorylation states. J Biol Chem 1985;260: 9805-17
42. Lee VM-Y, Garden MJ, Schaepfer WW, Trojanowski JQ. Monoclonal antibodies distinguish several differentially phosphorylated states of the largest rat neurofilament subunits. (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats. J Neurosci 1987;7:3474-88
43. Nixon RA, Sihag RM. Neurofilament phosphorylation: A new look at regulation and function. TINS 1991;14:501-6
44. Nixon RA, Paskevich PA, Sihag RK, Thayer CY. Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: Influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber. J Cell Biol 1994;126:1031-46
45. Goldstein ME, Sternberger NH, Sternberger LA. Phosphorylation protects neurofilaments against proteolysis. J Neuroimmunol 1988;14:149-60
46. Tu P-H, Elder G, Lazzarini RA, Nelson D, Trojanowski JQ, Lee VM-Y. Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits. J Cell Biol 1995;129:1629-40
47. Billger M, Margareta W, Karlsson JO. Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules. Cell Calcium 1988:33-44
48. Cottin P, Poussard S, Georgescauld D, Ducastaing A. Free calcium and calpain I activity. Biochim Biophys Acta 1991;1079:139-45
49. Job D, Fischer EH, Margolis RL. Rapid disassembly of cold-stable microtubules by calmodulin. Proc Natl Acad Sci USA 1981;78: 4679-82
50. 2+, and its effect on the neurofilament triplet. J Neurosci Res 1985;13:391-403
51. Ishizaki Y, Tashiro T, Kurokawa M. A calcium-activated protease which preferentially degrades the 160-kDa component of the neurofilament triplet. J Neurosci 1994;14:3934