Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease

Neuropathology and Applied Neurobiology

Volumn 23, Issue 6, 1997, Pages 483-491

  Dickson, T C ^a   Saunders, H L ^a   Vickers, J C ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Ageing; Alzheimer's disease; Apolipoprotein E; Neocortex; Senile plaques

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; GENETIC RISK; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NEOCORTEX; NEURITE; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; RISK FACTOR; SENILE PLAQUE;

EID: 0031459646     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2990.1997.tb01325.x     Document Type: Article

References (30)

1. Arriagada PV, Growdon JH, Hedly-Whyte T, Hyman BT. Neurofibrillary tangles not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992; 42: 631-9
2. Benzing WC, Mufson WJ. Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to tau and PHF in Alzheimer's disease. Exp Neurol 1995; 132: 162-71
3. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239-59
4. Corder EH, Saunders AM, Strittmatter WJ et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921-3
5. Chargé SPB, Esiri MM, Bethune CA, Hansen BC, Clark A. Apolipoprotein E is associated with islet amyloid and other amyloidoses: implications for Alzheimer's disease. J Pathol 1996; 179: 443-7
6. Gearing M, Schneider JA, Robhins RS et al. Regional variation in the distribution of apolipoprotein E and Aβ in Alzheimer's disease. J Neuropath Exp Neurol 1995; 54: 833-41
7. Han S, Hulette C, Saunders AM et al. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Exp Neurol 1994; 128: 13-26
8. Kida E, Golabek AA, Wisniewski T, Wisniewski KE. Regional differences in apolipoprotein E immunoreactivity in diffuse plaques in Alzheimer's disease brain. Neurosci Lett 1994; 167: 73-6
9. Kindy MS, King AR, Perry G, Debeer MC, Debeer FC. Association of apolipoprotein E with murine amyloid A protein amyloid. Lab Invest 1995; 73: 469-75
10. Ma J, Yee A, Brewer B, Das S, Potter H. Amyloid-associated proteins α-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature 1994; 372: 92-4
11. Masliah E, Mallory M, Hansen L, Alford M, DeTeresa R, Terry RD. An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease. Am J Pathol 1993; 142: 871-82
12. Morris JC, Storandt M, McKel DW. Cerebral amyloid deposition and diffuse plaques in 'normal' aging: evidence from presymptomatic and very mild Alzheimer's disease. Neurology 1996; 46: 707-19
13. Mirra SS, Heyman A, McKeel D et al. The consortium to establish a registry for Alzheimer's disease, part II. standardisation of the neuropathologic assessment of Alzheimer's disease. Neurology 1991; 41: 479-86
14. Olichney JM, Hansen LA et al. The apolipoprotein E ∈4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant. Neurology 1996; 47: 190-6
15. Poirer J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 1994; 17: 525-30
16. Price JL, Davis PB, Morris JC, White DL. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol Aging 1991; 12: 295-312
17. Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 1993; 11: 575-80
18. Rogers J, Morrison JH. Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease. J Neurosci 1985; 5: 2801-8
19. Sampson VL, Morrison JH, Vickers JC. The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease. Exp Neurol 1997; 145: 295-302
20. Saunders AM, Strittmatter WJ, Schmechel D et al. Association of apolipoprotein E allele ∈4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993; 43: 1467-72
21. Sheng JG, Mrak RE, Griffin WST. Apolipoprotein E distribution among different plaque types in Alzheimer's disease: implications for its role in plaque progression. Neuropath Appl Neurobiol 1996; 22: 334-41
22. Strittmatter WJ, Weisgraber KH, Huang DY et al. Binding of human apolipoprotein E to synthetic amyloid β peptide: isoform-specific effects and implications for late-onset Alzheimer's disease. Proc Natl Acad Sci USA 1993; 90: 8098-102
23. Su JH, Cummings BJ, Cotman CW. Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res 1996; 739: 79-87
24. Uchihara T, Duyckaerts C, He Y et al. ApoE immunoreactivity and microglial cells in Alzheimer's disease brain. Neurosci Lett 1995; 195: 5-8
25. Ulrich J. Alzheimer changes in nondemented patients younger than sixty-five: Possible early stages of Alzheimer's disease and senile dementia of Alzheimer type. Ann Neurol 1985; 17: 273-7
26. Vickers JC, Delacourte A, Morrison JH. Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease. Brain Res 1992; 594: 273-8
27. Vickers JC, Morrison JH, Friedrich VL Jr et al. Age-associated and cell type-specific neurofibrillary pathology in transgenic mice expressing the human mid-sized neurofilament subunit. J Neurosci 1994; 14: 5603-12
28. Vickers JC, Chin D, Edwards A-M, Sampson V, Harper C, Morrison J. Dystrophic neurite formation associates with age-related β-amyloid deposition in the neocortex: clues to the genesis of neurofibrillary pathology. Exp Neurol 1996; 141: 1-11
29. Vickers JC. A cellular mechanism for the neuronal changes underlying Alzheimer's disease. Neuroscience 1997; 38: 629-39
30. Wisniewski T, Frangione B. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 1992; 135: 235-8