The APOE-ε4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics

JAMA

Volumn 279, Issue 10, 1998, Pages 751-755

  Tang, Ming Xin ^a,b   Stern, Yaakov ^a,b,c   Marder, Karen ^a,b,c   Bell, Karen ^a,b,c   Gurland, Barry ^b,c   Lantigua, Rafael ^b,c   Andrews, Howard ^b,d   Feng, Lin ^b,c   Tycko, Benjamin ^b,c   Mayeux, Richard ^a,b,c  

^a Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^b Affiliated Faculty Global Institute of Public Health   (United States)

^c New York State Psychiatric Institute ^*  (United States)

^d NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; APOLIPOPROTEIN E;

ALLELISM; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DEMENTIA; ETHNOLOGY; FAMILY HISTORY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; OUTCOMES RESEARCH; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; AGED; ALLELE; CAUCASIAN; FEMALE; GENE FREQUENCY; GENETICS; HISPANIC; LONGITUDINAL STUDY; MALE; NEGRO; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY;

AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; HISPANIC AMERICANS; HUMANS; LONGITUDINAL STUDIES; MALE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 0032507032     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.279.10.751     Document Type: Article

References (36)

1. Mayeux R, Stern Y, Ottman R, et al. The apolipoprotein ∈4 allele in patients with Alzheimer's disease. Ann Neurol. 1993;34:752-754.
2. Maestre G, Ottman R, Stern Y, et al. Apolipoprotein-E and Alzheimer's disease: ethnic variation in genotypic risks. Ann Neurol. 1995;37:254-259.
3. Tang M-X, Maestre G, Tsai W-Y, et al. Relative risk of Alzheimer's disease and age-at-onset based on APOE genotypes among elderly African Americans, Caucasians and Hispanics in New York City. Am J Hum Genet. 1996;58:554-574.
4. Sahota A, Yang M, Gao S, et al. Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype-dependent. Ann Neurol. 1997;42:659-661.
5. Osuntokun BO, Sahota A, Ogunniyi AO, et al. Lack of an association between apolipoprotein E ∈4 and Alzheimer's disease in elderly Nigerians. Ann Neurol. 1995;38:463-465.
6. Stern Y, Andrews H, Pittman J, et al. Diagnosis of dementia in a heterogenous population: development of a neuropsychological paradigm and quantified correction for education. Arch Neurol. 1992;49: 453-460.
7. Pittman J, Andrews H, Tatemichi T, et al. Diagnosis of dementia in a heterogenous population: a comparison of paradigm-based diagnosis and physician's diagnosis. Arch Neurol. 1992;49:461-467.
8. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Re-vised Third Edition. Washington, DC: American Psychiatric Association; 1987.
9. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34:989-944.
10. Hughes CP, Berg L, Danziger W, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982;140:566-572.
11. 1990 Census of Population and Housing: Summary Tape File 1, Technical Documentation [computer diskette]. Washington, DC: Bureau of the Census; 1991. STF 1A database.
12. Mayeux R, Ottman R, Tang M-X, et al. Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community-dwelling elderly persons and thejr first-degree relatives. Ann Neurol. 1993;33:494-501.
13. Hixson J, Vernier D. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhAI. J Lipid Res. 1991;31:545-548.
14. Fleiss JL. Combining evidence from fourfold tables. In: Statistical Methods for Rates and Proportions. 2nd ed. New York, NY: John Wiley & Sons Inc; 1981:160-187.
15. Cox DR, Oakes D. Analysis of Survival Data. New York, NY: Chapman & Hall; 1984.
16. Korn EL, Graubard BI, Midthune D. Time-to-event analysis of longitudinal follow-up of a survey: choice of the time scale. Am J Epidemiol. 1997;145: 72-80.
17. Collet D. Model checking in the proportional hazards model. Modeling Survival Data in Medical Research. London, England: Chapman & Hall Ltd; 1994:149-197.
18. Gurland B, Wilder D, Cross P, et al. Relative rates of dementia by multiple case definitions, over 2 prevalence periods, in 3 cultural groups. Am J Geriatr Psychiatry. 1995;3:6-12.
19. Gurland BJ, Wilder DE, Lantigua R, et al. Differences in rates of dementia between ethnoracial groups. In: Martin LG, Soldo BJ, eds. Racial and Ethnic Difference in the Health of Older Americans. Washington, DC: National Academy Press; 1997:232-268.
20. Stern Y, Gurland B, Tatemichi TK, Tang MX, Wilder D, Mayeux R. Influence of education and occupation on the incidence of Alzheimer's disease. JAMA. 1994;271:1004-1010.
21. Saunders AM, Strittmatter, WJ, Schmechel D, et al. Association of apolipoprotein E allele-∈4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993;43:1467-1472.
22. Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein-E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921-923.
23. Roses AD, Strittmatter WJ, Pericak-Vance MA, Corder EH, Saunders AM, Schmechel DE. Clinical application of apolipoprotein E genotyping to Alzheimer's disease. Lancet. 1994;343:1564-1566.
24. van Duijn CM, de Knijff P, Cruts M, et al. Apolipoprotein ∈4 allele in a population-based study of early-onset Alzheimer's disease. Nat Genet. 1994;7: 74-78.
25. Hendrie HC, Hall KS, Hui S, et al. Apolipoprotein-E genotypes and Alzheimer's disease in a community study of elderly African Americans. Ann Neurol. 1995;37:118-120.
26. Henderson AS, Easteal S, Jorm AF, et al. Apolipoprotein E allele ∈4, dementia, and cognitive decline in a population sample. Lancet. 1995;346:1387-1390.
27. Polvikoski T, Sulkava R, Haltia M, et al. Apolipoprotein E, dementia, and cortical deposition of β-amyloid protein. N Engl J Med. 1995;333:1242-1247.
28. Farrer LA, Cupples LA, Haines JL, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotypes and Alzheimer disease. JAMA. 1997;278:1349-1356.
29. van Duijn CM, de Knijff P, Wehnert A, et al. The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. Ann Neurol. 1995;37:605-610.
30. Scott WK, Saunders AM, Gaskell PC, et al. Apolipoprotein E ∈2 does not increase risk of early-onset sporadic Alzheimer disease. Ann Neurol. 1997;42: 376-378.
31. Corder EH, Saunders AM, Strittmatter WJ, et al. Apolipoprotein E, survival in Alzheimer's disease patients and the competing risks of death and Alzheimer's disease. Neurology. 1995;45:1323-1328.
32. Stern Y, Brandt J, Albert M, et al. The absence of the apolipoprotein-E ∈4 allele is associated with a more aggressive form of Alzheimer's disease. Ann Neurol. 1997;41:615-620.
33. De la Monte SM, Hutchins GM, Moore GW. Racial differences in the etiology of dementia and frequency of Alzheimer lesions in the brain. J Natl Med Assoc. 1989;81:644-652.
34. Bohnstedt M, Fox PJ, Kohatsu ND. Correlates of Mini-Mental Status Examination scores among elderly demented patients: the influence of raceethnicity. J Clin Epidemiol. 1994;47:1381-1387.
35. Saunders AM, Hulette C, Welsh-Bohmer KA, et al. Specificity, sensitivity and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet. 1996;348:90-93.
36. Hobbs FB, Damon BL. 65+ in the United States. Washington, DC: Bureau of the Census; 1996. Publication P23-190.