메뉴 건너뛰기




Volumn 139, Issue 2, 1997, Pages 485-495

Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N1411)

Author keywords

[No Author keywords available]

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; GREEN FLUORESCENT PROTEIN; MUTANT PROTEIN; PROTEIN PRECURSOR;

EID: 0030771534     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.139.2.485     Document Type: Article
Times cited : (115)

References (60)
  • 1
    • 0029115555 scopus 로고
    • The structure of the Presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
    • Alzheimer's Disease Collaborative Group. 1995. The structure of the Presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nat. Genet. 11:219-222.
    • (1995) Nat. Genet. , vol.11 , pp. 219-222
  • 9
    • 0029813255 scopus 로고    scopus 로고
    • The presenilin genes: A new gene family involved in Alzheimer's disease pathology
    • Cruts, M., L. Hendriks, and C. Van Broeckhoven. 1996. The presenilin genes: a new gene family involved in Alzheimer's disease pathology. Hum. Mol. Genet. 5:1449-1455.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1449-1455
    • Cruts, M.1    Hendriks, L.2    Van Broeckhoven, C.3
  • 10
    • 0030580281 scopus 로고    scopus 로고
    • Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cell
    • Deng, G., C.J. Pike, and C.W. Cotman. 1996. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cell. FEBS Lett. 397:50-54.
    • (1996) FEBS Lett. , vol.397 , pp. 50-54
    • Deng, G.1    Pike, C.J.2    Cotman, C.W.3
  • 13
    • 0029042718 scopus 로고
    • Nuclear changes in apoptosis
    • Earnshaw, W.C. 1995. Nuclear changes in apoptosis. Curr. Opin. Cell Biol. 7: 337-343.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 337-343
    • Earnshaw, W.C.1
  • 14
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • Graham, R., and A.J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 52:456-467.
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, R.1    Van Der Eb, A.J.2
  • 15
    • 0030922421 scopus 로고    scopus 로고
    • Presenilins: Genes for life and death
    • Haass, C. 1997. Presenilins: genes for life and death. Neuron. 18:687-690.
    • (1997) Neuron , vol.18 , pp. 687-690
    • Haass, C.1
  • 16
    • 0029266653 scopus 로고
    • β-Amyloid, protein processing and Alzheimer's disease
    • Haass, C., Y. Hung, M, Citron, D.B. Teplow, and D.J. Selkoe. 1995. β-Amyloid, protein processing and Alzheimer's disease. Drug Res. 45:398-402.
    • (1995) Drug Res. , vol.45 , pp. 398-402
    • Haass, C.1    Hung, Y.2    Citron, M.3    Teplow, D.B.4    Selkoe, D.J.5
  • 17
    • 0024470862 scopus 로고
    • Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note
    • Kaufmann, S.H. 1989. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res. 49:5870-5878.
    • (1989) Cancer Res. , vol.49 , pp. 5870-5878
    • Kaufmann, S.H.1
  • 18
    • 0030890399 scopus 로고    scopus 로고
    • Endoproteolytic cleavage and proteosomal degradation of presenilin 2 transfected cells
    • Kim, T.W., W.H. Pettingell, O.G. Hallmark, R.D. Moir, W. Wasco, and R.E. Tanzi, 1997. Endoproteolytic cleavage and proteosomal degradation of presenilin 2 transfected cells. J. Biol. Chem. 272:11006-11010.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11006-11010
    • Kim, T.W.1    Pettingell, W.H.2    Hallmark, O.G.3    Moir, R.D.4    Wasco, W.5    Tanzi, R.E.6
  • 20
    • 0028981717 scopus 로고
    • The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice
    • LaFerla, F.M., B.T. Tinkle, C.J. Bieberich, C. Haudenschild, and G. Jay. 1995. The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat. Genet. 9:21-30.
    • (1995) Nat. Genet. , vol.9 , pp. 21-30
    • LaFerla, F.M.1    Tinkle, B.T.2    Bieberich, C.J.3    Haudenschild, C.4    Jay, G.5
  • 21
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:680-685.
    • (1970) Nature (Lond.) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 23
    • 0027293898 scopus 로고
    • Neurofilaments are obligate heteropolymers in vivo
    • Lee, M.K., Z. Xu., P.C. Wong, and D.W. Cleveland. 1993. Neurofilaments are obligate heteropolymers in vivo. J. Cell Biol. 122:1337-1350.
    • (1993) J. Cell Biol. , vol.122 , pp. 1337-1350
    • Lee, M.K.1    Xu, Z.2    Wong, P.C.3    Cleveland, D.W.4
  • 25
    • 0030922146 scopus 로고    scopus 로고
    • Evidence for a six-transmembrane domain structure of presenilin 1
    • Lehmann, S., R. Chiesa, and D.A. Harris. 1997. Evidence for a six-transmembrane domain structure of presenilin 1. J. Biol Chem. 272:12047-12051.
    • (1997) J. Biol Chem. , vol.272 , pp. 12047-12051
    • Lehmann, S.1    Chiesa, R.2    Harris, D.A.3
  • 26
    • 0029116848 scopus 로고
    • Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
    • Levitan, D., and I. Greenwald. 1995. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature (Lond.). 377:351-354.
    • (1995) Nature (Lond.) , vol.377 , pp. 351-354
    • Levitan, D.1    Greenwald, I.2
  • 30
    • 0030293894 scopus 로고    scopus 로고
    • Membrane topology of the C. elegans SEL-12 presenilin
    • Li, X., and I. Greenwald. 1996. Membrane topology of the C. elegans SEL-12 presenilin. Neuron. 17:1015-1021.
    • (1996) Neuron , vol.17 , pp. 1015-1021
    • Li, X.1    Greenwald, I.2
  • 31
    • 0029618686 scopus 로고
    • Identification and expression analysis of a potentially familial Alzheimer disease gene on chromosome 1 related to AD3
    • Li, J., J. Ma, and H. Potter. 1995. Identification and expression analysis of a potentially familial Alzheimer disease gene on chromosome 1 related to AD3. Proc. Natl. Acad. Sci. USA. 92:12180-12184.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 12180-12184
    • Li, J.1    Ma, J.2    Potter, H.3
  • 32
    • 0026817463 scopus 로고
    • A new series of trpE vectors that enable high expression of nonfusion proteins in bacteria
    • Mercy, M.R., J.C. Troncoso, and M.J. Monteiro. 1992. A new series of trpE vectors that enable high expression of nonfusion proteins in bacteria. Protein Expr. Purif. 3:57-64.
    • (1992) Protein Expr. Purif. , vol.3 , pp. 57-64
    • Mercy, M.R.1    Troncoso, J.C.2    Monteiro, M.J.3
  • 33
    • 0029913235 scopus 로고    scopus 로고
    • Resolution of kinase activities during the HeLa cell cycle: Identification of kinases with cyclic activities
    • Monteiro, M.J., and T. Mical. 1996. Resolution of kinase activities during the HeLa cell cycle: identification of kinases with cyclic activities. Exp. Cell Res. 223:443-451.
    • (1996) Exp. Cell Res. , vol.223 , pp. 443-451
    • Monteiro, M.J.1    Mical, T.2
  • 34
    • 0028096967 scopus 로고
    • Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments
    • Monteiro, M.J., C. Hicks, L. Gu, and S. Janicfci. 1994. Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments. J. Cell Biol. 127:1327-1343.
    • (1994) J. Cell Biol. , vol.127 , pp. 1327-1343
    • Monteiro, M.J.1    Hicks, C.2    Gu, L.3    Janicfci, S.4
  • 35
    • 0027422751 scopus 로고
    • Genetic and molecular advances in Alzheimer's disease
    • Mullan, M., and F. Crawford. 1993. Genetic and molecular advances in Alzheimer's disease. Trends Neurosci. 16:398-403.
    • (1993) Trends Neurosci. , vol.16 , pp. 398-403
    • Mullan, M.1    Crawford, F.2
  • 36
    • 0027989510 scopus 로고
    • Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase
    • Oberhammer, F.A., K. Hochegger, G. Froschl, R. Tiefenbacher, and M. Pavelka. 1994. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J. Cell Biol. 126:827-837.
    • (1994) J. Cell Biol. , vol.126 , pp. 827-837
    • Oberhammer, F.A.1    Hochegger, K.2    Froschl, G.3    Tiefenbacher, R.4    Pavelka, M.5
  • 37
    • 0026072875 scopus 로고
    • Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cells
    • Opas, M., E. Dziak, L. Fliegel, and M. Michalak. 1991. Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cells. J. Cell Physiol. 149:160-171.
    • (1991) J. Cell Physiol. , vol.149 , pp. 160-171
    • Opas, M.1    Dziak, E.2    Fliegel, L.3    Michalak, M.4
  • 39
    • 0030465544 scopus 로고    scopus 로고
    • Lamin proteolysis facilitates nuclear events during apoptosis
    • Rao, L., D. Perez, and E. White. 1996. Lamin proteolysis facilitates nuclear events during apoptosis. J. Cell Biol. 135:1441-1455.
    • (1996) J. Cell Biol. , vol.135 , pp. 1441-1455
    • Rao, L.1    Perez, D.2    White, E.3
  • 40
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindereds with missense mutations in the gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev, E.I., R. Sherrington, E.A. Rogaeva, G. Levesque, M. Ikeda, Y. Liang, H. Chi, C. Lin, K. Holman, T. Tsuda, et al. 1995. Familial Alzheimer's disease in kindereds with missense mutations in the gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature (Lond.). 376:775-778.
    • (1995) Nature (Lond.) , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3    Levesque, G.4    Ikeda, M.5    Liang, Y.6    Chi, H.7    Lin, C.8    Holman, K.9    Tsuda, T.10
  • 41
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner, D., C. Eckman, X. Song, M. Citron, N. Suzuki, T.D. Bird, J. Hardy, M. Hutton, W. Kukull, E. Larson, et al. 1996. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:864-870.
    • (1996) Nat. Med. , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Song, X.3    Citron, M.4    Suzuki, N.5    Bird, T.D.6    Hardy, J.7    Hutton, M.8    Kukull, W.9    Larson, E.10
  • 46
    • 0030638139 scopus 로고    scopus 로고
    • Bax protein expression is increased in Alzheimer's brain: Correlation with DNA damage, Bcl-2 expression, and brain pathology
    • Su, J.H., G. Deng, and C.W. Cotman. 1997. Bax protein expression is increased in Alzheimer's brain: correlation with DNA damage, Bcl-2 expression, and brain pathology. J. Neuropathol. Exp. Neurol. 56:86-93.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 86-93
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 49
    • 12644258498 scopus 로고    scopus 로고
    • The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
    • Tomita, T., K., Maruyama, T.C. Saido, H. Kume, K. Shinozaki, S. Tokuhiro, A. Capell, J. Walter, H. Grunberg, C. Hass, et al. 1997. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc. Natl. Acad. Sci. USA. 94:2025-2030.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2025-2030
    • Tomita, T.1    Maruyama, K.2    Saido, T.C.3    Kume, H.4    Shinozaki, K.5    Tokuhiro, S.6    Capell, A.7    Walter, J.8    Grunberg, H.9    Hass, C.10
  • 50
    • 0026672306 scopus 로고
    • Activation driven cell death: Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death
    • Ucker, D.S., J. Myers, and P.S. Obermiller. 1992. Activation driven cell death: quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death. J. Immunol 149:1583-1592.
    • (1992) J. Immunol , vol.149 , pp. 1583-1592
    • Ucker, D.S.1    Myers, J.2    Obermiller, P.S.3
  • 51
    • 0028883252 scopus 로고
    • Molecular genetics of Alzheimer's disease: Identification of genes and gene mutations
    • Van Broeckhoven, C. 1995. Molecular genetics of Alzheimer's disease: identification of genes and gene mutations. Eur. Neurol. 35:8-19.
    • (1995) Eur. Neurol. , vol.35 , pp. 8-19
    • Van Broeckhoven, C.1
  • 57
    • 0019225636 scopus 로고
    • Cell death: Significance of apoptosis
    • Wyllie, A.H. 1980. Cell death: significance of apoptosis. Int. Rev. Cytol. 68:251-306.
    • (1980) Int. Rev. Cytol. , vol.68 , pp. 251-306
    • Wyllie, A.H.1
  • 60
    • 0028208253 scopus 로고
    • Identification and characterization of a novel (115 kDa) neurofilament-associated kinase
    • Xiao, J., and M.J. Monteiro. 1994. Identification and characterization of a novel (115 kDa) neurofilament-associated kinase. J. Neurosci. 14:1820-1833.
    • (1994) J. Neurosci. , vol.14 , pp. 1820-1833
    • Xiao, J.1    Monteiro, M.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.