-
1
-
-
0029115555
-
The structure of the Presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
-
Alzheimer's Disease Collaborative Group. 1995. The structure of the Presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nat. Genet. 11:219-222.
-
(1995)
Nat. Genet.
, vol.11
, pp. 219-222
-
-
-
2
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
Borchelt, D.R., G. Thinakaran, C.B. Eckman, M.K. Lee, F. Davenport, T. Ratovitsky, C.-M. Prada, G. Kim, S. Seekins, D. Yager, et al. 1996. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron. 17:1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.-M.7
Kim, G.8
Seekins, S.9
Yager, D.10
-
3
-
-
0029664568
-
Mutation analysis of presenilin 1 gene in Alzheimer's disease
-
Boteva, K., M. Vitek, H. Mitsudade, H. Silva, P.-T. Xu, G. Small, and J.R. Gilbert. 1996. Mutation analysis of presenilin 1 gene in Alzheimer's disease. Lancet. 347:130-131.
-
(1996)
Lancet
, vol.347
, pp. 130-131
-
-
Boteva, K.1
Vitek, M.2
Mitsudade, H.3
Silva, H.4
Xu, P.-T.5
Small, G.6
Gilbert, J.R.7
-
4
-
-
0028812820
-
Mutations in the presenilin 1 gene in families with early-onset Alzheimer's disease
-
Campion, D., J.M. Flaman, A. Brice, D. Hannequin, B. Dubois, C. Martin, V. Moreau, F. Charbonnier, O. Didierjean, S. Tardieu, et al. 1995. Mutations in the presenilin 1 gene in families with early-onset Alzheimer's disease. Hum. Mol. Genet. 4:2373-2377.
-
(1995)
Hum. Mol. Genet.
, vol.4
, pp. 2373-2377
-
-
Campion, D.1
Flaman, J.M.2
Brice, A.3
Hannequin, D.4
Dubois, B.5
Martin, C.6
Moreau, V.7
Charbonnier, F.8
Didierjean, O.9
Tardieu, S.10
-
5
-
-
0029094267
-
Familial Alzheimer's disease associated with S182 codon 286 mutation
-
Chapman, J., A. Asherova, N. Wang, T.A. Treves, A.D. Korczyn, and L.G. Goldfarb. 1995. Familial Alzheimer's disease associated with S182 codon 286 mutation. Lancet. 346:1040.
-
(1995)
Lancet
, vol.346
, pp. 1040
-
-
Chapman, J.1
Asherova, A.2
Wang, N.3
Treves, T.A.4
Korczyn, A.D.5
Goldfarb, L.G.6
-
6
-
-
0029812077
-
Expression and analysis of presenilin-1 in a human neuronal system: Localization in cell bodies and dendrites
-
Cook, D.B., J.C. Sung, T.E. Golde, K.M. Felsenstein, B.S. Wojczyk, R.E. Tanzi, J.Q. Trojanowski, V.M.Y. Lee, and R.M. Doms. 1996. Expression and analysis of presenilin-1 in a human neuronal system: localization in cell bodies and dendrites. Proc. Natl. Acad. Sci. USA. 93:9223-9228.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9223-9228
-
-
Cook, D.B.1
Sung, J.C.2
Golde, T.E.3
Felsenstein, K.M.4
Wojczyk, B.S.5
Tanzi, R.E.6
Trojanowski, J.Q.7
Lee, V.M.Y.8
Doms, R.M.9
-
7
-
-
0027194791
-
Gene dose apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder, E.H., A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, G.W. Small, A.D. Roses, J.L. Haines, and M.A. Pericak-Vance. 1993. Gene dose apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science (Wash. DC). 261:921-923.
-
(1993)
Science (Wash. DC)
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
8
-
-
0028861041
-
Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14Q24.3
-
Cruts, M., H. Backhovens, S. Y. Wang, G. Vangassen, J. Theurns, C. Dejonghe, A. Wehnert, J. Devoecht, G. deWinter, P. Cras, et al. 1995. Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14Q24.3. Hum. Mol. Genet. 4:2363-2371.
-
(1995)
Hum. Mol. Genet.
, vol.4
, pp. 2363-2371
-
-
Cruts, M.1
Backhovens, H.2
Wang, S.Y.3
Vangassen, G.4
Theurns, J.5
Dejonghe, C.6
Wehnert, A.7
Devoecht, J.8
Dewinter, G.9
Cras, P.10
-
9
-
-
0029813255
-
The presenilin genes: A new gene family involved in Alzheimer's disease pathology
-
Cruts, M., L. Hendriks, and C. Van Broeckhoven. 1996. The presenilin genes: a new gene family involved in Alzheimer's disease pathology. Hum. Mol. Genet. 5:1449-1455.
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 1449-1455
-
-
Cruts, M.1
Hendriks, L.2
Van Broeckhoven, C.3
-
10
-
-
0030580281
-
Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cell
-
Deng, G., C.J. Pike, and C.W. Cotman. 1996. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cell. FEBS Lett. 397:50-54.
-
(1996)
FEBS Lett.
, vol.397
, pp. 50-54
-
-
Deng, G.1
Pike, C.J.2
Cotman, C.W.3
-
11
-
-
0030293854
-
Protein topology of presenilin 1
-
Doan, A., G. Thinakaran, D.R. Borchelt, H.H. Slunt, T. Rativitsky, M. Podlisny, D.J. Selkoe, M. Seeger, S.E. Gandy, D.L. Price, and S.S. Sisodia. 1996. Protein topology of presenilin 1. Neuron. 17:1023-1030.
-
(1996)
Neuron
, vol.17
, pp. 1023-1030
-
-
Doan, A.1
Thinakaran, G.2
Borchelt, D.R.3
Slunt, H.H.4
Rativitsky, T.5
Podlisny, M.6
Selkoe, D.J.7
Seeger, M.8
Gandy, S.E.9
Price, D.L.10
Sisodia, S.S.11
-
12
-
-
16044366039
-
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
-
Duff, K., C. Eckman, C. Zehr, X. Yu, C.-M. Prada, J. Perez-tur, M. Hutton, L. Buee, Y. Harigaya, D. Yager, et al. 1996. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature (Lond.). 383:710-713.
-
(1996)
Nature (Lond.)
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.-M.5
Perez-tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
-
13
-
-
0029042718
-
Nuclear changes in apoptosis
-
Earnshaw, W.C. 1995. Nuclear changes in apoptosis. Curr. Opin. Cell Biol. 7: 337-343.
-
(1995)
Curr. Opin. Cell Biol.
, vol.7
, pp. 337-343
-
-
Earnshaw, W.C.1
-
14
-
-
0015847039
-
A new technique for the assay of infectivity of human adenovirus 5 DNA
-
Graham, R., and A.J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 52:456-467.
-
(1973)
Virology
, vol.52
, pp. 456-467
-
-
Graham, R.1
Van Der Eb, A.J.2
-
15
-
-
0030922421
-
Presenilins: Genes for life and death
-
Haass, C. 1997. Presenilins: genes for life and death. Neuron. 18:687-690.
-
(1997)
Neuron
, vol.18
, pp. 687-690
-
-
Haass, C.1
-
16
-
-
0029266653
-
β-Amyloid, protein processing and Alzheimer's disease
-
Haass, C., Y. Hung, M, Citron, D.B. Teplow, and D.J. Selkoe. 1995. β-Amyloid, protein processing and Alzheimer's disease. Drug Res. 45:398-402.
-
(1995)
Drug Res.
, vol.45
, pp. 398-402
-
-
Haass, C.1
Hung, Y.2
Citron, M.3
Teplow, D.B.4
Selkoe, D.J.5
-
17
-
-
0024470862
-
Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note
-
Kaufmann, S.H. 1989. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res. 49:5870-5878.
-
(1989)
Cancer Res.
, vol.49
, pp. 5870-5878
-
-
Kaufmann, S.H.1
-
18
-
-
0030890399
-
Endoproteolytic cleavage and proteosomal degradation of presenilin 2 transfected cells
-
Kim, T.W., W.H. Pettingell, O.G. Hallmark, R.D. Moir, W. Wasco, and R.E. Tanzi, 1997. Endoproteolytic cleavage and proteosomal degradation of presenilin 2 transfected cells. J. Biol. Chem. 272:11006-11010.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11006-11010
-
-
Kim, T.W.1
Pettingell, W.H.2
Hallmark, O.G.3
Moir, R.D.4
Wasco, W.5
Tanzi, R.E.6
-
19
-
-
13344282063
-
Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
-
Kovacs, D.M., H.J. Fausett, K.J. Page, T.-W. Kim, R.D. Moir, D.E. Merriam, R.D. Hollister, O.G. Hallmark, R. Mancini, K.M. Felsenstein, et al. 1996. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat. Med. 2: 224-229.
-
(1996)
Nat. Med.
, vol.2
, pp. 224-229
-
-
Kovacs, D.M.1
Fausett, H.J.2
Page, K.J.3
Kim, T.-W.4
Moir, R.D.5
Merriam, D.E.6
Hollister, R.D.7
Hallmark, O.G.8
Mancini, R.9
Felsenstein, K.M.10
-
20
-
-
0028981717
-
The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice
-
LaFerla, F.M., B.T. Tinkle, C.J. Bieberich, C. Haudenschild, and G. Jay. 1995. The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat. Genet. 9:21-30.
-
(1995)
Nat. Genet.
, vol.9
, pp. 21-30
-
-
LaFerla, F.M.1
Tinkle, B.T.2
Bieberich, C.J.3
Haudenschild, C.4
Jay, G.5
-
21
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:680-685.
-
(1970)
Nature (Lond.)
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
22
-
-
0029046470
-
Studies of lamin proteinase reveal multiple parallel pathways during apoptotic execution
-
Lazebnik, Y.A., R. Takahashi, R. Moir, R. Goldman, G. Poirier, S. Kaufmann, and W. Earnshaw. 1995. Studies of lamin proteinase reveal multiple parallel pathways during apoptotic execution. Proc. Natl. Acad. Sci. USA. 92:9042-9046.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9042-9046
-
-
Lazebnik, Y.A.1
Takahashi, R.2
Moir, R.3
Goldman, R.4
Poirier, G.5
Kaufmann, S.6
Earnshaw, W.7
-
23
-
-
0027293898
-
Neurofilaments are obligate heteropolymers in vivo
-
Lee, M.K., Z. Xu., P.C. Wong, and D.W. Cleveland. 1993. Neurofilaments are obligate heteropolymers in vivo. J. Cell Biol. 122:1337-1350.
-
(1993)
J. Cell Biol.
, vol.122
, pp. 1337-1350
-
-
Lee, M.K.1
Xu, Z.2
Wong, P.C.3
Cleveland, D.W.4
-
24
-
-
10544229795
-
Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues
-
Lee, M.K., H.H. Slunt, L.J. Martin, G. Thinakaran, G. Kim, S.E. Gandy, M. Seeger, E. Koo, D.L. Price, and S.S. Sisodia. 1996. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J. Neurosci. 16:7513-7525.
-
(1996)
J. Neurosci.
, vol.16
, pp. 7513-7525
-
-
Lee, M.K.1
Slunt, H.H.2
Martin, L.J.3
Thinakaran, G.4
Kim, G.5
Gandy, S.E.6
Seeger, M.7
Koo, E.8
Price, D.L.9
Sisodia, S.S.10
-
25
-
-
0030922146
-
Evidence for a six-transmembrane domain structure of presenilin 1
-
Lehmann, S., R. Chiesa, and D.A. Harris. 1997. Evidence for a six-transmembrane domain structure of presenilin 1. J. Biol Chem. 272:12047-12051.
-
(1997)
J. Biol Chem.
, vol.272
, pp. 12047-12051
-
-
Lehmann, S.1
Chiesa, R.2
Harris, D.A.3
-
26
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
Levitan, D., and I. Greenwald. 1995. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature (Lond.). 377:351-354.
-
(1995)
Nature (Lond.)
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
27
-
-
0029906585
-
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
-
Levitan, D., T.G. Doyle, D. Brousseau, M.K. Lee, G. Thinakaran, H.H. Slunt, S.S. Sisodia, and I. Greenwald. 1996. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA. 93:14940-14944.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14940-14944
-
-
Levitan, D.1
Doyle, T.G.2
Brousseau, D.3
Lee, M.K.4
Thinakaran, G.5
Slunt, H.H.6
Sisodia, S.S.7
Greenwald, I.8
-
28
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad, E., W. Wasco, P. Poorkaj, D.M. Romano, J. Oshima, W.H. Pettingell, C. Yu, P.D. Jondro, S.D. Schmidt, K. Wang, et al. 1995a. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science (Wash. DC). 269:973-977.
-
(1995)
Science (Wash. DC)
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
Yu, C.7
Jondro, P.D.8
Schmidt, S.D.9
Wang, K.10
-
29
-
-
0029150716
-
A familial Alzheimer's disease locus on chromosome 1
-
Levy-Lahad, E., E.M. Wijsman, E. Nemens, L. Anderson, K.A.B. Goddard, J.L. Weber, T.D. Bird, and G.D. Schellenberg. 1995b. A familial Alzheimer's disease locus on chromosome 1. Science (Wash. DC). 269:970-973.
-
(1995)
Science (Wash. DC)
, vol.269
, pp. 970-973
-
-
Levy-Lahad, E.1
Wijsman, E.M.2
Nemens, E.3
Anderson, L.4
Goddard, K.A.B.5
Weber, J.L.6
Bird, T.D.7
Schellenberg, G.D.8
-
30
-
-
0030293894
-
Membrane topology of the C. elegans SEL-12 presenilin
-
Li, X., and I. Greenwald. 1996. Membrane topology of the C. elegans SEL-12 presenilin. Neuron. 17:1015-1021.
-
(1996)
Neuron
, vol.17
, pp. 1015-1021
-
-
Li, X.1
Greenwald, I.2
-
31
-
-
0029618686
-
Identification and expression analysis of a potentially familial Alzheimer disease gene on chromosome 1 related to AD3
-
Li, J., J. Ma, and H. Potter. 1995. Identification and expression analysis of a potentially familial Alzheimer disease gene on chromosome 1 related to AD3. Proc. Natl. Acad. Sci. USA. 92:12180-12184.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 12180-12184
-
-
Li, J.1
Ma, J.2
Potter, H.3
-
32
-
-
0026817463
-
A new series of trpE vectors that enable high expression of nonfusion proteins in bacteria
-
Mercy, M.R., J.C. Troncoso, and M.J. Monteiro. 1992. A new series of trpE vectors that enable high expression of nonfusion proteins in bacteria. Protein Expr. Purif. 3:57-64.
-
(1992)
Protein Expr. Purif.
, vol.3
, pp. 57-64
-
-
Mercy, M.R.1
Troncoso, J.C.2
Monteiro, M.J.3
-
33
-
-
0029913235
-
Resolution of kinase activities during the HeLa cell cycle: Identification of kinases with cyclic activities
-
Monteiro, M.J., and T. Mical. 1996. Resolution of kinase activities during the HeLa cell cycle: identification of kinases with cyclic activities. Exp. Cell Res. 223:443-451.
-
(1996)
Exp. Cell Res.
, vol.223
, pp. 443-451
-
-
Monteiro, M.J.1
Mical, T.2
-
34
-
-
0028096967
-
Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments
-
Monteiro, M.J., C. Hicks, L. Gu, and S. Janicfci. 1994. Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments. J. Cell Biol. 127:1327-1343.
-
(1994)
J. Cell Biol.
, vol.127
, pp. 1327-1343
-
-
Monteiro, M.J.1
Hicks, C.2
Gu, L.3
Janicfci, S.4
-
35
-
-
0027422751
-
Genetic and molecular advances in Alzheimer's disease
-
Mullan, M., and F. Crawford. 1993. Genetic and molecular advances in Alzheimer's disease. Trends Neurosci. 16:398-403.
-
(1993)
Trends Neurosci.
, vol.16
, pp. 398-403
-
-
Mullan, M.1
Crawford, F.2
-
36
-
-
0027989510
-
Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase
-
Oberhammer, F.A., K. Hochegger, G. Froschl, R. Tiefenbacher, and M. Pavelka. 1994. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J. Cell Biol. 126:827-837.
-
(1994)
J. Cell Biol.
, vol.126
, pp. 827-837
-
-
Oberhammer, F.A.1
Hochegger, K.2
Froschl, G.3
Tiefenbacher, R.4
Pavelka, M.5
-
37
-
-
0026072875
-
Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cells
-
Opas, M., E. Dziak, L. Fliegel, and M. Michalak. 1991. Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cells. J. Cell Physiol. 149:160-171.
-
(1991)
J. Cell Physiol.
, vol.149
, pp. 160-171
-
-
Opas, M.1
Dziak, E.2
Fliegel, L.3
Michalak, M.4
-
38
-
-
0029554875
-
A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene
-
Perez-Tur, J., S. Froelich, G. Prihar, R. Crook, M. Baker, K. Duff, M. Wragg, F. Busfield, C. Lendon, R.F. Clark, et al. 1995. A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. Neuroreport. 7:297-301.
-
(1995)
Neuroreport
, vol.7
, pp. 297-301
-
-
Perez-Tur, J.1
Froelich, S.2
Prihar, G.3
Crook, R.4
Baker, M.5
Duff, K.6
Wragg, M.7
Busfield, F.8
Lendon, C.9
Clark, R.F.10
-
39
-
-
0030465544
-
Lamin proteolysis facilitates nuclear events during apoptosis
-
Rao, L., D. Perez, and E. White. 1996. Lamin proteolysis facilitates nuclear events during apoptosis. J. Cell Biol. 135:1441-1455.
-
(1996)
J. Cell Biol.
, vol.135
, pp. 1441-1455
-
-
Rao, L.1
Perez, D.2
White, E.3
-
40
-
-
0029101491
-
Familial Alzheimer's disease in kindereds with missense mutations in the gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev, E.I., R. Sherrington, E.A. Rogaeva, G. Levesque, M. Ikeda, Y. Liang, H. Chi, C. Lin, K. Holman, T. Tsuda, et al. 1995. Familial Alzheimer's disease in kindereds with missense mutations in the gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature (Lond.). 376:775-778.
-
(1995)
Nature (Lond.)
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
-
41
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner, D., C. Eckman, X. Song, M. Citron, N. Suzuki, T.D. Bird, J. Hardy, M. Hutton, W. Kukull, E. Larson, et al. 1996. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:864-870.
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Song, X.3
Citron, M.4
Suzuki, N.5
Bird, T.D.6
Hardy, J.7
Hutton, M.8
Kukull, W.9
Larson, E.10
-
42
-
-
0030779784
-
Skeletal and CNS defects in presenilin-1-deficient mice
-
Shen, J., R.T. Bronson, D.F. Chen, W. Xia, D.J. Selkoe, and S. Tonegawa. 1997. Skeletal and CNS defects in presenilin-1-deficient mice. Cell. 89:629-639.
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
Tonegawa, S.6
-
43
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington, R., E.I. Rogaev, Y. Liang, E.A. Rogaeva, G. Levesque, M. Ikeda, H. Chi, C. Lin, G. Li, K. Holman, et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature (Lond.). 375:754-760.
-
(1995)
Nature (Lond.)
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
-
44
-
-
8944241774
-
Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant
-
Sherrington, R., S. Froelich, S. Sorbi, D. Campion, H. Chi, E.A. Rogaeva, G. Levesque, E.I. Rogaev, C. Lin, Y. Liang, et al. 1996. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum. Mol. Genet. 5:985-988.
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 985-988
-
-
Sherrington, R.1
Froelich, S.2
Sorbi, S.3
Campion, D.4
Chi, H.5
Rogaeva, E.A.6
Levesque, G.7
Rogaev, E.I.8
Lin, C.9
Liang, Y.10
-
46
-
-
0030638139
-
Bax protein expression is increased in Alzheimer's brain: Correlation with DNA damage, Bcl-2 expression, and brain pathology
-
Su, J.H., G. Deng, and C.W. Cotman. 1997. Bax protein expression is increased in Alzheimer's brain: correlation with DNA damage, Bcl-2 expression, and brain pathology. J. Neuropathol. Exp. Neurol. 56:86-93.
-
(1997)
J. Neuropathol. Exp. Neurol.
, vol.56
, pp. 86-93
-
-
Su, J.H.1
Deng, G.2
Cotman, C.W.3
-
47
-
-
0025853971
-
Molecular cloning and characterization of two voltagegated K channel cDNAs from human ventricle
-
Tamkun, M.M., K.M. Knoth, J.A. Wabridge, H. Kroemer, D.M. Roden, and K.M. Glover. 1991. Molecular cloning and characterization of two voltagegated K channel cDNAs from human ventricle. FASEB (Fed. Am. Soc. Exp. Biol.) J. 5:331-337.
-
(1991)
FASEB (Fed. Am. Soc. Exp. Biol.) J.
, vol.5
, pp. 331-337
-
-
Tamkun, M.M.1
Knoth, K.M.2
Wabridge, J.A.3
Kroemer, H.4
Roden, D.M.5
Glover, K.M.6
-
48
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Thinakaran, G., D.R. Borchelt, M.K. Lee, H.H. Slunt, L. Spitzer, G. Kim, T. Ratovitsky, F. Davenport, C. Nordstedt, M. Seeger, et al. 1996. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17:181-190.
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
-
49
-
-
12644258498
-
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
-
Tomita, T., K., Maruyama, T.C. Saido, H. Kume, K. Shinozaki, S. Tokuhiro, A. Capell, J. Walter, H. Grunberg, C. Hass, et al. 1997. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc. Natl. Acad. Sci. USA. 94:2025-2030.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2025-2030
-
-
Tomita, T.1
Maruyama, K.2
Saido, T.C.3
Kume, H.4
Shinozaki, K.5
Tokuhiro, S.6
Capell, A.7
Walter, J.8
Grunberg, H.9
Hass, C.10
-
50
-
-
0026672306
-
Activation driven cell death: Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death
-
Ucker, D.S., J. Myers, and P.S. Obermiller. 1992. Activation driven cell death: quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death. J. Immunol 149:1583-1592.
-
(1992)
J. Immunol
, vol.149
, pp. 1583-1592
-
-
Ucker, D.S.1
Myers, J.2
Obermiller, P.S.3
-
51
-
-
0028883252
-
Molecular genetics of Alzheimer's disease: Identification of genes and gene mutations
-
Van Broeckhoven, C. 1995. Molecular genetics of Alzheimer's disease: identification of genes and gene mutations. Eur. Neurol. 35:8-19.
-
(1995)
Eur. Neurol.
, vol.35
, pp. 8-19
-
-
Van Broeckhoven, C.1
-
53
-
-
0029856850
-
Requirement of the familial Alzheimer's disease gene PS2 for apoptosis
-
Vito, P., B. Wolozin, J.K. Ganjei, K. Iwasaki, E. Lacana, and L.D. D'Adamio. 1996b. Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. J. Biol. Chem. 271:31025-31028.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 31025-31028
-
-
Vito, P.1
Wolozin, B.2
Ganjei, J.K.3
Iwasaki, K.4
Lacana, E.5
D'Adamio, L.D.6
-
54
-
-
15844386159
-
G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP
-
Yamatsuji, T., T. Matsui, T. Okamoto, K. Komatsuzaki, S. Takeda, H. Fukumoto, T. Iwatsubo, N. Suziki, A. Asami-Odaka, S. Ireland, et al. 1996. G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP. Science (Wash. DC). 272:1349-1352.
-
(1996)
Science (Wash. DC)
, vol.272
, pp. 1349-1352
-
-
Yamatsuji, T.1
Matsui, T.2
Okamoto, T.3
Komatsuzaki, K.4
Takeda, S.5
Fukumoto, H.6
Iwatsubo, T.7
Suziki, N.8
Asami-Odaka, A.9
Ireland, S.10
-
55
-
-
8044231311
-
The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum
-
Walter, J., A. Capell, J. Grunberg, B. Presold, A. Schindzielorz, R. Prior, M.B. Podlisny, P. Fraser, P.H. St. George-Hyslop, D.J. Selkoe, and C. Hass. 1996. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol. Med. 2:673-691.
-
(1996)
Mol. Med.
, vol.2
, pp. 673-691
-
-
Walter, J.1
Capell, A.2
Grunberg, J.3
Presold, B.4
Schindzielorz, A.5
Prior, R.6
Podlisny, M.B.7
Fraser, P.8
St. George-Hyslop, P.H.9
Selkoe, D.J.10
Hass, C.11
-
56
-
-
0029052710
-
Familial Alzheimer's chromosome 14 mutations
-
Wasco, W., W.P. Pettingell, P.D. Jondro, S.D. Schmidt, S. Gurubhagavatula, L. Rodes, T. DiBlasi, D.M. Romano, S.Y. Guenette, D.M. Kovacs, et al. 1995. Familial Alzheimer's chromosome 14 mutations. Nat. Med. 1:848.
-
(1995)
Nat. Med.
, vol.1
, pp. 848
-
-
Wasco, W.1
Pettingell, W.P.2
Jondro, P.D.3
Schmidt, S.D.4
Gurubhagavatula, S.5
Rodes, L.6
Diblasi, T.7
Romano, D.M.8
Guenette, S.Y.9
Kovacs, D.M.10
-
57
-
-
0019225636
-
Cell death: Significance of apoptosis
-
Wyllie, A.H. 1980. Cell death: significance of apoptosis. Int. Rev. Cytol. 68:251-306.
-
(1980)
Int. Rev. Cytol.
, vol.68
, pp. 251-306
-
-
Wyllie, A.H.1
-
58
-
-
10544224542
-
Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
-
Wolozin, B., K. Iwasaki, P. Vito, J.K. Ganjei, E. Lacana, T. Sunderland, B. Zhao, J.W. Kusiak, W. Wasco, and L. D'Adamio. 1996. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science (Wash. DC). 274:1710-1713.
-
(1996)
Science (Wash. DC)
, vol.274
, pp. 1710-1713
-
-
Wolozin, B.1
Iwasaki, K.2
Vito, P.3
Ganjei, J.K.4
Lacana, E.5
Sunderland, T.6
Zhao, B.7
Kusiak, J.W.8
Wasco, W.9
D'Adamio, L.10
-
59
-
-
17744401440
-
Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm
-
Wong, P.C., H. Zeng, H. Chen, M.W. Becher, D.J.S. Sirinathsinghji, M.E. Trumbauer, H.Y. Chen, D.L. Price, L.H.T. Van der Ploeg, and S.S. Sisodia. 1997. Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm. Nature (Lond.). 387:288-292.
-
(1997)
Nature (Lond.)
, vol.387
, pp. 288-292
-
-
Wong, P.C.1
Zeng, H.2
Chen, H.3
Becher, M.W.4
Sirinathsinghji, D.J.S.5
Trumbauer, M.E.6
Chen, H.Y.7
Price, D.L.8
Van Der Ploeg, L.H.T.9
Sisodia, S.S.10
-
60
-
-
0028208253
-
Identification and characterization of a novel (115 kDa) neurofilament-associated kinase
-
Xiao, J., and M.J. Monteiro. 1994. Identification and characterization of a novel (115 kDa) neurofilament-associated kinase. J. Neurosci. 14:1820-1833.
-
(1994)
J. Neurosci.
, vol.14
, pp. 1820-1833
-
-
Xiao, J.1
Monteiro, M.J.2
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