Perforant path transection induces complement C9 deposition in hippocampus

Experimental Neurology

Volumn 138, Issue 2, 1996, Pages 198-205

  Johnson, Steven A ^a,b   Young Chan, Cissy S ^a,c   Laping, Nicholas J ^a,d   Finch, Caleb E ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Cortex Pharmaceuticals Inc ^*  (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLUSTERIN; COMPLEMENT COMPONENT C9;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MALE; NERVE TRANSECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029876687     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.0058     Document Type: Article

References (32)

1. AUGER, M. J., AND J. A. ROSS. 1992. The biology of the macrophage. Pages 1-74 in C. E. Lewis and J. O. McGee, Eds., The Macrophage. IRL Press, Oxford.
2. BRUCK, W., AND R. L. FRIEDE. 1991. The role of complement in myelin phagocytosis during PNS wallerian degeneration. J. Neurol. Sci. 103: 182-187.
3. CABALKA, L. M., B. T. HYMAN, C. R. GOODLETT, T. C. RITCHIE, AND G. W. VAN HOESEN. 1992. Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions. Neurobiol. Aging 13: 283-291.
4. CACERES, A., AND O. STEWARD. 1983. Dendritic reorganization in the denervated dentate gyrus of the rat following entorhinal cortical lesions: A golgi and electron microscopic analysis. J. Comp. Neurol. 214: 387-403.
5. CHAN-PALAY, V. 1987. Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/ silver intensification on vibrotome sections: Coexistence with neuropeptide Y neurons, and effects in Alzheimer-type dementia. J. Comp. Neurol. 260: 201-223.
6. CUMMINGS, B. J., G. J. YEE, AND C. W. COTMAN. 1992. bFGF promotes the survival of entorhinal layer II neurons after perforant path axotomy. Brain Res. 591: 271-276.
7. DE LANEROLLE, N. C., J. H. KIM, R. J. ROBBINS, AND D. D. SPENCER. 1989. Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain Res. 495: 387-395.
8. DELLER, T., AND C. LERANTH. 1990. Synaptic connections of neuropeptide Y (NPY) immunoreactive neurons in the hilar area of the rat hippocampus. J. Comp. Neurol. 300: 433-447.
9. EIKELENBOOM, P., S-S. ZHAN, W. A. VAN GOOL, AND D. ALLSOP. 1994. Inflammatory mechanisms in Alzheimer's disease. Trends Pharmacol. Sci. 15: 447-450.
10. GEDDES, J. W., D. T. MONAGHAN, C. W. COTMAN, I. T. LOTT, R. C. KIM, AND H. C. CHUI. 1985. Plasticity of hippocampal circuitry in Alzheimer's disease. Science 230: 1179-1181.
11. GEHRMAN, J., S. W. SCHOEN, AND G. W. KREUTZBERG. 1991. Lesion of the rat entorhinal cortex leads to a rapid microglial reaction in the dentate gyrus. A light and electron microscopical study. Acta Neuropathol. 82: 442-455.
12. HAGA, S., K. IKEDA, M. SATO, AND T. ISHII. 1993. Synthetic Alzheimer amyloid β/A4 peptides enhance production of complement C3 component by cultured microglial cells. Brain Res. 601: 88-94.
13. HOFF, S. F., S. W. SCHEFF, AND C. W. COTMAN. 1982. Lesion-induced synaptogenesis in the dentate gyrus of aged rats: II. Demonstration of an impaired degeneration clearing response. J. Comp. Neurol. 205: 253-259.
14. HYMAN, B. T., G. W. VAN HOESEN, A. R. DAMASIO, AND C. L. BARNES. 1984. Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation. Science 225: 1168-1170.
15. JENNE, D. E., AND J. TSCHOPP. 1993. Clusterin: The intriguing guises of a widely expressed glycoprotein. Trends Biochem. Sci. 17: 154-159.
16. JOHNSON, S. A., T. MCNEILL, B. CORDELL, AND C. E. FINCH. 1990. Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease. Science 248: 854-857.
17. JOHNSON, S. A., M. LAMPERT-ETCHELLS, G. M. PASINETTI, I. ROZOVSKY, AND C. E. FINCH. 1992. Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental brain lesioning. Neurobiol. Aging 13: 641-648.
18. JOHNSON, S. A., G. M. PASINETTI, AND C. E. FINCH. 1994. Expression of complement C1qB and C4 mRNAs during rat brain development. Dev. Brain Res. 80: 163-174.
19. LAMPERT-ETCHELLS, M., G. PASINETTI, C. FINCH, AND S. JOHNSON. 1993. Regional localization of cells containing C1q and C4 mRNAs in the frontal cortex during Alzheimer's disease. Neurodegeneration 2: 113-121.
20. MAY, P. C., AND FINCH, C. E. 1992. Sulfated glycoprotein-2: New relationships of this multifunctional protein to neurodegeneration. Trends Neurosci. 15: 391-396.
21. MCGEER, P. L., H. AKIYAMA, S. ITAGAKI, AND E. G. MCGEER. 1989. Immune system response in Alzheimer's disease. Can. J. Neurol. Sci. 16: 516-527.
22. MCGEER, P. L., T. KAWAMATA, AND D. G. WALKER. 1992. Distribution of clusterin in Alzheimer brain tissue. Brain Res. 579: 337-341.
23. ODA, T., G. M. PASINETTI, H. H. OSTERBURG, C. ANDERSON, S. A. JOHNSON, AND C. E. FINCH. 1994. Purification and characterization of brain clusterin. Biochem. Biophys. Res. Commun. 204: 1131-1136.
24. PASINETTI, G. M., S. A. JOHNSON, I. ROZOVSKY, M. LAMPERT-ETCHELLS, D. G. MORGAN, M. N. GORDON, T. E. MORGAN, D. WILLOUGHBY, AND C. E. FINCH. 1992. Complement C1qB and C4 mRNAs responses to lesioning in rat brain. Exp. Neurol. 118: 117-125.
25. PASINETTI, G. M., S. A. JOHNSON, T. ODA, I. ROZOVSKY, AND C. E. FINCH. 1994. Clusterin (SGP-2): A multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain. J. Comp. Neurol. 339: 387-400.
26. PETERSON, D. A., C. A. LUCIDI-PHILLIPI, K. L. EAGLE, AND F. H. GAGE. 1994. Perforant path damage results in progressive neuronal death and somal atrophy in layer II of entorhinal cortex and functional impairment with increasing postdamage age. J. Neurosci. 14: 6872-6885.
27. ROGERS, J., N. R. COOPER, S. WEBSTER, J. SCHULTZ, P. L. MCGEER, S. D. STYREN, W. H. CIVIN, L. BRACHOVA, B. BRADT, P. WARD, AND I. LIEBERBURG. 1992. Complement activation by beta-amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 89: 10016-10020.
28. ROTHER, K., AND G. O. TILL, EDS. 1988. Page 535 in The Complement System. Springer-Verlag, Berlin.
29. ROZOVSKY, I., T. E. MORGAN, D. A. WILOUGHBY, M. M. DUGICH-DJORDEVICH, G. M. PASINETTI, S. A. JOHNSON, AND C. E. FINCH. 1994. Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxins in vivo and in vitro. Neuroscience 62: 741-758.
30. STEWARD, O., AND S. L. VINSANT. 1983. The process of reinnervation in the dentate gyrus of the adult rat: A quantitative electron microscopic analysis of terminal proliferation and reactive synaptogenesis. J. Comp. Neurol. 214: 370-386.
31. VEERHUIS, R., P. VAN DER VALK, I. JANSSEN, S. S. ZHAN, W. E. VAN NOSTRAND, AND P. EIKELENBOOM. 1995. Complement activation in amyloid plaques in Alzheimer's disease brains does not proceed further than C3. Virchows Arch. 426: 603-610.
32. WALKER, D. G., AND P. L. MCGEER. 1992. Complement gene expression in human brain: Comparison between normal and Alzheimer disease cases. Mol. Brain Res. 14: 109-116.