Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites

Acta Neuropathologica

Volumn 96, Issue 5, 1998, Pages 463-471

  Su, Joseph H ^a   Cummings, Brian J ^a   Cotman, Carl W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Developmental sequence; Dystrophic neurites; Progressive transformation; Senile plaques

Indexed keywords

AMYLOID PRECURSOR PROTEIN; TAU PROTEIN;

AGED; AGING; ALZHEIMER DISEASE; ANTIBODY LABELING; ARGENTAFFIN CELL; ARTICLE; BIOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HUMAN TISSUE; HYPOTHESIS; NEURITE; NEUROFILAMENT; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; SENILE PLAQUE;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; BRAIN; CADAVER; CELL AGING; HUMANS; NEURITES; NEUROFILAMENT PROTEINS; SENILE PLAQUES; SILVER STAINING; TAU PROTEINS;

EID: 0031716440     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050920     Document Type: Article

References (48)

1. Arriagada PV, Marzloff BA, Hyman BT (1992) Distribution of Alzheimer-type pathologic changes in nondemented eldrerly individuals matches the pattern in Alzheimer's disease. Neurology 42 : 1681-1688
2. Benzing WC, Brady DR, Mufson EJ, Armstrong DM (1993) Evidence that transmitter-containing dystrophic neurites precede those containing paired helical filaments within senile plaques in the entorhinal cortex of nondemented elderly and Alzheimer's disease patients. Brain Res 619 : 55-68
3. Biernat J, Mandelkow EM, Schroter C. Lichtenberg-Kraag B, Steiner B, Berling B, Meyer H, Merchen M, Vandermeeren A, Goedert M, Mandelkow E (1992) The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motif upstream of the microtubule binding region. EMBO J 11 : 1593-1597
4. 396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10 : 1089-1099
5. Busciglio J, Lorenzo A, Yeh J, Yanker BA (1995) β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 14 : 879-888
6. Cras P, Kawai M, Lowery D, Gonzalez-DeWhitt P, Greenberg B, Perry G (1991) Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci USA 88 : 7552-7556
7. Cummings BJ, Su JH, Geddes JW, Van Nostrand W, Wagner S, Cunningham D, Cotman CW (1992) Aggregation of the amyloid precursor protein (APP) within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience 48 : 763-777
8. Cummings BJ, Su JH, Cotman CW, White R, Russell MJ (1993) β-Amyloid accumulation in aged canine brain: a model of plaque formation in Alzheimer's disease. Neurobiol Aging 14 : 547-560
9. Cummings B, Head E, Ruehl W, Milgram N, Cotman C (1996) The canine as an animal model of human aging and dementia. Neurobiol Aging 17 : 259-268
10. Cummings BJ, Pike CJ, Shankle R, Cotman CW (1996) β-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease (see comments). Neurobiol Aging 17 : 921-933
11. Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savaee MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW (1996) Diffuse plaques contain C-terminal A β 42 and not A β 40: evidence from cats and dogs. Neurobiol Aging 17 : 653-659
12. Dickson DW, Crystal HA, Bevona C, Honer W, Vincent I, Davies P (1995) Correlations of synaptic and pathological markers with cognition of the elderly. Neurobiol Aging 16 : 285-298; discussion 298-304
13. Goedert M, Jakes R, Croether RA, Six J, Luebke U, Vandermeeren M, Cras P, Trojanowski JQ, Lee VM-Y (1993) The abnormal phosphorylation of tau protein at serine 202 in Alzheimer's disease recapitulates phosphorylation during development. Proc Natl Acad Sci USA 90 : 5066-5070
14. Greenberg SG, Davies P, Schein JD, Binder LI (1992) Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. J Biol Chem 267 : 564-569
15. Ishii T, Kametani F, Haga S, Sato M (1989) The immunohistochemical demonstration of subsequences of the precursor of the amyloid A4 protein in senile plaques in Alzheimer's disease. Neuropathol Appl Neurobiol 15 : 135-147
16. Iversen LL, Mortishire-Smith RJ, Pollack SJ, Shearman MS (1995) The toxicity in vitro of β-amyloid protein. Biochem J 311 : 1-16
17. Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y (1994) Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron 13 : 45-53
18. Kosik KS (1992) Alzheimer's disease: a cell biological perspective. Science 256 : 780-783
19. Kowall NW (1994) Beta amyloid neurotoxicity and degeneration in Alzheimer's disease. Neurobiol Aging 15 : 257-258
20. Kowall NW, Kosik KS (1987) Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease. Ann Neurol 22 : 639-643
21. Kowall NW, McKee AC, Yankner BA, Beal MF (1992) In vivo neurotoxicity of beta-amyloid [beta (1-40)] and the beta (25-35) fragment. Neurobiol Aging 13 : 591-594
22. Ksiezak-Reding H, Dickson DW, Davies P, Yen S-H (1987) Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles. Proc Natl Acad Sci USA 84 : 3410-3414
23. Le WD, Xie WJ, Kong R, Appel SH (1997) Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of beta-amyloid precursor protein. J Neurochem 69 : 978-985
24. Lee VM-Y, Otvos L, Carden MJ, Hollosi M, Dietzschold B, Lazzarini R (1988) Identification of the major multiphosphorylation site in mammalian neurofilaments. Proc Natl Acad Sci USA 85 : 1998-2002
25. Lichtenberg-Kraag B, Mandelkow E-M, Biernat J, Steiner B, Schroter C, Gustke N, Meyer HE, Mandelkow E (1992) Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau. Proc Natl Acad Sci USA 89 : 5384-5388
26. Mann DM (1988) The pathological association between Down syndrome and Alzheimer disease. Mech Ageing Dev 43 : 99-136
27. Mercken M, Vandermeeren M, Lubke LJ, Six J, Boons J, Van De Voorde A, Martin J-J, Gheuens J (1992) Monoclonal antibodies with selective specificity for Alzheimer's tau are directed against phosphatase-sensitive epitopes. Acta Neuropathol 84 : 265-272
28. Mirra SS, Heyman A, McKeel D, Sumi SM, Grain BJ, Brownlee LM, Vogel FS, Hughes JP, Belle G van, Berg L (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41 : 479-486
29. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW (1991) In vitro aging of β-amyloid protein cause peptide aggregation and neurotoxicity. Brain Res 563 : 311-314
30. Pike CJ, Cummings BJ, Cotman CW (1992) β-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology. Neuroreport 3 : 769-772
31. Schmidt ML, DiDario AG, Lee VM-Y, Trojanowski JQ (1994) An extensive network of PHFt-rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer's disease. FEBS Lett 344 : 69-73
32. Selkoe DJ (1991) The molecular pathology of Alzheimer's disease. Neuron 6 : 487-498
33. Selkoe DJ (1993) Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease. Trendo Neurosci 16 : 403-408
34. Sherriff FE, Bridges LR, DeSouza DSM (1994) Non-Alzheimer neurofibrillary tangles show β-amyloid-like immunoreactivity. Neuroreport 5 : 1897-1900
35. Sternberger LA, Sternberger NH (1983) Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc Natl Acad Sci USA 80 : 6126-6130
36. Su JH, Cummings BJ, Cotman CW (1993) Identification and distribution of axonal dystrophic neuntes in Alzheimer's disease. Brain Res 625 : 228-237
37. Su JH, Cummings BJ, Cotman CW (1994) Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites. Neuroreport 5 : 2358-2362
38. Su JH, Cummings BJ, Cotman CW (1994) Subpopulations of dystrophic neurites in Alzheimer's brain with distinct immunocytochemical and argentophilic characteristics. Brain Res 637 : 37-44
39. Su JH, Cummings BJ, Cotman CW (1996) Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res 739 : 79-87
40. Tabaton M, Cammarata S, Mandybur T, Richey P, Kawai M, Perry G, Gambetti P (1992) Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormalities. Brain Res 593 : 299-303
41. Takashima A, Noguchi K, Michel G, Mercken M, Hoshi M, Ishiguro K, Imahori K (1996) Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta. Neurosci Lett 203 : 33-36
42. Takashima A, Noguchi K, Sato K, Hosino T, Imahori K (1993) Tau protein kinase I is essential for amyloid β-protein-induced neurotoxicity. Proc Natl Acad Sci USA 90 : 7789-7793
43. Trojanowski JQ, Schmidt ML, Shin R-W, Bramblett GT, Goedert M, Lee VM-Y (1993) PHFτ (A68): from pathological marker to potential mediator of neuronal dysfunction and degeneration in Alzheimer's disease. Clin Neurosci 1 : 1-4
44. Vickers JC, Delacourte A, Morrison JH (1992) Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease. Brain Res 594 : 273-278
45. Vickers JC, Riederer BM, Marugg RA, Buee-Scherrer V, Buee L, Delacourte A, Morrison JH (1994) Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease. Neuroscience 62 : 1-13
46. Vickers JC, Chin D, Edwards A-M, Sampson V. Harper C, Morrison JH (1996) Dystrophic neunte formation associated with age-related β amyloid deposition in the neocortex: clue to the genesis of neurofibrillary pathology. Exp Neurol 141 : 1-11
47. Yamamoto T, Hirano A (1986) A comparative study of Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles. Neuropathol Appl Neurobiol 12 : 3-9
48. Yankner BA (1996) Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16 : 921-932